• Title/Summary/Keyword: Feasibility studies

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Rasch Analysis of the Clinimetric Properties of the Korean Dizziness Handicap Inventory in Patients with Parkinson Disease (파킨슨병 환자에서 한국어판 Dizziness Handicap Inventory의 라쉬 분석에 의한 임상측정 특성 평가)

  • Lee, Da-Young;Yang, Hui-Jun;Yang, Dong-Seok;Choi, Jin-Hyuk;Park, Byoung-Soo;Park, Ji-Yun
    • Research in Vestibular Science
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    • v.17 no.4
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    • pp.152-159
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    • 2018
  • Objectives: The Korean Dizziness Handicap Inventory (KDHI), which includes 25 patient-reported items, has been used to assess self-reported dizziness in Korean patients with Parkinson disease (PD). Nevertheless, few studies have examined the KDHI based on item-response theory within this population. The aim of our study was to address the feasibility and clinimetric properties of the KDHI instrument using polytomous Rasch measurement analysis. Methods: The unidimensionality, scale targeting, separation reliability, item difficulty (severity), and response category utility of the KDHI were statistically assessed based on the Andrich rating scale model. The utilities of the orderedresponse categories of the 3-point Likert scale were analyzed with reference to the probability curves of the response categories. The separation reliability of the KDHI was assessed based on person separation reliability (PSR), which is used to measure the capacity to discriminate among groups of patients with different levels of balance deficits. Results: Principal component analyses of residuals revealed that the KDHI had unidimensionality. The KHDI had satisfactory PSR and there were no disordered thresholds in the 3-point rating scale. However, the KDHI showed several issues for inappropriate scale targeting and misfit items (items 1 and 2) for Rasch model. Conclusions: The KDHI provide unidimensional measures of imbalance symptoms in patients with PD with adequate separation reliability. There was no statistical evidence of disorder in polytomous rating scales. The Rasch analysis results suggest that the KDHI is a reliable scale for measuring the imbalance symptoms in PD patients, and identified parts for possible amendments in order to further improve the linear metric scale.

Oncologic Feasibility of Proximal Gastrectomy in Upper Third Advanced Gastric and Esophagogastric Junctional Cancer

  • Yun, Won-Gun;Lim, Myung-Hoon;Kim, Sarah;Kim, Sa-Hong;Park, Ji-Hyeon;Kong, Seong-Ho;Park, Do Joong;Lee, Hyuk-Joon;Yang, Han-Kwang
    • Journal of Gastric Cancer
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    • v.21 no.2
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    • pp.169-178
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    • 2021
  • Purpose: The aim of this study was to investigate the oncologic safety and identify potential candidates for proximal gastrectomy (PG) in upper third advanced gastric cancer (AGC) and esophagogastric junction (EGJ) cancers. Materials and Methods: Among 5,665 patients who underwent gastrectomy for gastric adenocarcinoma between January 2011 and December 2017, 327 patients who underwent total gastrectomy with standard lymph node (LN) dissection for upper third AGC and Siewert type II EGJ cancers were enrolled. We analyzed the correlation between the metastatic rates of distal LNs (No. 4d, 5, 6, and 12a) around the lower part of the stomach and the clinicopathological characteristics. We identified subgroups with no metastasis to the distal LNs. Results: The metastatic rate of distal LNs in proximal AGC and Siewert type II EGJ cancers was 7.0% (23 of 327 patients). On multivariate analysis, pathological T stage (P=0.001), tumor size (P=0.043), and middle third invasion (P=0.003) were significantly associated with distal LN metastases. Pathological 'T2 stage' (n=88), or 'T3 stage with ≤5 cm tumor size' (n=87) showed no metastasis in distal LNs, regardless of middle third invasion. Pathological T3 stage with tumor size > 5 cm (n=61) and T4 stage (n=91) had metastasis in the distal LNs. Conclusions: In the upper third AGC and Siewert type II EGJ cancer, pathological T2 and small-sized T3 stage groups are possible candidates for PG in cases without distal LN metastasis. Further validation studies are required for clinical application.

