• 제목/요약/키워드: Family Protection Factor

검색결과 45건 처리시간 0.03초

쥐의 insulin-like growth tractor리 유전자 발현의 대사조절기전에 관안 연구 (Metabolic Regulation of Insulin-like Growth Factor-1 Expression)

  • 안미라
    • KSBB Journal
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    • 제17권3호
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    • pp.283-289
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    • 2002
  • Insulin-like growth factor-I(IGF-I)은 성장호르몬의 여러 가지 성정촉진 작용을 매개하는 분열 유발성 폴리펩티드이며, 조직의 수선과 재생, 창상치유 및 골대사와 같은 과정들에서 중요한 역할을 하는 것으로 알려져 있고, 비교적 여러 조직에서 발현되고 있는 IGF-I 유전자의 전사조절에 대한 정확한 분자적 기전과 호르몬 및 대사 상태가 그것을 어떻게 조절하는지 아직 밝혀져 있지 않다. 쥐를 절삭시키므로써 대사 상태를 변조시켰을 때, 간 조직내 IGF-I mRNA의 발현에 미치는 절식의 영향을 살펴보기 위하여 solution hybridizatioon/RNase protection 방법으로 분석 하였다. IGF-I의 exon 1 및 exon 2에 의하여 encode된 tran-scripts 모두가 감소된 결과를 얻었고, 이러한 감소는 전사 수준에서 일어난 것으로 nuclear run-on 분석에 의하여 확인하였다. 또한 절식시킨 쥐에서 IGF-I mRNA의 양을 조절하는 cia-acting elements를 IGF-I 유전자의 5'-flanking 지역과 exon 1과 econ 2에서 밝히고자 절식시킨 쥐의 신선한 간조직에서 핵 추출물을 얻어 IGF-I의 여러 가지 DNA fragments와 반응시켜 DNase I protection 분석을 한 결과, IGF-I 유전자의 주요한 전사 개 시점으로부터 downstream에 있는 sequences가 절식으로 변조시킨 대사상태에서 IGF-I의 발현 조절에 중요하며 이곳에는 전사인자인 C/EBP family의 isoform들을 포함한 간조직에 풍부하게 존재하는 여러 전사인자들이 결합할 것으로 제안하였다.

융합적 가족 기능과 청소년 보호요인의 매개검증에 관한 연구 (A Study on Convergence Family Function and parameter validation fusion of youth protection factor)

  • 장춘옥
    • 한국융합학회논문지
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    • 제6권4호
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    • pp.121-126
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    • 2015
  • 한국청소년패널(2008)의 중2 패널 5차년도 자료를 가지고 기술통계 분석과 회귀분석을 실시하여 가족의 기능적 결손이라는 위험상황에서 위험요인, 보호요인, 심리적응 간의 관계와 보호요인의 매개효과의 기제를 검증하고, 심리적응 수준이 높은 청소년을 보호해주는 보호요인을 분석하는 데에 그 목적이 있다. 분석방법으로는 대상자의 빈도분석과 개인특성에 따른 차이를 알아보기 위해 PASW(Predictive Analytics Software) 18.0을 이용해 t검증을 실시하였다. 또한 적응에 대한 보호요인의 작용 검증을 위하여 위계적 회귀분석을 실시하여 매개효과를 검증하였다. 연구결과 사회복지실천 현장에서 청소년의 위험요인에 초점을 맞추기보다는 위험요인을 완화시키는 과정이나 보호요인에 초점을 맞춤으로써 위험요인에 노출된 청소년을 바라보는 시각을 전환시킬 수 있으며 이들에 대한 개입도 달라질 것으로 판단된다. 사회복지실천 현장에서 청소년의 위험요인에 초점을 맞추기보다는 위험요인을 완화시키는 과정이나 보호요인에 초점을 맞춤으로써 위험요인에 노출된 청소년을 바라보는 시각을 전환시킬 수 있다. 또한, 가족의 기능적 결손이라는 어려움을 경험하는 청소년을 대상으로 사회복지 실천적 개입 방향을 마련 할 수 있는 기초를 마련한 것으로 판단된다.

