• 대한산업공학회지
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• 제42권1호
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• pp.57-64
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• 2016

Pen-based interaction is universally available on smart devices and especially on Tablet PCs. Previous studies compared various input methods like fingers, a mouse or a stylus pen on PCs or on a touchscreen based devices such as smart phones. At the same time, various soft keyboard applications are being developed on application stores of smart devices. However, these previous studies did not suggest which one is a suitable keyboard application for Tablet PCs when users perform a certain interaction as input type. In this study, we compared two types of input methods (finger and pen) and three types of soft keyboard applications (QWERTY, Gesture and Swype) in a Tablet PC using performance measurements (accuracy and input speed) and discussed what types of applications showed better performance with each interaction on tablet PC. From these results, recommendations for the keyboard types depending on the input methods on tablet PCs were developed.

• 제어로봇시스템학회논문지
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• 제11권5호
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• pp.445-450
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• 2005

In this paper, we suggest an integrated tactile display system that provides kinesthetic force, pressure distribution, vibration and slip/stretch. The system consists of two parts: a 2 DOF force feedback device for kinesthetic display and a tactile feedback device for displaying the normal stimulation to the skin and the skin slip/stretch. Psychophysical experiments measure the effects of fingerpad selection, the direction of finger movements and the texture width on tactile sensitivity. We also investigate the characteristics of lateral finger movement while subjects perceive different textures. From the experimental results, the principal parameters for designing a tactile display are suggested. A tactile display device, using eight piezoelectric bimorphs and a linear actuator, Is implemented and attached to a 2 DOF translational force feedback device to simultaneously simulate the texture and stiffness of the object. As a result, we find out that the capability of the suggested device is sufficient to display physical quantities to display the texture.

• 한국정보통신학회논문지
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• 제20권6호
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• pp.1103-1108
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• 2016

각종 센서 기술의 발달로 일반 사용자들이 스마트폰, 콘솔게임기와 같은 동작인식 장치를 접해 볼 수 있는 환경이 증가하면서 동작인식 기반 입력장치에 대한 사용자 요구가 증가하는 추세이다. 기존 동작인식 마우스는 소형으로 제작이 되어 버튼을 조작하는데 어려움이 있으며, 동작인식 기술을 커서의 포인팅에만 사용되어 동작인식 기술을 적용에는 한계가 있다. 이에 본 논문에서는 MEMS 기반 동작인식 센서를 이용, 인체의 2지점(엄지와 검지)의 동작을 인식하여 동작데이터와 제어신호를 생성하고, 생성된 제어신호를 무선 송신하는 컴퓨터 입력장치에 관해 연구하였다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제29권11호
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• pp.851-859
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• 2002

본 연구는 마우스의 입력을 사람의 손동작으로 대체하는 휴먼마우스 시스템을 위한 새로운 손끝 좌표 추적기법과 마우스 포인터 움직임 결정법을 제안한다. 손끝좌표 추적에는 얼굴영역 추적을 위해 제안되었던 CAMSHIFT 알고리즘을 개선하여 적용하였다. 정확한 손 영역 검출을 위하여 각 사용자의 환경에 최적화된 피부영역 컬러 정보를 얻을 수 있는 실시간 피부영역 학습과 손의 자유로운 움직임으로 인하여 발생하는 손 영역의 크기 및 방향변화를 고려한 영역제한 기법을 적용하였다. 또한 손의 주축을 이용한 손끝좌표 계산법을 통해 빠르고 정확하게 손끝의 위치를 찾을 수 있다. 실시간 손끝좌표 검출에는 처리속도의 한계가 있어 얻어지는 좌표의 연속성이 결여되어 마우스 포인터의 움직임이 연결되지 않는 문제점이 있다. 연속적인 마우스 포인터의 움직임 표현을 위해 손끝좌표의 이동거리를 통해 마우스 포인터의 속도와 가속도를 계산하여 마우스 포인터의 운동방정식을 정의하고 이를 이용하여 마우스 포인터의 위치를 결정한다. 제안한 알고리즘을 적용하여 실험한 결과 빠르고 정확한 손끝좌표 추적과 마우스 포인터의 자연스러운 움직임이 가능함을 보였다.

