• Bulletin of the Korean Chemical Society
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• 제16권6호
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• pp.518-523
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• 1995

New square planar nickel(Ⅱ) complexes with various 1-alkyl (4a-4c) and 1-hydroxyalkyl (4d-4f) derivatives of the 14-membered pentaaza macrocycle 8-ethyl-8-nitro-1,3,6,10,13-pentaazacyclotetradecane have been synthesized by two-step metal template condensation reactions of ethylenediamine, nitroethane, formaldehyde, and appropriate primary amines. The nitro group and/or hydroxyl group of 4a-4f are not directly involved in the coordination. The nickel(Ⅱ) complexes exist in coordinating solvents such as MeCN, Me2SO, and H2O as equilibrium mixtures of the square planar [Ni(L)]2+(L=4a-4f) and octahedral species [Ni(L)S2]2+(S=solvent molecule). Although the ligand field strength and redox potentials of the complexes are not affected by the nature of the substituents, the formation of octahedral species for 4d-4f in MeCN is strongly restricted by the hydroxyl group. Synthesis, characterization, and solution behaviors of the nickel(Ⅱ) complexes are described.

• 한국식품위생안전성학회지
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• 제24권3호
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• pp.189-193
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• 2009

본 연구는 $\varepsilon$-polylysine, 키토을리고당, 복합황금추출(BMB-FS)을 조합한 10가지 혼합조성물의 효모에 대한 항균력을 평가하여 식품산업에 적용하고자 하였다. 천연항균제 10종의 formula에 따라 각 효모의 성장 속도가 차이가 났으나, 14일까지는 균수가 증가하였고 $14{\sim}28$ 일 사이에 항균효과가 나타나 28일 이후에는 S. cerevisiae, Z. bailii, P. anolmala는 검출한계 (ND < 10 CFU/mL)이하까지 감소하여 천연항균제에 민감한 반응을 보였다. P. membranaefaciens는 가장 저항성이 강한 균으로 14일까지 $0.12{\sim}1.48\;\log_{10}\;CFU$/mL가 증가하였으나, 28일이 지난 후 $1.61{\sim}3.55\;\log_{10}\;CFU$/mL가 감소하였고, F10에서는 2 개월이 지난 후 검출한계 이하로 감소하여 가장 항균효과가 크게 나타났다. 대부분 6개월이 지난 후 $2.68{\sim}s.62\;\log_{10}\;CFU$/mL가 감소한 것으로 나타났다. C. albicans는 두 번째로 저항성이 강한 균으로 14일까지 $0.13{\sim}28\;\log_{10}\;CFU$/mL가 증가하였으나 $14{\sim}28$일 사이에 감소하기 시작하여 28일 째에는 $1.51{\sim}5.30\;\log_{10}\;CFU$/mL가 감소하였고, F2, F4, F5, F6, F10은 검출한계 이하로 감소시켰다. 6개월이 지난 후에는 F1, F3, F8, F9도 검출한계 이하로 감소한 것으로 나타났다. 이에 따라 본 연구는 기능성 음료의 효모에 의한 변질을 막을 수 있는 천연 항균제 조성물을 개발하여 실용화 하고자 하였다.

• Journal of Microbiology and Biotechnology
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• 제25권11호
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• pp.1827-1834
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• 2015

The SMG1 lipase from Malassezia globosa is a newly found mono- and diacylglycerol (DAG) lipase that has a unique lid in the loop conformation that differs from the common alpha-helix lid. In the present study, we characterized the contribution of three residues, L103 and F104 in the lid and F278 in the rim of the binding site groove, on the function of SMG1 lipase. Site-directed mutagenesis was conducted at these sites, and each of the mutants was expressed in the yeast Pichia pastoris, purified, and characterized for their activity toward DAG and p-nitrophenol (pNP) ester. Compared with wild-type SMG1, F278A retained approximately 78% of its activity toward DAG, but only 11% activity toward pNP octanoate (pNP-C8). L103G increased its activity on pNP-C8 by approximately 2-fold, whereas F104G showed an approximate 40% decrease in pNP-C8 activity, and they both showed decreased activity on the DAG emulsion. The deletion of 103-104 retained approximately 30% of its activity toward the DAG emulsion, with an almost complete loss of pNP-C8 activity. The deletion of 103-104 showed a weaker penetration ability to a soybean phosphocholine monolayer than wild-type SMG1. Based on the modulation of the specificity and activity observed, a pNP-C8 binding model for the ester (pNP-C8, N102, and F278 form a flexible bridge) and a specific lipid-anchoring mechanism for DAG (L103 and F104 serve as "anchors" to the lipid interface) were proposed.