치매환자의 증상정도가 주부양자의 우울에 미치는 영향 : 가족지지의 보호효과를 중심으로 (The effects of symptoms of dementia elderly on the primary caregiver's depression : moderating effects of family support)

  • 박선원;곽주연
    • 한국가족관계학회지
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    • 제21권3호
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    • pp.3-23
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    • 2016
  • Objectives: The purpose of this study is to examine the effects of symptoms of dementia elderly on the primary caregiver's depression. In addition, moderating effect of family support was examined. Based on the results, the necessity for intervention in the level of social welfare as a way to mitigate primary caregiver's depression was suggested. Method: In order to accomplish these purposes, a total of 197 who are spouse and adult-children of dementia elderly using day care facilities or services in Seoul, Gyeonggi, Busan province, South Korea were utilized. Data were analyzed by frequency analysis and descriptive statistics, regression model analysis with SPSS 18.0. Results: In case of analysis results, the mean value was reported 0.9 out of four point about primary caregiver's depression and the mean value of family support was reported 3.34 out of five point. And besides, the analysis result of dementia elderly's symptoms showed that prevalence of depression/dysphoria were 62.2%, prevalence of aberrant motor were 61.3%, prevalence of apathy/indifference were 56.6%. Crucial findings are as follows: the symptoms of dementia elderly was significantly associated with the primary caregiver's depression. At the same time, family support significantly influenced lower level of the primary caregiver's depression. While, in the relationship between the symptoms of dementia elderly and the primary caregiver's depression, family support has a moderation effect by important protection factor. Conclusions: From these findings, the necessities to provide the care service for dementia elderly to help improve symptoms of dementia as well as the policy and service to manage the mental health of the family as primary caregiver were suggested. Also, the necessities to provide the family therapy program to improve the relationship with family members were suggested.

Transcription Factor PU.1 Inhibits Aspergillus fumigatus Infection via Surfactant Protein-D

  • Kim, Sung-Su
    • 대한의생명과학회지
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    • 제24권3호
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    • pp.175-182
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    • 2018
  • Aspergillosis is a life-threatening disease in individuals with compromised immune systems. Fungal invasion is a highly critical process during host cellular infection. Several papers have reported that transcription factors are responsible for the infection process. To investigate what transcription factors are involved in the process in an effort to inhibit fungal infection into cells, I checked the surfactant protein family and PU.1 transcription factor levels in A549 cells infected with A. fumigatus conidia. PU.1 and surfactant protein-D levels were reduced in cells infected with fungal conidia. I then observed an increase in surfactant protein-D on PU.1-overexpressed cells. Infection of A. fumigatus conidia was decreased in PU.1-overexpressed cells, whereas the suppression of PU.1 did not lead to any changes in cases of A. fumigatus conidia infection. These results indicate that PU.1 inhibits the infection of A. fumigatus conidia via the expression of surfactant protein-D, suggesting that PU.1 is a key transcription factor for protection against A. fumigatus invasion.

북한이탈주민 범죄피해 예방정책의 효과성에의 영향요인 (The Factor Influencing to the Effectiveness of Prevention Policies of the Criminal Victimization of North Korean Defectors)