Geotechnical Characteristics of Reduced Slag-soil Mixtures in Electric Furnace (전기로 제강 환원 슬래그 혼합토의 지반공학적 특성)

  • Shin, Jaewon;Yoon, Yeowon;Yoon, Gillim
    • Journal of the Korean GEO-environmental Society
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    • v.12 no.7
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    • pp.31-37
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    • 2011
  • Only a few studies have been conducted using reduced slag as recycled material. The reduced slag in electric furnace is produced as a by-product in making a steel and a few applications of the reduced slag as expensive additives and bonding materials or as the stabilized soils was reported. The purpose of this study is to present the feasibility of the reduced slag as recycled material, especially, in a field of civil engineering. In order to achieve the purpose experiments such as SEM and XRF analysis was conducted for the reduced slag in electric furnace. Based on the results various geotechnical experiments were conducted to know engineering properties of slag-soil mixtures. Weathered soils and clay are mixed with reduced slag for various ratios. As the ratio of reduced slag to weathered soil increases, the maximum dry unit weight of the mixture decreased with increasing optimum moisture content. The results indicates that there is no effect on a reduced slag by compaction efforts. The shear strengths of the weathered soil-slag mixtures are slightly higher or similar to those of weathered soils. The permeability of the weathered soil-slag mixtures is similar to that of silty or sandy soils. Therefore, it is possible to use the mixtures as embankment or backfill materials in the fields. The unconfined strength of the mixtures of reduced slag and clay is higher than that of clay and it tends to increase with the curing time. Therefore it can be used to improve the soft ground.

Teaching Methods of Inclusive Music Classes at Elementary Schools Based on Application of Understanding by Design and Differentiated Instruction (이해중심 교육과정과 맞춤형 수업의 적용을 통한 초등학교 통합학급의 음악과 수업 방안 연구)

  • Won, Chorong
    • Journal of Music and Human Behavior
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    • v.18 no.1
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    • pp.79-102
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    • 2021
  • The purpose of this study was to identify the teaching methods used in inclusive music classes at elementary schools by of music in elementary school inclusive classes through the application of understanding by design and differentiated instruction, and to explore the feasibility of inclusive education. To this end, based on the 2.0 version of the backward design template, a unit for music lessons for 3rd and 4th grade inclusive classes was developed. The unit presented elements of differentiated instruction that considered students with intellectual disabilities at each stage. In the first stage, goals and essential questions were presented by analyzing the curriculum's achievement standards. In the second stage, a performance task was developed using the GRASPS technique, guidelines and examples were presented. Various evaluation methods based on students' readiness, interest, and learning type were suggested. In the third stage, the unit's seven lessons were planned using the WHERETO model. Examples of differentiated instruction for students with intellectual disabilities were presented by flexibly using classroom elements. This study indicated that understanding by design and differentiated instruction can be applied to inclusive education. Future studies on more diversified educational design and strategies are needed for promoting inclusive education.

A Study on the Development of Human Resource Factors in the Service Economy Era (서비스경제시대 인재상요소 개발에 관한 연구)

  • Baek, Kyeonghui;Kim, Hyunsoo
    • The Journal of the Korea Contents Association
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    • v.21 no.2
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    • pp.572-586
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    • 2021
  • With the advent of the 4th Industrial Revolution, the modern economy is transforming into a service-oriented economic society, and there is a growing need for companies to reorganize organizational culture, values, and human resources to suit the changing environment. Especially, even when times change, human capital is the most important factor in maintaining sustainable development and Corporate value, since all work is done by people. Therefore, in this study, in order to recognize the importance of human resources and verify the appropriate human resources for the changing service economy era, we reviewed the literature and that drew the human resources suitable for the recent service economy era Based on this, an empirical study was conducted on whether the suggested human resources factors were useful. To this end, a feasibility analysis, reliability analysis, correlation analysis, confirmatory factor analysis, and reference validity were conducted by dividing into a preliminary survey and a main survey. As a result, it was finally drawn with 30 items, 7 factors. The results of this study are expected to be used as basic data in various fields of research on human resources in the service economy era, and in-depth empirical studies are needed in the future.