• Biomolecules & Therapeutics
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• 제31권5호
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• pp.573-582
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• 2023

Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderate-intensity aerobic exercise in a methylglyoxal-induced muscle atrophy animal model. Each mouse was randomly divided into three groups: control, methylglyoxal-treated, and methylglyoxal-treated within aerobic exercise. In the exercise group, each mouse was trained on a treadmill for 2 weeks. On the last day, all groups were evaluated for several atrophic behaviors and skeletal muscles, including the soleus, plantaris, gastrocnemius, and extensor digitorum longus were analyzed. In the exercise group, muscle mass was restored, causing in attenuation of muscle atrophy. The gastrocnemius and extensor digitorum longus muscles showed improved fiber cross-sectional area and reduced myofibrils. Further, they produced regulated atrophy-related proteins (i.e., muscle atrophy F-box, muscle RING-finger protein-1, and myosin heavy chain), indicating that aerobic exercise stimulated their muscle sensitivity to reverse skeletal muscle atrophy. In conclusion, shortness of the gastrocnemius caused by methylglyoxal may induce the dynamic imbalance of skeletal muscle atrophy, thus methylglyoxal may be a key target for treating skeletal muscle atrophy. To this end, aerobic exercise may be a powerful tool for regulating methylglyoxal-induced skeletal muscle atrophy.

• Asian-Australasian Journal of Animal Sciences
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• 제30권6호
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• pp.781-787
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• 2017

Objective: The early growth response (Egr) family consists of four members (Egr1, Egr2, Egr3, and Egr4) that are zinc finger transcription factors. Among them, Egr3 is involved in transcriptional regulation of target genes during muscle spindle formation and neurite outgrowth. We previously showed that the immunoreactive Egr3 is localized on oocyte spindle and accumulate near the microtubule organizing center during meiosis I in mice. Egr3 was also shown to be localized on spermatocytes. We herein investigated if Egr3 is expressed in mouse gonads and if Egr3 blockade results in any defect in oocyte maturation. Methods: Expression of Egr3 in mouse gonads was examined by reverse transcription-polymerase chain reaction. Full-length Egr3 and truncated Egr3 (${\Delta}Egr3$) complementary RNAs (cRNAs) with Xpress tag at N-terminus and DsRed2 at C-terminus, and small interfering RNA (siRNA) targeting Egr3 were microinjected into mouse oocytes at germinal vesicle stage. Localization of microinjected Egr3 was examined by confocal live imaging and immunofluorescence staining. Results: Egr3 mRNA was detected in mouse ovaries and testes from 1 to 4 week-old mice. An uncharacterized longer transcript containing 5'untranslated region was also detected in 3 and 4 week-old gonads. Microinjected Xpress-Egr3-DsRed2 or Xpress-${\Delta}Egr3$-DsRed2 localized to nuclei and chromosomes during meiotic progression. Microinjection of these cRNAs or Egr3 siRNA in oocytes did not affect meiotic maturation. Immunofluorescence staining of Egr3 in Xpress-${\Delta}Egr3$-DsRed2-injected oocytes showed a positive signal only on meiotic spindle, suggesting that this antibody does not detect endogenous or exogenous Egr3 in mouse oocytes. Conclusion: The results show that Egr3 localizes to chromosomes during meiotic progression and that certain antibodies may not faithfully represent localization of target proteins in oocytes. Egr3 seems to be dispensable during oocyte maturation in mice.

