• Journal of Life Science
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• v.26 no.3
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• pp.364-375
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• 2016

Post-translational modification is an efficient process to rapidly transduce external stimulus into cellular response. Ubiquitination is a typical post-translational modification which is a highly conserved process in eukaryotes. UPS (Ubiquitin/Proteasome System) mediated by the ubiquitination is to target diverse cellular proteins for degradation. Among E3 ubiquitin ligases that function as the key determinant for substrate recognition, CRL (cullin–RING E3 ubiquitin ligase) is the largest family and forms the complex composed of cullin, RBX1, adaptor and substrate receptor. Although CRL1, also known as SCF complex, has been widely researched for its biological role, the functional studies of CRL4 have been relatively elusive. In Arabidopsis, there are 119 substrate receptors named DCAF (DDB1 CUL4 Associated Factor) proteins for CRL4 and a fraction of DCAF proteins have been identified for their potential functions so far. In this paper, current understanding on structure and biological roles of plant CRL4 complexes in a diverse of cellular events is reviewed, especially focusing on CRL4 substrate receptors. Moreover, the regulatory mechanism of CRL4’s activity is also introduced. These studies will be helpful to further understand the signal transduction pathways in which such CRL4 complexes are involved and give a clue to establish the action network of entire CRL4 complexes in plants.

• The KIPS Transactions:PartA
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• v.12A no.1 s.91
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• pp.53-58
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• 2005

The use of computers for control and monitoring of industrial process has expanded greatly in recent years. The computer used in such applications is shared between a certain number of time-critical control and monitor function and non time-critical batch processing job stream. Embedded systems encompass a variety of hardware and software components which perform specific function in host computer. Many embedded system must respond to external events under certain timing constraints. Failure to respond to certain events on time may either seriously degrade system performance or even result in a catastrophe. In the design of real-time embedded system, decisions made at the architectural design phase greatly affect the final implementation and performance of the system. Flexibility indicates how well a particular system architecture can tolerate with respect to satisfying real-time requirements. The degree of flexibility of real-time system architecture indicates the capability of the system to tolerate perturbations in timing related specifications. Given degree of flexibility, one may compare and rank different implementations. A system with a higher degree of flexibility is more desirable. Flexibility is also an important factor in the trade-off studies between cost and performance. In this paper, it is identified the need for flexibility function and shows that the existing real-time analysis result can be effective. This paper motivated the need for a flexibility for the efficient analysis of potential design candidates in the architectural design exploration or real time embedded system.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.2
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• pp.44-62
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• 2020

Objectives: The purpose of this study is to evaluate the effectiveness of herbal medicine for recovery and treatment of cervical intraepithelial neoplasia (CIN) after loop electrosurgical excision procedure (LEEP). Methods: We searched two english, one chinese and four korean database up to November 4, 2019. Randomised controlled trials (RCTs) were eligible. Primary outcome included Human papilloma virus (HPV) clearance rate and the effective ratio of treatment. And vaginal bleeding time and volume, improvement of symptoms, and recovery of wound were regarded as secondary outcomes. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool. Results: Of 47 screened, 10 RCTs were included. Number of participants per study ranged from 58 to 360. The studies which used HPV clearance rate as primary outcome were considered as low risk of bias. Most of the studies had considerable heterogeneity in terms of type of intervention, comparison and time-points for outcome measurement. Compared to LEEP alone, herbal vaginal suppository combined group showed favorable results for HPV clearance in patients (5 studies, n=627, 95% CI 1.26 to 1.55, I²=75%). And compared to LEEP alone, herbal external application also showed favorable results for HPV clearance in patients (2 studies, n=252, 95% CI 1.19 to 1.61, I²=86%). Three studies reported mild and temporary adverse events, and no serious adverse events were reported. Conclusions: The studies showed that herbal medicine can significantly effective on recovery of CIN after LEEP. However, included studies suffered from incomplete reporting, high or unclear risk of bias and substantial heterogeneity between studies. In the Future, further high-quality RCTs are needed to prove effectiveness of herbal medicine for CIN after LEEP and reduce the risk of bias.

