Herbal Medicine for Cervical Intraepithelial Neoplasia After Loop Electrosurgical Excision Procedure: A Systematic Review and Meta-Analysis
![]() |
Lee, Su-Jeong
(Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
Ji, Hae-Ri (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) Lee, Hye-Jung (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) Hwang, Deok-Sang (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) Lee, Chang-Hoon (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) Jang, Jun-Bock (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) Lee, Jin-Moo (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) |
1 | Feng BB, et al. Study on the efficacy of LEEP operation combined with Qilin Traditional Chinese Medicine (TCM) decoction in the treatment of CIN I-II. Chinese Journal of Reproductive Health. 2019;30(4):332-7. |
2 | Cai WW. Observation Study on the Treatment of Cervical Intraepithelial Neoplasia of High-risk HPV Infection by Traditional Chinese Medicine Xunxi Fang.(中药熏洗方对宫颈环形电切术治疗高危型HPV感染的宫颈上皮内瘤变术后的护理观察). Strait Pharmaceutical Journal. 2013;25(5):132-3. |
3 | Tao PP, et al. Effect of paiteling on human papillomavirus infection of the cervix. Molecular and clinical oncology. 2017;7(6):957-64. |
4 | Wang CL, Yan HY. Clinical study of integrated traditional Chinese and western medicine treating HPV persistent infection after LEEP surgery. China modern medicine. 2015;22(14):132-4. |
5 | Tang CM. Clinical Application of Traditional Chinese Medicine in Reducing Wound Hemorrhage After LEEP.(中药在减少宫頸上皮内瘤变LEEP术后创面出血的临床应用). Contemporary Medicine. 2016;22(11):160-1. |
6 | Zhu QF. Observation of Curative Effect of Qushizhidai Decoction Combined with Circular Cervical Resection on Cervical Intraepithelial Neoplasia.(祛湿止带汤联合宫颈环形电切术治疗宫颈上皮内瘤变疗效观察). Journal of new chinese medicine. 2015;47(4):164-5. |
7 | Insinga RP, Glass AG, Rush BB. Diagnoses and outcomes in cervical cancer screening: a population-based study. Am J Obstet Gynecol. 2004;191(1):105-13. DOI |
8 | Lian LJ. Lin Qiao Childhood Gynecology Oncology.(林巧稚妇科肿瘤学). 3rd ed. Beijing:People's Medical Publishing House. 2001:256. |
9 | Kerkar A, Rajendra A, Kulkarni YV. Screening for cervical cancer: an overview. J Obstet Gynecol India. 2006;56(2):115-22. |
10 | Pierce JG Jr, Bright S. Performance of a colposcopic examination, a loop electrosurgical procedure, and cryotherapy of the cervix. Obstet Gynecol Clin North Am. 2013;40(4):731-57. DOI |
11 | Rodriguez AC, et al. Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections. J Natl Cancer Inst. 2008;100(7):513-7. DOI |
12 | Ferenczy A, Franco E. Persistent human papillomavirus infection and cervical neoplasia. The Lancet Oncology. 2002;3(1):11-6. DOI |
13 | Maria A, et al. Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1. Antiviral Res. 1999;43(2):79-92. DOI |
14 | Tian LL, et al. Protective effect of (+/-) isoborneol against 6-OHDA-induced apoptosis in SH-SY5Y cells. Cell Physiol Biochem. 2007;20(6):1019-32. DOI |
15 | Jang JB, Lee GS, Song BK. Anti-bacterial and trypsin-inhibitory activities of extracts from Galla Rhois, Artemisiae folium, Sophorae Radix, Zanthoxyli Fructus and Phellodendri Cortex, externally used in gynecology. J Korean med. 1993;14(2):270-80. |
16 | Ortiz LM, et al. Berberine, an epiphany against cancer. Molecules. 2014;19(8):12349-67. DOI |
17 | Shin KH, Yoon KY, Cho TS. Pharmacological Activities of Sesquiterpenes from the Rhizomes of Curcuma zedoaria. Kor J Pharmacogn. 1994;25(3):221-5. |
18 | Sutapa M, et al. Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Mol Cancer. 2011;10:39. DOI |
19 | Park KD, Bae JE, Yoon YJ. Systematic Review of Fumigation Therapy for Atrophic Vaginitis. J Korean Obstet Gynecol. 2016;29(1):92-101. DOI |
20 | Hwang YS, et al. Analysis for Randomized Controlled Clinical Trials of Korean Medicine External Treatment on Bacterial Vaginosis. J Korean Obstet Gynecol. 2019;32(2):50-70. DOI |
21 | Ghantous A, et al. What made sesquiterpene lactones reach cancer clinical trials? Drug Discov Today. 2010;15(15-16):668-78. DOI |
22 | Zhang XY, et al. Study on the mechanism of the proliferative inhibition of baofukang suppository on human papillomavirus in vitro. Journal of China-Japan Friendship Hospital. 2007;21(4):216-9. DOI |
23 | Kang SJ, et al. 5 Cases of Regressions of cervical intraepithelial neoplasia with High-risk human papilloma virus treated with traditional korean medicine. J Korean Obstet Gynecol. 2019;32(1):94-107. DOI |
24 | Li D. Clinical Observation of Baofukang Suppository in Treating HPV Infection and CIN1. Medical Innovation of China. 2012;9(11):112. |
25 | Schiffman M, et al. Human papillomavirus and cervical cancer. Lancet. 2007;370(9590):890-907. DOI |
26 | Santesso N, et al. World Health Organization Guidelines for treatment of cervical intraepithelial neoplasia 2-3 and screen-and-treat strategies to prevent cervical cancer. Int J Gynaecol Obstet. 2016;132(3):252-8. DOI |
27 | Martin-Hirsch PP, et al. Surgery for cervical intraepithelial neoplasia. Cochrane Database Syst Rev. 2013;(12):CD001318. |
28 | Giovanni Maciocia. Obstetrics and Gynecology in Chinese Medicine. 2nd Edition. London:Churchill livingstone. 2011:807-11. |
29 | Park CS, Jung Hs, Sohn YJ. Clinical Study on 3 Cases of Cervical Dysplasia. J Korean Obstet Gynecol. 2008;21(4):237-46. |
30 | Yoo JE, et al. A review on Korean Traditional Medicine Research against Cervical Dysplasia-Focused on Studies of Cervical Cancer and Cervical Dysplasia. J Korean Obstet Gynecol. 2013;26(4):191-203. DOI |
31 | Chung JR, et al. A Review on Korean Traditional Medicine Research against Human Papillomavirus Infection and Cervical Dysplasia-Focased on Randomized Controlled Trial of Human Papillomavirus Infection and Cervical Dysplasia. J Korean Obstet Gynecol. 2019;32(4):55-66. |
32 | Lin J, et al. Traditional Chinese medicine for human papillomavirus(HPV) infections : a systematic review. BioScience Trends. 2017;11(3):267-73. DOI |
33 | Mei L, et al. Detoxification therapy of traditional Chinese medicine for genital tract high-risk human papillomavirus infection: A systematic review and meta-analysis. PLos One. 2019;14(3):e0213062. DOI |
34 | Zhu Y, Zhou M. Clinical efficiency of cervical loop electrosurgical excision procedure combined with Fukang suppository on cervical intraepithelial neoplasia. Journal of Hainan Medical university. 2011;17(8):1111-3. |
35 | Shi P. External Application of Chinese Medicine Combined with LEEP in the Treatment of Cervical Intraepithelial Neoplasia. Guang ming Zhong yi. 2012;27(9):1810-12. |
36 | Li LZ. Cervical ring electrosurgical resection combined with traditional Chinese medicine for the treatment of 86 cases of cervical intraepithelial neoplasia.(宫颈环形电刀切除术联合中药治疗宫颈上皮内瘤变86例临床研究). Guizhou Medical Journal. 2014;38(5):403-5. |
37 | Han JH, et al. A case of intractable cervical dysplasia patient treated with Korean medicine for three months. J Korean Obstet Gynecol. 2012;25(4):154-60. DOI |
38 | Zheng LR. Clinical Studies about Treating the Cervical Intraepithelial Neoplasia with Human Papilloma Virus Infection with Loop Electrosurgical Excision Procedure United Zhi Ming Ling Shuan. Fujian University of Traditional Chinese Medicine. 2013. |
![]() |