• 한국동물생명공학회지
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• 제37권1호
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• pp.27-33
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• 2022

Functional dyspepsia (FD) is a gastrointestinal disorder with diverse symptoms but no structural or organic manifestations. Benachio-F^® (herein named 'BF-1') is an over-the-counter liquid digestive formulated with multiple herbal extracts, which has been reported to improve symptoms of FD. A total two experiments were conducted. First, we examined whether BF-1 can modulate the progression of FD through two experimental rat models. A total of three doses (0.3x, 1x, 3x of the human equivalent dose) were used. In the gastric emptying model, both 1x (standard) or 3x (3-fold-concentrated) BF-1 enhanced gastric emptying was compared with that of vehicle-treated animals. In a feeding inhibition model induced by acute restraint stress, treatment with 1x or 3x BF-1 led to a similar degree of restoration in food intake that was comparable to that of acotiamide-treated animals. Among the constituents of BF, fennel is known for its choleretic effect. Thus, we next investigated whether a novel BF-based formula (named 'BF-2') that contains an increased amount of fennel extract (3.5-fold over BF-1), has greater potency in increasing bile flow. BF-2 showed a superior choleretic effect compared to BF-1. Furthermore, the postprandial concentration of serum secretin was higher in animals pretreated with BF-2 than in those pretreated with BF-1, suggesting that the increased choleretic effect of BF-2 is related to secretin production. Our results demonstrate that BF-1 can modulate the pathophysiological mechanisms of FD by exerting prokinetic and stress-relieving effects, and that BF-2 has a better choleretic effect than BF-1.

• 대한한의학방제학회지
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• 제30권4호
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• pp.259-267
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• 2022

Objectives : In this study, erythrocyte micronucleus test of pomace Schisandra chinensis extracts was conducted in order to up-cycling to a high value-added industry using by-products discarded in the production process of Schisandra chinensis products and active ingredients such as dibenzocyclooctadiene lignans in Schisandra chinensis. Methods : The micronucleus test was performed according to the 'OECD Guidelines'. Including the negative control group(0 mg/kg) and the positive control group(CPA 70 mg/kg), pomace Schisandra chinensis extracts were orally administered to ICR mouse at doses of 500, 1,000, and 2,000 mg/kg. After sacrificing the experimental animals bone marrow cells were collected and micronucleated polychromatic erythrocyte were counted. And genetic toxicity was confirmed according to the frequency of micronucleus. Results : As a result of the micronucleus test, there were no changes in body weight, clinical signs, or death in any group. But, a significant increase was observed in the frequency of micronucleated polychromatic erythrocyte among polychromatic erythrocytes in the positive control group administered with CPA compared to the negative control group(p<0.05). Whereas, no significant increase was observed in the group administered with pomace Schisandra chinensis extracts compared to the negative control group. Conclusions : Pomace Schisandra chinensis extracts did not induce micronucleus in bone marrow cells of ICR mouse up to a concentration of 2,000 mg/kg, and it was judged that no genetic toxicity was observed.

• 대한한의학방제학회지
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• 제31권1호
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• pp.21-28
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• 2023

Objective : Scolopendra, a dried body of Scolopendra subspinipes mutilans, is one of Korean medicine. Several reports revealed that Scolopendra has therapeutic effects for arthritis, neuroinflammatory diseases and neuropathic pain. However, the fetal adaptive response or teratogenicity associated with administration of Scolopendra is unclear. Therefore, this study aimed to investigate the fetal toxicity effects that were induced following oral administration of Scolopendra water extract (SWE) in pregnant mice. Methods : The pregnant mice were administrated SWE at dosed of 0, 100, 500 and 1000 mg/kg/day during gestation day 0-18. The mortality, body weight and clinical signs of pregnant mice were observed throughout experimental period. Also, the mortality and malformations in foetus were examined. Results : No meaningful changes were observed in the mortality and clinical signs of pregnant mice between the normal control group and SWE administrated groups. Additionally, there are no significant changes in fetal mortalities, and malformations by SWE administration. conclusion : These results suggest that oral exposure to SWE during pregnancy at oral dosages up to 1000 mg/kg/day did not induce teratogenic toxicity in regard to fetal mortality and morphology.

