• Genomics & Informatics
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• 제19권1호
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• pp.5.1-5.11
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• 2021

Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity, paranasal sinuses, oral cavity, tongue, pharynx, and larynx. The Wnt signaling pathway is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. The present study aims to assess the gene alterations in the Wnt family of genes so as to derive an association with HNSCC. Computational approaches have been utilized for the identification of gene alterations in the Wnt family of genes. Several databases such as cBioportal, STRING, and UALCAN were used for the purpose. The frequency of alteration was high in case of Wnt family member 11 (5%). Gene amplification, deep deletions, missense and truncating mutations were observed in HNSCC patients. There was a marked difference in the gene expression profile of WNT11 between grades as well as normal samples. The survival probability measured using the Kaplan-Meier curve also presented with a significant difference among male and female subjects experiencing a low/medium level expression. The female patients showed less survival probability when compared to the male subjects. This provides the prognostic significance of the WNT11 gene in HNSCC. Taken together, the present study provides clues on the possible association of WNT11 gene alterations with HNSCC, which has to be further validated using experimental approaches.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7657-7661
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• 2013

Background: This study concerns uptake and results of colorectal cancer (CRC) screening of government servant as part of the Health Screening Program that was conducted in Brunei Darussalam in 2009. Materials and Methods: Government servants above the age of 40 or with family history of CRC were screened with a single fecal occult blood test (FIT, immunohistochemistry). Among 11,576 eligible subjects, 7,360 (66.9%) returned their specimen. Subjects with positive family history of CRC (n=329) or polyps (n=135) were advised to attend clinics to arrange screening. All the subjects with positive FIT (n=142, 1.9%) were referred to the endoscopy unit for counselling for screening colonoscopy. Results: Overall only 17.7% of eligible subjects attended for screening; 54.9% (n=79/142) of positive FIT, 8.8% (n=29/329) of positive family history of CRC and none with history of polyps (n=0/135). Of these, only 54 patients (50.5%) agreed for colonoscopy, 52 (48.6%) declined as they were asymptomatic, and one was not offered (0.9%) due to his very young age. On screening colonoscopy, 12.9% (n=7) had advanced lesions including a sigmoid carcinoma in situ and six advanced polyps. The other findings included non advanced polyps (n=21), diverticular (n=11) and hemorrhoids (n=26). One patient who missed his screening colonoscopy appointment re-presented two years later and was diagnosed with advanced right sided CRC. All the advanced lesions were detected in patients with positive FIT, giving a yield of 20.5% for advanced lesions including cancers in the 5.1% FIT positive subjects. Conclusions: Our study showed screening for CRC even with a single FIT was effective. However, the uptake rate was poor with just over half of the patients agreeing to screening colonoscopy. Measures to increase public awareness are important. Since one limitation of our study was the relatively small sample size, larger studies should be conduced in future.

• 한국주거학회논문집
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• 제14권6호
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• pp.41-50
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• 2003

The parking problem is caused by the parking demand. The ratio of parking demand at multi-family housing sites has been increased significantly, therefore several parking problems have occurred. The goal of this study is to investigate the parking demand per housing size of public-sized apartments, and to prepare that with the architectural regulations about parking supply. According to the results of this study, the parking demand of the small size housing unit(exclusive size：60 $m^2$ below) shows 1.09 car per the unit. and that of the medium size housing unit(exclusive size：60 $m^2$ over 85 $m^2$ below) shows 1.34 car per the unit. The parking demand of the small size housing unit was exceeded 56% more than the legal supply limit, and the parking demand of the medium size housing unit was exceeded 34% more. It is means that the level of architectural regulation about parking supply was not enough than the parking demand. So, it needs recon-sideration about the architectural regulations of parking supply.

• 간호행정학회지
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• 제21권5호
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• pp.469-479
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• 2015

Purpose: The purpose of this study was to compare hospitalized patients in comprehensive nursing care units and general care units as to satisfaction with nursing care and factors influencing their intent to revisit the hospital. Methods: A cross-sectional study was conducted with 178 patients who had been hospitalized in a comprehensive nursing care unit and a general care unit in one hospital. Participants completed self-report questionnaires. Data were analyzed using SPSS 21.0. Results: There was a significant difference between the comprehensive nursing care unit and general care unit for intent to revisit the hospital (p=.036). Factors influencing intent to revisit the hospital for patients in the comprehensive nursing care unit were 'satisfaction with nursing care' (p<.001) and 'use of additional costs for comprehensive nursing care' (p=.041). The factor influencing intent to revisit hospital for patients in the general care unit was 'satisfaction with nursing care' (p<.001). Conclusion: Findings indicate that comprehensive nursing care service in which all care is provided by nursing staff only, without family or private caregivers, increases intent to revisit the hospital. These results can be used as the foundation of reviewing the operation and expansion of comprehensive nursing care service.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2005년도 추계학술대회 논문집
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• pp.171-175
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• 2005

The purpose of this study was to suggest the Support and Infill system for 126.6m$^2$-sized housing unit which meets residents' variety. The subjects were 100 housewives who lived in 126.6m$^2$-sized housing unit in the apartment complex, Busan. The data was collected by using model and questionnaire. The model was made to be same as the current 126.6m$^2$-sized floor plan. The residents preferred the flexible housing unit apartment complex. Also, the residents' needs for floor plan of housing unit were various. Therefore, the development of flexible housing unit is needed. On the basis of these findings, the support and infill system for 126.6m$^2$-sized housing unit was suggested.

