• Progress in Medical Physics
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• v.15 no.4
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• pp.237-246
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• 2004

Even though the wedge factor was defined by ICRU, RTPS uses other definition different from the wedge factor to consider the wedge effect to correct dose. Because the factors with different concept are defined in a very different way, replacement of different factor could make severe error of dose and is unacceptable because their values are very different from each other. Radiotherapy machine installed in department includes physical wedges and function of dynamic wedge by upper jaws, and Eclipse and Pinnacle$^{3}$ such as RTPS are used. The wedge factors, relative wedge output factors and wedge field output factors of physical wedges and dynamic wedges were measured by an ionization chamber in water phantom. They are analyzed and compared in according to wedge position, field size, wedge angle, X-ray quality, measurement condition. Wedge factor, relative wedge output factors and wedge field output factors of dynamic wedges comparing physical wedges have an effect of several factors. Main factors effecting to the factors of dynamic wedges were field size and wedge angle. Beam quality of X-ray introduces a few effect to the factors. Because the factors related to wedge and defined with different concepts are different from each other, to reduce dose error it should be input by values proper to RTPS.

• Journal of the Korean Arthroscopy Society
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• v.6 no.2
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• pp.177-182
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• 2002

Purpose : To validate the arthroscopic synovectomy for the treatment of hemophilic knee. Materials and Methods: From January 1996 to January 2001, 28 arthroscopic synovectolny were performed in 26 patients with hemophilic arthropathy of the knee. The mean age was 17.8 years. The mean follow-up period was 3 years 11 months. We used six portals (two anterior, two suprapatellar and two posterior) and posterior trans-septal portal in all cases. Result : The mean frequency of hemarthrosis was 4 times per month preoperatively and 2 postoperatively. The mean amount of factor replacement was 4,633 units preoperatively and 1,505 postoperatively. The mean range of motion was $112^{\circ}$ preoperatively and $107^{\circ}$ postoperatively. On radiographic evaluation, three cases were progressed at the latest follow-up. On the subjective evaluation, significant or moderate improvement were in 19 cases $(68\%)$, and no improvement or deterioration in 9 cases $(32\%)$. Conclusion : With complete synovectomy through the appropriate arthroscopic portals, arthroscopic synovectomy of the knee in hemophilic patients is the successful method in decreasing bleeding episodes, amount of factor replacement, knee pain and preventing or delaying onset of end-stage hemophilic arthropathy.

• Journal of Yeungnam Medical Science
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• v.13 no.2
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• pp.225-233
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• 1996

From August 1992 to July 1996, 63 consecutive patients underwent coronary artery bypass surgery. The mean age of these patient was 57 years(range form 30 to 71years). There were 44 men and 19 women. Preoperative 12 patients had stable angina pectoris and 23 patients were unstable angina pectoris. 8 patients had previous myocardial infarctation history and emergency or urgent myocardial revascularization were performed in 9 cases. In the risk factors of coronary atherosclerosis, 25 patients(40%) were hypercholesterolemia, 38 patients(60%) have smoking history and 19 patients(30%) have hypertension history. In the patterns of disease, 9 patients were single vessel disease, 18 patients were two vessele disease and 33 patients were three vessel disease. We performed total 284 distal anastomosis(mean 3.5 anastomosis per patient) and performed one case of ascending aorta graft interposition, two cases of mitral valve replacement, one case of aortic valve replacement, one case of ventricular septal defect repair and one case of atrial septal defect repair and the mean aortic cross clamp time was 115.3 minutes. The common complications were arrhythmia(7cases), wound infection(5cases), perioperative myocardial infarction(4cases), reoperation for bleeding control(4cases) and stroke(4cases). There were six hospital deaths due to low cardiac output syndrome, ventricular arrhythmia and respiratory failure. In the evaluation of operative risk factors, preoperative intravenous nitroglycerin requirement and prolonged aortic cross clamp tirne(>2hours) were found to be predective factor of morbidity and old age(>65years) was found to be predective factor of mortality.

