• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6955-6960
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• 2014

Background: The cytokinesis-block micronucleus (CBMN) assay is a standard cytogenetic tool employed to evaluate chromosomal damage subsequent to pesticide exposure. Objectives: To evaluate the pooled levels of total micronuclei (MN) and binucleated cells with micronuclei (MNC) in 1000 binucleated lymphocytes among population occupationally exposed to pesticides and further determine the more sensitive biomarker of CBMN. Materials and Methods: A meta-analysis on the pooled levels of MN and MNC in binucleated lymphocytes among occupationally pesticide-exposed populations was conducted using STATA 10.0 software and Review Manager 5.0.24 in this study. Results: We found significant differences in frequencies of MN and MNC in 1000 binucleated lymphocytes between pesticide-exposed groups and controls, and the summary estimates of weighted mean difference were 6.82 [95% confidence interval (95% CI): 4.86-8.78] and 5.08 (95% CI: 2.93-7.23), respectively. However, when we conducted sensitivity analyses further, only the MN remained statistically different, but not the MNC, the summary estimates of weight mean difference were 2.86 (95% CI: 2.51-3.21) and 0.50 (95% CI: -0.16-1.17), respectively. We also observed pesticide-exposed subjects had significantly higher MN frequencies than controls among smokers and nonsmokers, male and female populations, and American, Asian and European countries in stratified analyses. Conclusions: The frequency of MN in peripheral blood lymphocytes might be a more sensitive indicator of early genetic effects than MNC using the CBMN assay for occupationally pesticide-exposed populations.

• Journal of environmental and Sanitary engineering
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• v.11 no.3
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• pp.1-7
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• 1996

Mandelic acid is the major metabolite and phenylglyoxylic acid is the minor metabolite of styrene in human. This study was conducted to investigate the correlation between exposure concentrations of styrene and concentration of the metabolites in urine The concentrations of metabolites in urine and exposure concentrations were measured in 60 workers who were occupationally exposed to styrene in FRP industry as well as paint industry and musical instrument manufacturing industry and the concentrations of metabolites in urine ware measured in 90 workers not occupationally exposed to styrene for review the background level in the unexposed population. The results obtained were as follows; 1. The mean exposure concentration is 16.6 $\pm $12.2 ppm (range 0.4-49.9ppm) in the styrene exposed workers. 2. The concentration of mandelic acid in urine collected at the end of shift from worker exposed 8 hours to 50ppm of styrene, based on extrapolation from correlation equations was 578.5 mg/g creatinine and 176.8 mg/g creatinine for next morning urine, the concentration of phenylglyoxylic acid in urine collected at the end of shift was 291.1 mg/g creatinine, 177.9 mg/g creatinine in next morning urine. In the sum of mandelic acid and phenylglyoxylic acid in the urine 870.2 mg/g creatinine in urine sampled at the end of shift corresponds to an exposure of 50ppm of styrene and 366.0 mg/g creatinine for next morning sample corresponds to 50ppm. 3. The correlation of the degree of exposed with sum concentration of mandeliacid and phenylglyoxylic acid in the urine was better(r=0.079 for end of shift, r=0.78 for next morning) than the correlation with single determinant measurement in urine(r=0.75 for mandelic acid at end of shift, r=0.73 for mandelic acid at next morning, r=0.69 for phenylglyoxylic acid at end of shift, r=0.62 for phenylglyoxylic acid at next morning). The monitoring of sum concentration of mandelic acid and phenylglyoxylic acid in urine is a valuable indicator of time weighted average daily exposure ti styrene. And the exposure standard of urinary metabolites produced by styrene should be set, in distinction urine at the end of shift from urine at next morning.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.948-951
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• 2014

Road traffic noise is closely related with urban forms and urban components, such as population, building, traffic and land-use, etc. Hence, it is possible to minimize the noise exposure problem depending on how to plan new town or urban planning alteration. This paper provides ways to apply for urban planning in consideration of noise through exposed noise estimation for urban planning alteration. Spatial autoregressive model which explains about 81.4% of road traffic noise from the former paper is used. The simulation results by the spatial statistical model are compared with those by the engineering program-based modeling for 5 small-scaled scenarios of urban planning alteration. The error from the limitation of containing informations inside the grid cell and the difficulties of reflecting acoustic phenomena is existed. Nevertheless, in the stage of preliminary design, the use of the statistical models that have been estimated well is useful in time and economically.

• Journal of Food Hygiene and Safety
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• v.1 no.1
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• pp.97-106
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• 1986

Pesticides constitute a unique group of biologically active chemicals in that they are produced for deliberate release into the environment, usually to produce some specific biocidal effect. Workers at all stages of pesticide production and application become exposed, at least on an occasional basis, while some experience routine exposure. The general population is, in turn, exposed to the residues, in air, water and food. This review is intended to survey the present knowledge of the immunotoxicity of 20 pesticides. As will be readily seen, knowledge of pesticide immunotoxicology to date is largely descriptive with only modest beginnings toward understanding mechanisms underlying the effects. In most cases the effects have not yet to be defined in immunological state, and just as little is presently known about how these chemicals exert their effects. There is an equally great gap in perceiving any relationship between the structure of a chemical and immunotoxicological potential.

