• Title/Summary/Keyword: Family G11

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Non-specific Immune Response of Rainbow Trout (Oncorhynchus Mykiss) by Dietary Heat-inactivated Potential Probiotics

  • Choi, Sang-Hoon;Yoon, Taek-Joon
    • IMMUNE NETWORK
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    • v.8 no.3
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    • pp.67-74
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    • 2008
  • Background: The effects of the dietary administration of two heat-inactivated whole bacteria from the Vibrionaceae family, singly or combined, on innate immune response of the rainbow trout were studied. The two bacteria (Pdp11 and 51M6), which were obtained from the skin of rainbow trout, showed in vitro characteristics that suggested they could be considered as potential fish probiotics. Methods: The fish were fed four different diets: control (non-supplemented), or diets supplemented with heat-inactivated bacteria at $10^8$ cfu/g Pdp11, $10^8$ cfu/g 51M6 or with $0.5{\times}10^8$ cfu/g Pdp11 plus $0.5{\times}10^8$ cfu/g 51M6 for 4 weeks. Six fish were sampled at weeks 1, 2, 3 and 4, and then the main humoral (natural haemolytic complement activity and serum peroxidase content) and cellular innate immune responses (leucocyte peroxidase content, phagocytosis, respiratory burst and cytotoxicity) were evaluated. Results: The serum peroxidase content and the natural haemolytic complement activity increased with time, reaching the highest values in the third and fourth weeks of feeding, respectively. The phagocytic ability of specimens fed the mixture of the two inactivated bacteria was significantly higher than in the controls after 2 and 3 weeks of treatment. The same activity increased significantly in rainbow trout fed the Pdp11 diet for 2 weeks or the 51M6 diet for 3 weeks. Respiratory burst activity was unaffected by all the experimental diets at all times assayed. Cytotoxic activity had significantly increased after 3 weeks in fish fed the 51M6 diet. Conclusion: Our results demonstrated the usefulness of incorporating inactivated probiotic bacteria into fish diets.

SOME RESULTS ON STARLIKE TREES AND SUNLIKE GRAPHS

  • Mirko, Lepovic
    • Journal of applied mathematics & informatics
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    • v.11 no.1_2
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    • pp.109-123
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    • 2003
  • A tree is called starlike if it has exactly one vertex of degree greate. than two. In [4] it was proved that two starlike trees G and H are cospectral if and only if they are isomorphic. We prove here that there exist no two non-isomorphic Laplacian cospectral starlike trees. Further, let G be a simple graph of order n with vertex set V(G) : {1,2, …, n} and let H = {$H_1$, $H_2$, …, $H_{n}$} be a family of rooted graphs. According to [2], the rooted product G(H) is the graph obtained by identifying the root of $H_{i}$ with the i-th vertex of G. In particular, if H is the family of the paths $P_k_1,P_k_2,...P_k_2$ with the rooted vertices of degree one, in this paper the corresponding graph G(H) is called the sunlike graph and is denoted by G($k_1,k_2,...k_n$). For any $(x_1,x_2,...,x_n)\;\in\;{I_*}^n$, where $I_{*}$ = : {0,1}, let G$(x_1,x_2,...,x_n)$ be the subgraph of G which is obtained by deleting the vertices $i_1,i_2,...i_j\;\in\;V(G)\;(O\leq j\leq n)$, provided that $x_i_1=x_i_2=...=x_i_j=o.\;Let \;G[x_1,x_2,...x_n]$ be characteristic polynomial of G$(x_1,x_2,...,x_n)$, understanding that G[0,0,...,0] $\equiv$1. We prove that $G[k_1,k_2,...,k_n]-\sum_{x\in In}[{\prod_{\imath=1}}^n\;P_k_i+x_i-2(\lambda)](-1)...G[x_1,x_2,...,X_n]$ where x=($x_1,x_2,...,x_n$);G[$k_1,k_2,...,k_n$] and $P_n(\lambda)$ denote the characteristic polynomial of G($k_1,k_2,...,k_n$) and $P_n$, respectively. Besides, if G is a graph with $\lambda_1(G)\;\geq1$ we show that $\lambda_1(G)\;\leq\;\lambda_1(G(k_1,k_2,...,k_n))<\lambda_1(G)_{\lambda_1}^{-1}(G}$ for all positive integers $k_1,k_2,...,k_n$, where $\lambda_1$ denotes the largest eigenvalue.

Reliability analysis of a complex system, attended by two repairmen with vacation under marked process with the application of copula

  • Tiwari, N.;Singh, S.B.;Ram, M.
    • International Journal of Reliability and Applications
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    • v.11 no.2
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    • pp.107-122
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    • 2010
  • This paper deals with the reliability analysis of a complex system, which consists of two subsystems A and B connected in series. Subsystem A has only one unit and B has two units $B_1$ and $B_2$. Marked process has been applied to model the complex system. Present reliability model incorporated two repairmen: supervisor and novice to repair the failed units. Supervisor is always there and the novice remains in vacation and is called for repair as per demand. The repair rates for supervisor and novice follow general and exponential distributions respectively and the failure time for both the subsystems follows exponential distribution. The model is analyzed under "Head of line repair discipline". By employing supplementary variable technique, Laplace transformation and Gumbel-Hougaard family of copula various transition state probabilities, reliability, availability and cost analysis have been obtained along with the steady state behaviour of the system. At the end some special cases of the system have been taken.

