• Molecules and Cells
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• v.45 no.1
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• pp.26-32
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• 2022

Living cells generate, sense, and respond to mechanical forces through their interaction with neighboring cells or extracellular matrix, thereby regulating diverse cellular processes such as growth, motility, differentiation, and immune responses. Dysregulation of mechanosensitive signaling pathways is found associated with the development and progression of various diseases such as cancer. Yet, little is known about the mechanisms behind mechano-regulation, largely due to the limited availability of tools to study it at the molecular level. The recent development of molecular tension probes allows measurement of cellular forces exerted by single ligand-receptor interaction, which has helped in revealing the hitherto unknown mechanistic details of various mechanosensitive processes in living cells. Here, we provide an introductory overview of two methods based on molecular tension probes, tension gauge tether (TGT), and molecular tension fluorescence microscopy (MTFM). TGT utilizes the irreversible rupture of double-stranded DNA tether upon application of force in the piconewton (pN) range, whereas MTFM utilizes the reversible extension of molecular springs such as polymer or single-stranded DNA hairpin under applied pN forces. Specifically, the underlying principle of how molecular tension probes measure cell-generated mechanical forces and their applications to mechanosensitive biological processes are described.

• Cartoon and Animation Studies
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• s.11
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• pp.1-10
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• 2007

The trend of making film from the comic source, which is a prototype of so-called media mix, is indeed a different phenomenon from the traditional ones from novel or play sources. Historically comics are recently adapted to film although they have narratives and continuity of images. It is due to the lack of social conception of comics genre and extension of imagination that is a characteristics of the comics. However, it is conspicuous that comics has been a source of film along with the development of technology of visual image reproduction and the trend of enlarging reproduction of popular media image. Since comics can provide narratives and he visual sense for film making, these trend will be continued and more vivid.

• The Journal of Korean Physical Therapy
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• v.33 no.3
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• pp.162-167
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• 2021

Purpose: A hyperextended knee is described as knee pain associated with an impaired knee extensor mechanism. Additionally, a hyperextended knee may involve reduced position sense of the knee joint that decreases the individual's ability to control end-range knee extension movement. The purpose of this study was to investigate the effects of visual biofeedback information for plantar pressure distribution on knee joint angle and lower extremity muscle activities in participants with hyperextended knees. Methods: Twenty-three participants with hyperextended knees were recruited for the study. Surface electromyography signals were recorded for the biceps femoris, rectus femoris, gastrocnemius, and tibialis anterior muscle activities. The plantar pressure distribution was displayed and measured using a pressure distribution measuring plate. Knee joint angle kinematic parameters were recorded using a motion analysis system. The visual biofeedback condition was the point at which the difference between the forefoot and backfoot plantar foot pressure on the monitor was minimized. The Wilcoxon signed-rank test was used to determine the significance between the visual biofeedback condition and the preferred condition. Results: The knee joint angle was significantly decreased in the visual biofeedback condition compared to that in the preferred condition (p<0.05). The rectus femoris and gastrocnemius muscle activities were significantly different between the visual biofeedback and preferred conditions (p<0.05). Conclusion: The results of this study showed that visual biofeedback of information about plantar pressure distribution is effective for correcting hyperextended knees.

• Physical Therapy Rehabilitation Science
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• v.11 no.2
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• pp.259-268
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• 2022

Objective: The purpose of this study was to measure the immediate effect of hip hinge exercise stretching on hamstring flexibility, pelvic tilting angle, proprioception, and dynamic balance in individual with tightness of the hamstring. Design: A randomized controlled trial. Methods: A total of 35 healthy young adults (27 males, 8 females) volunteered for this study and randomly divided into three groups (Hip hinge exercise stretching group, passive stretching group, and PNF stretching group). The hamstring flexibility, pelvic tilting angle, knee joint proprioception, dynamic balance was conducted for 3 times. In order to evaluate the hamstring flexibility, the active knee extension test was performed. Forward bending test was performed to examine pelvic tilting angle.The proprioception was tested by the joint position sense test and dynamic balance was evaluated by Y balance test. Results: The hamstring flexibility, pelvic tilting angle and dynamic balance were significantly improved between three groups before and after intervention (p<0.05). Dynamic balance was significantly difference between the three groups in the posterolateral direction (p<0.05). Conclusions: This study result showed that hip hinge exercise stretching was the most effective method for increasing hamstring flexibility, pelvic tilting angle and dynamic balance. In addition, it is necessary to study whether hamstring stretching is effective in low back pain patient with hamstrings tightness.

• Korean Institute of Interior Design Journal
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• v.27 no.1
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• pp.39-47
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• 2018

This study is intended to suggest an improvement scheme of activating container multiplex cultural space through an analysis of container architecture characteristics and a survey of user satisfaction, focusing on container multiplex cultural space located in Seoul city. Hence, the elements of multiplex cultural space and the characteristics of container architecture were deduced and analyzed through precedent study and literature review relating to multiplex cultural space and container architecture, and then an analysis framework was established with items to measure the user satisfaction. Based on this, a questionnaire was created, and users were surveyed through on-site visit. The results of analyzing the container multiplex cultural space users' satisfaction are as follows. First, in order to increase user satisfaction, it is necessary to highlight visual element. Second, there is necessity for distinct space configuration, such as connection, stack and extension by utilizing the fixed specifications, the characteristics of container. Third, there is necessity for extended space where people feel a sense of openness. Fourth, it should be improved so that air is well circulated by installing glass, operable window, etc. In further research, it is thought necessary to make a study of commercial space and facilities inside university besides multiplex cultural space.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.6 s.237
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• pp.860-875
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• 2005