• 대한기계학회논문집A
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• 제40권10호
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• pp.907-911
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• 2016

본 논문에서는 회귀분석법(regression analysis method)을 사용하여 개발된 복합재 적층판의 압축 파손강도값을 수록하였다. 본 논문에 사용된 복합재료는 $350^{\circ}F(177^{\circ}C$)에서 경화되는 Carbon/Epoxy UD Tape 프리프레그(Cycom G40-800/5276-1)이며 운용온도 범위는 $-60^{\circ}F{\sim}+200^{\circ}F$($-55^{\circ}C{\sim}+95^{\circ}C$)이다. 시편은 $0^{\circ}$, $+45^{\circ}$, $-45^{\circ}$ 및 $90^{\circ}$층으로 적층된 8종류의 노치없는 적층판으로 총 56개 시편으로 구성하였다. 시험방법은 ASTM-D-6484 규정을 사용하였다. 적층판의 압축 파손강도값은 적층판 내 $0^{\circ}$와 ${\pm}45^{\circ}$층의 적층비율을 변수로 하는 회귀 분석법(regression analysis method)을 사용하여 획득하였다.

• 한국축산식품학회지
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• 제36권1호
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• pp.77-83
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• 2016

This study aimed to investigate the anti-obesity effects of yogurt fermented by Lactobacillus plantarum Q180 in diet-induced obese rats. To examine the effects, male Sprague-Dawley rats were fed on six different diets, as follows: Group A was fed an ND and orally administrated saline solution; Group B, an HFD and orally administrated saline solution; Group C, an HFD and orally administrated yogurt fermented by ABT-3 and L. plantarum Q180; Group D, an HFD and orally administrated yogurt with added Garcinia cambogia extract, fermented by ABT-3 and L. plantarum Q180; Group E, an HFD and orally administrated yogurt fermented by L. plantarum Q180; and Group F, an HFD and orally administrated yogurt with added Garcinia cambogia extract, fermented by L. plantarum Q180 for eight weeks. After eight weeks, the rate of increase in bodyweight was 5.14%, 6.5%, 3.35% and 10.81% lower in groups C, D, E and F, respectively, compared with group B; the epididymal fat weight of groups E and F was significantly lower than that of group B; and the level of triglyceride and leptin was significantly reduced in groups C, D, E and F compared to group B. In addition, the level of AST was reduced in group C compared to the other groups. To examine the effects of yogurt on the reduction of adipocyte size, the adipocyte sizes were measured. The number of large-size adipose tissue was less distributed in groups A, C, D, E and F than in group B.

• 한국환경보건학회지
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• 제17권2호
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• pp.67-77
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• 1991

The purpose of this study was to investigate the psychosomatic health status of printers. The 77 printers and 24 control group were analysed about salary, drinking, smoking, education, sex, marriage, age and working age by the THI (Todai Health Index) questionaire. THI was modified from CMI(Cornell Medical Index) and developed by Tokyo University Research Team in Japan. The resuts obtained were summarized as follows. 1. The printers, who get more salary showed high score about mental conplaints, especially, mental irritability(j), nervusness (E), lie Scale(L), aggressiveness(F) and irregualr life(G) and lower salary showed generally high score about physical complaints, especially, mouth and anus (D), digestive symptom(C) multiple subjective symptom(I). 2. According to the printers drinking amount shows the difference, eg nondrinker scored higher on mouth and anus(D), 90mg/week drinker scored higher on multiple subjective symptom(I), digestive symptom(C), depression(K), nervousness(E), and irregular life(G), 91~179mg/week drinker scored higher on impulsiveness(H), mental irritability(J), 270~359mg/week drinker scored higher on respiratory(A), lie scale (L) and aggressiveness (F). 3. The nonsmoker scored high level on mouth and anus(D), mental irritability(J). The previous smoker scored on multiple symptom(I), eyes and skin(B), digestive(C), lie scale(L), and depression(K). The present smoker scored on respiratory(A), impulsivehess(H), aggressiveness(F), nervousness(E), and irregular life(G). 4. According to the printers working age showed almost high score about subjective symptoms on 1~3 year. 5. Men printers high scored on respiratory(A). lie scale(L), aggressiveness(F), women printers scored about mental complaints, especially, impulsiveness(H), mental irritability(J), depression (K), nervousness (E). 6. According to the printers age showed high scored about, below 20 years were lie scale(L). aggressiveness(F), irregular life(G) 21~30years were multiple subjective symptom(I) respiratory (A), eyes and skin(B), mouth and anus(D), impulsiveness(H), mental irritability(J), depression (K), nervousness(E), and over 41 years were digestive(C). 7. Married printers scored high level on eyes and skin(B), digestive(C) and impulsivehess(H), and single printers on respiratory(A), mouth and anus(D), lie scale(L), mental irritability(J). 8. According to education shows the difference, eg high school scored higher on eyes and skin (B), mental irritability(J), depression(K), nervousness(E), collage and over scored higher on multiple subjective symptom(I ), respiratory (A), mouth and anus (D), lie scale (L), aggressiveness (F), irregular life (G), and middle school scored high on digestive (C), impulsiveness (H).