  • 임창호;김윤영
    • 시큐리티연구
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    • 제51호
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    • pp.223-249
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    • 2017
  • 이 연구의 목적은 북한이탈주민들의 범죄피해 실태를 분석하고, 북한이탈주민 지원제도 및 보호제도들 중에서 어떤 제도가 범죄피해 예방정책의 효과성 인식에 통계적으로 유의한 영향을 미치는지를 검증하는 것이다. 이 연구의 조사대상자는 전국 17개 지방경찰청의 신변보호 경찰관 107명이며, 독립변수는 (1) 하나원 사회적응교육, (2) 보호담당관제도, (3) 법률적 지원제도, (4) 민간 참여제도, (5) 가정생활 안정지원, (6) 지역사회 참여활동이고, 종속변수는 북한이탈주민 범죄피해 예방정책의 효과성이다. 다중회귀분석의 결과 북한이탈주민 범죄피해 예방정책의 효과성에 유의한 영향을 미치는 독립변수는 보호담당관제도와 민간 참여제도인 것으로 나타났다. 따라서, 북한이탈주민 범죄피해 예방정책의 효과성을 향상시키기 위해서 다음과 같은 정책적 제언을 제시하고자 한다. 첫째, 북한이탈주민의 범죄피해를 사전에 예방하기 위해서는 거주지 편입 후에 받게 되는 3가지 종류의 보호담당관제도가 제 역할을 다해야 한다. 둘째, 북한이탈주민의 성공적인 지역사회 조기 정착을 위해서는 정부와 지방자치단체만의 노력만으로는 부족하다. 따라서, 시민단체와의 협력을 통해 북한이탈주민 지원 및 보호 프로그램을 다양화할 필요가 있다. 셋째, 사회적응교육 과정에서 법률교육 시간을 대폭 확대하여 북한이탈주민들이 법률지식의 부족으로 인하여 범죄피해를 당하지 않도록 해야 할 것이다. 넷째, 북한이탈주민들이 각종 범죄피해를 당하지 않도록 하기 위해서 무엇보다도 가정생활이 안정될 수 있도록 적극적으로 지원할 필요가 있다.

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유아의 부정적 정서성, 주의력 결핍 과잉행동 성향과 또래놀이 상호작용 관계에서 언어능력의 중재영향 (Moderating Effects of Language Abilities Associated with Emotionality, Attention Deficit Hyperactivity Disorder, and Peer Play Interactions)

  • 이현정;이예진;신유림
    • Human Ecology Research
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    • 제51권4호
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    • pp.395-401
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    • 2013
  • The purpose of this study is to investigate the moderating effects of language abilities associated with between emotionality, attention deficit hyperactivity disorder (ADHD) and peer play interactions. Two hundred fifty-two participants were 3 year olds, with 136 boys and 116 girls. They were recruited from day care centers and preschools in Gyunggi province and Incheon city. Peer play interaction was assessed by the Penn Interactive Peer Play Scale (PIPPS). Emotionality was measured by Child Behavior Questionnaire (CBQ). ADHD was assessed by teacher ratings of ADHD syndrome. Language abilities were measured by Korean Wechsler Preschool and Primary Scale of Intelligence (K-WPPSI). Teachers completed questionnaires to assess peer play interactions, emotionality, ADHD. The results revealed that language abilities moderated relationships between emotionality and play in isolation. The magnitude of associations between emotionality and play in isolation was greater for high levels of language abilities. Moreover, there were moderating effects of language abilities associated between ADHD and play disruptions. Although ADHD was significantly associated with play disruptions, the association was stronger at the higher levels than the low levels of language abilities. It can be deduced that language abilities of 3 year old children affects the protection factor between emotionality and peer play isolation; whilst, it affects the risk factor on peer play disruptions and ADHD propensity.

Differential gene expression pattern in brains of acrylamide-administered mice

  • Han, Chang-Hoon
    • 대한수의학회지
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    • 제52권2호
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    • pp.99-104
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    • 2012
  • The present study was performed to evaluate the relationship between the neurotoxicity of acrylamide and the differential gene expression pattern in mice. Both locomotor test and rota-rod test showed that the group treated with higher than 30 mg/kg/day of acrylamide caused impaired motor activity in mice. Based on cDNA microarray analysis of mouse brain, myelin basic protein gene, kinesin family member 5B gene, and fibroblast growth factor (FGF) 1 and its receptor genes were down-regulated by acrylamide. The genes are known to be essential for neurofilament synthesis, axonal transport, and neuroprotection, respectively. Interestingly, both FGF 1 and its receptor genes were down-regulated. Genes involved in nucleic acid binding such as AU RNA binding protein/enoyl-coA hydratase, translation initiation factor (TIF) 2 alpha kinase 4, activating transcription factor 2, and U2AF 1 related sequence 1 genes were down-regulated. More interesting finding was that genes of both catalytic and regulatory subunit of protein phosphatases which are important for signal transduction pathways were down-regulated. Here, we propose that acrylamide induces neurotoxicity by regulation of genes associated with neurofilament synthesis, axonal transport, neuro-protection, and signal transduction pathways.