• Animal Bioscience
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• v.35 no.12
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• pp.1892-1903
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• 2022

Objective: A series of experiment were conducted to evaluate the effects of replacing a part of soybean meal (SBM) at 6% of broiler diets with fermented soybean meal (FSBM) obtained by single or two-stage fermentation by measuring growth performance, antioxidant activity in the jejunum and distal intestinal microflora. Methods: Soybean meal samples were prepared by single-stage fermentation using Bacillus velezensis (Bv) (FSBM_B), or Lactobacillus spp. (as commercial control) (FSBM_L). Additional SBM sample was prepared by two-stage fermentation using Bv and subsequently using Lactobacillus brevis ATCC 367 (Lb) (FSBM_B+L). Enzyme activity, chemical composition, trichloroethanoic acid-nitrogen solubility index (TCA-NSI) and antioxidant activity were measured. Then, in an in vivo study, 320 Ross308 broilers were divided into four groups with ad libitum supply of feed and water. Four groups were fed either a corn-soybean meal diet (SBM), or one of fermented SBM diets (FSBM_B+L, FSBM_B, and FSBM_L). Growth, serum characteristics, microflora, and the mRNA expression of selected genes were measured. Results: Compared to SBM, FSBM_B+L contained lower galacto-oligosaccharide, allergic protein, and trypsin inhibitor, and higher TCA-NSI by about three times (p<0.05). Reducing power and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging ability correlated positively with the TCA-NSI content in FSBM. Growth performances were not significantly different among four groups. In jejunum of 35-day-old broilers, partial replacement of SBM by FSBM_B+L increased the activity of superoxide dismutase and catalase (CAT), and the FSBM_B group had the highest catalase activity (p<0.05). Partial replacement of SBM by FSBM increased relative mRNA expressions of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and peptide transporter 1 (PepT1) (p<0.05); however, FSBM_B+L increased CAT mRNA level to 5 times of the control (p<0.05). Conclusion: Using Bv- and Lb-processed SBM through two-stage fermentation to partially replace 6% of diets will improve the gut's antioxidant activity under commercial breeding in broilers.

• International Journal of Oral Biology
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• v.34 no.4
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• pp.177-183
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• 2009

Human mesenchymal stem cell (hMSCs) isolated from human adult bone marrow have self-renewal capacity and can differentiate into multiple cell types in vitro and in vivo. A number of studies have now demonstrated that MSCs can differentiate into various neuronal populations. Due to their autologous characteristics, replacement therapy using MSCs is considered to be safe and does not involve immunological complications. The basic helix-loop-helix (bHLH) transcription factor Olig2 is necessary for the specification of both oligodendrocytes and motor neurons during vertebrate embryogenesis. To develop an efficient method for inducing neuronal differentiation from MSCs, we attempted to optimize the culture conditions and combination with Olig2 gene overexpression. We observed neuron-like morphological changes in the hMSCs under these induction conditions and examined neuronal marker expression in these cells by RTPCR and immunocytochemistry. Our data demonstrate that the combination of Olig2 overexpression and neuron-specific conditioned medium facilitates the neuronal differentiation of hMSCs in vitro. These results will advance the development of an efficient stem cell-mediated cell therapy for human neurodegenerative diseases.

• Journal of Korean Academy of Nursing
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• v.36 no.4
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• pp.637-644
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• 2006

Purpose. The purpose of this study was to construct a measurement instrument for climacteric symptoms among Korean and Japanese women. Methods. From Dec. $1^{st}$ of 2003 to March $30^{th}$ of 2004, in-depth interviews were made with 26 women (15 in Jinju, Korea and 11 in Nagasaki, Japan) aged from 45 to 59 years who had not taken hormone replacement therapy to relieve the climacteric symptoms. A draft questionnaire with 45 items was constructed on the basis of the interview data and literature review. Three obstetricians, three PhDs in nursing science, and a chief nurse who was exclusively in charge of the climacteric management, examined the draft questionnaire to evaluate content validity. After deletions 39 items remained for a preliminary questionnaire. A survey was conducted by using a convenient sampling method in Jinju of Korea and Nagasaki of Japan during the period from April $1^{st}$, 2004 to July $10^{th}$, 2005. Results. Factor analysis identified 4 factors, which were 'mental and psychological symptoms', 'physical symptoms', 'loss of autonomic nervous system symptoms', 'sexual symptoms'. These four factors explained 46.9% of total variance. Conclusions. The results demonstrated that climacteric symptom scale was multidimensional, and the reliability and validity of the scale was supported.

