• Korean Journal of Veterinary Research
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• v.51 no.2
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• pp.139-149
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• 2011

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease in the murine central nervous system (CNS) and has long been used as an animal model for human multiple sclerosis. Development of EAE requires coordinated expression of a number of genes that are involved in the activation and effector functions of inflammatory cells. Galectin-3 (Gal-3) is a member of the betagalactoside- binding lectin family and plays an important role in inflammatory responses through its functions on cell activation, cell migration or inhibition of apoptosis. We investigated the functional role of Gal-3 in EAE mice following immunization with myelin oligodendrocyte glycoprotein $(MOG)_{35-55}$ peptide. During the peak stage of EAE, the localization of Gal-3 in inflammatory cells markedly increased in subarachnoid membranes and perivascular regions of CNS. In contrast, Gal-3 was weakly detected in cerebrum and spinal of the recovery stage of EAE. Consistent with this finding, western blot analysis revealed that Gal-3 expression was significantly increased at the peak stage while it was slightly decreased at the recovery stage in the CNS. In addition, the population of $CD11b^{+}$ macrophage expressing Gal- 3 in spleen of EAE mice was markedly increased compared with control mice. In fact, most of activated macrophages isolated from spleen of EAE mice expressed Gal-3. Taken together, our results demonstrate that the over-expression of Gal-3 in activated macrophages may play a key role in promoting inflammatory cells in the CNS during EAE.

• The Korean Journal of Petroleum Geology
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• v.14 no.1
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• pp.12-20
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• 2008

Oil sands in Canada are representative example of unconventional resources whose reserve estimates are as large as those in Saudi Arabia. Typical reservoir rocks of oil sands consist of channel-related deposits formed in a tide-dominated depositional setting. The tidal deposits are commonly characterized by spatially complicated and heterogeneous properties. Successful engineering methods to develop oil sands require in-depth understanding in the spatial distribution of reservoir properties. Geological model for oil sand reservoir characterization can be built on the basis of comparative studies of ancient and modem analogues. In particular, modern analogue studies become increasingly indispensable, since they provide better understanding in the reservoir-rock forming process and more importantly in the external mechanism responsible for the reservoir heterogeneity. Tide-dominated environment along the west coast of Korea is considered as one of the most excellent modem analogues of oil-sand forming depositional environment. Korean tidal environment provides insights on the origin of mud breccia, facies and stratigraphic architecture which are key issues to the characterization of oil sand reservoirs.

• Korean Journal of Food Science and Technology
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• v.38 no.1
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• pp.82-87
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• 2006

Twenty one strains strongly producing protease were isolated from Korean traditional Cheonggukjang. Eight strains selected by sensory evaluation on Cheonggukjang prepared with isolated strains were identified with based on biochemical properties a and 16S rDNA sequencing. Identified strains were Bacillus subtilis MB4, and Bacillus amyloliquefaciens A1, A2, B1, MC1, SB2, SC1, and SD1. Protease activities, important strain selection factor, were higher in Cheongjukjang prepared with B. subtilis MB4 (179.6 Unit) and B. amyloliquefaciens SB2 (201.9 Unit) than commercial traditional Cheonggukjang (97.9 Unit). Sensory evaluation revealed Cheonggukjang prepared with B. subtilis MB4 had flavor very similar to commercial traditional Cheonggukjang. Cheonggukjang prepared with B. suhtilis MB4 (0.0006 Pa s) and commercial traditional Cheonggukjang (0.0002 Pa s) revealed lower viscosities than those of Cheonggukjang prepared with B. amyloliquefaciens SB2, MC1, B1, A1, SD1, A2, and SC1 (0.006 to 0.008 Pa s at 1001/s. Results show Cheonggukjang could be prepared using single strain of B. subtilis MB4, maintaining high protease activity and very similar sensory and viscosity qualities with those of commercial traditional Cheonggukjang.

