• Journal of Korean Institute of Industrial Engineers
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• v.42 no.1
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• pp.57-64
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• 2016

Pen-based interaction is universally available on smart devices and especially on Tablet PCs. Previous studies compared various input methods like fingers, a mouse or a stylus pen on PCs or on a touchscreen based devices such as smart phones. At the same time, various soft keyboard applications are being developed on application stores of smart devices. However, these previous studies did not suggest which one is a suitable keyboard application for Tablet PCs when users perform a certain interaction as input type. In this study, we compared two types of input methods (finger and pen) and three types of soft keyboard applications (QWERTY, Gesture and Swype) in a Tablet PC using performance measurements (accuracy and input speed) and discussed what types of applications showed better performance with each interaction on tablet PC. From these results, recommendations for the keyboard types depending on the input methods on tablet PCs were developed.

• Journal of Institute of Control, Robotics and Systems
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• v.11 no.5
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• pp.445-450
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• 2005

In this paper, we suggest an integrated tactile display system that provides kinesthetic force, pressure distribution, vibration and slip/stretch. The system consists of two parts: a 2 DOF force feedback device for kinesthetic display and a tactile feedback device for displaying the normal stimulation to the skin and the skin slip/stretch. Psychophysical experiments measure the effects of fingerpad selection, the direction of finger movements and the texture width on tactile sensitivity. We also investigate the characteristics of lateral finger movement while subjects perceive different textures. From the experimental results, the principal parameters for designing a tactile display are suggested. A tactile display device, using eight piezoelectric bimorphs and a linear actuator, Is implemented and attached to a 2 DOF translational force feedback device to simultaneously simulate the texture and stiffness of the object. As a result, we find out that the capability of the suggested device is sufficient to display physical quantities to display the texture.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.6
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• pp.1103-1108
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• 2016

The development of a variety of sensor technology, users smart phone, the use of motion recognition apparatus such as a console game machines is increasing. It tends to user needs motion recognition-based input device are increasing. Existing motion recognition mouse is equipped with a modified form of the mouse button on the outside and serves as a wheel mouse left and right buttons. Existing motion recognition mouse is to manufacture a small, there is a difficulty to operate the button. It is to apply the motion recognition technology the motion recognition technology is used only pointing the cursor there is a limit. In this paper, use of MEMS-based motion recognition sensor, the body of the two-point operation data by recognizing the operation of the (thumb and forefinger) and generating a control signal, followed by studies on the generated control signal to a wireless transmitting computer input device.

• Journal of KIISE:Software and Applications
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• v.29 no.11
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• pp.851-859
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• 2002

This paper discusses the design of a working system that visually recognizes hand gestures for the control of a window based user interface. We present a method for tracking the fingertip of the index finger using a single camera. Our method is based on CAMSHIFT algorithm and performs better than the CAMSHIFT algorithm in that it tracks well particular hand poses used in the system in complex backgrounds. We describe how the location of the fingertip is mapped to a location on the monitor, and how it Is both necessary and possible to smooth the path of the fingertip location using a physical model of a mouse pointer. Our method is able to track in real time, yet not absorb a major share of computational resources. The performance of our system shows a great promise that we will be able to use this methodology to control computers in near future.

• Biomolecules & Therapeutics
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• v.31 no.5
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• pp.573-582
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• 2023

Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderate-intensity aerobic exercise in a methylglyoxal-induced muscle atrophy animal model. Each mouse was randomly divided into three groups: control, methylglyoxal-treated, and methylglyoxal-treated within aerobic exercise. In the exercise group, each mouse was trained on a treadmill for 2 weeks. On the last day, all groups were evaluated for several atrophic behaviors and skeletal muscles, including the soleus, plantaris, gastrocnemius, and extensor digitorum longus were analyzed. In the exercise group, muscle mass was restored, causing in attenuation of muscle atrophy. The gastrocnemius and extensor digitorum longus muscles showed improved fiber cross-sectional area and reduced myofibrils. Further, they produced regulated atrophy-related proteins (i.e., muscle atrophy F-box, muscle RING-finger protein-1, and myosin heavy chain), indicating that aerobic exercise stimulated their muscle sensitivity to reverse skeletal muscle atrophy. In conclusion, shortness of the gastrocnemius caused by methylglyoxal may induce the dynamic imbalance of skeletal muscle atrophy, thus methylglyoxal may be a key target for treating skeletal muscle atrophy. To this end, aerobic exercise may be a powerful tool for regulating methylglyoxal-induced skeletal muscle atrophy.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.6
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• pp.781-787
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• 2017

