• Biomolecules & Therapeutics
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• v.20 no.1
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• pp.1-18
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• 2012

Schizophrenia is a devastating psychiatric illness that afflicts 1% of the population worldwide, resulting in substantial impact to patients, their families, and health care delivery systems. For many years, schizophrenia has been felt to be associated with dysregulated dopaminergic neurotransmission as a key feature of the pathophysiology of the illness. Although numerous studies point to dopaminergic abnormalities in schizophrenia, dopamine dysfunction cannot completely account for all of the symptoms seen in schizophrenia, and dopamine-based treatments are often inadequate and can be associated with serious side effects. More recently, converging lines of evidence have suggested that there are abnormalities of glutamate transmission in schizophrenia. Glutamatergic neurotransmission involves numerous molecules that facilitate glutamate release, receptor activation, glutamate reuptake, and other synaptic activities. Evidence for glutamatergic abnormalities in schizophrenia primarily has implicated the NMDA and AMPA subtypes of the glutamate receptor. The expression of these receptors and other molecules associated with glutamate neurotransmission has been systematically studied in the brain in schizophrenia. These studies have generally revealed region- and molecule-specifi c changes in glutamate receptor transcript and protein expression in this illness. Given that glutamatergic neurotransmission has been implicated in the pathophysiology of schizophrenia, recent drug development efforts have targeted the glutamate system. Much effort to date has focused on modulation of the NMDA receptor, although more recently other glutamate receptors and transporters have been the targets of drug development. These efforts have been promising thus far, and ongoing efforts to develop additional drugs that modulate glutamatergic neurotransmission are underway that may hold the potential for novel classes of more effective treatments for this serious psychiatric illness.

• Journal of the Korean Society of Costume
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• v.54 no.8
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• pp.35-48
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• 2004

This thesis researches consumers' behaviors in Purchasing avatar fashion products depending on their motives and point of reference as the avatar fashion marketing is conducted. Also, it explores the correlation between avatar's fashion products and the point of reference by which consumers actually purchase casual wear. The results were as follows: First, Avatar's fashion product purchasing motivation is done through four classified dimensions, conformity, differentiation, fashionability, and substitution. The standard of Avatar's fashion product choice was classified by the symbol (Product name recognition) and two dimensions of aesthetics. Second. the more valued the aesthetic component of Avatar's fashion product the greater effect on the order the dimensions used in correlation in this case being substitution, differentiation, conformity, and fashionability. Should the consumer place greater value on the Product symbol the dimension order is affected in order by fashionability, conformity, and differentiation. Third, fashionability was a stronger consideration for women as opposed to men in terms of demographical feature. whereas symbol (Product recognition) was of greater importance to higher income people. Last, when aesthetics is considered to buy Avatar's fashion products it is favorably comparable to other casual wear lines. In other words, symbol is considered to buy casual's, it brings to the same result when buying Avatar's. Avatar's fashion product was great tool to research new casual wear line because of approving by the correlation to each other.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.2
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• pp.153-158
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• 2017

In this paper, we take into account topology optimization problems considering spatial randomness in the material property of elastic modulus. Based on 88 lines MATLAB Code, Monte Carlo analysis has been performed for MBB(messerschmidt-$b{\ddot{o}}lkow$-blohm) model using 5,000 random sample fields which are generated by using the spectral representation scheme. The random elastic modulus is assumed to be Gaussian in the spatial domain of the structure. The variability of the volume fraction of the material, which affects the optimum topology of the given problem, is given in terms of correlation distance of the random material. When the correlation distance is small, the randomness in the topology is high and vice versa. As the correlation distance increases, the variability of the volume fraction of the material decreases, which comply with the feature of the linear static analysis. As a consequence, it is suggested that the randomness in the material property is need to be considered in the topology optimization.

