• Journal of Acupuncture Research
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• 제27권2호
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• pp.11-21
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• 2010

Objectives : We tried to investigate the effects of Carthami Semen(CF) pharmacopuncture and Bovis Calculus Fei Ursi(BU) pharmacopuncture on the heart rate variability(HRV) in adult men. As well as we tried to observe how CF pharmacopuncture and BU pharmacopuncture effect on the balance of the autonomic nervous system. Methods : We investigated on 40 healthy volunteers consisted of 20 subjects in CF pharmacopuncture group and 20 subjects in BU pharmacopuncture group respectively. We ruled out subjects whose vital sign isn't in normal range, yet they had taken a rest. The study established by a randomized, single-blind clinical trial. CF pharmacopuncture and BU pharmacopuncture was applied on each group. We measured HRV 7 times : baseline measurement and every 5 minutes for 30 minutes after injection. The SPSS 15.0 for Windows was used to analyze the data by the paired t-test(in group) and Independent sample t-test(between the groups). Results 1. After injection of CF pharmacopuncture, SDNN, Ln(TP), Ln(VLF) and Ln(LF) increased significantly, and Complexity, pNN50 decreased significantly. 2. After injection of BU pharmacopuncture, RMSSD, SDSD and HRV-index increased significantly. Conclusions : We suggest that CF pharmacopuncture activate sympathetic nervous system and BU pharmacopuncture tend to activate the autonomic nervous system.

• Natural Product Sciences
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• 제21권4호
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• pp.227-230
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• 2015

Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3 and 4), along with 5'-O-acetyl uridine (5) first isolated as a natural product. The structure of the new compound (1) was established by comprehensive spectroscopic analysis and chemical methods. Compounds 1 - 4 possessed varying degrees of antiviral activities, which was reported for the first time. Compared to the positive control ribavirin ($IC_{50}=418.0{\mu}M$), pestalotiolide A (1) exhibited significant anti-EV71 activity in vitro, with an $IC_{50}$ value of $27.7{\mu}M$. Furthermore, the preliminary structure-activity relationship of antiviral activities was also discussed.

• 한국표면공학회지
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• 제43권2호
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• pp.64-72
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• 2010

CuSnZn electroplating was investigated as alternative to Ni plating. Evaluation of electrolyte and plating process was performed to control physical characteristics of the film, and to collect practical data for application. Hull-cell test was conducted for basic comparison of two commercialized products and developed product. Based on hull-cell test results, long term test of three electrolytes was performed. Various analysis on long term tested electrolyte and samples have been done. Reliable and practical data was collected using FE-SEM (FEI, Sirion), EDX (ThermoNoran SIX-200E), ICP Spectrometer (GBC Scientifi c, Integra XL), FIB (FEI, Nova600) for anlysis. Physical analysis and reliability test of the long term tested film were also carried out. Through this investigation plating time, plating speed, electrolyte composition, electrolyte metal consumption, hardness and corrosion resistance has been compared. This set of data is used to predict and control the chemical composition of the film and modify the physical characteristics of the CuSnZn alloy.

• Journal of Microbiology and Biotechnology
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• 제28권12호
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• pp.2019-2028
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• 2018

Natural astaxanthin mainly derives from a microalgae producer, Haematococcus pluvialis. The induction of nitrogen starvation and high light intensity is particularly significant for boosting astaxanthin production. However, the different responses to light intensity and nitrogen starvation needed to be analyzed for biomass growth and astaxanthin accumulation. The results showed that the highest level of astaxanthin production was achieved in nitrogen starvation, and was 1.64 times higher than the control group at 11 days. With regard to the optimization of light intensity utilization, it was at $200{\mu}mo/m^2/s$ under nitrogen starvation that the highest astaxanthin productivity per light intensity was achieved. In addition, both high light intensity and a nitrogen source had significant effects on multiple indicators. For example, high light intensity had a greater significant effect than a nitrogen source on biomass dry weight, astaxanthin yield and astaxanthin productivity; in contrast, nitrogen starvation was more beneficial for enhancing astaxanthin content per dry weight biomass. The data indicate that high light intensity synergizes with nitrogen starvation to stimulate the biosynthesis of astaxanthin.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권11호
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• pp.4043-4064
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• 2021

