• Korean Chemical Engineering Research
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• 제61권4호
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• pp.570-575
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• 2023

Targeted anticancer drug delivery systems are needed to enhance therapeutic efficacy by selectively delivering drugs to tumor cells while minimizing off-target effects, improving treatment outcomes and reducing toxicity. In this study, a silica-based nanocarrier capable of targeting drug delivery to cancer cells was developed. First, silica nanoparticles were synthesized by the Stöber method using the surfactant cetyltrimethylammonium bromide (CTAB). Increasing the ratio of EtOH in the solvent produced uniformly spherical silica nanoparticles. Washing the nanoparticles removed unreacted residues, resulting in a non-toxic carrier for drug delivery in cells. Upon surface modification, the pH-responsive polymer, polyethyleneimine (PEI) exhibited slow doxorubicin release at pH 7.4 and accelerated release at pH 5.5. By exploiting this feature, we developed a system capable of targeted drug release in the acidic tumor microenvironment.

• 디지털산업정보학회논문지
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• 제19권4호
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• pp.163-177
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• 2023

In this study, delivery workers were regarded as workers and industrial accident and serious accident prevention were studied. As a result of the study, first, it was confirmed that awareness of safety guidelines has an effect on disaster prevention and is related to reducing serious accidents. Second, among the forms of organizational culture, rational culture was shown to have a positive impact on serious accidents. Third, the moderating effect of organizational culture Rational culture, a sub-concept, was found to have a moderating effect on serious accidents. Fourth, according to the opinions of workers for disaster prevention of delivery workers, it was classified into policy part, environmental part, and worker's duty part, and the necessity of strengthening safety education and strong regulation was suggested in the policy part.

• 디지털산업정보학회논문지
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• 제15권4호
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• pp.159-171
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• 2019

The purpose of this study was to understand the influence of research of consumers' consumption values and toward usage attitude, usage intention and willingness to pay of modern people. The study is a consumer research about food delivery services which is rapidly grown up due to recent transformation on a modern dietary life. This study was based on the main survey had conducted from 23th May 2019 to 26th May 2019 by 336 consumers, aged 18 and older, who had experienced Food delivery services in the past. Statistical analysis was performed by using the IBM SPSS v.25.0. In summary, the results of this study are as follows. First, consumption values of food delivery services had a positive influence on usage attitude. Consumption values were catagorized in five sub-values: functional value, social value, emotional value, epistemic value, and conditional value, all of which were found to be significant in affecting on usage attitude. Second, usage attitude toward food delivery services had a positive influence on usage intention. Third, usage attitude toward food delivery services had a positive influence on willingness to pay. Fourth, usage intention of food delivery services had a positive influence on willingness to pay. The results of the study renders industrial and academic implications to the area of Food delivery services industry.

• Animal Bioscience
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• 제36권9호
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• pp.1376-1383
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• 2023

Objective: We aimed to determine the effects of 12-oxoeicosatetraenoic acid (12-KETE)-induced placenta release on the performance of mother cows (milk yield, ovarian function, and blood plasma biochemical properties). Methods: Experimental treatments were as follows: i) natural delivery including natural placental release (control cows); ii) induced calf delivery with placental retention (RP cows); and iii) induced calf delivery and 12-KETE-induced placental release (KE cows). Delivery in pregnant KE cows was induced with dexamethasone and prostaglandin. These cows were injected with 12-KETE after calf discharge, resulting in the release of the fetal placenta. RP cows were not treated with 12-KETE after inducing delivery, resulting in placental retention. Results: The milk yield in RP cows during the first 50 days after delivery was significantly lower than that in control cows (p<0.05), whereas KE cows exhibited a similar milk yield to that of control cows. The postpartum plasma progesterone levels of control cows increased 14 days after delivery on average; however, its increase was delayed by 10 days in RP cows. Meanwhile, the 12-KETE treatment (KE cows) brought the timing of progesterone increase forward to the normal level (control cows). Among the 20 biochemical parameters examined, the total cholesterol levels in blood plasma 14 days after delivery were lower in RP cows than that in the other two treatment groups (control cows and KE cows) (p<0.05). In addition, the plasma level of haptoglobin tended to be low in cows that discharged their placentas shortly after delivery. Conclusion: These findings indicate that 12-KETE treatment can alleviate the disorder caused by placental retention.

