• The Korean Journal of Physiology and Pharmacology
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• v.25 no.1
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• pp.59-68
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• 2021

Arterial thrombosis and its associated diseases are considered to constitute a major healthcare problem. Arterial thrombosis, defined as blood clot formation in an artery that interrupts blood circulation, is associated with many cardiovascular diseases. Oxidative stress is one of many important factors that aggravates the pathophysiological process of arterial thrombosis. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (Ref-1) has a multifunctional role in cells that includes the regulation of oxidative stress and anti-inflammatory function. The aim of this study was to investigate the therapeutic effect of adenovirus-mediated Ref-1 overexpression on arterial thrombosis induced by 60% FeCl3 solution in rats. Blood flow was measured to detect the time to occlusion, thrombus formation was detected by hematoxylin and eosin staining, reactive oxygen species (ROS) levels were detected by high-performance liquid chromatography, and the expression of tissue factor and other proteins was detected by Western blot. FeCl3 aggravated thrombus formation in carotid arteries and reduced the time to artery occlusion. Ref-1 significantly delayed arterial obstruction via the inhibition of thrombus formation, especially by downregulating tissue factor expression through the Akt-GSK3β-NF-κB signaling pathway. Ref1 also reduced the expression of vascular inflammation markers ICAM-1 and VCAM-1, and reduced the level of ROS that contributed to thrombus formation. The results showed that adenovirus-mediated Ref-1 overexpression reduced thrombus formation in the rat carotid artery. In summary, Ref-1 overexpression had anti-thrombotic effects in a carotid artery thrombosis model and could be a target for the treatment of arterial thrombosis.

• Journal of the Korean Geosynthetics Society
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• v.19 no.4
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• pp.75-84
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• 2020

This paper described the analysis result on heaving of soft ground with DCM column type, based on the results of laboratory model tests on the soft ground with DCM column. The heave characteristics of the soft ground were evaluated according to the application of DCM column in soft ground. The results showed that the heaving of soft ground without DCM column occurred rapidly when the lateral deformation of soft ground increased significantly under the 4th load step condition. In addition, the heaving of soft ground in final load step caused tensile failure of the ground surface. The maximum heaving of the soft ground with the DCM column occurred in the final load step, and the heaving quantity decreased in the order of pile, wall, and grid type. Especially, the soft ground with DCM of grid type effectively resisted ground heaving, even if it was extremely failure in the bottom ground of embankment. The results of the maximum heaving according to the measurement point showed that the heaving of the soft ground with DCM of grid type was 3.1% and 1.6% compared to that of the pile and wall type at the location of LVDT-1, and the heaving of the LVDT-2 position was 1.0% and 2.1%, respectively.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.40 no.6
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• pp.555-561
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• 2020

In this study, the applicability of Hunt's analytical solution for a two-layered leaky aquifer system, which was developed to estimate stream depletion due to the groundwater pumping of the upper shallow aquifer, was evaluated. The 5-year averaged stream depletions were estimated using Hunt's analytical solution for various combinations of hydraulic characteristic values such as transmissivity, storage coefficient of the two aquifers, interlayer leakage coefficient, stream-well distance, hydraulic conductivity of the streambed, and stream width. Through comparison with the numerical solution accurately simulated with a MODFLOW groundwater flow model, the analytical solution derived by regarding the stream width as a point was evaluated. It was found that the error in the stream depletion calculated by the analytical solution can be reduced to less than 0.05 when the stream-well distance is greater than the stream width or when the stream depletion factor (SDF) is more than about 3,000 days. In addition, when the streambed hydraulic conductivity is less than 1 m/d, the hydraulic diffusion coefficient of the lower aquifer layer is less than 100 ㎡/d, the hydraulic diffusion coefficient ratio of the upper and lower aquifer layers is 5 or more, and the leakage coefficient between the layers is less than 0.0004 m/d, the overall analytical solutions were overestimated compared with the numerical solutions.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.33 no.6
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• pp.308-320
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• 2021

