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http://dx.doi.org/10.20307/nps.2015.21.4.227

Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp.  

Jia, Yan-Lai (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China)
Guan, Fei-Fei (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China)
Ma, Jie (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China)
Wang, Chang-Yun (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China)
Shao, Chang-Lun (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China)
Publication Information
Natural Product Sciences / v.21, no.4, 2015 , pp. 227-230 More about this Journal
Abstract
Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3 and 4), along with 5'-O-acetyl uridine (5) first isolated as a natural product. The structure of the new compound (1) was established by comprehensive spectroscopic analysis and chemical methods. Compounds 1 - 4 possessed varying degrees of antiviral activities, which was reported for the first time. Compared to the positive control ribavirin ($IC_{50}=418.0{\mu}M$), pestalotiolide A (1) exhibited significant anti-EV71 activity in vitro, with an $IC_{50}$ value of $27.7{\mu}M$. Furthermore, the preliminary structure-activity relationship of antiviral activities was also discussed.
Keywords
Marine Fungus; Pestalotiopsis sp.; Structure-Activity Relationship; Antiviral Activity;
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