• 한국의상디자인학회지
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• 제6권2호
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• pp.49-62
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• 2004

By delivery means of fashion information, fashion dolls appeared in 18th century. According to development of printing, delivery means of fashion information changed from fashion dolls to fashion plates. Fashion plates offer a colorful and in depth view of the stylish fashions of the past. First fashion plate was Hollars print that was inserted to $\ulcorner$La Galerie des Modes et Costumes Francais$\lrcorner$ and that was published at England in 1643. First fashion plate in France could assumes as winter deshabill that was inserted to $\ulcorner$Le Mercure Galant$\lrcorner$ in 1678. The widespred publication of fashion plates began in England and France in the late 18th century. The first true fashion magazine $\ulcorner$The Ladys Magazine$\lrcorner$ was published at London in 1770. And suddenly similar plates were being published all over Europe. Fashion plates reached their height of popularity in the mid-1800s. Modern age in Europe for fashion magazines golden age, hundreds kinds of fashion magazines published in Europe. Copyright laws in Europe were not enforced, resulting in widespread piracy of fashion designs and plates. After 19th century, America and Europe used much Paris imitation plate. $\ulcorner$The Ladys Magazine$\boxUl$, $\ulcorner$La Gallerie des Modes et Costumes Francais$\lrcorner$, $\ulcorner$Les Cabinet des Modes$\lrcorner$, $\ulcorner$Journal des Dames et des Modes$\lrcorner$, $\ulcorner$The Ladys Monthly Museum$\lrcorner$ were the important fashion magazines in 18th century. $\ulcorner$The Ladys Pocket Magazine$\lrcorner$, $\ulcorner$La Mode$\lrcorner$, $\ulcorner$Le Follet$\lrcorner$, $\ulcorner$La Mode Illustree$\lrcorner$, $\ulcorner$$\ulcorner$The Queen$\lrcorner$ were the important fashion magazines in 19th century. $\ulcorner$Journal des Dames et des Modes$\lrcorner$, $\ulcorner$Gazette du bon ton$\lrcorner$ were the important fashion magazines in early 20th century.

• Journal of Chest Surgery
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• 제6권1호
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• pp.89-94
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• 1973

Esophagel atresia and tracheoesophageal fistula may occur as separate entities but usually occur in combination. First described by Durston in 1670, esophageal atresia was not successfully treated until 1939 when Ladd in Boston and Leven in St. Paul obtained the first survivors utilizing the methods of gastrostomy, esophagostomy and extrapleural ligation of the tracheoesophageal fistula as multiple operations which required months of hospitalization. Two years later Cameron Haight performed the first successful primary repair and afterward about 2000 cases of esophageal atresia with distal tracheoesophageal fistula reported in the world. In Korea, there appeared about 27 cases in the literature and 8 successful repaired cases noted in these year. Anther report two cases of esophageal atresia, of which one case was successfully treated with Haight`s method. Case 1.: Normal full term delivered boy with chief complaints of respiratory difficulty and persistent drooling with chocking, 3. lkg, was admitted with emergency 5 hours after delivery. Physical findings revealed no specific abnormal signs except distended abdomen and grunting respiration. Esophagograrn and bronchogram revealed proximal esophageal atresia and distal tracheoesophageal fistula proximal to the carina. Parent refused operative therapy and patient died 24 hours after discharge. Case 2. :3. lkg. normal full term delivered girl was admitted 4 days after delivery with chief complaints of regurgitation after feeding, chocking, cyanotic spell and fever since the day after delivery. Physical examination revealed persistent drooling, grunting respiration, and fever with moderate dehydration. Tracheoesophageal suction and fluid therapy with antibiotics improved her condition and subsided ]pneumonic condition. Esophagogram revealed markedly dilated proximal esophagus as blind loop and stomach distended with gas, and repairing operation as Haight`s method was performed on the 7th day after delivery. Patient tolerated all the operative procedure well and recovered uneventfully. Esophagogram on the 7th postoperative day showed passage of the lipiodol through the anastomotic side with moderate stricture,and feeding permitted. Patient tolerated all the feeding amount well and discharged on the 11th postoperative day. Followup revealed intermittent regurgitation after feeding and corrected with bougination.

• 대한지역사회영양학회지
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• 제6권2호
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• pp.182-191
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• 2001

Anemia in women during pregnancy and after delivery has been known to affect the mother, the fetus, and the infant's growth and health status. Studies examining, changes in iron and folate status associated with anemia during pregnancy and during pregnancy, and those supplements are stopped after postpartum. However, the effects of those have not been clearly determined in pregnant and lactating Korea women. Therefore, this study was performed to determine the changes in maternal iron and folate status during pregnancy and six months after delivery longitudinally in six pregnant women who consumed supplements from 20 wk to delivery. We concluded that the iron status deteriorated during pregnancy and especially was weak in the third trimester, but had a tendency to recovery after delivery. On the other hand, the folate status deteriorated in the first and second trimester and was good in the third trimester, but had a tendency to decrease after delivery. These results suggested that the iron status was not improved despite consuming total iron supplements of 50 mg/day through diets and supplements during the second half of the pregnancy. On the other hand, the folate status improved at the end of pregnancy by consuming folate supplements of a total of 800 mg/day through diets and supplements. However, folate status was poor in the first half of the pregnancy, and the tendency of folate status to decrease during postpartum was advanced. At the point in which iron and therefore supplementation is essential. However, the effects of supplement intake time and intake dosage need to be verified and the nutritional status changes of postpartum women should be carefully monitored.