• Korean Journal of Ecology and Environment
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• v.33 no.4 s.92
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• pp.350-357
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• 2000

This paper evaluated the influence of point source and flow events on inorganic nitrogen fractions at 17 sites of Taechung Reservoir during 1993${\sim}$1994. Total nitrogen (TN) averaged 1.53 mg/L during the study and ranged between 0.70 and 2.56 mg/L. Dissolved inorganic nitrogen(DIN) accounted for >90% of TN regardless of season and location, indicating a nitrogen-rich system showing eutrophic${\sim}$hypereutrophic conditions. Some 67${\sim}$94% of DIN was NO$_{3}$-N, whereas mean level of NH$_{4}$-N was less than 5% of DIN. During monsoon 1993, dilution of NO$_{3}$-N was evident in the headwaters as a result of mixing of lake water with rain water, while NH$_{4}$-N increased>100% compared to the premonsoon. Values of NH$_{4}$-N had a positive correlation with rainfall (r=0.85; p<0.001) and negative correlations with theoretical water residence time(r=-0.90; p<0.001) and conductivity(r=-0.78, p<0.001), respectively. These outcomes suggest that NH$_{4}$-N came from external input from the watershed during the monsoon. In both years, mean TN was greater in the mid-lake sites than any other sites. A great amount of TN in the mid-lake was most pronounced in monsoon 1994 because of an accumulated influence of the point sources during low inflow. Overall data suggest that concentrations of TN in this system did not show large differences along the longitudinal gradients and its distributions is likely determined by point-sources rather than inflow regime.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.299-323
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• 2018

This study confirmed the life career branching points, and studied qualitatively the career strategy and career identity at that time. The participants in this study were three students from third graders of middle school, three ones from third graders of high school, and three before and after college graduation, which correspond to the vertical transition stage of school education. Three participants were selected before and after 30 years of age, three before and after 40 years of age, and three before and after 60 years of age. Subject analysis of the contents of the 18 interviews, showed that the life career branching point appeared in middle school grade 3, high school grade 3, until employment after graduation, within 3 years after entering their first job, early 40 years, 60 years old, and 80 years old. Second, external situations were due to the influence of important others, or external stimuli, environment, and career events. Third, negative emotions were repeated for each life career branching point. Fourth, as a result of the interview, the career identity confusion was repeated in every life career branching point. Fifth, the career strategy at the life career branching point was categorized as an approach strategy and avoidance strategy.

• Journal of KIISE:Software and Applications
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• v.37 no.12
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• pp.892-908
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• 2010

Services in SOA are typically perceived as black-box to service consumers, and can be dynamically evolved at runtime, and run on a number of unknown and heterogeneous environments. Because of these characteristics of the services, effective and efficient monitoring of various aspects on services is an essential functionality for autonomous management of service. But the problem with or limitation in conventional or existing approaches is, that they focus on services themselves, ignoring the effects by business processes. Consequently, there is a room for service monitoring which provides more useful information of business level by acquisition of only external monitoring data that depend on specific BPEL engine and middleware. Moreover, there is a strong demand to present effective methods to reduce monitoring overhead which can degrade quality of services. EDA can cope with such limitations in SOA by collecting and analyzing events efficiently. In this paper, we first describe EDA benefits in service monitoring, and classify monitorring target, and present an appropriate monitoring method for each monitoring target. Also to provide the applicability of our approach, an event meta-model is defined, and event processing model and architecture based on the meta-model are proposed. And, with the proposed architecture and method, we implement a prototype of an event-driven dynamic monitoring framework which can collect and process internal and external data at runtime. Finally, we present the result of a case study to demonstrate the effectiveness and applicability of the proposed approach.

• The Journal of Internal Korean Medicine
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• v.38 no.5
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• pp.641-649
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• 2017

Objective: Our aim was to report a case of hematoma in the lower extremity induced by anti-platelet agents (Astrix, Plavix). Methods: The patient was prescribed anti-platelet agents and a hematoma occurred three times in the lower extremity. Before admission, the hematoma had occurred in the lateral compartment area of left lower extremity ($2{\times}2cm$). We detected a spontaneous hematoma in the lateral compartment area of right lower extremity ($8{\times}4cm$) and we stopped the Astrix medication. We also used herbal medicine (大黃左經湯加味方 (Daehwangjwagyeong-tang-gami)), external therapy of 大黃梔子 (Dae-hwang-Chi-ja) powder, and wet cupping therapy. We then detected a spontaneous hematoma in the posterior compartment area of the left lower extremity ($5{\times}5cm$) and we stopped the Plavix medication. We also used herbal medicine and external therapy. Results: After cessation of the anti-platelet agents (Astrix, Plavix), no recurrence of hematoma was observed in lower extremity and there was no recurrence of cerebral infarction. Conclusions: When anti-platelet agents are administered, attention should be paid to the patient's age and adverse events of the drugs. Bleeding symptoms and adverse effects should be continuously monitored.