• East Asian mathematical journal
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• 제39권3호
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• pp.271-278
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• 2023

We consider a 1-dimensional reaction diffusion equation with the following boundary conditions arising in a theory of the thermal explosion {-u"(t) = λf(u(t)), t ∈ (0, l), -u'(0) + C(0)u(0) = 0, u'(l) + C(l)u(l) = 0, where C : [0, ∞) → (0, ∞) is a continuous and nondecreasing function, λ > 0 is a parameter and f : [0, ∞) → (0, ∞) is a continuous function. We establish the extension of Quadrature method introduced in [8]. Using this extension, we provide numerical results for models with a typical function of f and C in a thermal explosion theory, which verify the existence, uniqueness and multiplicity results proved in [6].

• 대한수학회논문집
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• 제34권2호
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• pp.487-494
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• 2019

We classify all the extreme and exposed bilinear forms of the unit ball of ${\mathcal{L}}(^2l^3_{\infty})$ which leads to a complete formula of ${\parallel}f{\parallel}$ for every $f{\in}{\mathcal{L}}(^2l^3_{\infty})^*$. It follows from this formula that every extreme bilinear form of the unit ball of ${\mathcal{L}}(^2l^3_{\infty})$ is exposed.

• 대한수학회보
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• 제46권1호
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• pp.35-43
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• 2009

We say that an isometric immersed hypersurface x : $M^n\;{\rightarrow}\;{\mathbb{R}}^{n+1}$ is of $L_k$-finite type ($L_k$-f.t.) if $x\;=\;{\sum}^p_{i=0}x_i$ for some positive integer p < $\infty$, $x_i$ : $M{\rightarrow}{\mathbb{R}}^{n+1}$ is smooth and $L_kx_i={\lambda}_ix_i$, ${\lambda}_i\;{\in}\;{\mathbb{R}}$, $0{\leq}i{\leq}p$, $L_kf=trP_k\;{\circ}\;{\nabla}^2f$ for $f\;{\in}\'C^{\infty}(M)$, where $P_k$ is the kth Newton transformation, ${\nabla}^2f$ is the Hessian of f, $L_kx\;=\;(L_kx^1,\;{\ldots},\;L_kx^{n+1})$, $x=(x^1,\;{\ldots},\;x^{n+1})$. In this article we study the following(hyper)surfaces in ${\mathbb{R}}^{n+1}$ from the view point of $L_1$-finiteness type: totally umbilic ones, generalized cylinders $S^m(r){\times}{\mathbb{R}}^{n-m}$, ruled surfaces in ${\mathbb{R}}^{n+1}$ and some revolution surfaces in ${\mathbb{R}}^3$.

• Archives of Pharmacal Research
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• 제11권2호
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• pp.87-92
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• 1988

A number of substituted furodiketochroman derivatives ($lll_{a-f}$) have been synthesized by fusion of aromatic aldehydes with 5-hydroxybergapten and 5-hydroxyisopimpinellin. On the other hand, when the reaction was carried out in a solvent, the corresponding bis-furoccumarin derivatives ($lV_{c-n}$) were obtained. The anticoagulant effect of compounds $lll_{a,b,d}$ and $lv_{b,c,f,g,i,k}$ was tested. They failed to demonstrate any significant effect. The effect of the tested compounds on the arterial blood pressure was studied. Compounds $lV_c$, $lll_d$, $lll_b$, $lV_b$, $lV_k$ and $lV_i$ showed lowering effects on the normal systolic blooc pressure of anaesthetized rats in a decreasing manner.