• Journal of the Geological Society of Korea
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• v.54 no.6
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• pp.657-675
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• 2018

The apparent thickening of the subducting slab in the shallow lower mantle has been attributed to slab buckling. However, the scaling laws have not been quantitatively evaluated for the buckling behavior of the subducting slab when phase transformations are considered. Thus, two-dimensional dynamic subduction experiments are formulated to evaluate the effect of phase transformations on the buckling behavior of the subducting slab. The model calculations show that the phase transformation from olivine to wadsleyite at a depth of 410 km plays an important role in the development of slab buckling; increased slab pull due to the endothermic phase transformation accelerates slab sinking in the upper mantle and the subducting slab reaches the lower mantle in a shorter time than that of the experiments without the phase transformation. However, the phase transformation from ringwoodite to perovskite plus $magnesiow{\ddot{u}}stite$ at a depth of 660 km retards slab sinking into the lower mantle and the subducting slab tends to be accumulated in the transformation (transition) zone. Buckling analyses show that the scaling laws predict the buckling amplitude and period of the subducting slab with small relative errors even if the phase transformations are considered. The universal phenomenon of the slab buckling can explain apparent slab thickening in the shallow lower mantle and transformation zone under the subduction zones such as Java-Sunda and Northeast Japan. In addition, the buckling behavior of the subducting slab may be related to the periodic compressions and extensions in the Cretaceous Gyeongsang basin.

• Journal of the Geological Society of Korea
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• v.54 no.6
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• pp.615-630
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• 2018

Basin analysis is a research field to understand the formation and evolution of sedimentary basins. This task requires various geoscientific datasets as well as numerical and graphical modelling techniques to synthesize results dimensionally in time and space. For basin analysis and modelling in a comprehensive workflow, BasinVis 1.0 was released as a MATLAB-based program in 2016, and recently the software has been extended to BasinVis 2.0, with new functions and revised user-interface. As a case study, this work analyses the southern Vienna Basin and visualizes the sedimentation setting and subsidence evolution to introduce the basin modelling functions of BasinVis 2.0. This is a preliminary study for a basin-scale modelling of the Vienna Basin, together with our previous studies using BasinVis 1.0. In the study area, during the late Early Miocene, sedimentation and subsidence are significant along strike-slip and en-echelon listric normal faults. From the Middle Miocene onwards, however, subsidence decreases abruptly over the area and this situation continues until the Late Miocene. This is related to the development of the pull-apart system and corresponds to the episodic tectonic subsidence in strike-slip basins. The subsidence of the Middle Miocene is confined mainly to areas along the strike-slip faults, while, from the late Middle Miocene, the depocenter shifts to a depression along the N-S trending listric normal faults. This corresponds to the regional paleostress regime transitioning from NE-SW trending transtension to E-W trending extension. This study applies various functions and techniques to this case study, and the modelled results demonstrate that BasinVis 2.0 is effective and applicable to the basin modelling.

• Korean Journal of Breeding Science
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• v.41 no.4
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• pp.595-598
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• 2009

A new yellow gerbera (Gerbera hybrida Hort.) cultivar "Golden Time" was developed from a cross between '99-ga-2' and '99-na-7-6', followed by seedling and line selections at the Flower Research Institute, Gyeongnam Agricultural Research and Extension Services (ARES) in 2007. Detailed characteristics of the new cultivar were evaluated from 2004 to 2007. "Golden Time" has semi-double type large flowers in a good harmony with yellow (RHS, 17-B) ray floret and brown center. It has good, stable flower shape and strong peduncles, and its vase life was 12.3 days. The average flower yield of "Golden Time" was about 49.5 stems per plant/year in greenhouse trails during 2004 and 2007. This cultivar was registered to the Korea Seed and Variety Service (KSVS) for commercialization in 2009. Year-round production of this cultivar is possible in the greenhouse condition throughout the Korean climate.

• Journal of the Korean Society for Railway
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• v.19 no.4
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• pp.539-546
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• 2016

It is over 12 years since the launch of Korea Train eXpress (KTX) services. Demand for the KTX has been on the increase continuously but few studies have been produced related to this phenomenon. KTX passenger demand has been constantly increasing due to influencing factors such as the expansion of network, rise of oil prices, etc. In this study, our main focus is to verify that there are other types of elements that are causing an increase in KTX demand; our approach looks at changes in social and psychological aspect that have occurred due to the reduction of travel time and cost, as well as the imposition of a five-day workweek. In other words, we considered diffusion theory in the marketing area, which affects product selection and purchasing attitudes, as a key factor that is causing passenger demand to increase. That is to say that it is hypothesized that the demand for travel on the KTX has increased due to the train's utility, which is spread by the diffusion effect Therefore, the Bass diffusion model was applied to explain the dramatic increase in KTX passenger demand. Based on this foundation, it was also discussed how certain marketing strategies that incorporate the diffusion effect should be considered variously for sustainable management of rail transportation, while considering a steady passenger demand.

