• Title/Summary/Keyword: Exponential Type

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Transcriptional Regulation of a DNA Repair Gene in Saccharomyces cerevisiae

  • Jang, Yeon-Kyu;Sancar, Gwen-B.;Park, Sang-Dai
    • Proceedings of the Zoological Society Korea Conference
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    • 1998.10b
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    • pp.113-113
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    • 1998
  • In Saccharomyces cerevisiae UV irradiation and a variety of chemical DNA -damaging agents induce the transcription of specific genes, including several involved in DNA repair. One of the best characterized of DNA -damage inducible genes is PHRI, which encodes the apoenzyme for DNA photolyase. Basal-level and damage-induced expression of PHRI require an upstream activation sequence, UASPHRI. Here we report the identification of the UlvIE6 gene of S. cerevisiae as a regulator of UASPHRl activity. Surprisingly, the effect of deletion of UME6 is growth phase dependent. In wild-type cells PHRI is induced in late exponential phase, concomitant with the initiation of glycogen accumulation that precedes the diauxic shift. Deletion of UNIE6 abolishes this induction, decreases the steady-state concentration of photolyase molecules and PHRI mRNA, and increases the UV sensitivity of a rad2 mutant. The results suggest that UM E6 contributes to the regulated expression of a subset of damage-responsive genes in yeast. Furthermore, the upstream repression sequence, URSPHRI, is required for repression and damage-induced expression of PHRl. Here we show identification of YER169W and YDR096W as putative regulators acting through $URS_{PHRI}$. These open reading frames were designated as RPHI (YERl69W) and RPH2 (YDR096W) indicating regulator of PHRI. Simultaneous disruption of both genes showed a synergistic effect, producing a four-fold increase in basal level expression and a similar decrease m the induction ratio following treatment of methyl methanesulfonate(MMS). Mutation of the sequence ($AG_4$) bound by Rphlp rendered the promoter of PHRI insensitive to changes in RPHI or RPH2 status. The data suggest that RPHI and RPH2 act as damage-responsive negative regulators of PHRI. Surprisingly, the sequence bound by Rphlp in vitro is found to be $AG_4$ which is identical to the consensus binding site for the regulators Msn2p and Msn4p involved in stress-induced expression. Deletion of MSN2 and MSN4 has little effect on the induction$.$ ratio following DNA damage. However, all deletions led to a significant decrease in basal-level and induced expression of PHRI. These results imply that MSN2 and MSN4 are positive regulators of P HRI but are not required for DNA damage repression. [Supported by grant from NIH]om NIH]

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Mat Drying Characteristics of the Wet-thresheds Rough-rice and Effect of Drying Environment on the Cracks Formation (생탈곡(生脱糓)벼의 깔아말림 특성(特性)과 건조조건(乾燥條件)이 동할미(胴割米) 발생(發生)에 미치는 영향(影響))

  • Chun, Jae Kun;Choi, Boo Dol;Lee, Jeong Cheol
    • Journal of Biosystems Engineering
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    • v.6 no.2
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    • pp.58-64
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    • 1982
  • The fresh threshed paddy-mat dryings on the various environments were analyzed on their drying characteristics and rice quality resulted. The moisture content of paddy was mainly determined by the accumulated solar energy received, and which was expressed as a simple equation. The drying characteristics revealed to follow a constant rate drying type, and as the depth increased the more typical constant-rate drying pattern was observed. The relationship between the drying rate and bed depth was established with a simple exponential equation. The raking operation during the drying period showed a favorable effect both on the drying rate and the reduction of crack formation. Drying environments such as straw mat, concrete, ground, polyethylene film did not affect significantly the drying rate and rice quality. Considering the drying rate and quality, the optimum bed depth of mat paddy drying was around 6 cm.

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A Study on Clogging and Water Quality Improvement in Floodplain Filtration with Flood/rest Raw-water Supply (범람/휴지식 홍수터여과에서 폐색현상 및 수질개선도 연구)