Life Cycle Assessment of Carbon Monoxide Production via Electrochemical CO2 Reduction: Analysis of Greenhouse Gas Reduction Potential (전기화학적 이산화탄소 환원을 통한 일산화탄소 생산 공정의 전과정평가 : 온실가스 저감 잠재량 분석)

  • Roh, Kosan
    • Clean Technology
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    • v.28 no.1
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    • pp.9-17
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    • 2022
  • Electrochemical carbon dioxide (CO2) reduction technology, one of the promising solutions for climate change, can convert CO2, a representative greenhouse gas (GHG), into valuable base chemicals using electric energy. In particular, carbon monoxide (CO), among various candidate products, is attracting much attention from both academia and industry because of its high Faraday efficiency, promising economic feasibility, and relatively large market size. Although numerous previous studies have recently analyzed the GHG reduction potential of this technology, the assumptions made and inventory data used are neither consistent nor transparent. In this study, a comparative life cycle assessment was carried out to analyze the potential for reducing GHG emissions in the electrochemical CO production process in a more transparent way. By defining three different system boundaries, the global warming impact was compared with that of a fossil fuel-based CO production process. The results confirmed that the emission factor of electric energy supplied to CO2-electrolyzers should be much lower than that of the current national power generation sector in order to mitigate GHG emissions by replacing conventional CO production with electrochemical CO production. Also, it is important to disclose transparently inventory data of the conventional CO production process for a more reliable analysis of GHG reduction potential.

A Study on the Improvement of the Consultations on Amendment in Environmental Impact Assessment of Industrial Complex Development (산업단지 조성사업의 환경영향평가 변경협의 개선방안 연구)

  • Joo, Yong-Joon;Sagong, Hee
    • Journal of Environmental Impact Assessment
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    • v.31 no.3
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    • pp.129-140
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    • 2022
  • Environmental impact assessment on development projects is a process in which various stakeholders derive consultations by reflecting project characteristics and regional environmental status, and implementation of consultations is a prerequisite for securing sustainability of the local environment. The business plan can be changed to respond to changes in social and environmental conditions. And the business plan for which the environmental impact assessment consultation has been completed, it can be changed as a systematically prepared procedure (called Consultations on Amendment). As a result of investigating and analyzing the current status and major changes in the development project, Consultations on Amendment in industrial complexes were the most common, and the environmental impact is increasing accordingly. As the results of the analysis of operational status and the case studies, the main causes of Consultations on Amendment in industrial complex can be summarized into three categories: (1) formal demand forecasting for tenant industries, (2) excessive omission and simplification of administrative procedures under the Special Act, and (3) the use of an expedient change consultation system to facilitate environmental impact assessment consultation and shorten the period. This study proposes the following three measures to prevent the deterioration of the environmental impact assessment function due to frequent consultations on industrial complex changes; (1) Ensuring residents' participation procedures for Consultations on Amendment that changes important matters, (2) Reasonable revision of the "Simplification of Industrial Complex Procedures Act" to enhance the feasibility of industrial complex development plans and locations, (3) Development of evaluation criteria and methods for verification of real demand for objective demand management for industrial complexes, and (4) Preparation of a review guideline for Consultations on Amendment.

