• Cross-Cultural Studies
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• v.29
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• pp.391-411
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• 2012

Request expressions can be defined as expressions that demand or ask the other person to do certain movements. There are direct request expressions that ask the other person to do certain movements directly and indirect request expressions that ask the other person to do certain movements by describing the speaker's condition. The study analyzed gender and hierarchy of speakers and listeners who used 'tekure' and 'tekudasai' in dialog examples of the Meiji Period and the Taisho Period. In those periods, the modern Tokyo dialect was formed and established. "Toseishoseikatagi"in Meiji 10s,"Ukigumo""Natsukodachi""Tajotakon"in Meiji 20s,"Hakai""Botchan"in Meiji 30s,"Huton""Inakakyoshi" in Meiji 40s and "Aruonna"in the Taisho Period were analyzed for the study. 'kure' was used more by male speakers than female speakers. Examples by female speakers were shown on the novels after Meji 30s. In case of male speakers, they often used it to listeners with an equitable relationship at "Toseishoseikatagi"in Meiji 10s but they often used it to younger listeners at "Hakai"in Meiji 30s. 'okure' was used more by female speakers than male speakers. Listeners were varied from older ones to younger ones. In case of female speakers, 'okure' was used more often at "Aruonna"in the Taisho Period than the other novels. In case of male speakers, 'okure' was used only at "Ukigumo""Natsukodachi"and "Hakai". 'Okurenasai' was used outstandingly by female speakers on the form of 'okun_'. In case of 'kudasai', female speakers used it more than male speakers at "Toseishoseikatagi" and "Aruonna"but male speakers used it more than female speakers at "Tajotakon"and "Hakai". Listeners were varied from older ones to younger ones. 'o~kudasai' was not shown until Meiji 20s but shown after Meiji 30s among the analyzed novels. According to gender, it was used a little bit more often by female speakers than male speakers. According to hierarchy, listeners were usually older than speakers. 'o~nasatekudasai' was used more often by male speakers than female speakers. Listeners were also usually older than speakers.

• Journal of Korean Philosophical Society
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• v.141
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• pp.187-202
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• 2017

The aim of this paper is to clarify the difference between the concept of deduction-induction and Aristotle's concept of syllogismos-epagoge. First, Aristotle does not use the expression 'invalid syllogismos'. But a valid deduction is distinguished from a invalid deduction in modern logic. Second, from Aristotle's point of view syllogismos is paralleled by epagoge. Because syllogismos is equivalent to epagoge in logical form. But a disturbing lack of parallelism exists between deduction and induction by which the standards for establishing inductive conclusions are more demanding than those for deductive ones. Third, instructors in introductory logic courses ordinarily stress the need to evaluate arguments first in terms of the strength of the conclusion relative to the premises. Accordingly, students may be told to assume that premises are true. But Aristotle does not assume that premises are true. A syllogismos start from the conceptually true premise and a epagoge start from the empirically true premise.

• The Journal of the Korea Contents Association
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• v.19 no.10
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• pp.32-44
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• 2019

Based on the characteristics of cultural expressions, this paper compares and analyzes the cases of representative commercial architectural spaces of six largest cities in China.In order to promoting the sustainable development of the indoor space culture of modern commercial buildings in China.Six cases were analyzed from the viewpoints of cultural tradition, locality, popularity, technology, and ecology. The results are as follows. First, the tradition of culture requires the emphasis on the traditional elements of specific areas in the interior space of commercial architecture.Second, the regional character of culture is closely related to the social and natural environment factors such as the economic development of the interior space of commercial architecture, historical intrinsic space, geographical environmental conditions, and climate.Fourth, the technicality of culture is to integrate construction method, structure form, and material with local culture into commercial architecture interior space.Fifth, cultural ecology places attention to placing plants in the interior space of commercial architecture and creating a healthy, pleasant and safe environment.