• 한국건축시공학회지
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• 제23권2호
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• pp.143-152
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• 2023

본 연구에서는 굳지 않은 콘크리트의 단위수량 정밀 측정방법으로써 고주파가열법을 검토하기 위해 3가지의 대표적인 가열건조 시험방법에 사용되는 단위수량 추정식을 선정하고 계산의 원리 및 실제 시험과정에서 발생할 수 있는 오차 요인을 고찰하였다. 또한, 각 단위수량 추정식의 계산과정에서 고려될 수 없는 실험적 요인인 분체 및 골재의 구성비나 물리특성을 변화시킨 콘크리트에 대해 고주파가열법을 통한 굳지 않은 콘크리트의 단위수량 시험을 진행하였다. 고주파 가열법를 이용한 굳지 않은 콘크리트의 단위수량 시험방법은 ± 20kg/m³의 허용오차 범위를 대부분 만족하였으나, 추정식에 따라 경향 및 오차의 크기가 차이를 나타냈다. 웻스크리닝 과정에서 발생하는 시료 편차 또는 시료 샘플링 과정에서 발생하는 굵은골재채취량 편차로 인한 추정오차의 영향을 최소화하기 위해서는 가열 건조시 콘크리트 시료를 이용하고 이후 시료의 굵은골재의 채취량 편차를 추정식에서 보정하는 방법으로 추정한 단위수량이 가장 정확한 결과를 나타내는 것을 실내 배합시험을 통해 확인할 수 있었다.

• 한국해안·해양공학회논문집
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• 제35권3호
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• pp.49-56
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• 2023

해안구조물 설계시 허용평균월파량은 설계요소 중의 하나이며, 구조물의 마루높이는 구조물의 안전, 보행자의 안전 및 운영 등에 요구되는 월파량 이하가 되도록 하여야 한다. 본 연구에서는 경사식구조물의 기하학적 형상을 고려하고, 다양한 수심조건에서 평균월파량 계측을 위한 2차원 수리실험을 수행하였다. 수리실험은 서로 다른 파형경사, 상대여유고, 상대파고 등을 적용하여 수행되었다. 실험결과를 이용하여 경사식구조물의 평균월파량을 산정할 수 있는 경험식을 제안하였다.

• 대한한의학방제학회지
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• 제31권4호
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• pp.327-339
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• 2023

Objectives : This study conducted a repeated dose 90-day oral toxicity test in order to up-cycling Schisandra fruit extract powder(SFEP) using discarded Schisandra chinensis by-products and evaluated the NOAEL of SFEP. Methods : SD-rats were orally administered SFEP at concentrations of 0, 62.5, 125, and 250 mg/kg once daily for 90 days. Body weights and clinical signs were observed during the administration period. After completion of the experiment, the experimental animals were autopsied to observe necropsy findings and organ weights changes, and hematological parameters and blood chemistry values were measured. Results : During the SFEP administration period, clinical signs such as salivation, wounds, and erosion were sporadically observed in 1 to 2 animals. In the SFEP 250 mg/kg administered group, weights of the liver and thyroid gland significantly increased compared to the control group, but no significant changes were observed in organ weights according to body weights. As a result of measuring hematological parameters and blood chemistry values, a decrease in RDW, T-BIL, and TBA, and an increase in TP, ALB, and Ca were observed due to SFEP administration. However, these changes following SFEP administration were accidental and not dose-dependent. Additionally, no correlation was found between gender and other parameters. Conclusions : Therefore, the NOAEL of SFEP was confirmed to be 250 mg/kg.

• 대한한의학방제학회지
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• 제31권4호
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• pp.341-360
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• 2023

Background : To investigate the effect of Hwanggeumjackyak-tang (HJT) on Dextran sulfate sodium (DSS) induced ulcerative colitis. Methods : The experimental animals were divided into three groups; group 1, normal group(Normal); group 2, DSS-induced colitis and untreated group(UT+DSS); group 3, DSS-induced colitis and HJT 200 mg-treated group(HJT200+DSS). We evaluated cytotoxicity after HJT administration and confirmed the anti-inflammatory effect by histological changes in the intestine and genetic analysis of mucosal cells after HJT administration for each group. In addition, microbiological weapons and metabolites in faeces were examined, and the correlation between gut microbiome and metabolites was also investigated. