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http://dx.doi.org/10.5625/lar.2018.34.4.311

Genetic and morphometric characteristics of Korean wild mice (KWM/Hym) captured at Chuncheon, South Korea  

Nam, Hajin (Department of Medical Genetics, College of Medicine, Hallym University)
Kim, Yoo Yeon (Department of Medical Genetics, College of Medicine, Hallym University)
Kim, Boyoung (Department of Medical Genetics, College of Medicine, Hallym University)
Yoon, Won Kee (Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Kim, Hyoung-Chin (Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Suh, Jun Gyo (Department of Medical Genetics, College of Medicine, Hallym University)
Publication Information
Laboraroty Animal Research / v.34, no.4, 2018 , pp. 311-316 More about this Journal
Abstract
Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a newly developing inbred strain (KWM/Hym) captured from Chuncheon, Korea. All of five Korean wild male mice have the zinc-finger Y (ZfY) gene. Also, all of 19 Korean wild mice used in this analysis have the AKV-type murine leukemia virus gene, indicating that Korean wild mice might be Mus musculus musculus. To identify the genetic polymorphism in KWM/Hym, SNP analysis was performed. In a comparison with 28 SNP markers, there was a considerable difference between KWM/Hym and several inbred strains. The homogeneity between KWM/Hym and the inbred strains was as follows: C57BL/6J (39.3%), BALB/c AJic (42.9%), and DBA/2J (50%). KWM/Hym is most similar to the PWK/PhJ inbred strain (96.4%) derived from wild mice (Czech Republic). To identify the morphometric characteristics of KWM/Hym, the external morphology was measured. The tail ratio of male and female was $79.60{\pm}3.09$ and $73.55{\pm}6.14%$, respectively. KWM/Hym has short and agouticolored hairs and its belly is white with golden hair. Taking these results together, KWM/Hym, a newly developing inbred mouse originated from wild mouse, might be use as new genetic resources to overcome the limitations of the current laboratory mice.
Keywords
Korean wild mouse; Mus musculus; subspecies; polymorphism; genetic resources;
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