• 한국컴퓨터정보학회논문지
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• 제19권2호
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• pp.143-150
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• 2014

본 논문에서는 트리에서의 배달문제를 제안하고, 이를 해결하는 두 개의 알고리즘을 제안한다. 트리상에서의 배달문제는 n개의 서로 다른 이동속도를 갖는 로봇을 이용하여 배달물을 트리의 한 노드에서 다른 노드로 배달하는 시간을 최소화 하는 문제이다. 첫 번째 알고리즘은 핸드오버가 발생하는 장소에 대한 제한을 두어 트리에서의 배달문제를 위한 최적해를 생성한다. 이 알고리즘에서 핸드오버는 주어진 트리의 정점에서만 발생하는 것으로 가정하며, 시작점에서 도착점까지 핸드오버가 발생하는 위치와 핸드오버에 참여하는 로봇의 색인을 순서대로 찾는 방법으로 문제를 해결한다. 두 번째 알고리즘은 첫 번째 알고리즘을 확장하여 핸드오버 장소에 대한 제약을 제거하며, 여전히 최적해를 생성한다. n을 로봇의 수라 하고, m을 트리의 노드 수라 할 때 두 개의 알고리즘은 모두 $O((n+m)^2)$ 시간복잡도를 갖는다.

• 한국도로학회논문집
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• 제20권2호
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• pp.45-55
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• 2018

PURPOSES : This study aims to survey and analyze the status of the design and completion documents output delivery system in public construction projects in order to assess the problems of the Ministry of Land, Infrastructure and Transport (MOLIT)'s electronic delivery system, with a focus on roads and rivers, and to offer improvement measures. METHODS : This study first surveys and analyzes laws and existing study trends with regard to the design and completion documents output delivery system in public construction projects. It further analyzes the status of the output delivery system in public construction projects, including roads, rivers, expressways, water resources, and railroads. In addition, a comparative analysis of the current electronic delivery system of MOLIT and Korea Expressway Corporation in the road field is conducted, and the problems and improvement measures for MOLIT's electronic output delivery system are presented. This study seeks to analyze problems and prepare improvement measures with regard to road and river public construction projects, as ordered by MOLIT's five regional offices. RESULTS : This study sought to prepare the electronic output delivery system with regard to public construction projects and present the analysis of its major problems and improvement measures in four categories: "the preparation of electronic design documents output delivery system improvement measures including inspection and delivery," "preparation of guidelines, systems, etc., concerning electronic design documents," "preparation of improvement measures for the construction project management system and electronic design document support tools", and "linking of MOLIT's electronic output delivery system with relevant agencies and the expansion thereof to local governments." CONCLUSIONS : This study analyzed the current status and problems of the MOLIT's electronic output delivery system in the field of road and river construction projects, and presented corresponding improvement measures. This study is expected to address the problems of the MOLIT's electronic output delivery system, and to provide the foundation for the preparation of an efficient electronic output delivery system for design and completion documents. In addition, this study is expected to boost the quality and utilization of the electronic design documents output, and to exchange, share, and link construction information among relevant agencies so as to prepare the foundation for sharing construction information.

• Journal of Periodontal and Implant Science
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• 제53권1호
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• pp.20-37
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• 2023

Purpose: Our pilot study showed that a 3-dimensional dual drug delivery scaffold (DDDS) loaded with Chinese herbs significantly increased the regenerated bone volume fraction. This study aimed to confirm the synergistic anti-inflammatory and osteogenic preclinical effects of this system. Methods: The targets and pathways of parthenolide and naringin were predicted. Three cell models were used to assess the anti-inflammatory effects of parthenolide and the osteogenic effects of naringin. First, the distance between the cementoenamel junction and alveolar bone crest (CEJ-ABC) and the bone mineral density (BMD) of surgical defects were measured in a rat model of periodontitis with periodontal fenestration defects. Additionally, the mRNA expression levels of matrix metallopeptidase 9 (MMP9) and alkaline phosphatase (ALP) were measured. Furthermore, the number of inflammatory cells and osteoclasts, as well as the protein expression levels of tumor necrosis factor-alpha (TNF-α) and levels of ALP were determined. Results: Target prediction suggested prostaglandin peroxidase synthase (PTGS2) as a potential target of parthenolide, while cytochrome P450 family 19 subfamily A1 (CYP19A1) and taste 2 receptor member 31 (TAS2R31) were potential targets of naringin. Parthenolide mainly targeted inflammation-related pathways, while naringin participated in steroid hormone synthesis and taste transduction. In vitro experiments revealed significant antiinflammatory effects of parthenolide on RAW264.7 cells, and significant osteogenic effects of naringin on bone marrow mesenchymal stem cells and MC3T3-E1 cells. DDDS loaded with parthenolide and naringin decreased the CEJ-ABC distance and increased BMD and ALP levels in a time-dependent manner. Inflammation was significantly alleviated after 14 days of DDDS treatment. Additionally, after 56 days, the DDDS group exhibited the highest BMD and ALP levels. Conclusions: DDDS loaded with parthenolide and naringin in a rat model achieved significant synergistic anti-inflammatory and osteogenic effects, providing powerful preclinical evidence.