  • Kim, Hoh-Seok;Kim, Seung-Hyun
    • Journal of Korean Society of Environmental Engineers
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    • v.33 no.2
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    • pp.120-131
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    • 2011
  • A pilot-scale experiment of floodplain filtration with a filtration depth of 3.6m was performed employing flood/rest type raw-water supply system in an effort to find ways to improve river water quality by additional treatments of discharged effluent from sewage treatment plant. Soil samples were taken from 3 sites including Gumi, Daegu and Gimhae along the Nakdong river. Reductions of infiltration rates following increases in operating time was investigated in each soil sample, along with the analysis of removal efficiencies of various pollutants according to different depths and infiltration rates. The results show incremental development of clogging on the soil surface with increases in operation time, and illustrate exponential decrease in the infiltration rate. The time required for the removal of the clog from the soil surface was longer than 2 weeks for all soil samples analyzed. The stable infiltration rates for soils were 5 m/day for Gumi and for Daegu and Gimhae was 1 m/day. In unsaturated soils dissolved oxygen levels increased following the increase of filtration depth, suggesting that alternating application of flood and rest for raw-water supply effectively keeps the soil environment aerobic. For all soils, the nature of pollutant removal depending on the depth of filtration remained the same regardless of the infiltration rate. Most of the BOD and turbidity were removed within 1.2 m, about 30% of COD was removed within 3.6m and was expected to be removed further with increases in filtration depth. Nitrification occurred near the surface of all soils; however there was no significant removal of nitrogen in the filtration depths tested in this study. Although removal rate of phosphorus was low for Gumi's soil, it was high enough for other soils, suggesting that the method developed in this study could significantly improve river water quality.

Growth Curves Fitting for Body Weight and Backfat Thickness of Swine by Sex (성별에 따른 돼지 체중 및 등지방두께 성장곡선 추정)

  • Choi, Te-Jeong;Seo, Kang-Seok;Choi, Je-Gwan;Kim, Si-Dong;Cho, Kwang-Hyun;Choe, Ho-Sung
    • Food Science of Animal Resources
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    • v.28 no.2
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    • pp.187-195
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    • 2008
  • The purpose of this study was to establish proper shipping weight and backfat thickness by applying the growth model to backfat thickness, measured by means of not only body weight, but also ultrasonography, and predicting the changes by age. Three breeds, i.e. Duroc, Landrace, and Yorkshie, were analyzed, and the Gompertz, logistic, and Von Bertalanffy model were used for inference with the parameter of the growth model being sex. As a result, both body weight and backfat thickness showed different growth curve parameters and characteristics at inflection points depending on model selection and sex. As for backfat thickness, in estimating the inflection point, unlike the case of body weight, the inflection ages of the boars of the Duroc breed was earlier than that of sows, whereas the inflection ages of the sows of the Landrace and Yorkshire breeds was earlier than that of boars. More than anything else, in the analysis of the changes in backfat thickness according to body weight, as the body weight reached 145kg, the backfat thickness showed much variation as great as 1.7-3.2 cm in each breed and sex. In addition, unlike the other breeds, the boars of the Landrace breed showed an exponential type of relationship between body weight and backfat thickness. As they grow to become 100 kg or heavier, abrupt change in back fat thickness was confirmed. If the growth of body weight and backfat thickness is understood and the genetic relationship is taken advantage of like this, it would be possible to set desired body weight and backfat thickness, and thus help effectively set the shipping time. If not only the phenotype, but also genetic parameters about growth characteristics are estimated and analyzed additionally, more effective data can be generated.

A comparative study of borehole size and tool effect on dispersion curves (시추공경과 공내검층기가 분산곡선에 미치는 영향에 대한 비교 연구)

  • Zhao, Weijun;Kim, Jong-Man;Kim, Yeong-Hwa
    • Geophysics and Geophysical Exploration
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    • v.12 no.1
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    • pp.154-162
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    • 2009
  • Sonic wave dispersion characteristics are one of the most important targets of study, particularly in estimating shear wave velocity from borehole sonic logging. We have tested dispersion characteristics using monopole and dipole sources. Theoretical dispersion curves were computed for tool-absent and tool-included models having the same physical properties but different diameters (including ${\Phi}520mm$, ${\Phi}150mm$, and ${\Phi}76mm$). Comparisons were made between boreholes of different sizes and between tool-absent and tool-included models. Between the tool-included and the tool-absent boreholes, a close similarity in dispersion curve shape was revealed for the monopole source, and a significant difference was shown for the dipole source. However, for the cut-off frequency, particularly in the engineering boreholes (${\Phi}76mm$ and ${\Phi}50mm$), a significant difference was observed for signals from the monopole source, but approximately the same cut-off frequencies were found with the dipole source. This indicates the need of careful choice of source frequency in monopole-source sonic logging, particularly in an engineering borehole. The results of numerical experiments show that cut-off frequency is exponentially proportional to the inverse of borehole radius, irrespective of the mode type and the presence of a tool, and that the cut-off frequencies for each borehole environment could be expressed as an exponential function, rather than the inversely proportional relationship between the cut-off frequency and the borehole radius that was previously generally recognised. From the direct comparison of dispersion curves, the effects on the dispersion characteristics of borehole size and the presence of the tool can be revealed more clearly than in previous studies, which presented the dispersion curve and/or characteristics for each borehole environment separately.