• Archives of Pharmacal Research
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• v.27 no.7
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• pp.683-692
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• 2004

Curcumin (diferuloylmethane) is a major naturally-occurring polyphenol of Curcuma species, which is commonly used as a yellow coloring and flavoring agent in foods. Curcumin has shown anti-carcinogenic activity in animal models. Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase and inducible nitric oxide synthase; and an effective inducer of heme oxygenase-1. Curcumin is also a potent inhibitor of protein kinase C(PKC), EGF(Epidermal growth factor)-receptor tyrosine kinase and LĸB kinase. Subsequently, curcumin inhibits the activation of NF(nucleor factor)KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs and iNOS. It is proposed that curcumin may suppress tumor promotion through blocking signal transduction path-ways in the target cells. The oxidant tumor promoter TPA activates PKC by reacting with zinc thiolates present within the regulatory domain, while the oxidized form of cancer chemopreventive agent such as curcumin can inactivate PKC by oxidizing the vicinal thiols present within the catalytic domain. Recent studies indicated that proteasome-mediated degradation of cell proteins playa pivotal role in the regulation of several basic cellular processes including differentiation, proliferation, cell cycling, and apoptosis. It has been demonstrated that curcumin-induced apoptosis is mediated through the impairment of ubiquitin-proteasome pathway. Curcumin was first biotransformed to dihydrocurcumin and tetrahydrocurcumin and that these compounds subsequently were converted to monoglucuronide conjugates. These results suggest that curcumin-glucuronide, dihydrocurcumin-glucuronide, tetrahydrocurcumin-glucuronide and tetrahydrocurcumin are the major metabolites of curcumin in mice, rats and humans.

• ETRI Journal
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• v.43 no.5
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• pp.869-880
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• 2021

Herein, we estimate the direction of arrival (DOA) of non-Gaussian signals for nested arrays (NAs) by implementing the fourth-order difference co-array (FODC) and successive methods. In particular, considering the property of the fourth-order cumulant (FOC), we first construct the FODC of the NA, which can obtain O(N⁴) virtual elements using N physical sensors, whereas conventional FOC methods can only obtain O(N²) virtual elements. In addition, the closed-form expression of FODC is presented to verify the enhanced degrees of freedom (DOFs). Subsequently, we exploit the vectorized FOC (VFOC) matrix to match the FODC of the NA. Notably, the VFOC matrix is a single snapshot vector, and the initial DOA estimates can be obtained via the discrete Fourier transform method under the underdetermined correlation matrix condition, which utilizes the complete DOFs of the FODC. Finally, fine estimates are obtained through the spatial smoothing-Capon method with partial spectrum searching. Numerical simulation verifies the effectiveness and superiority of the proposed method.

• Development and Reproduction
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• v.24 no.4
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• pp.297-306
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• 2020

Repetitive changes in the intracellular calcium concentration ([Ca²⁺]i) triggers egg activation, including cortical granule exocytosis, resumption of second meiosis, block to polyspermy, and initiating embryonic development. [Ca²⁺]i oscillations that continue for several hours, are required for the early events of egg activation and possibly connected to further development to the blastocyst stage. The sources of Ca²⁺ ion elevation during [Ca²⁺]i oscillations are Ca²⁺ release from endoplasmic reticulum through inositol 1,4,5 tri-phosphate receptor and Ca²⁺ ion influx through Ca²⁺ channel on the plasma membrane. Ca²⁺ channels have been characterized into voltage-dependent Ca²⁺ channels (VDCCs), ligand-gated Ca²⁺ channel, and leak-channel. VDCCs expressed on muscle cell or neuron is specified into L, T, N, P, Q, and R type VDCs by their activation threshold or their sensitivity to peptide toxins isolated from cone snails and spiders. The present study was aimed to investigate the localization pattern of N and P/Q type voltage-dependent calcium channels in mouse eggs and the role in fertilization. [Ca²⁺]i oscillation was observed in a Ca²⁺ contained medium with sperm factor or adenophostin A injection but disappeared in Ca²⁺ free medium. Ca²⁺ influx was decreased by Lat A. N-VDCC specific inhibitor, ω-Conotoxin CVIIA induced abnormal [Ca²⁺]i oscillation profiles in SrCl₂ treatment. N or P/Q type VDC were distributed on the plasma membrane in cortical cluster form, not in the cytoplasm. Ca²⁺ influx is essential for [Ca²⁺]i oscillation during mammalian fertilization. This Ca²⁺ influx might be controlled through the N or P/Q type VDCCs. Abnormal VDCCs expression of eggs could be tested in fertilization failure or low fertilization eggs in subfertility women.