Objective: The early growth response (Egr) family consists of four members (Egr1, Egr2, Egr3, and Egr4) that are zinc finger transcription factors. Among them, Egr3 is involved in transcriptional regulation of target genes during muscle spindle formation and neurite outgrowth. We previously showed that the immunoreactive Egr3 is localized on oocyte spindle and accumulate near the microtubule organizing center during meiosis I in mice. Egr3 was also shown to be localized on spermatocytes. We herein investigated if Egr3 is expressed in mouse gonads and if Egr3 blockade results in any defect in oocyte maturation. Methods: Expression of Egr3 in mouse gonads was examined by reverse transcription-polymerase chain reaction. Full-length Egr3 and truncated Egr3 (${\Delta}Egr3$) complementary RNAs (cRNAs) with Xpress tag at N-terminus and DsRed2 at C-terminus, and small interfering RNA (siRNA) targeting Egr3 were microinjected into mouse oocytes at germinal vesicle stage. Localization of microinjected Egr3 was examined by confocal live imaging and immunofluorescence staining. Results: Egr3 mRNA was detected in mouse ovaries and testes from 1 to 4 week-old mice. An uncharacterized longer transcript containing 5'untranslated region was also detected in 3 and 4 week-old gonads. Microinjected Xpress-Egr3-DsRed2 or Xpress-${\Delta}Egr3$-DsRed2 localized to nuclei and chromosomes during meiotic progression. Microinjection of these cRNAs or Egr3 siRNA in oocytes did not affect meiotic maturation. Immunofluorescence staining of Egr3 in Xpress-${\Delta}Egr3$-DsRed2-injected oocytes showed a positive signal only on meiotic spindle, suggesting that this antibody does not detect endogenous or exogenous Egr3 in mouse oocytes. Conclusion: The results show that Egr3 localizes to chromosomes during meiotic progression and that certain antibodies may not faithfully represent localization of target proteins in oocytes. Egr3 seems to be dispensable during oocyte maturation in mice.

• Biomolecules & Therapeutics
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• v.17 no.4
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• pp.438-445
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• 2009

We investigated global gene expression from both mouse liver and mouse hepatic cell lines treated with acetaminophen (APAP) in order to compare in vivo and in vitro profiles and to assess the feasibility of the two systems. During our analyses of gene expression profiles, we picked up several down-regulated genes, such as the cytochrome P450 family 51 (Cyp51), sulfotransferase family cytosolic 1C member 2 (Sult1c2), 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), and several genes that were up-regulated by APAP, such as growth arrest and DNA-damage-inducible 45 alpha (Gadd45a), transformation related protein 53 inducible nuclear protein 1 (Trp53inp1) and zinc finger protein 688 (Zfp688). For validation of gene function, synthesized short interfering RNAs (siRNAs) for these genes were transfected in a mouse hepatic cell line, BNL CL.2, for investigation of cell viability and mRNA expression level. We found that siRNA transfection of these genes induced down-regulation of respective mRNA expression and decreased cell viability. siRNA transfection for Cyp51 and others induced morphological alterations, such as membrane thickening and nuclear condensation. Taken together, siRNA transfection of these six genes decreased cell viability and induced alteration in cellular morphology, along with effective inhibition of respective mRNA, suggesting that these genes could be associated with APAP-induced toxicity. Furthermore, these genes may be used in the investigation of hepatotoxicity, for better understanding of its mechanism.

• Journal of the Korea Society of Computer and Information
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• v.15 no.5
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• pp.33-38
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• 2010

In this paper, we proposed an algorithm implementing mouse functions using hand motion and number of fingers which are extracted from an image sequence. The sequence is acquired through a web camera and processed with image processing algorithms. The sequence is first converted from RGB model to YCbCr model to efficiently extract skin area and the extracted area is further processed using labeling, opening, and closing operations to decide the center of a hand. Based on the center position, the number of fingers is decided, which serves as the information to decide and perform a mouse function. Experimental results show that 94.0% of pointer moves and 96.0% of finger extractions are successful, which opens the possibility of further development for a commercial product.

• Laboraroty Animal Research
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• v.34 no.4
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• pp.311-316
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• 2018

Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a newly developing inbred strain (KWM/Hym) captured from Chuncheon, Korea. All of five Korean wild male mice have the zinc-finger Y (ZfY) gene. Also, all of 19 Korean wild mice used in this analysis have the AKV-type murine leukemia virus gene, indicating that Korean wild mice might be Mus musculus musculus. To identify the genetic polymorphism in KWM/Hym, SNP analysis was performed. In a comparison with 28 SNP markers, there was a considerable difference between KWM/Hym and several inbred strains. The homogeneity between KWM/Hym and the inbred strains was as follows: C57BL/6J (39.3%), BALB/c AJic (42.9%), and DBA/2J (50%). KWM/Hym is most similar to the PWK/PhJ inbred strain (96.4%) derived from wild mice (Czech Republic). To identify the morphometric characteristics of KWM/Hym, the external morphology was measured. The tail ratio of male and female was $79.60{\pm}3.09$ and $73.55{\pm}6.14%$, respectively. KWM/Hym has short and agouticolored hairs and its belly is white with golden hair. Taking these results together, KWM/Hym, a newly developing inbred mouse originated from wild mouse, might be use as new genetic resources to overcome the limitations of the current laboratory mice.

• 한국전산유체공학회:학술대회논문집
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• 2004.03a
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• pp.56-61
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• 2004

As the size and dimension of target problems in the field of computational engineering including CFD gets bigger and higher, it is needed to have more efficient and flexible data visualization environment in terms of software and hardware. Even though it is still manageable to use a mouse in controlling 3-dimensional data visualization, it would be beneficial to use 3-D input device for 3-D visualization. 'Data Glove' is one of the best 3-D input devices, because human hands are best tools understanding 3-D space. Signals coming from 'Data Glove' are analog and very sensitive to finger motions, so we decided to use a digital filter. This paper describes our experience and benefits of using data glove in controlling 3-Dimensional Postprocess Software.