Stage-Discharge Rating Curve Model Development and Modification (하천 수위-유량곡선식 개선 및 모형개발)

  • Chang, Ki-Hwan;Lee, Jae-Hyoung
    • Journal of Korea Water Resources Association
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    • v.38 no.4 s.153
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    • pp.271-280
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    • 2005
  • The goal of this study is to recommend a new type of stage-discharge rating curve ($Q=p(h-e)^{\beta}-{\gamma}$) useful for satisfying divergence, and one other seemingly irresolvable problem related to exited rating curves, while also extending this rating curve model. The problem of divergence is that during the finding of the CZF (cease-to-zero flow) parameter e and while minimizing the sum of total errors of the estimated curve, the exponential parameter ${\beta}$ become an abnormally large value. The insoluble problem is that when the value e is greater then the recorded minimum at the gauged stage, it is impossible to have a negative logarithm value (h-e). The two problems above can be satisfied by adapting the control value ${\gamma}$, which affects the reduction of ${\gamma}$ and gives us the possibility of controlling (h-e) over zero. The study results show that the effects of parameter ${\gamma}$ are very similar to that of e when conducting physical and sensitivity analyses. This system can be used towards developing a new stage-discharge rating curve for river discharge, for use in evaluating the acceptability of existing stage-discharge rating curves generated by using hydrologic analyses at all stations.

Characteristics and Prediction of Total Ozone and UV-B Irradiance in East Asia Including the Korean Peninsula (한반도를 포함한 동아시아 영역에서 오존전량과 유해자외선의 특성과 예측)

  • Moon, Yun-Seob;Seok, Min-Woo;Kim, Yoo-Keun
    • Journal of Environmental Science International
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    • v.15 no.8
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    • pp.701-718
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    • 2006
  • The average ratio of the daily UV-B to total solar (75) irradiance at Busan (35.23$^{\circ}$N, 129.07$^{\circ}$E) in Korea is found as 0.11%. There is also a high exponential relationship between hourly UV-B and total solar irradiance: UV-B=exp (a$\times$(75-b))(R$^2$=0.93). The daily variation of total ozone is compared with the UV-B irradiance at Pohang (36.03$^{\circ}$N, 129.40$^{\circ}$E) in Korea using the Total Ozone Mapping Spectrometer (TOMS) data during the period of May to July in 2005. The total ozone (TO) has been maintained to a decreasing trend since 1979, which leading to a negative correlation with the ground-level UV-B irradiance doting the given period of cloudless day: UV-B=239.23-0.056 TO (R$^2$=0.52). The statistical predictions of daily total ozone are analyzed by using the data of the Brewer spectrophotometer and TOMS in East Asia including the Korean peninsula. The long-term monthly averages of total ozone using the multiplicative seasonal AutoRegressive Integrated Moving Average (ARIMA) model are used to predict the hourly mean UV-B irradiance by interpolating the daily mean total ozone far the predicting period. We also can predict the next day's total ozone by using regression models based on the present day's total ozone by TOMS and the next day's predicted maximum air temperature by the Meteorological Mesoscale Model 5 (MM5). These predicted and observed total ozone amounts are used to input data of the parameterization model (PM) of hourly UV-B irradiance. The PM of UV-B irradiance is based on the main parameters such as cloudiness, solar zenith angle, total ozone, opacity of aerosols, altitude, and surface albedo. The input data for the model requires daily total ozone, hourly amount and type of cloud, visibility and air pressure. To simplify cloud effects in the model, the constant cloud transmittance are used. For example, the correlation coefficient of the PM using these cloud transmissivities is shown high in more than 0.91 for cloudy days in Busan, and the relative mean bias error (RMBE) and the relative root mean square error (RRMSE) are less than 21% and 27%, respectively. In this study, the daily variations of calculated and predicted UV-B irradiance are presented in high correlation coefficients of more than 0.86 at each monitoring site of the Korean peninsula as well as East Asia. The RMBE is within 10% of the mean measured hourly irradiance, and the RRMSE is within 15% for hourly irradiance, respectively. Although errors are present in cloud amounts and total ozone, the results are still acceptable.