• Journal of Animal Science and Technology
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• v.61 no.2
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• pp.55-60
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• 2019

Colibacillosis is one of the major health problems in young piglets resulting in poor health and death caused by Escherichia coli producing F18 pili and Shiga toxin 2e. It is pivotal to reduce colibacillosis in weaned piglets to enhance production performance. In this study, we evaluated synbiotics as the gut health improvement agents in the mouse model challenged with Shiga toxin-producing E. coli (STEC) isolated from piglets. Prebiotic lactulose was formulated with each $5.0{\times}10^6CFU/mL$ of Pediococcus acidilactici GB-U15, Lactobacillus plantarum GB-U17, and Lactobacillus plantarum GB 1-3 to produce 3 combinations of synbiotics. A total of 40 three weeks old BALB/c mice were randomly assigned to 4 groups (n = 10): a control group and 3 synbiotics treated groups. Each treatment groups were daily administrated with $5.0{\times}10^6CFU/mL$ of one synbiotics for the first week, and every 3 days during the second week. All the mice were challenged with $8.0{\times}10^8CFU/mL$ of STEC 5 days after animals began to receive synbiotics. Mice treated with synbiotics based on Pediococcus acidilactici GB-U15 and Lactobacillus plantarum GB-U17 significantly improved daily weight gain compared to mice in other groups. While mice treated with GB-U15 showed better fecal index, no significant differences were observed among groups. Gross lesion and histopathological evaluations showed that mice treated with GB-U15 moderately improved recovery from STEC infection. In conclusion, our results suggest that the synbiotics formulated with lactulose and Pediococcus acidilactici GB-U15 have potential benefits to prevent and improve colibacillosis in weaned piglets.

• The Korean Journal of Emergency Medical Services
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• v.22 no.3
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• pp.7-34
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• 2018

Purpose: The purposes of this research were to study the validity of the National Examination based on smart based test(SBT) by 7 types of healthcare occupation. Methods: We conducted a questionnaires survey among 1,219 people including 210 professors for all 7 types of healthcare occupation and 573 clinical specialists ; 436 students from random sampling participated and the reliability of the questionnaire was tested using Cronbach's alpha. Results: Professors from 7 types of healthcare occupation were investigated for their opinions on the introduction of the SBT system ; 65.9% of the professors answered positively on the introduction of the SBT National Examination System, while 40.1% of the clinical experts answered likewise. In particular, professors and the clinical experts recognized altogether that the multimedia questionnaire, being effective for the evaluation of clinical and practical competence of the subjects, enabling the evaluation of various areas and strengthening the school education in clinical practices, the 42.0% of the students from 7 departments answered that the future direction of the national test is in the SBT test system with significant difference (p=.000) found in students majoring in order of Emergency Medical Services, Radiology and Physical therapy, compared to students from other majors, showing the positive response to the SBT system. Conclusion: The results of this study comprehensively evaluated the positive recognition of development of multimedia items and SBT system in national examination of 7 types of healthcare occupation in professors, field specialists and students.

• International Area Studies Review
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• v.15 no.3
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• pp.29-53
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• 2011

This paper studies the contribution of imports and inward foreign direct investment (FDI) as a vehicle of technology transfer onto the EU new member states at both macroeconomic and industry level. The paper takes the effectiveness of the recipient's utilization into account by constructing a new index, the so-called Effective Absorption (EA) Index, to measure ability to absorb and utilize the foreign technology in the recipient country. Using data from 12 donors and 10 recipients from 1998 to 2009, the study at macroeconomic level indicates that technical spillovers of foreign research and development (R&D) play more crucial role relatively to domestic R&D on total factor productivity (TFP) growth of the new member states. Imports are found as the major vehicle of technical spillovers rather than inward FDI. The study at industry level is conducted by using data from 17 manufacturing industries of 10 donors and 6 recipients during 1998 to 2009. The empirical results also support the findings at country level. The patterns of technology transfer are different across industries. Nonetheless, technical spillovers exhibit significantly high contribution on TFP growth in high-tech manufacturing industries.