• Korean Journal of Pharmacognosy
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• v.52 no.2
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• pp.99-104
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• 2021

This study was performed to elucidated the inhibitory effects of 6,8-diprenylorobol on melanin synthesis by measuring the levels of cell viability, mRNA expression, tyrosinase activity, and melanin production in the B16F10 cell line. The effects of 6,8-diprenylorobol on tyrosinase-related protein 1 (TYRP1), TYRP2, tyrosinase (TYR), and microphthalmia-associated transcription factor (MITF) mRNA expression levels and melanin content were determined. Quantitative real-time RT-PCR shows that 6,8-diprenylorobol decreases the mRNA expression levels of TYRP1, TYRP2, TYR, and MITF in B16F10 cell line, resulting in lower levels of melanin production compared to α-MSH-treated B16F10 cells. Tyrosinase activity assays reveal that 6,8-diprenylorobol decreases melanin production in B16F10 cells. These results demonstrate the whitening effects of 6,8-diprenylorobol on B16F10 cells; thus, 6,8-diprenylorobol is a potent ingredient for skin whitening. Further research is needed on the mechanism of action of 6,8-diprenylorobol. Such research will benefit not only cosmetics, but also the health food and medical industries.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2001.05a
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• pp.448-451
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• 2001

일반적으로 전기기기는 사람의 스위칭조작으로 작동이 되고 있다. 이를 개선하기 위하여 본 연구는 전기기기의 자동 스위칭과 홈네트워킹을 위한 제어용 임베디드 시스템을 설계하고, 제작하였다. 설계 제작한 제어 시스템은 PIC16F84에서 접근 센서의 입력 신호를 이용하여 전원 단속, 기기의 on/off를 수행하였으며, 내부의 상태를 감지하여 기기의 상태 표시용LED구동, 솔레노이드 밸브의 open/close 기능을 부여하였다. 본 임베디드 시스템은 통신 모듈을 구성하여 PIC의 기능을 강화하면 홈네트워킹용 시스템으로 발전할 수 있다.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.210.1-210.1
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• 2003

In this study, we investigated the effect of inhibition of proliferation and antioxidant effect on B16F10 murine melanoma cell. Also, we examined by MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and intracellular reactive oxygen intermediate levels and the levels of catalase(CAT), superoxide dismutase (SOD), and glutathione peroxidase(GPX) an adaptive response of oxidative stress on B16F10 murine melanoma cell of pretreated with hydrogen peroxide. (omitted)

• Biomolecules & Therapeutics
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• v.11 no.2
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• pp.151-156
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• 2003

Cornis fructus have various biological effects and major chemical components have been tannins, saponins, ursolic acids, gallic acids, linoleic acids, morronisides, cornins and loganins. The main aim of the present study is measurment the effect of chloroform extract from Cornis fructus on proliferation inhibition and Cell death. Cells were cultured in the presence of chloroform extracts from Cornis fructus for 48 h. after 48h treatment of B16/F10 melanoma cells with chloroform extracts, the cells were observed a dose-dependent inhibitions of cell viability with cell death in their proliferation. the cells were estimated cell viability, cell number, total DNA fragmentation and chromatin condensation in a dose-dependent manner. It also caused cell death as measured by cell morphology, DNA fragmentation and nucleus chromatin condensation. therefore, these results suggest that chloroform extracts from C. fructus is inhibitory proliferation and is related to cell death in this cells.

• Journal of the military operations research society of Korea
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• v.24 no.2
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• pp.43-56
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• 1998

This paper focuses on the optimal replacement time of engine modules of the F16 aircraft. Generally, the optimal replacement time of those should be determined to minimize the replacement cost due to out of order and opportunistic replacement cost of operation cost of remaining period. This paper determined the optimal replacement time by using the opportunistic replacement algorithm that is developed by Forbes and Wyatt. Some real data are utilized but a few data is estimated due to limitation of data. As a result, fan module only reaches to the opportunistic replacement time. The optimal replacement time of the fan module is derived as 1740 cycles. Therefore, the optimal replacement policy of engine modules of the F16 is that fan module should be replaced whenever it is out of order under 1740 cycles and whenever core module is out of order over 1740 cycles.

• Journal of Microbiology and Biotechnology
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• v.30 no.5
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• pp.749-752
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• 2020

In the search for novel, natural melanogenesis inhibitors, a new sesquiterpene, inularin, was isolated from the flowers of Inula britannica, and the structure was determined using spectroscopic and chemical methods. The antimelanogenic effects of inularin on B16F10 melanoma cells and zebrafish embryos were evaluated. Inularin dose-dependently reduced melanocyte-stimulating hormone-induced melanin production and L-DOPA oxidation in B16F10 cells. Zebrafish embryos were used to confirm the antimelanogenic activity. Inularin significantly decreased the pigmentation of embryos compared with untreated controls.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2006.05a
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• pp.328-331
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• 2006

In Ubiquitous age, data collection that using wireless sensor node is increasing necessity. In this paper, collect data because uses PIC16F877 and Bluetooth, and constructs database in PC. The PIC16F877 is control radio sensor node. The PC construct to propose algorithm that updates control data with table. It is changes sensing cycle time of node into intelligence style because compare collected data of DB. Result of study inexpensive , and practical, and I can apply to industry spot constructing system briefly.

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.3
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• pp.320-326
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• 2017

This study investigated the water extracts of fallen pear (FPWE) on tyrosinase activity and melanogenesis. In the present study, we examined the effects of FPWE on mushroom tyrosinase activity in vitro, B16F10 melanoma cell tyrosinase activity, melanin contents, and expression of melanogenic enzyme proteins such as tyrosinase. An apparent down-regulatory effect on tyrosinase activity was observed when B16F10 cells were incubated with FPWE. Results of melanin assay using B16F10 cells treated with different concentrations (50, 125, and $250{\mu}g/mL$) of FPWE showed a dose-dependent decrease in melanin content. To determine whether or not FPWE indirectly affects tyrosinase activity, we assessed mushroom tyrosinase activity upon treatment with various concentrations (125, 250, 500, and $1,000{\mu}g/mL$) of FPWE. In addition, we investigated changes in the protein level of tyrosinase by using Western blotting. Tyrosinase and microphthalmia-associated transcription factor expression levels in B16F10 melanoma cells were reduced in a dose-dependent manner by FPWE. These results suggest that FPWE reduced melanin formation by inhibition of tyrosinase activity. Therefore, we suggest that FPWE could be used an effective whitening agent for skin.

• Proceedings of the Optical Society of Korea Conference
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• 1996.09a
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• pp.16-16
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• 1996

• Journal of the Korean Institute of Intelligent Systems
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• v.16 no.3
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• pp.338-348
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• 2006

We classify the 3-classes In the semigroup M$_5$(F) of all 5$\times$5 Boolean matrices over F=(0,1).