A new meshfree method for the analysis of elasto-plastic deformations is presented. The method is based on the proposed first-order least-squares formulation, to which the moving least-squares approximation is applied. The least-squares formulation for the classical elasto-plasticity and its extension to an incrementally objective formulation for finite deformations are proposed. In the formulation, the equilibrium equation and flow rule are enforced in least-squares sense, while the hardening law and loading/unloading condition are enforced exactly at each integration point. The closest point projection method for the integration of rate-form constitutive equation is inherently involved in the formulation, and thus the radial-return mapping algorithm is not performed explicitly. Also the penalty schemes for the enforcement of the boundary and frictional contact conditions are devised. The main benefit of the proposed method is that any structure of cells is not used during the whole process of analysis. Through some numerical examples of metal forming processes, the validity and effectiveness of the method are presented.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.49 no.2
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• pp.122-129
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• 2012

As a greedy algorithm reconstructing the sparse signal from underdetermined system, orthogonal matching pursuit (OMP) algorithm has received much attention in recent years. In this paper, we present an extension of OMP for pursuing efficiency of the index selection. Our approach, referred to as generalized OMP (gOMP), is literally a generalization of the OMP in the sense that multiple (N) columns are identified per step. Using the restricted isometry property (RIP), we derive the condition for gOMP to recover the sparse signal exactly. The gOMP guarantees to reconstruct sparse signal when the sensing matrix satisfies the RIP constant ${\delta}_{NK}$ < $\frac{\sqrt{N}}{\sqrt{K}+2\sqrt{N}}$. In addition, we show recovery performance and the reduced number of iteration required to recover the sparse signal.

• The Journal of Korean Academy of Sensory Integration
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• v.6 no.1
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• pp.35-46
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• 2008

Objective : This study verifies the effects of sensory integrative (SI) therapy on vestibular- and proprioceptive sensory (BPS) processing ability of a child with Asperger Syndrome (AS). Method : A boy who is 11 years and 2 months old took the Functional Independence Measure for Children (Wee-FIM), Canadian Occupational Performance Measure (COPM), Short Sensory Profile, Bruininks-Oserestky Test of Motor Proficiency-2 (BOT-2), and Test of Playfulness (ToP) for the baseline. The child participated in 3 evaluation sessions and 8 therapy sessions based on the AB research design. Duration of each session is 50 min and the therapy session is divided into 40 minutes for treatment and 10 minutes for evaluation. Since the vestibular sense and proprioception build up one's ability of postural control, several tests were employed to evaluate the child' postural control as outcome measure; distance from front leg of chair to heel of the child with sitting (C-H distance), angle between trunk and thigh (hip joint angle) with sitting, and the 'prone-extension posture' which is a subtest of Clinical Observation of Motor and Postural Skill (COMPS) to examine postural control embodied with integration of reflex and BPS processing. Result : During the therapy, average data of the C-H distance is decreased from 27.33cm to 11.69cm, average data of the hip joint angle is also decreased from $43.3^{\circ}$ to $20^{\circ}$, and average time for the prone-extension posture is increased from 13.15seconds to 24.84seconds. Conclusion : This result indicates that the ability to postural control in sitting and to maintain the prone-extension posture can be improved by sensory integrative therapy, with enhanced BPS processing.

• Journal of The Korean Society of Integrative Medicine
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• v.3 no.2
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• pp.39-46
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• 2015

Purpose: For this study, low back pain was analyzed by determining the influences of pain threshold, proprioceptive sense, and balance ability. Method: A total of 80 college students participated in this study with 30 adults regarded as normal and 50 adults regarded as having lower back pain. Measurements for participants regarding pain threshold, proprioception, and balance ability were conducted from April 10 to May 16, 2014. Result: Results from this study show significant differences between groups for back with regards to cold pain threshold, warm pain threshold measurements. There were also significant differences in proprioception for extension measurements. Finally, there were significant differences when comparing groups regarding balance for total balance score. Conclusion: With this data, practicing physical therapists can realize that a difference may exist between the patient's perception of treatment received and the actual treatment given by professionals due to differences in threshold, proprioception and balance ability. It is important for physical therapists to understand the reliance on objective data showing the effects of threshold, proprioception and balance ability on patients with back pain.

• Journal of Navigation and Port Research
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• v.43 no.5
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• pp.320-327
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• 2019

This study examined the port expansion plan for the fishery port at the east coast of Korea, in accordance with permission conditions for coastal ports such as a limit on the cargo volume and passenger demand for the coastal tourism belt formation. The site was chosen as a municipal coastal port attracting the new ocean industry and building waterfront zone as a hub of new marine tourism. Two different numerical models (Swan and Bouss 2D) were used. Before applying to the target sea area, some numerical tests were conducted for the variation according to Bouss-2D's strong/weak and nonlinear technique compared to the irregular diffraction of semi-infinite breakwater with a theoretical solution. As a result, there was a difference in strong nonlinearity with breaking waves and it was necessary to experiment with a strong nonlinear analysis technique for the actual site. Two numerical models were applied to the fishery port site and the tranquility of some alternatives were analyzed. The numerical results show the most suitable plan was ALT-1, with satisfied harbor tranquility and reasonable economic sense. The extension of the east breakwater and enlarged turning basin of the F-Land plan have brought generally more stable harbor tranquility than the ALT-1. The result can be used as a reference for the port expansion plan in the future.