• Journal of The Korean Society of Agricultural Engineers
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• v.55 no.6
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• pp.101-112
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• 2013

Shuttle Radar Topography Mission Digital Elevation Model (SRTM DEM) offers opportunities to make advances in many research areas including hydrology by providing near-global scale elevation measurements at a uniform resolution. Its wide coverage and complimentary online access especially benefits researchers requiring topographic information of hard-to-access areas. However, SRTM DEM also contains inherent errors, which are subject to propagation with its manipulation into analysis outputs. Sensitivity of hydrologic analysis to the errors has not been fully understood yet. This study investigated their impact on estimation of hydrologic derivatives such as slope, stream network, and watershed boundary using Monte Carlo simulation and spatial moving average techniques. Different amount of the errors and their spatial auto-correlation structure were considered in the study. Two sub-watersheds of Geum and Deadong River areas located in South and North Korea, respectively, were selected as the study areas. The results demonstrated that the spatial presentations of stream networks and watershed boundaries and their length and area estimations could be greatly affected by the SRTM DEM errors, in particular relatively flat areas. In the Deadong River area, artifacts of the SRTM DEM created sinks even after the filling process and then closed drainage basin and short stream lines, which are not the case in the reality. These findings provided an evidence that SRTM DEM alone may not enough to accurately figure out the hydrologic feature of a watershed, suggesting need of local knowledge and complementary data.

• Korean Chemical Engineering Research
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• v.50 no.3
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• pp.479-491
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• 2012

In this paper we performed evaluation of the economics of a district heating system (DHS) consisting of energy suppliers and consumers, heat generation and storage facilities and power transmission lines in the capital region, as well as identification of optimal operating conditions. The optimization problem is formulated as a mixed integer linear programming (MILP) problem where the objective is to minimize the overall operating cost of DHS while satisfying heat demand during 1 week and operating limits on DHS facilities. This paper also propose a new forecasting model of the system marginal price (SMP) using past data on power supply and demand as well as past cost data. In the optimization, both the forecasted SMP and actual SMP are used and the results are analyzed. The salient feature of the proposed approach is that it exhibits excellent predicting performance to give improved energy efficiency in the integrated DHS.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2017.05a
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• pp.21-25
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• 2017

The umbilical system used for launch vehicle is to connect all ground supply lines (Pneumatic, hydraulic and electrical) to launch vehicle and disconnect those at few second before launch vehicle lift-off (or simultaneously with launch vehicle lift-off). During launch preparation stage, all umbilical shall be securely connected and also at separation stage, separation of all umbilical line shall be guaranteed. Therefore finding an appropriate connection force is a key factor on development of umbilical system. According to these design requirement, various kind of umbilical system has been developed from early stage of space development till today. In this paper, various kind of umbilical system developed so far is introduced according to its feature and operational concept. Also, umbilical system used for KSLV-II is introduced

• Molecules and Cells
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• v.37 no.11
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• pp.767-776
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• 2014

Alzheimer's disease (AD) is clinically characterized with progressive memory loss and cognitive decline. Synaptic dysfunction is an early pathological feature that occurs prior to neurodegeneration and memory dysfunction. Mounting evidence suggests that aggregation of amyloid-${\alpha}$ ($A{\alpha}$) and hyperphosphorylated tau leads to synaptic deficits and neurodegeneration, thereby to memory loss. Among the established genetic risk factors for AD, the ${\varepsilon}4$ allele of apolipoprotein E (APOE) is the strongest genetic risk factor. We and others previously demonstrated that apoE regulates $A{\alpha}$ aggregation and clearance in an isoform-dependent manner. While the effect of apoE on $A{\alpha}$ may explain how apoE isoforms differentially affect AD pathogenesis, there are also other underexplored pathogenic mechanisms. They include differential effects of apoE on cerebral energy metabolism, neuroinflammation, neurovascular function, neurogenesis, and synaptic plasticity. ApoE is a major carrier of cholesterols that are required for neuronal activity and injury repair in the brain. Although there are a few conflicting findings and the underlying mechanism is still unclear, several lines of studies demonstrated that apoE4 leads to synaptic deficits and impairment in long-term potentiation, memory and cognition. In this review, we summarize current understanding of apoE function in the brain, with a particular emphasis on its role in synaptic plasticity and the underlying cellular and molecular mechanisms, involving low-density lipoprotein receptor-related protein 1 (LRP1), syndecan, and LRP8/ApoER2.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 1999.11a
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• pp.146-150
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• 1999