• Journal of Veterinary Clinics
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• v.21 no.3
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• pp.286-290
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• 2004

Cytogenetic and hematological analysis was performed in peripheral blood of pig in the vicinity of Yeonggwang nuclear power station and control area. The frequency of micronuclei (MN) in peripheral blood lymphocytes from pig was used as a biomarker of radiobiological effects resulting from exposure to environmental radiation. An estimated dose of radiation was calculated by a best fitting linear-quadratic model based on the radiation-induced MN formation from the swine lymphocytes exposed in vitro to radiation over the range from 0 Gy to 4 Gy. MN rates in lymphocytes of pig from Yeonggwang nuclear power station and control area were 10.60/1,000 and 11.10/1,000, respectively. There were no significant differences in MN frequencies and hematological values in pig between Yeonggwang and control area. The study indicates that the MN assay in lymphocyte of pig is a rapid, sensitive and accurate method that can be used to monitor a large population exposed to radiation.

• Environmental Mutagens and Carcinogens
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• v.19 no.2
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• pp.102-107
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• 1999

A population monitoring studies for assessing the genotoxicity of occupationally exposed mixed organic solvents to printers were performed by using the chromosome aberration assay and the cytokinesis-blocked micronucleus assay. The incidence of chromosome aberrations and micronuclei was studied in the peripheral blood lymphocytes of 51 male printers and their matched controls in Seoul area. Smoking habits and duration of employment were taken into account. The frequencies of micronucleus in peripheral lymphocytes of printers were significantly different in comparision with control subjects. Also there were significant increase in the frequencies of micronucleus by duration of exposure. The frequencies of chromosome aberrations showed no significant differences between printers and their matched controls.

• Korean System Dynamics Review
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• v.15 no.1
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• pp.75-96
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• 2014

This research primarily aims at analyzing major crises originating from marginalizing population, especially in counties. In addition, based on the system dynamics approaches, it pays attention to divulging causal loop structure which has been rather strengthened by diverse interactions among key variables. Judging from simulation works, even though Korea is exposed to unprecedented aging trends over decades, its counter response seems inadequate and insufficient, mostly dismissing a series of impact embedded in the aging dynamics. This research statistically confirms that demographic marginalization trends have already begun in the villages within Eup and Myon counties. Furthermore, this research pinpoints out the fact that it would be almost impossible for majority of villages within Eup and Myon counties to escape from going out of existence in the course of time, as they tend to be entrapped vicious cycle of marginalization or extinction.

• Journal of the Korean Mathematical Society
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• v.54 no.3
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• pp.987-997
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• 2017

A deterministic model for the spread of pine wilt disease with asymptomatic carrier trees in the host pine population is designed and rigorously analyzed. We have taken four different classes for the trees, namely susceptible, exposed, asymptomatic carrier and infected, and two different classes for the vector population, namely susceptible and infected. A complete global analysis of the model is given, which reveals that the global dynamics of the disease is completely determined by the associated basic reproduction number, denoted by $\mathcal{R}_0$. If $\mathcal{R}_0$ is less than one, the disease-free equilibrium is globally asymptotically stable, and in such a case, the endemic equilibrium does not exist. If $\mathcal{R}_0$ is greater than one, the disease persists and the unique endemic equilibrium is globally asymptotically stable.

• Ocean and Polar Research
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• v.24 no.1
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• pp.47-53
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• 2002

To evaluate the effect of reed population on the distribution and activities of microorganisms, vertical distribution of heterotrophic bacteria, degradation rate of cellulose, extracellular aminopeptidase activity (APA) and metabolic diversity based on GN2 Microlog plate were measured at two salt marsh stations in Hogok-ri, Namyang Bay, west coast of Korea. The number of heterotrophic bacteria at station 1 (reed population inhabited area) showed 2 to 6 times higher than that of station 2 (exposed area) with exception in the surface layer. Cellulose degradation rates in station 1 showed more than 50%. month-I and higher than that of station 2 (10.2 to 38.4%. $month^{-1}$). Yet the APA at two stations did not show difference except surface layer and suggested that APA might not be a significant factor in degrading marsh plant debris. Lipid class compounds, cell wall polymers and L-alanine were widely used by microorganisms. The number and activities of bacterial populations especially concerned in plant debris degradation seemed to be stimulated by the reed communities.

• Journal of Agricultural Extension & Community Development
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• v.12 no.1
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• pp.17-28
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• 2005

This study investigated structural changes of the Korea's agriculture and proposed the new direction of rural and agricultural policy in Korea after economic opening. The major results may be summarized as follows: Firstly, the study identified structural changes of the country's peasantry under the economic opening system. Korean agriculture has been deteriorated in population structure, arable land size, and income composition. Secondly, according to above analysis on these changes it suggested that the traditional rural communities were exposed to collapse and this unwanted disaster could result in serious adversities to the national economy. Thirdly, this study proposed preservation policies for small scale farming households and also administrative preparations of multi-dimensional approaches leading to successful rural and agricultural planning.