• The Journal of the Korea Contents Association
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• v.19 no.3
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• pp.197-212
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• 2019

This study points out how the two conflicting elements of empathy and estrangement that constitute the dual structure of are incorporated by dialectic; finally, this paper explores the spontaneous estrangement effects' meaning and value on the point of view of reception aesthetics. As results of these studies, First, the Brechtian set of estrangement effects techniques showed that in it could function as an empathy technique for audiences. Second, the role of Sanbazi to increase the audience's participation was to produce both the immersion effect and the estrangement effect simultaneously. These double features of Sanbazi are dialectically incorporated and simultaneously bring about both the social reality reflection and enjoyment of the audience. Third, the puppetry is valid as not a way to describe reality but one of the ways to look at social reality. Conclusionally, in terms of producing counter-discourse, the puppet show has more extensible than any other form of performance with regard to expression.

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.117-125
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• 2019

Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. However, the definite anti-angiogenic mechanism of MBZ remains unclear. In this study, we explored the inhibitory mechanism of MBZ in endothelial cells (ECs) and developed a novel strategy to improve its anti-angiogenic therapy. Treatment of ECs with MBZ led to inhibition of EC proliferation in a dose-dependent manner in several culture conditions in the presence of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) or FBS, without selectivity of growth factors, although MBZ is known to inhibit VEGF receptor 2 kinase. Furthermore, MBZ inhibited EC migration and tube formation induced by either VEGF or bFGF. However, unexpectedly, treatment of MBZ did not affect FAK and ERK1/2 phosphorylation induced by these factors. Treatment with MBZ induced shrinking of ECs and caused G2-M arrest and apoptosis with an increased Sub-G1 fraction. In addition, increased levels of nuclear fragmentation, p53 expression, and active form of caspase 3 were observed. The marked induction of autophagy by MBZ was also noted. Interestingly, inhibition of autophagy through knocking down of Beclin1 or ATG5/7, or treatment with autophagy inhibitors such as 3-methyladenine and chloroquine resulted in marked enhancement of anti-proliferative and pro-apoptotic effects of MBZ in ECs. Consequently, we suggest that MBZ induces autophagy in ECs and that protective autophagy can be a novel target for enhancing the anti-angiogenic efficacy of MBZ in cancer treatment.

• Korean Journal of Pharmacognosy
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• v.49 no.4
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• pp.349-361
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• 2018

Socheongryong-tang (SCRT) was one of the major traditional herbal medicines wildly used in the treatment of respiratory disease. SCRT is being commercially produced in the form of mix extracts powder and soft dry extract by different extract methods in the Korean Herbal Pharmacopeia (KHP). In this study, the contents of marker components and biological activities of the SCRT mix extract powder were compared with those of the SCRT decoction. To analyze the marker components of SCRT, nine marker from eight herbal preparations were chosen. And the method using high performance liquid chromatography (HPLC) with diode-array detector method was established for the simultaneous analysis. Method validation was accomplished by linearity, precision test, and recovery test. The contents of nine marker components in this extract was ascertained by ratio. The biological activities were examined the effect of SCRT on anti-oxidation and pro-inflammation mediated by LPS-stimulation. We confirmed that both of SCRT mix extrct powder and decoction have the similar contents on total polyphenol and flavonoid and inhibited the secretion of nitric oxide (NO), $IL-1{\beta}$, IL-6, tumor necrosis factor $(TNF)-{\alpha}$ and the expression of iNOS, COX-2, $IL-1{\beta}$, IL-6, $TNF-{\alpha}$. These results suggest that SCRT mix extract powder and decoction have a significant correlation.

• Journal of Fashion Business
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• v.23 no.4
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• pp.13-23
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• 2019

This study aims to understand the concept of pixel, the most important factor in constituting a digital image, draw the formative characteristics of pixelation image expressed through non-digital media, and develop fashion design reflecting the characteristics. As a research method, the literature review was conducted in the present study by involving domestic and foreign publications, related academic journals, and theses and dissertations on the pixel and pixelation image based on a qualitative research process. In addition, through an analysis of the cases that borrowed pixelation images in non-digital media like contemporary art and design, etc., an attempt was made to draw the formative characteristics of the pixelation image. Apparently, six fashion design looks are presented in the present study. The formative characteristics of the pixelation image include: first, the repeatability that repeats the minimum unit; second, the incompleteness of the shape appearing through the phenomenon of aliasing due to the characteristics of the pixel; and third, the combination that completes the shape through the combination of individual independent pixels. The results of the expression through reflecting them in fashion design are as follows: first, this study chose one small geometric formative element and presented repeatability by repetitively expressing that element in a textile pattern; second, for incompleteness, this study expressed an incomplete form, handling the edge part of the shape with the method of disentangling the strand; and third, the combination by completing a single look through overlapping of independent textiles and the combination of different independent individuals is expressed.