• 한국가정과교육학회지
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• 제27권4호
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• pp.19-35
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• 2015

본 연구는 급변하는 교육환경에서 더욱 요구되는 인성을 갖춘 학습자 역량을 기르기 위해 고등학교 기술 가정 교과서 '가족이 여는 행복한 가정생활 문화' 단원을 중심으로 배려와 나눔 실천 교수 학습 과정안을 개발하여 평가하였다. 자료는 SPSS 20.0 프로그램을 이용하여 요인분석, 빈도분석, 상관분석, t-test를 실시하였다. 본 연구의 결과는 크게 배려와 나눔 실천 교수 학습 과정안 테마 I과 II 개발, 학생 활동 및 결과물 평가, 사전 사후 설문지 평가 3부분으로, 요약하면 다음과 같다. 첫째, 총 13차시분의 배려와 나눔 실천 교수 학습 과정안은 테마I(나눔으로 통하는 배려)과 테마 II(실천으로 통하는 배려)로 나누어, 테마 I은 '건강한 가족문화'와 '지속가능한 소비생활 문화' 단원을 중심으로 총 5차시분을, 테마 II는 '의식주 생활 속 배려와 나눔' 단원을 중심으로 총 8차시분을 개발하였다. 둘째, 테마 I에서 추출된 배려와 나눔 실천 요소(소통, 감사, 용기, 사랑, 공감, 환경)를 우리나라 가정생활에서 실천할 수 있도록 다양한 가족의 상황(맞벌이, 한부모, 다문화, 장애인, 3세대, 수험생 가족)에 맞게 테마 II에 적용한 결과, 스마트 기기를 활용한 모둠별 활동이 활발하게 이루어졌으며 가족과 이웃 그리고 환경을 고려한 배려와 나눔 실천 활동이 매우 다양한 형태로 이루어졌다. 셋째, 사전 검사로 실시한 청소년 인성 측정 문항의 요인 분석 결과 자아인식, 배려와 나눔 인식, 배려와 나눔 실천 3가지 요인으로 나타났으며, 연구 대상자의 가족관계 만족도나 학교생활 만족도가 높을수록 세 인성 변수간 정적 상관관계가 나타났다. 배려와 나눔 실천 수업 활동 결과, 다양한 측면에서 긍정적으로 적용되었고 배려심, 배려와 나눔 실천 능력 향상과 인성 함양에도 도움이 되었다. 학생들은 배려와 나눔 실천 수업을 통해 배려와 나눔 실천의 중요성과 필요성을 알게 되었고 실천에 대해 더욱 관심 갖게 되었으며, 연구자 역시 배려와 나눔 실천 활동 수업이 학생들로 하여금 일상 생활에서도 배려와 나눔 공동체 문화를 형성하는데 도움을 주었고 인성함양에 긍정적인 영향을 주었다는 것에 큰 의미를 두고 수업을 진행하는 내내 보람과 행복감을 느꼈다. 이에 따라 가정 교과가 인성교육이 체계적으로 이루어지고 있는 가장 적합한 교과로 자리매김 하는데 기여하기를 기대한다.

• 한국실내디자인학회논문집
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• 제18권5호
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• pp.137-146
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• 2009

The purpose of this study is to analyze the planning concept and spatial characteristics of the multi-housing units in prize-wining works of design competition since 2007. Literature review and content analysis were used for this study and 199units over $59m^2$ were analyzed to review the planning concept, spatial composition and layout. The results of this study were as follows; 1)The planning concept of these units were divided into three aspects; that is, eco-friendly, rational and sustainable unit plan by means of functional, environmental-friendly and future-oriented aspects. 2)Most unit plans had 3LDK+2bath and 4Bay types including family room as a public space. This results shows that family-room and bathroom has recently become more important than number of rooms in multi-housing units planning. 2)In terms of the spatial composition of LDK and Master Bed room, LDK area become large, open type and master-zone were showed 'bed room+dress and powder room+bath' type. 3)The entrance has a intermediated space as a balcony or a former space and the privacy of LDK space was protected from the entrance. This study has a significant moaning on grasping current trend in Korean multi-housing and to provide Information for future direction on housing-unit design.

