Browse > Article
http://dx.doi.org/10.5851/kosfa.2016.36.1.77

Anti-obesity Effect of Yogurt Fermented by Lactobacillus plantarum Q180 in Diet-induced Obese Rats  

Park, Sun-Young (Korea Food Research Institute)
Seong, Ki-Seung (Korea Food Research Institute)
Lim, Sang-Dong (Korea Food Research Institute)
Publication Information
Food Science of Animal Resources / v.36, no.1, 2016 , pp. 77-83 More about this Journal
Abstract
This study aimed to investigate the anti-obesity effects of yogurt fermented by Lactobacillus plantarum Q180 in diet-induced obese rats. To examine the effects, male Sprague-Dawley rats were fed on six different diets, as follows: Group A was fed an ND and orally administrated saline solution; Group B, an HFD and orally administrated saline solution; Group C, an HFD and orally administrated yogurt fermented by ABT-3 and L. plantarum Q180; Group D, an HFD and orally administrated yogurt with added Garcinia cambogia extract, fermented by ABT-3 and L. plantarum Q180; Group E, an HFD and orally administrated yogurt fermented by L. plantarum Q180; and Group F, an HFD and orally administrated yogurt with added Garcinia cambogia extract, fermented by L. plantarum Q180 for eight weeks. After eight weeks, the rate of increase in bodyweight was 5.14%, 6.5%, 3.35% and 10.81% lower in groups C, D, E and F, respectively, compared with group B; the epididymal fat weight of groups E and F was significantly lower than that of group B; and the level of triglyceride and leptin was significantly reduced in groups C, D, E and F compared to group B. In addition, the level of AST was reduced in group C compared to the other groups. To examine the effects of yogurt on the reduction of adipocyte size, the adipocyte sizes were measured. The number of large-size adipose tissue was less distributed in groups A, C, D, E and F than in group B.
Keywords
Lactobacillus plantarum; anti-obesity activity; adipocyte size; yogurt; diet-induced rats;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Lee, K., Paek, K., Lee, H. Y., Park, J. H., and Lee. Y. (2007) Antiobesity effect of trans-10, cis-12 conjugated linoleic acidproducing Lactobacillus plantarum PL62 on diet-induced obese mice. J. Appl. Microbiol. 103, 1140-1146.   DOI
2 Lye, H. S., Kuan, C. Y., Ewe, J. A., Fung, W. Y., and Liong, M. T. (2009) The improvement of hypertension by probiotics: effects on cholesterol, diabetes, renin, and phytoestrogens. Int. J. Mol. Sci. 10, 3755-3775.   DOI
3 Marques, B. G., Hausman, D. B., and Martin, R. J. (1998) Association of fat cell size and paracrine growth factors in development of hyperplastic obesity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 275, 1898-1908.   DOI
4 Park, S. Y., Cho, S. A., Kim, S. H., and Lim, S. D. (2014) Physiological characteristics and anti-obesity effect of Lactobacillus plantarum Q180 isolated from feces. Korean J. Food. Sci. An. 34, 645-653.
5 Plessis, S. S. D., Cabler, S., McAlister, D. A., Sabanegh, E., and Agarwal, A. (2010) The effect of obesity on sperm disorders and male infertility. Nat. Rev. Urol. 7, 153-161.   DOI
6 Parvez, S., Malik, K. A., Kang, S. A., and Kim, H. Y. (2006) Probiotics and their fermented food products are beneficial for health. J. Appl. Microbiol. 100, 1171-1185.   DOI
7 Perdigon, G., Alvarez, S., Rachid, M., Aguero, G., and Gobbato, N. (1995) Immune system stimulation by probiotics. J. Dairy Sci. 78, 1597-1606.   DOI
8 Pereira, D. I. and Gibson, G. R. (2002) Effects of consumption of probiotics and prebiotics on serum lipid levels in humans. Crit. Rev. Biochem. Mol. Biol. 37, 259-281.   DOI
9 Faust, I. M., (1984) Role of the fat cell in energy balance physiology, In: Stunkardand, A. J. and Stellar, E (eds.) In Eating and its Disorders, New York, pp. 97-107.