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A Korean Family with Cholesterol Ester Transfer Protein Deficiency

  • Youn, Seo-Young;Shin, Ik-Soon;Hong, Yong-Hee;Lee, Dong-Hwan
    • Journal of Genetic Medicine
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    • v.9 no.1
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    • pp.38-41
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    • 2012
  • A 32-year-old female patient and her sister show high levels of high density lipoprotein (HDL) cholesterol in regular health checkups, since female patient was 11 years old. The patient's serum total cholesterol was 285 mg/dL and HDL cholesterol was 113 mg/dL. Her sister's total cholesterol was 240 mg/dL and the HDL cholesterol measured to be 90 mg/dL. Lipoprotein pattern and cholesteryl ester transfer activity gene analysis were examined in these patients. We found c.1321+1G>A (IVS14+1G/A) hetero mutation in cholesteryl ester transfer protein (CETP) genes. Generally, CETP mediates transfer and exchange of triglycerides and cholesteryl ester between plasma lipoproteins. Also we investigated a key role of HDL-CE and Apo A-1 metabolism. Patients with low levels of CETP have increased serum HDL levels. We hereby report two Korean cases of CETP deficiency in a family. Brief literature review ensues with the cases.

Significance of Cell Cycle and Checkpoint Cnotrol (세포주기조절에 관한 최근 연구)

  • 최영현;최혜정
    • Journal of Life Science
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    • v.11 no.4
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    • pp.362-370
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    • 2001
  • Regulation of cell proliferation is a complex process involving the regulated expression and /or modification of discrete gene products. which control transition between different stages of the cycle. The purpose of this short review is to provide an overview of somatic cell cycle events and their controls. Cycline have appeared as major positive regulators in this network, because their association to the cyclin-dependent kinases(Cdks) allows the subsequent activation on the Cdk/cyclin complexes and their catalatic activity. In mammalian cells, early to mid G1 progression and late G1 progression leading to S phase entry are directed by D-type cyclins-Cdk4, 6 and cyclin E-Cdk 2 both of which can phosphorylate the retinoblastoma protein (pRB). pRB is a transcriptional repressor which, in its unphosphorylated state, binds to members of the E2F transcription factor family and blocks E2F-dependent transcription of genes controlling the G1 to S phase transition an subsequent DNA synthesis. Cyclin A is produced in late G1 and expressed during S and G2 phae, and expression of B-type cyclins is typically maximal during the G2 to M phase transition and it controls the passage through M phase. They primarily associate with the activate Cdk2, and Cdc2, respectively. On the other hand, the Cdk inhibitors negatively control the activity of C아/cyclin complex by coordinating internal and/or external signals and impending proliferation at several key checkpoints. These current and further findings will provide novel approaches to understanding and treating major diseases.

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A NONCOMMUTATIVE BUT INTERNAL MULTIPLICATION ON THE BANACH ALGEBRA $A_t$

  • Ryu, Kun-Sik;Skoug, David
    • Bulletin of the Korean Mathematical Society
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    • v.26 no.1
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    • pp.11-17
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    • 1989
  • In [1], Johnson and Lapidus introduced a family { $A_{t}$ :t>0} of Banach algebras of functionals on Wiener space and showed that for every F in $A_{t}$ , the analytic operator-valued function space integral $K_{\lambda}$$^{t}$ (F) exists for all nonzero complex numbers .lambda. with nonnegative real part. In [2,3] Johnson and Lapidus introduced a noncommtative multiplication having the property that if F.mem. $A_{t}$ $_{1}$ and G.mem. $A_{t}$ $_{2}$ then $F^{*}$G.mem. A$t_{1}$+$_{t}$ $_{2}$ and (Fig.) Note that for F, G in $A_{t}$ , $F^{*}$G is not in $A_{t}$ but rather is in $A_{2t}$ and so the multiplication * is not internal to the Banach algebra $A_{t}$ . In this paper we introduce an internal noncommutative multiplication on $A_{t}$ having the property that for F, G in $A_{t}$ , F G is in $A_{t}$ and (Fig.) for all nonzero .lambda. with nonnegative real part. Thus is an auxiliary binary operator on $A_{t}$ .TEX> .