TLR4 Mediates Pneumolysin-Induced ATF3 Expression through the JNK/p38 Pathway in Streptococcus pneumoniae-Infected RAW 264.7 Cells

  • Nguyen, Cuong Thach;Kim, Eun-Hye;Luong, Truc Thanh;Pyo, Suhkneung;Rhee, Dong-Kwon
    • Molecules and Cells
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    • 제38권1호
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    • pp.58-64
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    • 2015
  • Activating transcription factor-3 (ATF3) acts as a negative regulator of cytokine production during Gram-negative bacterial infection. A recent study reported that ATF3 provides protection from Streptococcus pneumoniae infection by activating cytokines. However, the mechanism by which S. pneumoniae induces ATF3 after infection is still unknown. In this study, we show that ATF3 was upregulated via Toll-like receptor (TLR) pathways in response to S. pneumoniae infection in vitro. Induction was mediated by TLR4 and TLR2, which are in the TLR family. The expression of ATF3 was induced by pneumolysin (PLY), a potent pneumococcal virulence factor, via the TLR4 pathway. Furthermore, ATF3 induction is mediated by p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK). Thus, this study reveals a potential role of PLY in modulating ATF3 expression, which is required for the regulation of immune responses against pneumococcal infection in macrophages.

중년여성의 사회인구학적 변인, 자아분화, 내면체계가 자아정체감에 미치는 영향 (Effects of socio-demographic variables, self-differentiation and internal systems on ego-identity of middle-aged women)

  • 변외진;김춘경
    • 대한가정학회지
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    • 제44권12호
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    • pp.155-165
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    • 2006
  • The purpose of this study was to analyse the factor of the variables that contributed to the ego-identity of middle-aged women. The subjects were 751 middle-aged women whose age was from 40 to 60 years old. The instruments used in the study were the assessments of ego-identity, self-differentiation, and internal systems. The data were analysed by using pearson correlation and hierarchical multiple regression. The findings were as follows; (1) In the result of the analysis about relationships with ego-identity, the ego-identity was positively correlated with self-differentiation and the self of internal systems and negatively correlated with the parts of internal systems; (2) Predictors of ego-identity of the middle-aged women ordered occupation type, the level of education, cognitive-emotional function, self integration, family projection process, self, pleasing/abandoned part, and self-harming part. Based on these results, the recommendations for the future research in this area were discussed.

A Multifactorial Interpretation of a Teenager's Suicide: Based on Krystal's Death in Casual Vacancy

  • Bahn, Geon Ho;Park, Joo Seok
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • 제32권1호
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    • pp.3-9
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    • 2021
  • Objectives: It is hard to accumulate research data on adolescents' suicide, because friends and family of the suicide completers might be reluctant to share the experience. To overcome the lack of information on adolescent suicide victims, the authors examined the risk and protective factors for adolescents' suicide from a character in a novel. Methods: Krystal, an adolescent female in the novel The Casual Vacancy by Joanne Rowling, failed to overcome her unfortunate circumstances and committed suicide. The authors analysed Krystal's case based on the guideline for patients with suicidal behaviours to address the complicated situation of her death. Results: Krystal grew up in a poor and dangerous environment. Despite the environmental hardships, she developed ego maturation with affectionate help from Mr Fairbrother, an assistant coach of the Girls' Rowing Team and a parish councillor. The sudden passing away of Mr Fairbrother brought on a crisis of identity for Krystal. In addition, a villainous character raped her and her brother drowned to death, which brought her great sorrow. She felt helpless and committed suicide. Conclusion: In spite of many risk factors for suicide, Krystal was able to keep her life with a few protective factors, a younger brother in the home, and a sense of responsibility for the family. After the loss of her brother, however, she collapsed in a moment. Krystal's suicide might not only be a personal choice but a breakdown of the social protection system for the youth.