• Phonetics and Speech Sciences
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• v.7 no.3
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• pp.13-26
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• 2015

Speech production studies have suggested that bilinguals who are L2-dominant are the most likely to suppress the influence of the first language (L1) on the second language (L2). The voice onset times (VOTs) and fundamental frequencies (f0s) of monolingual and bilingual speakers of English and Korean were examined to address the question whether cross language influences occur particularly in L2 predominant bilinguals and to compare their outcomes with those of L2 proficient bilinguals and monolinguals. A total of 28 speakers participated in this experiment and they produced English and Korean stops in the carrier sentence. In English, for voiceless aspirated and unaspirated stops, L2 predominant bilingual speakers produced VOTs that were significantly shorter than those of monolingual English speakers. The outcome was analogous in Korean speech. For aspirated and lax stops, they produced shorter Korean VOTs than monolingual speakers. The results of f0s were slightly different from those of VOTs. In English, L2 predominant bilinguals produced f0s that were not significantly different from those of monolingual English speakers. In Korean, however, they produced f0s that were significantly different from those of monolingual Korean speakers. Taken VOT and f0 into consideration together, the overall results suggest that, although they tend to show a corresponding pattern of monolinguals, L2 predominant bilinguals had cross language phonetic influences between L1 and L2, similar to L2 proficient bilinguals. Between the two acoustic cues, f0 seemed to be a more reliable cue than VOT to examine the influences.

• Tuberculosis and Respiratory Diseases
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• v.44 no.6
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• pp.1382-1389
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• 1997

Hantavirus pulmonary syndrome(HPS) is a systemic disease that is caused by a newly discorved and characterized virus of the Hantavirus genus, which is most frequently referred to as the sin nombre virus. The clinical syndrome resembles other hantavirus syndromes worldwide, except that it is characterized by a brief prodromal illness followed by rapidly progressive, noncardiogenic edema, and that it is more deadly than any previously recognized hantavirus infection. The clinical manifestations of HPS are characterized by four clinical phases : prodrome, pulmonary edema and shock, diuresis, and convalescence. Mortality is greatest in the first 24 hours of the pulmonary edema and shock phase of the illness. These phases are strikingly similar to the clinical phases of Hemorrhagic fever with renal syndrome(HFRS) induced by Hantaan virus, except that HPS has not been associated with renal failure and Disseminated intravascular coagulation(DIC). We here report a case of hantavirus pulmonary syndrome developed in a 58 year-old man. He had a flu-like illness followed by the rapid onset of respiratory failure due to noncardiogenic pulmonary edema. HPS was diagnosed by clinical manifestations, identification of high titer antibody to Hantaan virus antigen and histologic finding of transbronchial lung biopsy (TBLB) specimen. The patient was treated with mechanical ventilation and initial corticosteroid pulse therapy resulting in successful outcome.

• Structural Engineering and Mechanics
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• v.12 no.5
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• pp.507-526
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• 2001

In standard finite element algorithms, the local stability conditions are not accounted for in the formulation of the tangent stiffness matrix. As a result, the loss of the local stability is not adequately related to the onset of the global instability. The phenomenon typically arises with material-type localizations, such as shear bands and plastic hinges. This paper addresses the problem in the context of the planar, finite-strain, rate-independent, materially non-linear beam theory, although the proposed technology is in principle not limited to beam structures. A weak formulation of Reissner's finite-strain beam theory is first presented, where the pseudocurvature of the deformed axis is the only unknown function. We further derive the local stability conditions for the large deformation case, and suggest various possible combinations of the interpolation and numerical integration schemes that trigger the simultaneous loss of the local and global instabilities of a statically determined beam. For practical applications, we advice on a procedure that uses a special numerical integration rule, where interpolation nodes and integration points are equal in number, but not in locations, except for the point of the local instability, where the interpolation node and the integration point coalesce. Provided that the point of instability is an end-point of the beam-a condition often met in engineering practice-the procedure simplifies substantially; one of such algorithms uses the combination of the Lagrangian interpolation and Lobatto's integration. The present paper uses the Galerkin finite element discretization, but a conceptually similar technology could be extended to other discretization methods.