Feasibility Study for Derivation of Tropospheric Ozone Motion Vector Using Geostationary Environmental Satellite Measurements (정지궤도 위성 대류권 오존 관측 자료를 이용한 대류권 이동벡터 산출 가능성 연구)

  • Shin, Daegeun;Kim, Somyoung;Bak, Juseon;Baek, Kanghyun;Hong, Sungjae;Kim, Jaehwan
    • Korean Journal of Remote Sensing
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    • v.38 no.6_1
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    • pp.1069-1080
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    • 2022
  • The tropospheric ozone is a pollutant that causes a great deal of damage to humans and ecosystems worldwide. In the event that ozone moves downwind from its source, a localized problem becomes a regional and global problem. To enhance ozone monitoring efficiency, geostationary satellites with continuous diurnal observations have been developed. The objective of this study is to derive the Tropospheric Ozone Movement Vector (TOMV) by employing continuous observations of tropospheric ozone from geostationary satellites for the first time in the world. In the absence of Geostationary Environmental Monitoring Satellite (GEMS) tropospheric ozone observation data, the GEOS-Chem model calculated values were used as synthetic data. Comparing TOMV with GEOS-Chem, the TOMV algorithm overestimated wind speed, but it correctly calculated wind direction represented by pollution movement. The ozone influx can also be calculated using the calculated ozone movement speed and direction multiplied by the observed ozone concentration. As an alternative to a backward trajectory method, this approach will provide better forecasting and analysis by monitoring tropospheric ozone inflow characteristics on a continuous basis. However, if the boundary of the ozone distribution is unclear, motion detection may not be accurate. In spite of this, the TOMV method may prove useful for monitoring and forecasting pollution based on geostationary environmental satellites in the future.

Recent Research Trends in Thioredoxin Reductase-targeted Anticancer Therapy (Thioredoxin reductase를 표적으로 하는 항암 최신 연구 동향)

  • Hwangbo, Hyun;Lee, Hyesook;Cheong, JaeHun;Choi, Yung Hyun
    • Journal of Life Science
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    • v.32 no.1
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    • pp.63-69
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    • 2022
  • The thioredoxin reductase (TrxR) system is essential for cell survival and function by playing a pivotal role in maintaining homeostasis of cellular redox and regulating signal transduction pathways. The TrxR system comprises thioredoxin (Trx), TrxR, and nicotinamide adenine dinucleotide phosphate. Trx reduced by the catalytic reaction of the TrxR enzyme reduces downstream proteins, resulting in protection against oxidative stress and regulation of cell differentiation, growth, and death. Cancer cells survive by improving their intracellular antioxidant capacity to eliminate excessively generated reactive oxygen species (ROS) due to infinite cell proliferation and a high metabolic rate. Therefore, cancer cells have high dependence and sensitivity to antioxidant systems, suggesting that focusing on TrxR, a representative antioxidant system, is a potential strategy for cancer therapy. Several studies have revealed that TrxR is expressed at high levels in various types of cancers, and research on anticancer activity targeting the TrxR system is increasing. In this review, we discuss the feasibility and value of the TrxR system as a strategy for anticancer activity research by examining the relationship between the function of the intracellular TrxR system and the development and progression of cancer, considering the anticancer activity and mechanism of TrxR inhibitors.

Review of Remote Sensing Applicability for Monitoring Marine Microplastics (해양 미세플라스틱 모니터링을 위한 원격탐사 적용 가능성 검토)

  • Park, Suhyeon;Kim, Changmin;Jeong, Seongwoo;Jang, Seonggan;Kim, Subeen;Ha, Taejung;Han, Kyung-soo;Yang, Minjune
    • Korean Journal of Remote Sensing
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    • v.38 no.5_3
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    • pp.835-850
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    • 2022
  • Microplastics have arisen as a worldwide environmental concern, becoming ubiquitous in all marine compartments, and various researches on monitoring marine microplastics are being actively conducted worldwide. Recently, application of a remote detection technology that enables large-scale real-time observation to marine plastic monitoring has been conducted overseas. However, in South Korea, there is little information linking remote detection to marine microplastics and some field studies have demonstrated remote detection of medium- and large-sized marine plastics. This study introduces research cases with remote detection of marine plastics in South Korea and overseas, investigates potential feasibility of using the remote detection technology to marine microplastic monitoring, and suggests some future works to monitor marine microplastics with the remote detection.