Night-time image quality evaluation is an urgent requirement in visual inspection. The lighting environment of night-time results in low brightness, low contrast, loss of detailed information, and colour dissonance of image, which remains a daunting task of delicately evaluating the image quality at night. A new blind quality assessment metric is presented for realistic night-time scenario through a comprehensive consideration of contrast, texture, and colour in this article. To be specific, image blocks' color-gray-difference (CGD) histogram that represents contrast features is computed at first. Next, texture features that are measured by the mean subtracted contrast normalized (MSCN)-weighted local binary pattern (LBP) histogram are calculated. Then statistical features in Lαβ colour space are detected. Finally, the quality prediction model is conducted by the support vector regression (SVR) based on extracted contrast, texture, and colour features. Experiments conducted on NNID, CCRIQ, LIVE-CH, and CID2013 databases indicate that the proposed metric is superior to the compared BIQA metrics.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4871-4876
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• 2014

Background: We sought to evaluate the role of tumor associated macrophages (TAMs) on the promotion of coal tar pitch extract (CTPE)-induced tumorigenesis of human bronchial epithelial cells (BEAS-2B) and tumor metastasis in nude mice, and related mechanisms. Materials and Methods: BEAS-2B cells were first treated with 2.4 mg/mL CTPE for 72 hours. After removal of CTPE, the cells were continuously cultured and passaged using trypsin-EDTA. THP-1 cells were used as macrophage-like cells. BEAS-2B cells under different conditions (n=6/group) were injected into the back necks of nude mice, and alterations of tumor xenograft growth, indicative of tumorigenicity, and tumor metastasis were determined. Pathological changes (tumor nests and microvascular lesions) of HE-stained tumor tissues were also evaluated. The expression of AP-1(c-Jun) in xenografts and metastatic tumors was determined using immunohistochemistry. Results: Tumor size and weight in nude mice transplanted with the mixture of CTPE-induced passage 30 BEAS-2B and THP-1 cells (2:1) were increased compared to those from the CTPE-treated BEAS-2B cells at passage 30 alone at different observation time points. Tumor metastasis to lymph nodes and liver was only detected after transplantation of a mixture the two kinds of cells. The numbers of tumor nests and microvascular lesions, and the expression levels of AP-1 (c-Jun) in tumors from the mixture of two kinds of cells were increased apparently in contrast to those in tumor from the CTPE-treated BEAS-2B cells of passage 30 alone. In addition, there was positive correlation between AP-1 (c-Jun) expression level and the number of microvascular lesions, or between AP-1 (c-Jun) expression level and tumor metastasis in these two groups. Conclusions: TAMs not only facilitate tumorigenesis transformation of CTPE-induced BEAS-2B cells, but also promote tumor growth, angiogenesis and metastasis in nude mice in vivo, which may be mediated by AP-1.

• Biotechnology and Bioprocess Engineering:BBE
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• 제5권6호
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• pp.407-412
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• 2000

Environmental biosensors and related techniques for monitoring organochlorines, endocrine disrupting chemicals and cyanobacterial toxins are described. The practical requirements for an ideal environmental biosensor are analyzed. Specific case studies for environmental applications are reported for triazines, chlorinated phenols, PCBs, microcystins, and endocrine disrupting chemicals. A new promising approach is reported for microcystins and alkylphenols that utilize electrooptical detection.

• Bulletin of the Korean Chemical Society
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• 제35권5호
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• pp.1556-1558
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• 2014

• 대한수학회보
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• 제53권4호
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• pp.1113-1122
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• 2016

Let (M, g(t)) be a compact Riemannian manifold and the metric g(t) evolve by the Yamabe flow. In the paper we derive the evolution for the first eigenvalue of geometric operator $-{\Delta}_{\phi}+{\frac{R}{2}}$ under the Yamabe flow, where ${\Delta}_{\phi}$ is the Witten-Laplacian operator, ${\phi}{\in}C^2(M)$, and R is the scalar curvature with respect to the metric g(t). As a consequence, we construct some monotonic quantities under the Yamabe flow.

• 대한수학회지
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• 제53권1호
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• pp.233-246
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• 2016

In this paper, we introduce the class of analytic extensions of M-hyponormal operators and we study various properties of this class. We also use a special Sobolev space to show that every analytic extension of an M-hyponormal operator T is subscalar of order 2k + 2. Finally we obtain that an analytic extension of an M-hyponormal operator satisfies Weyl's theorem.