An integrated sediment management approach that includes the recovery of the amount of declined sediment supply is effective as a fundamental solution to coastal erosion. During planning, it is essential to analyze the transfer mechanism of the sediments generated from estuaries (the junction between a river and sea) to assess the amount and rate of sediment discharge (from the river to sea) supplied back to the coast. Although numerical models that interpret the tidal sand bar flushing process during flooding have been studied, thus far, there has been no study focusing on the formation and development processes of tidal sand bars. Therefore, this study aims to construct wave deformation, flow regime calculation, and topographic change analysis models to assess the amount of recovered sediment discharge and reproduce the tidal sand bar formation process through numerical analysis for integrated littoral drift management. The tidal sand bar formation process was simulated, and the wave energy and duration of action concepts were implemented to predict the long-term littoral movement. The river flux and wave conditions during winter when tidal sand bars dominantly develop were considered as the external force conditions required for calculation. The initial condition of the topographic data directly after the Maeupcheon tidal sand bar flushing during flooding was set as the initial topography. Consequently, the tidal sand bar formation and development due to nearshore currents dependent on the incident wave direction were reproduced. Approximately 66 h after the initial topography, a sand bar formation was observed at the Maengbang estuary.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.1
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• pp.1-12
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• 2022

Wind tunnel test for a small scale electric ducted fan with a 104mm diameter was conducted to analyze the aerodynamic characteristics when it was used as a propulsion system of tilt-propeller UAV. Experimental conditions were derived from flight conditions of a sub-scaled OPPAV. Forces and moments of the ducted fan model were measured by a 6-axis balance and 3-dimensional wake vectors which could induce an aerodynamic influence in the vehicle were measured by 5-hole probes. Thrust and torque on hover and cruise conditions were measured and analyzed to drive out the operating conditions when it was applied in the sub-scaled OPPAV. On transition conditions, thrust keep its value with tilt angle variation below 40° and increase after that. But, sideforce increase constantly until 75°. The maximum axial velocity in the wake on hover and cruise conditions was around 60m/s and tangential velocity was around 12m/s. The position of the maximum axial velocity and vortex center move off the fan rotation center line as the tilt angle increases.

• Journal of the Korean Society of Marine Environment & Safety
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• v.28 no.4
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• pp.620-631
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• 2022

This paper shows the numerical prediction of the change in oil outflow rate according to the orifice shape of a damaged ship by using the computational fluid dynamics (CFD) analysis method. It also provides discharge coefficients for various orifice shapes to be used in theoretical prediction approaches. The oil outflow from the model ship was analyzed using a multiphase flow method under the condition that the Froude and Reynolds number similitudes were satisfied. The present numerical results were verified by comparing them with the available experimental data. Along with the aspect ratio of the orifice and the wall thickness of the cargo tank, the effects of the orifice shapes defined by mathematical figures on the oil outflow were investigated. To consider more realistic situations, the investigation of the ef ect of the crushed iron plate around the damaged part was also included. The numerical results confirmed the change in oil outflow time for various shapes of the damaged part of the oil tank, and discharge coefficients that quantify the viscous effects of those orifice shapes were extracted. To verify the predicted discharge coefficients, they were applied to an oil spill estimation equation. As a result, a good agreement between the CFD and theoretical results was obtained.

• Journal of Navigation and Port Research
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• v.46 no.3
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• pp.168-178
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• 2022

In this study, the resistance test, the vertical static angle of the attack test and VPMM test will be conducted to estimate the maneuverability of underwater vehicles with ahead propeller. The vertical static test will be conducted within the range of -40deg to 40deg, to investigate the cross-flow drag at high incidence angles. The tests will be conducted by dividing the propeller rotation into a case in which the propeller rotates at a specific rpm, and a case in which the propeller rotates naturally, according to the towing speed. Hydrodynamic coefficients of vertical direction will be estimated by the captive model tests. Additionally, the vertical dynamic stability index based on estimated hydrodynamic coefficients will be calculated and the impact of the propeller revolution state on the index will be investigated. The results are expected to be used as reference test data for underwater vehicles with ahead propeller.