• Radiation Oncology Journal
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• v.36 no.2
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• pp.147-152
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• 2018

Purpose: To evaluate the treatment outcomes of adjuvant external beam radiation therapy (EBRT) and vaginal brachytherapy (VB) following radical hysterectomy in cervical cancer patients with involved vaginal resection margin (VRM). Materials and Methods: We retrospectively reviewed the medical records of 21 patients treated with postoperative EBRT and VB for positive VRM FIGO stage IB-IIA cervical cancer between 2003 and 2015. Concurrent platinum-based chemotherapy was administered to all patients. Results: The median whole pelvis EBRT dose was 50.4 Gy (range, 45 to 50.4 Gy). In the VB, the median dose per fraction, number of fractions, and total dose delivered were: 4 Gy (range, 3.0 to 4.0 Gy), 4 fractions (range, 3 to 5 fractions), and 16 Gy (range, 12 to 20 Gy), respectively. At a median follow-up of 46 months (range, 9 to 122 months), local recurrence was observed in 2 patients, and distant metastasis was present in 7 patients. All patients with local recurrence subsequently developed distant metastases. The 5-year local control, disease-free survival, and overall survival rates were 89.1%, 65.9%, and 62.9%, respectively. Of the 21 patients, 7 patients (33.3%) reported grade 2 acute toxicity; however, there were no grade 3 or higher acute adverse events. Grade 1-2 late toxicities were observed in 8 patients. Late grade 3 urinary toxicity was reported in 1 patient. Conclusions: Adjuvant EBRT and VB showed excellent local control and low toxicity in cervical cancer patients with positive VRM. Although limited by its retrospective nature, the findings from our study provide evidence supporting the use of additional VB in pathologically involved VRM.

• Journal of the Korea Convergence Society
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• v.11 no.9
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• pp.325-332
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• 2020

This study aimed to identify the difference of scapular movements between tennis players with and without shoulder impingement syndrome(SIS) and to verify the effect of kinesiology taping applied to scapular. A total of 15 players were categorized in SIS group(n=7) and control(CON) group(n=8). The scapular movements evaluated using 3-dimensional motion analysis in the 5 events of the flat first serve before and after the application of taping. The male of SIS group(-7.31±1.19° and -5.28±1.08°, respectively) had tilted scapular more anteriorly compared to CON group(-0.98±5.38° and -0.44±3.52°, respectively) at the maximally humeral external rotation and the impact(Z=-2.309, p=.021 and Z=-2.309, p=.021, respectively). The scapular(-8.11±2.57°) of female in SIS group tilted more anteriorly than that of CON(-0.97±3.31°) group at the maximally humeral external rotation(Z=-2.121, p=.034). But the scapular movements had no statistical differences between before and after the application of taping.

• Korean Journal of Culture and Social Issue
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• v.21 no.2
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• pp.177-203
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• 2015

The aims of this study were 1) to compare irrational gambling beliefs of gamblers and non-gamblers, 2) to investigate the role of cognitive error on winning probability thinking error, and 3) to examine the relationship between attributional bias and gambling behavior. A total of 248 subjects were recruited for this study. All subjects were classified into non-gamblers, social gamblers and pathological gamblers, and administered self-report questionnaires to measure irrational gambling beliefs, the probability inference error, the attriburional style, and the attributional bias. A pathological gambler group scored highest on irrational gambling beliefs, especially the overestimation of self-ability factor, and a social gambler group and a non-gambler group follow. All three groups scored higher on the magnification of gambling skills than the mean (4.0) of the scale. Pathological gamblers and social gamblers scored higher on the probability thinking error than non-gamblers. Pathological gamblers displayed higher external attribution, lower internal attribution in their daily life events and higher internal attribution in failure situation than social gamblers and non-gamblers. The results indicate that cognitive errors would be a factor that differentiates pathological gamblers from social gamblers and non-gamblers. In predicting gambling behaviors, overestimation of self-ability of irrational gambling beliefs, internal attribution in failure situation, external attribution in daily live event, and probability thinking error were identified as significant factors. It is concluded that a public education about common cognitive bias featured in gamblers might be important in prevention of pathological gambling behaviors.