A Numerical Study on Characteristics of Solute Transport in a Rough Single Fracture with Spatial Correlation Length and Effect of Effective Normal Stress (공간적 상관길이와 유효수직응력의 효과에 따른 거친 단일 균열내의 용질이동특성에 관한 수치적 연구)

  • Jeong, Woochang
    • Journal of the Korean GEO-environmental Society
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    • v.10 no.1
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    • pp.5-14
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    • 2009
  • This study is to analyze numerically the spatial behaviors of the solute transport in a spatially correlated variable-aperture fracture under the effective normal stress conditions. Numerical results show that the solute transport in a fracture is strongly affected by the spatial correlation length of apertures and applied effective normal stress. According to increasing spatial correlation length, the mean residence time of solute is decreased and the tortuosity and Peclet number (is a dimensionless number relating the rate of advection of a flow to its rate of diffusion) is also decreased. These results mean that the geometry of the aperture distribution is favorable to the solute transport as the spatial correlation length is increased. However, according to the applied effective normal stress is increased, the mean residence time and tortuosity have a tendency to increase but the Peclet number is decreased. The main reason that the Peclet number is decreased, is that the solute is displaced by one or two channels with relatively higher local flow rate due to the increment of contact areas by increasing effective normal stress. Moreover, based on numerical results of the solute transport in this study, the exponential-type correlation formulae between the mean residence time and the effective normal stress are proposed.

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A Study on Estimating of Probability Distribution and Mean Life of Bridge Member for Effective Maintenance of the Bdrige (효율적인 고속도로 교량의 유지관리를 위한 교량 부재별 수명분포 및 평균수명 산정 방안 연구)

  • Lee, Yongjun;Lee, Minjae
    • Korean Journal of Construction Engineering and Management
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    • v.17 no.4
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    • pp.57-65
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    • 2016
  • This study found a proper parametric life distribution based on maintenance history data of each bridge member under the jurisdiction of the Korea Expressway Corporation for the past 10 years by introducing the concept of reliability and suggested a measure to calculate the mean life and reliability of each bridge member using the parameter obtained with the maximum-likelihood classification. As a result of analyzing the exponential distribution, weibull distribution and log normal distribution being utilized frequently in order to find the parametric life distribution type which well described the life data of each bridge member, it was found that the log normal distribution and weibull distribution described the characteristics of the relevant life data the best. As a result of calculating the mean life of each bridge member based on the estimated parameter, the average life of the steel bridge coating was 18.51 years which was the longest, followed by the bridge deck as 17.56 years. The mean life of the drainage facility and the bridge bearing were 12.27 years and 12.57 years respectively, showing the shortest life.

LATEST RESULTS OF THE MAXI MISSION

  • MIHARA, TATEHIRO
    • Publications of The Korean Astronomical Society
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    • v.30 no.2
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    • pp.559-563
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    • 2015
  • Monitor of All-sky X-ray Image (MAXI) is a Japanese X-ray all-sky surveyer mounted on the International Space Station (ISS). It has been scanning the whole sky since 2009 during every 92-minute ISS rotation. X-ray transients are quickly found by the real-time nova-search program. As a result, MAXI has issued 133 Astronomer's Telegrams and 44 Gamma-ray burst Coordinated Networks so far. MAXI has discovered six new black holes (BH) in 4.5 years. Long-term behaviors of the MAXI BHs can be classified into two types by their outbursts; a fast-rise exponential-decay type and a fast-rise flat-top one. The slit camera is suitable for accumulating data over a long time. MAXI issued a 37-month catalog containing 500 sources above a ~0.6 mCrab detection limit at 4-10 keV in the region ${\mid}{b}{\mid}$ > $10^{\circ}$. The SSC instrument utilizing an X-ray CCD has detected diffuse soft X-rays extending over a large solid angle, such as the Cygnus super bubble. MAXI/SSC has also detcted a Ne emission line from the rapid soft X-ray nova MAXI J0158-744. The overall shapes of outbursts in Be X-ray binaries (BeXRB) are precisely observed with MAXI/GSC. BeXRB have two kinds of outbursts, a normal outburst and a giant one. The peak dates of the subsequent giant outbursts of A0535+26 repeated with a different period than the orbital one. The Be stellar disk is considered to either have a precession motion or a distorted shape. The long-term behaviors of low-mass X-ray binaries (LMXB) containing weakly magnetized neutron stars are investigated. Transient LMXBs (Aql X-1 and 4U 1608-52) repeated outbursts every 200-1000 days, which is understood by the limit-cycle of hydrogen ionization states in the outer accretion disk. A third state (very dim state) in Aql X-1 and 4U 1608-52 was interpreted as the propeller effect in the unified picture of LMXB. Cir X-1 is a peculiar source in the sense that its long-term behavior is not like typical LMXBs. The luminosity sometimes decreases suddenly at periastron. It might be explained by the stripping of the outer accretion disk by a clumpy stellar wind. MAXI observed 64 large flares from 22 active stars (RS CVns, dMe stars, Argol types, young stellar objects) over 4 years. The total energies are $10^{34}-10^{36}$ erg $s^{-1}$. Since MAXI can measure the spectrum (temperature and emission measure), we can estimate the size of the plasma and the magnetic fields. The size sometimes exceeds the size of the star. The magnetic field is in the range of 10-100 gauss, which is a typical value for solar flares.