• Special Issue of the Society of Naval Architects of Korea
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• 2009.09a
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• pp.97-106
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• 2009

Many production methods are tried to enhance the productivity efficiency. Parallel connected floating cranes are one of the examples to lift mega-blocks quickly and efficiently. However, a general operation manual to operate parallel connected floating cranes and a method to consider risks during lifting operation are not confirmed. And if each floating crane is operated by itself, it is very hard to cooperate. Therefore, Synchronized operation system is installed to control parallel connected floating cranes simultaneously and to be informed of each floating cranes data. And weighting factor is calculated by considering all hazards during the operation and the general operation manual is confirmed based on the factor. This paper introduces the procedure for lifting operations by parallel Connected Floating Cranes using synchronized operation system, and its applications to lifting operation of a heavy cargo such as barge lifting test, floating dock installation and 900 ton goliath crane replacement operation, etc.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.4 no.1
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• pp.7-11
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• 2008

Hemophilia is a group of gender-linkage inherited bleeding disorders that impair the body's ability to control blood clotting or coagulation. This sex-linked disorder is transmitted on the X chromosome. These genetic disorders have lower blood plasma clotting factor level of coagulation factor. Most common form is Hemophilia A and B. Restorative dental care and simple surgery for the hemophiliac patient are quite often neglected for fear of bleeding during procedures. Even dental specialist avoid these patients and make them severe problem patients. On the dental treatment especially, invasive procedure, special considerations of bleeding control are required. Inter-consultation with the hematologist will provide orientation on the best approach to dental treatment, such as the need of replacement therapy, the modification of antifibrinolytic therapy, the application of local hemostatic methods. In this case reports, we successfully treat early childhood caries of patient with hemophilia B under the general anesthesia.

• Journal of The Korea Institute of Healthcare Architecture
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• v.25 no.4
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• pp.27-35
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• 2019

Purpose: As the improvement in quality of medical environment and the spatial consideration for the prevention of infection in the hospital have become increasingly important in the recent years, specific and practical planning for air conditioning room's area has become a major issue accordingly. However, the air conditioning room tends to be discussed focusing on technical factors such as air conditioning systems that are irrelevant to building plans, while discussions of most departments related to the medical functions have actively taken placed. Therefore, this study aims to investigate the factors influencing the planning for the air conditioning room area, and through subsequent analysis of the area of the air conditioning room, to propose a way to improve effective planning for the air conditioning room area. Methods: This study examines the case hospitals that fall into two types: each floor supply system and concentrated supply system, and compares and analyzes the air conditioning room area-related factors and the characteristics of changes in the interior of air conditioning room before and after remodeling through air conditioning floor plan of those case hospitals. Results: The air conditioning room can be classified into the net area of the functional space such as duct passages, and the public area such as aisle space, and of those the public area is an important factor in calculating the area of the air conditioning room. The public area of the air-conditioning room should not be planned considering only the spaces for mobile passage or maintenance activities, but should be planned taking into account internal changes such as expansion and replacement of equipment in the future from the beginning. Implications: When planning a medical facility, it is used as basic data for the planning of the air conditioning room area, which is a significant fixed factor in the initial setting.

• The Journal of the Korea institute of electronic communication sciences
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• v.5 no.6
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• pp.637-644
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• 2010

The purpose of this study is to analyze characteristics of water quality factor scientifically and develop the multiple regression model predicting dissolved oxygen to save periodic replacement costs for dissolved oxygen sensor. Correlation analysis using the environmental data obtained from 2 different land-based fish farms of the Geogeum-do, Geheung-gun coastal area during the periods from November 2008 to January 2009 shows that water temperature was negatively correlated with dissolved oxygen and pH butpH was positively correlated with salinity and dissolved oxygen. The information of Keumho fish farm in 2009 is presented by the tables which are monthly statistics of water quality factors and seasonable difference by the Duncan's post-test. Also we developed multiple regression model predicting dissolved oxygen, the usefulness of which was verified by the comparison graph between estimates and actual observations. The developed regression model shows that seawater temperature and salinity give negative affect to dissolved oxygen while pH gives positive affect to it. Lastly the seawater temperature has much higher explanatory power than pH factor.