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The Inhibitory Effects of Poria cocos Bark Extract on Melanogenesis (복령피 추출물의 멜라닌 생성 저해 효과)

  • Lee, Eung-Ji;Bae, Seong-Yun;Son, Rak-Ho;Lee, Yong-Hwa
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.35 no.3
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    • pp.243-250
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    • 2009
  • To develop a new natural whitening agent for cosmetics, we investigated the inhibitory effects of Poria cocos Bark extracts (PCBE) and its active compound on melanogenesis. PCBE showed ROS scavenging activities in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase system with the $IC_{50}$ values of $19.4{\pm}2.21{\mu}g$/mL and $IC_{50}=103{\pm}3.33{\mu}g$/mL, respectively. PCBE reduced intracellular tyrosinase activity about 34 % at concentration of $50{\mu}g$/mL. And PCBE reduced melanin contents of B16 melanoma cells about 51 % at concentration of $50{\mu}g$/mL without cell cytotoxicity (below $100{\mu}g$/mL). We purified one active compound from PCBE and identified its structure. It was identified as 3-$\beta$-hydroxylanosta-7,9(11),24-trien-4-oic acid, triterpene family, by $^1H$-NMR, $^{13}C$-NMR and Mass analysis. 3-$\beta$-hydroxylanosta-7,9(11),24-trien-4-oic acid showed ROS scavenging activities in DPPH radical and xanthine/xanthine oxidase system with the $IC_{50}$ values of $4.3{\pm}0.15{\mu}g$/mL and $54{\pm}1.67{\mu}g$/mL, respectively. Also, it was shown that 3-$\beta$-hydroxylanosta-7,9(11),24-trien-4-oic acid reduced intracellular tyrosinase activity about 43 % at concentration of $10{\mu}g$/mL. And it inhibited melanin synthesis in a dose dependent manner ($IC_{50}=3.6{\mu}g$/mL) without cell cytotoxicity (below $100{\mu}g$/mL). 3-$\beta$-hydroxylanosta-7,9(11),24-trien-4-oic acid inhibited tyrosinase, TRP-1 and TRP-2 expression at protein level. These results suggest that PCBE and 3-$\beta$-hydroxylanosta-7,9(11),24-trien-4-oic acid reduced melanin formation by the inhibition of tyrosinase activity and expression in B16 melanoma cells. Therefore, we suggest that PCBE could be used as a useful whitening agent.

Investigation on the Mitigation of Suicidal Thoughts in the Elderly Depending on Mobile Media Technology and Living Arrangement (모바일 미디어 기술과 주거형태에 따른 노인 자살생각 완화 연구)

  • Bum, Chul-Ho;Johnson, John A.;Choi, Chulhwan
    • The Journal of the Korea Contents Association
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    • v.20 no.11
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    • pp.534-545
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    • 2020
  • In the super-aged societies, an increased elderly population living in solitude has been causing many problems. Since the elderly may incur a sense of loss and interest in suicide when living alone, this study investigated the effects of smartphones as well as types of living arrangements on elderly peoples' sense of loss and suicidal thoughts. This study found social roles and relationships were lower for older individuals using smartphones than those using 2G phones. Not surprisingly, those living with family members or a partner had significantly fewer suicidal thoughts than those living in solitude. However, our results indicate subjects' loss of role and relationships was affected more significantly by their smartphone usage (2G phone vs. smartphone) rather than their living arrangements (i.e., living with family or a partner vs. living in solitude). Moreover, smartphone users showed a lower sense of loss in terms of social roles and relationships. Among the elderly, loss of health, social role, and relationships were identified as precedents for increased suicidal thoughts; yet, economic capacity was surprisingly not an indicator of suicidal thoughts.

Development of Prediction Model for Depression among Parents with Disabled Children: Based on the Mediation Effect of Social Supports and Family Resilience (장애아동부모의 사회적지지, 가족건강성 및 우울의 구조모형)

  • Keum, Hyesook;Shin, Yeonghee;Kim, Hyeyoung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.2
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    • pp.171-178
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    • 2016
  • In this study, a prediction model for depression among parents with disabled children was developed by verifying the effects of social support and family resilience. One hundred forty one parents with disabled children were recruited from three out-patient clinics of rehabilitation hospitals in D city between August and September, 2014. The instruments used were the QRS, CES-D, MSPSS, and KFSS-II. The average score of depression was 20.18/60. The levels of depression were significantly different among variables, e.g., sex, age, and monthly income. The mean scores of the item for social support and family resilience were 3.11/5 and 3.32/5, respectively. Family resilience differed significantly according to monthly income. Parental depression was negatively correlated with the social supports and family resilience. Social support was correlated positively with family resilience. In conclusion, family resilience and social support are predictable factors for depressed parents with disabled children.

CONVERGENCE THEOREMS OF IMPLICIT ITERATION PROCESS WITH ERRORS FOR ASYMPTOTICALLY NONEXPANSIVE MAPPINGS IN THE INTERMEDIATE SENSE IN BANACH SPACES

  • Saluja, G.S.
    • East Asian mathematical journal
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    • v.28 no.1
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    • pp.63-71
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    • 2012
  • The aim of this article is to study an implicit iteration process with errors for a finite family of non-Lipschitzian asymptotically non expansive mappings in the intermediate sense in Banach spaces. Also we establish some strong convergence theorems and a weak convergence theorem for said scheme to converge to a common fixed point for non Lipschitzian asymptotically nonexpansive mappings in the intermediate sense. The results presented in this paper extend and improve the corresponding results of [1], [3]-[8], [10]-[11], [13]-[14], [16] and many others.