On the advent of digital era, ECDIS has emerged as a new navigation aid that should result in significant benefits to safe navigation. More than simply a graphics display, ECDIS is a new concept navigation system capable of providing integrated information of geographical and texual data. As an official vector data for ECDIS, ENC consists of spatial and feature data to describe objects in form of points, lines and areas. IHO published International Standards for ENC, such as S-52(Specification for Chart Content and Display Aspects of ECDIS and S-57(IHO Transfer Standard for Digital Hydrographic Data). This paper deals with the implementation of an EUC representation system which meets S-52 presentation specification and S-57 transfer standards by analyzing S-57 data structures and converting then to an appropriate internal data structures and representing them onto screen adopting S-52 presentation specification.

• Plant Biotechnology Reports
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• v.2 no.1
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• pp.87-92
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• 2008

An improved protocol for high frequency plant regeneration via somatic embryogenesis from zygotic embryo-derived cell suspension cultures of watershield (Brasenia schreberi) was developed. Zygotic embryos formed pale-yellow globular structures and white friable callus at a frequency of 80% when cultured on halfstrength MS medium supplemented with $0.3mg\;l^{-1}$ 2,4-D. However, the frequency of formation of pale-yellow globular structures and white friable callus decreased slightly with increasing concentrations of 2,4-D up to $3mg\;l^{-1}$, where the frequency reached ~50% of the control. Cell suspension cultures from zygotic embryoderived white friable callus were established using half-strength MS medium supplemented with $0.3mg\;l^{-1}$ 2,4-D. Upon plating of cell aggregates on half-strength MS basal medium, approximately 8.3% gave rise to somatic embryos and developed into plantlets. However, the frequency of plantlet development from cell aggregates was sharply increased (by up to 55%) when activated charcoal and zeatin were applied. Regenerated plantlets were successfully transplanted to potting soil and grown to normal plants in a growth chamber. The distinctive feature of this study is the establishment of a high frequency plant regeneration system via somatic embryogenesis from zygotic embryo-derived cell suspension cultures of water-shield, which has not been previously reported. The protocol for plant regeneration of watershield through somatic embryogenesis could be useful for the mass propagation and transformation of selected elite lines.

• Journal of Fashion Business
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• v.13 no.4
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• pp.60-76
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• 2009

Expression of woman characters in fusion traditional dramas plays a role of making the progress of dramas not bigoted and new. Especially, woman characters have a high weight as a heroine by an increase in their image in fusion traditional dramas. Expression of characters harmonizing modern with tradition has also given a help in reflecting a trend of the present times. Hair style and face makeup of woman characters in fusion traditional dramas are in the process of fusionization getting an effect from postmodernism. They are expressing the hair style of symbolization modern elements of hair style to traditional hair styles. They also expressed a neutral image with faded hair styles in the shaggy cut style and dye of neoplaticism. Neo-hippie style was changed into the style of naturalism and nationalism and the hair style braided in various branches as the one of Indians was changed into a primitive and national feature. It is producing a new style by permitting even a long-hair permanent wave hair style. Expression of straight hair style, a long-hair shaggy & bulging wave style and a hair style of neoplaticism, was distinguished. In the side of face makeup, they expressed its luxurious and splendid style by attaching great importance to its luster and are exposing images of characters by a smoky makeup emphasizing eye lines. Their face makeup was almost never separated from present dramas as using pearl shadow in a glossy lips makeup and color, which made it possible to express it more dramatically in fusion traditional dramas than in present dramas. In the event of the makeup element of fusion traditional dramas permitting diversity, the character makeup of fusion traditional dramas made a foundation to show people diverse elements of makeup by mix & match a present elements and past elements of historical research, which made it possible to express a unique makeup or a special makeup. Diverse makeup expressions were limited by reflection of illumination even in the existing videos. Therefore, 'Fusion' made it possible to express it more freely in fusion traditional dramas than in present dramas.