• Molecules and Cells
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• v.41 no.2
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• pp.73-82
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• 2018

Cancer preventive activities of green tea and its main constituent, (-)-epigallocatechin gallate (EGCG) have been extensively studied by scientists all over the world. Since 1983, we have studied the cancer chemopreventive effects of EGCG as well as green tea extract and underlying molecular mechanisms. The first part of this review summarizes groundbreaking topics with EGCG and green tea extract: 1) Delayed cancer onset as revealed by a 10-year prospective cohort study, 2) Prevention of colorectal adenoma recurrence by a double-blind randomized clinical phase II trial, 3) Inhibition of metastasis of B16 melanoma cells to the lungs of mice, 4) Increase in the average value of Young's moduli, i.e., cell stiffness, for human lung cancer cell lines and inhibition of cell motility and 5) Synergistic enhancement of anticancer activity against human cancer cell lines with the combination of EGCG and anticancer compounds. In the second part, we became interested in cancer stem cells (CSCs). 1) Cancer stem cells in mouse skin carcinogenesis by way of introduction, after which we discuss two subjects from our review on human CSCs reported by other investigators gathered from a search of PubMed, 2) Expression of stemness markers of human CSCs compared with their parental cells, and 3) EGCG decreases or increases the expression of mRNA and protein in human CSCs. On this point, EGCG inhibited self-renewal and expression of pluripotency-maintaining transcription factors in human CSCs. Human CSCs are thus a target for cancer prevention and treatment with EGCG and green tea catechins.

• Journal of the Korean earth science society
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• v.23 no.5
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• pp.436-441
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• 2002

This study is concerned with the sea breeze criterion and climatological characteristics of the short-time sea breeze in the Gangneung coastal area. The sea breeze criteria in this area are listed here. First, the fact of the sea breeze blowing was considered to be a change of wind direction from land to sea and vice versa without terrain effect like easterly wind. Second, the sea breeze of which continuous time 1-hour or 2-hour was selected. Then the climatological characteristics of the short-time sea breeze were analyzed using the meterological data from a 10-year(1988${\sim}$1997) period. The climatological characteristics which were analyzed for the short-time sea breeze consist of the frequency, onset time, wind direction speed and temperature. Finally, this study will be helpful in meteorological application through the climatological characteristics of sea breeze along the east coast as well as Gangneung Airport.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1480-1485
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• 2009

We conducted this study to report the clinical manifestations of 5 acute viral hepatitis type A treated by oriental medical treatment. Five hepatitis A patients who visited OO oriental hospital from May 2008 to July 2009 were treated by oriental medical treatment, including herbal acupuncture, acupuncture and herbal medicine and western medical treatment, including fluid therapy and peroral medicine. Prodromes were similar to influenza and duration from symptom onset to first visit were $5.0\;{\pm}\;1.6$ days. Chief symptoms included jaundice, itching, dark urine, anorexia, fatigue, nausea, vomiting, abdominal discomfort. The mean values of the initial laboratory test were serum total bilirubin(TB) of $3.62\;{\pm}\;2.77\;mg/dL$, aspartate aminotransferase(AST) of $729\;{\pm}\;422\;IU/L$, alanine aminotransferase(ALT) $774\;{\pm}\;754\;IU/L$. The peak mean values of those were $6.30\;{\pm}\;2.13\;mg/dL$, $2177\;{\pm}\;2573\;IU/L$, $2238\;{\pm}\;1682\;IU/L$ respectively. The mean duration of hospitalization were $15\;{\pm}\;3$ days. Follow-up at 3 weeks after discharge showed that all patients recovered without complications. Treatment of oriental medicine has effectiveness on acute viral hepatitis type A. Further study is needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.6
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• pp.1655-1659
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• 2007

The purpose of this study was to investigate that which symptoms are adequate indicator of the deficiency of Eum pattern in the stroke patients. In the time period Dec. 2006 to Aug. 2007, 479 patients with a first-ever stroke admitted in the department of Internal Medicine of 12 Oriental Medical Hospitals were included. Patients were hospitalized within 1 months after the onset of stroke. Stroke patients had been interviewed by resident who studied standard operation procedures in Fundamental Study for Standardization and Objectification of Differentiation and Pattern Identification of Syndrome of Oriental Medicine for Stroke. Eum-deficiency patients was confirmed by medical specialist diagnosis, resident diagnosis, case report form analysis without a dissenting voice. Deficiency of Eum group included 65 case, Non Eum group 414 case out of 479 patients. dryness of mouth, short and rapid purse, white face and reddish zygoma, mirror-like tongue were higher among Eum group. Eum and Non Eum patients do not significantly differ in reddened tongue, dryness in tongue, night sweat, palpitation, afternoon tidal heat, palmar heat, sores of the mouth or tongue. This study was insufficiency because sample size is very small. More data from prospective cohort studies will help to Korean Standard Differentiation of the Symptoms and Signs for the Stroke.

