• Journal of Environmental Health Sciences
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• v.31 no.4 s.85
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• pp.287-293
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• 2005

Pollen has been used for Prevention or treatment of certain diseases such as diabetes, arthritis, or cancer in traditional medicine. In addition, pollen is under investigation as a host cell for a gene expression. This study was undertaken to evaluate the immunologic safety of pollen intake. BALB/c mice were administered with 500, 50,5, or 0.5 mg/kg bw of lily pollen for five times a week for four weeks through gastric intubation. Comparing the control mice administered with distilled water, no significant changes were observed in body weight gain, weight of liver, spleen, lung, and his-topathological findings of liver and kidney of the mice groups administered with the pollen. Plasma level of IgG1, IgG2a, and IgE was not different among the groups. When splenic B lymphocytes were stimulated in vitro with lipopolysaccharides for 7 days, level of IgGl and IgGwa produced in the culture supernatants was not significantly different among the groups. Furthermore, no significant alteration was observed in IL-4 and $IFN{\gamma}$ producing ability with splenic T lymphocytes stimulated in vitro with phytohemagglutinins for 48 hours between the pollen-administered and the control mice. Overall, this study suggests that the lily pollen intake is Inducing no significant modulation of humoral and cell-mediated immunity in mice.

• The korean journal of orthodontics
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• v.49 no.4
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• pp.246-253
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• 2019

Objective: To evaluate the effectiveness of three different caries-preventing agents on artificial caries in a Streptococcus mutans-based caries model. Methods: Sixty-five caries-free human molar enamel blocks were treated with a demineralization solution and a remineralization solution. The specimens were assigned to the following groups according to the caries-protective product applied: group A, chlorhexidine varnish; group B, fluoride-releasing chemically cured sealant; group C, fluoride-releasing lightcured sealant; group D, positive control (specimens that were subjected to de- and remineralization cycles without treatment with any caries-protective agents); and group E, negative control (specimens that were not subjected to de- and remineralization cycles). Samples in groups A-D were stored in demineralization solution with S. mutans and thereafter in artificial saliva. This procedure was performed for 30 days. Average fluorescence loss (${\Delta}F$) and surface size of the lesions were measured using quantitative light-induced fluorescence at baseline and on the 7th, 14th, and 30th days. Results: After 30 days, group A demonstrated a significant increase in ΔF and the surface size of the lesions, no significant difference in comparison with the positive control group, and a significant difference in comparison with the negative control group. Group B showed no significant changes in both parameters at any of the measurement points. While group C showed increased ${\Delta}F$ after 14 days, no significant fluorescence change was observed after 30 days. Conclusions: Both fluoride-releasing sealants (chemically or light-cured) show anti-cariogenic effects, but the use of chlorhexidine varnish for the purpose of caries protection needs to be reconsidered.

• Journal of Korean Society of Steel Construction
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• v.18 no.1
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• pp.23-32
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• 2006

This study was conducted to improve the design and construction technique of orthotropic steel-deck bridges. After conducting an F.E.M. analysis of the various rib types of the connection details, static and fatigue tests were conducted, using a three-dimensional, full-scaled, orthotropic, steel-deck-plate model with internal diaphrams, to check the fatigue strength depending on the types of details. The model structure was made of two types of longitudinal ribs: the domestic standard and the European rabbit types. The fatigue strength of the steel-deck system was found to have improved through the installation of an internal diaphram, as no cracks were found on the bottom round part of the scallop with a diaphram. There were no differences between the domestic and the European types of details in terms of strength may be partially influenced by the shape of the scallop and by the installation of an internal diaphram, but it can be improved more significantly according to the quality of the welding that will be done.

• Journal of the Korean Society for Railway
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• v.15 no.6
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• pp.623-630
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• 2012

Formation used as trackbed foundation for providing vertical bearing capacity onto rail foundation are composed of crushed stones usually with certain type of grain size distribution. Permanent deformation in trackbed foundation can be generated by increasing number of load repetition due to train traffic increases, causing track irregularity. In this study, a specially prepared trackbed foundation materials (M-40) used in Korea has been tested using a large repetitive triaxial compression apparatus in order to understand resilient and permanent deformation characteristics of the material. From these test results, resilient and permanent deformation characteristic are analyzed so that a permanent deformation model is developed which can consider number of load repetition N, confining stress (${\sigma}_3$), shear stress ratio(${\tau}/{\tau}_f$) and stiffness of the material.

• Molecular & Cellular Toxicology
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• v.4 no.1
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• pp.78-84
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• 2008

EGFR has been intensively investigated as a target to block the signal transduction pathway which stimulates cancer growth and metastasis. Studies about structure-activity relationship for tricyclic azepine derivatives were performed with topomer-CoMFA. The derived topomer-CoMFA model with steric and electrostatic field parameters based on fragment units gave reasonable statistics ($q^2$=0.561, $r^2$=0.679). The model explains why a halogen atom at the meta position of aniline is important to increases inhibitory activity. This comes from an electrostatically negative groups are favored near this region. The model also shows that there are sterically favored regions around methoxy group extended from oxazepine derivatives. The findings about steric and electrostatic effects can be utilized for designing new inhibitors.