10 Adolfsson, O., Meydani, S. N., and Russell, R. M. (2004) Yogurt and gut function. Am. J. Clin. Nutr. 80, 245-256.   DOI
11 Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., Kuriyama, H., Nishida, M., Yamashita, S., Okubo, K., Matsubara, K., Muraguchi, M., Ohmoto, Y., Funahashi, T., and Matsuzawa, Y. (1999) Paradoxical decrease of an adiposespecific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257, 79-83.   DOI
12 Weisberg, S. P., McCann, D., Desai, M., Rosenbaym, M., Leibel, R. L., and Ferrante, A. W. Jr. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808.   DOI
13 Saito, M., Ueno, M., Ogino, S., Kubo, K., Nagata, J., and Takeuchi, M. (2005) High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testes. Food Chem. Toxicol. 43, 411-419.   DOI
14 Sato, M., Uzu, K., Yoshida, T., Hamad, E. M., Kawakami, H., Matsuyama, H., Abd El-Gawad, I. A., and Imaizumi, K. (2008) Effects of milk fermented by Lactobacillus gasseri SBT2055 on adipocyte size in rats. Br. J. Nutr. 99, 1013-1017.
15 Usman and Hosono, A. (2000) Effect of administration of Lactobacillus gasseri on serum lipids and fecal steroids in hypercholesterolemic rats. J. Dairy 83, 1705-1711.   DOI
16 Haslam D. W. and James W. P. (2005) Obesity. Lancet. 366, 1197-1209.   DOI
17 Gibson, G. R., Saveedra, J. M., MacFarlane, S., and MacFarlane, G. T., (1997) Probiotics and intestinal infections, Probiotic. 2: Applications and practical Aspects. In: R. Fuller (eds). Chapman & Hall, New York, pp. 10-39.
18 van Goor, H., Gerrits, P. O., and Grond, J. (1986) The application of lipid-soluble stains in plastic-embedded sections. Histochemistry 85, 251-253.   DOI
19 Guo, K. Y., Halo, P., Leibel, R. L., and Zhang, Y. (2004) Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287, R112-R119.   DOI
20 Hirose, M., Ando, T., Shofiqur, R., Umeda, K., Kodama, Y., Nguyen, S. V., Goto, T., Shimada, M., and Nagaoka, S. (2013) Anti-obesity activity of hen egg anti-lipase immunoglobulin yolk, a novel pancreatic lipase inhibitor. Nutr. Metab. 10, 70-75.   DOI
21 Koerner, A., Kratzsch, J., and Kiess, W. (2005) Adipocytokines: leptin, the classical; resistin, the controversial; adiponectin, the promising; and more to come, Best Pract. Res. Clin. Endocrinol. Metab. 19, 525-546.   DOI
22 Hirsch, J. and Gallian, E. (1968) Methods of determining adipose cell size in man and animals. J. Lipid Res. 9, 110-119.
23 Hu, E., Liang, P., and Spiegelman, B. M. (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697-10703.   DOI
24 Kang, J. H., Yun, S. I., and Park, H. O. (2010) Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats. J. Microbiol. 48, 712-714.   DOI
25 Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., Waget, A., Delmee, E., Cousin, B., Sulpice, T., Chamontin, B., Ferrieres, J., Tanti, J. F., Gibson, G. R., Casteilla, L., Delzenne, N. M., Alessi, M. C., and Burcelin, R. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761-1772.   DOI
26 Kopelman, P. G. (2000) Obesity as a medical problem. Nature 404, 635-643.   DOI
27 Axelsson, R. (1998) Lactic acid bacteria: Microbiology and functional aspects, In: Salminen S. and von Wright A. (eds.), Marcel Dekker Inc., New York, pp. 1-53.
28 Bhathena, J., Martoni. C., Kunlamarva, A., Urbanska, A. M., Malhotra, M., and Prakash, S. (2009) Orally-delivered microencapsulated live probiotic formulation lowers serum lipids in hypercholesterolemic hamsters. J. Med. Food. 12, 310-319.   DOI
29 Frederich, R. C., Hamann, A., Anderson, S., Lollmann, B., Lowell, B. B., and Flier, J. S. (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Mad. 1, 1311-1314.   DOI
30 Cariou, B., van Harmelen, K., Duran-Sandoval, D., van Dijk, T. H., Grefhorst, A., Abdelkarim, M., Caron, S., Torpier, G., Frushart, J. C., Gonzalez, F. J., Kuipers, F., and Staels, B. (2006) The farnesoid X receptor modulates adiposity and peripheralinsulin sensitivity in mice. J. Biol. Chem. 281, 11039-11049.   DOI
31 Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., Mckee, L. J., Bauer, T. L., and Caro, J. F. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 292-295.   DOI