• Archives of Plastic Surgery
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• v.37 no.4
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• pp.489-491
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• 2010

Purpose: Retrobulbar hemorrhage is a rare complication followed by blepharoplasty, trauma, orbital reconstruction, and so on. Most of the cases occur within 24 hours, half of them in the first 6 hours. Some authors have reported delayed retrobulbar hemorrhage after blepharoplasty and trauma within 1 day to 9 days. However, there have been few reports of delayed retrobulbar hemorrhage resulting from the complication of orbital reconstruction. Methods: A 22-year-old male underwent orbital floor reconstruction due to the orbital floor fracture. In 84 hours after the surgery, he complained sudden onset orbital pain and decreased visual acuity immediately after defecation. Intraocular pressure was unmeasurable due to the swelling at that time. Emergency computed tomography was performed. Results: Computed tomography revealed subperiosteal hematoma on inferior orbital wall extended to the apex. Emergency decompressive surgery was performed within 1 hour. After evacuation of hematoma, orbital symptom was improved and visual acuity was restored. Conclusion: Delayed retrobulbar hemorrhage is rare but vision-threatening. Therefore early diagnosis and treatment of delayed retrobulbar hemorrhage is thought to be crucial. The cause of delayed hemorrhage was not clear, however, valsalva maneuver might be the cause of hemorrhage.

• Journal of Chest Surgery
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• v.39 no.4 s.261
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• pp.328-331
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• 2006

Recurrent spontaneous pneumothorax associated with menstrual cycle was described first by Maurer in 1958. Lilington and colleague established the term 'catamenial pneumothorax' and reported 5 patients in 1972. Catamenial pneumothorax is defined as recurrent spontaneous pneumothorax occurring within 72 hours before or after the onset of menstruation, but the pathophysiology is not clearly understood, We report a recent experience of 37 years-old woman with catamenial pneumothorax, who was treated by thoracoscopic surgery.

• Journal of Yeungnam Medical Science
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• v.18 no.1
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• pp.13-29
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• 2001

The enzyme activities of creatine kinase (CK), its isoenzyme MB (CK-MB) and of lactate dehydrogenase isoenzyme 1 (LD-1) have been used for years in diagnosing patients with chest pain in order to differentiate patients with acute myocardial infarction (AMI) from non-AMI patients. These methods are easy to perform as automated analyses, but they are not specific for cardiac muscle damage. During the early 90's the situation changed. First, creatine kinase ME mass (CK-MB mass) replaced the measurement of CK-MB activity. Subsequently cardiac-specific proteins, troponin T (cTnT) and troponin I (cTnI) appeared and displacing LD-1 analysis. However, troponin concentrations in blood increase only from four to six hours after onset of chest pain. Therefore a rapid marker such as myoglobin, fatty acid binding protein or glycogen phosphorylase BB could be used in early diagnosis of AMI. On the other hand, CK-MB isoforms alone may also be useful in rapid diagnosis of cardiac muscle damage. Myoglobin, CK-MB mass, cTnT and cTnI are nowadays widely used in diagnosing patients with acute chest pain. Myoglobin is not cardiac-specific and therefore requires supplementation with some other analyses such as troponins to support the myoglobin value. Troponins are very highly cardiac-specific. Only the sera of some patients with severe renal failure, which requires hemodialysis, have elevated cTnT and/or cTnI without there being any evidence of cardiac damage. The latest studies have shown that elevated troponin levels in sera of hemodialysis patients point to an increased risk of future cardiac events in a similar manner to the elevated troponin values in sera of patients with unstable angina pectoris. In addition, the bedside tests for cTnT and cTnI alone- or together with myoglobin and CK-ME mass can be used instead of quantitative analyses in the diagnosis of patients with chest pain. These rapid tests are easy to perform and they do not require expensive instrumentation. For the diagnosis of patient with chest pain, routinely myoglobin and CK-ME mass measurements should be performed whenever they are requested (24 h/day) and cTnT or cTnI on admission to the hospital and then 4-6 and 12 hours later and maintained less than 10% in imprecision.