• Journal of Intelligence and Information Systems
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• v.12 no.1
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• pp.139-161
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• 2006

In this paper, we introduce a new combinatorial auction mechanism - N-Bilateral Optimized Combinatorial Auction (N-BOCA). N-BOCA is a flexible iterative combinatorial auction model that offers optimized trading for multi-suppliers and multi-purchasers in the supply chain. We design the N-BOCA system from the perspectives of architecture, protocol, and trading strategy. Under the given N-BOCA architecture and protocol, auctioneers and bidders have diverse decision strategies f3r winner determination. This needs flexible modeling environments. Hence, we propose an optimization modeling agent for bid and auctioneer selection. The agent has the capability to automatic model formulation for Integer Programming modeling. Finally, we show the viability of N-BOCA through prototype and experiments. The results say both higher allocation efficiency and effectiveness compared with 1-to-N general combinatorial auction mechanisms.

• Korean Journal of Cognitive Science
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• v.9 no.1
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• pp.47-60
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• 1998

The study was designed to investigate implicit and explicit memory effec representations of bilinguals. Hierarchical model of bilingual information processing word naming and translation tasks in the context of semantically categorized or rar Experiments 1 and 2, bilinguals first viewed stimulus words and performed naming or tr then implicit and explicit memory tasks. In experiment I, word recognition times(exp were significantly faster for semantic category condition than random category condi naming task and lexical decision taskOmplicit memory task)showed no difference in e experiment 2, naming task and exlicit memory task showed categorization effect but fOWE a and implcit memory task showed no categorization effect. These findings support the which posits that memory representations of bilinguals are composed of two independer a and one common conceptual store.

• Journal of Electrical Engineering and Technology
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• v.10 no.3
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• pp.935-943
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• 2015

Permanent magnetic actuators (P.M.A.s) are widely used to drive medium-voltage-class vacuum circuit breakers (V.C.B.s). In this paper, a method for design optimization of a P.M.A. for V.C.B.s is discussed. An optimal design process employing the response surface method (R.S.M.) is proposed. In order to calculate electromagnetic and mechanical dynamic characteristics, an initial P.M.A. model is subjected to numerical analysis using finite element analysis (F.E.A.), which is validated by comparing the calculated dynamic characteristics of the initial P.M.A. model with no-load test results. Using tables of mixed orthogonal arrays and the R.S.M., the initial P.M.A. model is optimized to minimize the weight of the permanent magnet (P.M.) and to improve the dynamic characteristics. Finally, the dynamic characteristics of the optimally designed P.M.A. are compared to those of the initially designed P.M.A.

• Magazine of the Korea Concrete Institute
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• v.9 no.2
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• pp.121-132
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• 1997

The thermal behavior of' concrete can be ch;lracterized from a knowledge of concrete ternperatu1.e at early ages, environmental conditions, and cement hydration in the mixture. 'l'o account for thost. interactions, a computer model was developed for prwlicting the temperature pr.ol'ile in hnrdcning c o n c r c t ~ st.r~icture in terms of material and tmvironmcntal factors. The cerncnt hydration cha~.acteristics such as the activating energy, total heat 1ihei.atr.d. anti th\ulcorner degree of' hydration. can represent the internal heat gc,neration. In this study. th(> activating c1ncrgy and the tlcgree of' hydration curve were determined well fmm the rnortn~. compressive strength tests while total amount of heat liberated was determined by tht> isothermal calorimctcr method. The main purpose of' this study is to correlate measured tt>mperaturr distributions in a concrete st1,ucture during thc hardening process with the ~ c s u l t s computed f'ro~n theoretical considrl.ations. Using twodimensional heat transfer model, first. the importance of several parameters will be identified by a parametric analysis. Then, the tcmpcmture distribution of thc cylindrical concrete specimen in the laboratory was mensuwti and compared with that yielded by thc theoretical considel.ations.

• Smart Structures and Systems
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• v.24 no.2
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• pp.243-256
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• 2019

Determination of the most meaningful structural modes and gaining insight into how these modes evolve are important issues for long-term structural health monitoring of the long-span bridges. To address this issue, modal parameters identified throughout the life of the bridge need to be compared and linked with each other, which is the process of mode tracking. The modal frequencies for a long-span bridge are typically closely-spaced, sensitive to the environment (e.g., temperature, wind, traffic, etc.), which makes the automated tracking of modal parameters a difficult process, often requiring human intervention. Machine learning methods are well-suited for uncovering complex underlying relationships between processes and thus have the potential to realize accurate and automated modal tracking. In this study, Gaussian mixture model (GMM), a popular unsupervised machine learning method, is employed to automatically determine and update baseline modal properties from the identified unlabeled modal parameters. On this foundation, a new mode tracking method is proposed for automated mode tracking for long-span bridges. Firstly, a numerical example for a three-degree-of-freedom system is employed to validate the feasibility of using GMM to automatically determine the baseline modal properties. Subsequently, the field monitoring data of a long-span bridge are utilized to illustrate the practical usage of GMM for automated determination of the baseline list. Finally, the continuously monitoring bridge acceleration data during strong typhoon events are employed to validate the reliability of proposed method in tracking the changing modal parameters. Results show that the proposed method can automatically track the modal parameters in disastrous scenarios and provide valuable references for condition assessment of the bridge structure.