• 대한간호학회지
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• 제22권4호
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• pp.620-635
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• 1992

This study identified correlations between perceived family support and hopelessness in patients admitted to Neuro - surgical Intensive Care Units. The purpose was to enhance theoretical understanding of the relationships of these two variables. The subjects of this study were 51 patients admitted to N-lCU, at three general hospitals in Seoul. Data were collected by researcher in structured interviews from Aug. 12 to Oct. 13, 1992. The research tools were parts of the Moos Family Environment Scale and the Beck Hopelessness Scale. The general characteristic data were analyzed for frequency and percentage ; the hypothesis was tested by the pearson product Moment Correlation Coefficient. After normality tests by using Kolmogorov - Sminorvtest, and T- test, ANOVA and Mann-Whitney U test, Kruskal -Wallis test were used on the Family Support and the Hopelessness about general charcteristics. The results of the above analysis were as follows 1) The average family support score for the group was 63.61 (tool average 51) and item average was 3.74 (tool item average 3) : the family support score of this sample was higher than average. The average family cohesion score of family support was 35.25 (tool average 27) and item average was 3.91 (tool item average 3). The average family expression score of family support was 28.35 (tool average 24) and item average was 3.57 (tool average 3). In this sample, perceived family expression was lower than family cohesion. 2) The average hopelessness score was 45.88 (tool average 60) and item average was 2.29 (tool item average 3) : the hopelessness score of this sample was low in comparison to the average. 3) The hypothesis in this study was supported. The main hypothesis that the higher the perceived family support level, the lower the level Of the hopelessness, was Supported (r＝-.3869 p＝.003). The sub-hypothesis that the higher the perceived family cohesion level, the lower the level of hopelessness, was supported(r＝-.3688 p＝.004). The sub-hypothesis that the higher the perceived family expression level, the lower the level of hopelessness, was supported (r＝-.3068 p＝.014). 4) General characteristics of the objects related to family support were ‘economic status’(p＝.025) and ‘helping person’(P＝.044) : the higher the economic status, the greater the family support. When the patient identified the helping person as a spouse, family support was rated more highly. The only general characteristic related to family cohesion was ‘helping person’(p＝.041). No general characteristics were related to family expression. 5) The one general characteristic related to hopelessness was ‘education’(p＝.002) : the higher their education, the lower their hopelessness. For these ICU patients, were related perceived family support and hopelessness, and family expression level was low in comparison to family cohesion level. The perceived family support of these seriously ill patients in situational crisis may have influenced the patient's emotional reaction of hopelessness. This study concluded that nurses in the ICU confirm the family support of the patient, and involve the family as the most intimate support systems in the care of the patient to help reduce the patient's hopelessness.

• 대한가정학회지
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• 제46권2호
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• pp.85-96
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• 2008

Given the evolving nature of the family unit, a large number of children are being left unsupervised after school. The purpose of this study is to understand the adaptation ability and emotional capacity of these children. To achieve this objective, we investigated the different characteristics of 708 middle-school students in Seoul, dividing them into two categories adult-care children, for whom adults provide care after school, and self-care children for whom no adult supervision was present. In particular, we examined children's adaptation to the school environment and possible self-consciousness difference between self-care and adult-care children, in consideration of their family characteristic; divorced, separated, widowed parent, remarried parents, ordinary families. The results showed that self-care children tend to have a higher rate of shame-proneness and guilt-proneness compared to adult-care children. Furthermore, self-care children exhibited lower school adaptation rate than adult-care children. There was no significant difference in schoolmate relationships between the two groups. In relation to specific family structures, children from reorganized families showed no significant differences in school adaptation and self-conscious, while self-care children from ordinary families revealed low school adaptation and high self-conscious characteristics. The results of this study are critical in the effective analysis and understanding of children's adaptive and emotional behaviors arising from changes in their family structure.

• 재활간호학회지
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• 제2권2호
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• pp.184-192
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• 1999

Hemodialysis is a way of treatment for the patients with acute and chronic renal failure. "Marginal man" depicts the enormous amount of stress that hemodialytic patients suffer. It is known that family with chronic illness get stressed along with the patients and they need nursing care also. This qualitative study was conducted in order to identify the family adaptation process in patients with hemodialysis. 6 dyads of hemodialytic patients and caregivers were interviewed for this research. By way of grounded theoretical strategy the data was collected from October 20, 1999 to November 20, 1999. at a hemodialytic unit that was located in Iksan, Chonbuk by the researcher. The main research questions were "What's the adaptation experience of a patient since after being received with hemodialysis?" to the patients, and "What's the family adaptation experience of hemodialysis?" to the caregivers. The collected data was analyzed by grounded theoretical strategy built by Glaser & Strauss in 1967. Results were as follows; 7 grounded concepts were observed from the patients with hemodialysis and 4 grounded concepts were found from the caregivers. Two categories were derived ; 1) Holding hope that is related with treatment 2) Changing a value system.