• Biomolecules & Therapeutics
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• 제17권4호
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• pp.438-445
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• 2009

We investigated global gene expression from both mouse liver and mouse hepatic cell lines treated with acetaminophen (APAP) in order to compare in vivo and in vitro profiles and to assess the feasibility of the two systems. During our analyses of gene expression profiles, we picked up several down-regulated genes, such as the cytochrome P450 family 51 (Cyp51), sulfotransferase family cytosolic 1C member 2 (Sult1c2), 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), and several genes that were up-regulated by APAP, such as growth arrest and DNA-damage-inducible 45 alpha (Gadd45a), transformation related protein 53 inducible nuclear protein 1 (Trp53inp1) and zinc finger protein 688 (Zfp688). For validation of gene function, synthesized short interfering RNAs (siRNAs) for these genes were transfected in a mouse hepatic cell line, BNL CL.2, for investigation of cell viability and mRNA expression level. We found that siRNA transfection of these genes induced down-regulation of respective mRNA expression and decreased cell viability. siRNA transfection for Cyp51 and others induced morphological alterations, such as membrane thickening and nuclear condensation. Taken together, siRNA transfection of these six genes decreased cell viability and induced alteration in cellular morphology, along with effective inhibition of respective mRNA, suggesting that these genes could be associated with APAP-induced toxicity. Furthermore, these genes may be used in the investigation of hepatotoxicity, for better understanding of its mechanism.

• 한국컴퓨터정보학회논문지
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• 제15권5호
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• pp.33-38
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• 2010

본 논문에서는 USB 인터페이스 방식의 웹 카메라를 통해 입력받은 영상을 영상처리 기법을 통해 손의 움직임과 손가락 개수를 파악하여 실시간으로 마우스의 기능을 구현하는 알고리즘을 제안하였다. 웹 카메라로부터 입력받은 RGB 컬러모델 영상을 조명 변화에 강한 YCbCr 컬러 모델 영상으로 변환하여 휘도 성분을 제외한 색차 성분만으로 피부색을 추출해 이진화된 영상으로 만든다. YCbCr 컬러 모델을 이용하여 피부색을 추출할 경우, 주변 환경에 의해 정확한 손 영역을 추출할 수 없어 라벨링(labeling)과 열림(opening) 연산, 닫힘(closing) 연산을 수행하여 정확한 손 영역을 추출한다. 이렇게 추출된 손 영역의 중심을 이용하여 마우스 포인터를 이동시키며 손가락 개수를 이용하여 마우스의 클릭을 수행하였다. 구현된 제안 기법을 실험한 결과, 마우스 포인터 이동을 위한 기능 성공률은 평균 94.0%, 손가락 개수 인식률은 평균 96.0%로 실용화 가능성을 보였다.

• Laboraroty Animal Research
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• 제34권4호
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• pp.311-316
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• 2018

Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a newly developing inbred strain (KWM/Hym) captured from Chuncheon, Korea. All of five Korean wild male mice have the zinc-finger Y (ZfY) gene. Also, all of 19 Korean wild mice used in this analysis have the AKV-type murine leukemia virus gene, indicating that Korean wild mice might be Mus musculus musculus. To identify the genetic polymorphism in KWM/Hym, SNP analysis was performed. In a comparison with 28 SNP markers, there was a considerable difference between KWM/Hym and several inbred strains. The homogeneity between KWM/Hym and the inbred strains was as follows: C57BL/6J (39.3%), BALB/c AJic (42.9%), and DBA/2J (50%). KWM/Hym is most similar to the PWK/PhJ inbred strain (96.4%) derived from wild mice (Czech Republic). To identify the morphometric characteristics of KWM/Hym, the external morphology was measured. The tail ratio of male and female was $79.60{\pm}3.09$ and $73.55{\pm}6.14%$, respectively. KWM/Hym has short and agouticolored hairs and its belly is white with golden hair. Taking these results together, KWM/Hym, a newly developing inbred mouse originated from wild mouse, might be use as new genetic resources to overcome the limitations of the current laboratory mice.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2004년도 춘계 학술대회논문집
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• pp.56-61
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• 2004

As the size and dimension of target problems in the field of computational engineering including CFD gets bigger and higher, it is needed to have more efficient and flexible data visualization environment in terms of software and hardware. Even though it is still manageable to use a mouse in controlling 3-dimensional data visualization, it would be beneficial to use 3-D input device for 3-D visualization. 'Data Glove' is one of the best 3-D input devices, because human hands are best tools understanding 3-D space. Signals coming from 'Data Glove' are analog and very sensitive to finger motions, so we decided to use a digital filter. This paper describes our experience and benefits of using data glove in controlling 3-Dimensional Postprocess Software.