• Journal of Biomedical Engineering Research
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• v.43 no.3
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• pp.136-146
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• 2022

In this study, it is intended to provide basic data that can help develop a cardiovascular simulator for performance evaluation of pulse wave detectors by identifying the development status of domestic and overseas cardiovascular simulators. A total of 119 papers were selected by excluding duplicate literature, gray literature, and literature not related to a cardiovascular simulator. Based on the selected literature, the research trend of cardiovascular simulators was analyzed. As a result of analyzing the purpose of the study, most of the simulators were developed to evaluate the hemodynamic properties of artificial hearts and valves. In addition, it was used for simulation evaluation or hemodynamic studies such as pulse wave studies. As a result of analyzing configurations of the simulators, a heart most often consisted of only one left ventricle. For blood vessels, the Windkessel model was most often constructed using chambers and valves. In most studies, blood was reproduced by mixing glycerin and water to reproduce both density and viscosity. In addition, as a result of analysis from the perspective of medical device performance evaluation, simulators for evaluating artificial heart and artificial valves have been studied a lot, whereas simulators for blood pressure, pulse wave, and blood flow devices have been relatively insignificant. Based on the review results, we suggested considerations when developing a simulator for performance evaluations of a pulse wave detector.

• Journal of Korea Entertainment Industry Association
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• v.15 no.2
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• pp.159-167
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• 2021

The main purpose of this study is to closely investigate the constructive relationship between leisure satisfaction, leisure ability, exercise satisfaction, and consistent motor behavior patterns of the elderly's participation in leisure life sports. In order to achieve this, we surveyed and utilized the sampling of conveniences that selected Yongin and Seongnam city in Gyeonggi-do sports clubs, and accumulated samples of the elderly in living sports. The sample size was 239 elderly people. Based on this, according to the purpose of the study, statistical techniques, spss 23.0, and amos programs were used for analysis. The satisfaction analysis used in the research for a data analysis includes frequency analysis, exploatory factor analysis, confirmatory facor analysis, reliability analysis, correnlation analysis and structure equation model analysis. The research has drawn the following conclusions, based on the above mentioned research method and its procedures: First, it affects the satisfaction of the leisure satisfaction movement. Second, leisure ability affects exercise satisfaction. Third, exercise satisfaction affects the consistent exercise persistence and immersion satisfaction of exercise. As a result, it can be seen that the leisure immersion according to the experience of leisure competence has an effect on the satisfaction of the exercise. As a result, and the continuation of the exercise.

• The Journal of the Korea Contents Association
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• v.22 no.1
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• pp.99-115
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• 2022

In this study, domestic academic journal papers on tax compliance, tax consciousness, and faithful tax payment (hereinafter referred to as "tax compliance") were comprehensively analyzed from an interdisciplinary perspective as a representative research topic in the field of tax science. To achieve the research purpose, topic modeling technique was applied as part of text mining. In the flow of data collection-keyword preprocessing-topic model analysis, potential research topics were presented from tax compliance related keywords registered by the researcher in a total of 347 papers. The results of this study can be summarized as follows. First, in the keyword analysis, keywords such as tax investigation, tax avoidance, and honest tax reporting system were included in the top 5 keywords based on simple term-frequency, and in the TF-IDF value considering the relative importance of keywords, they were also included in the top 5 keywords. On the other hand, the keyword, tax evasion, was included in the top keyword based on the TF-IDF value, whereas it was not highlighted in the simple term-frequency. Second, eight potential research topics were derived through topic modeling. The topics covered are (1) tax fairness and suppression of tax offenses, (2) the ideology of the tax law and the validity of tax policies, (3) the principle of substance over form and guarantee of tax receivables (4) tax compliance costs and tax administration services, (5) the tax returns self- assessment system and tax experts, (6) tax climate and strategic tax behavior, (7) multifaceted tax behavior and differential compliance intentions, (8) tax information system and tax resource management. The research comprehensively looked at the various perspectives on the tax compliance from an interdisciplinary perspective, thereby comprehensively grasping past research trends on tax compliance and suggesting the direction of future research.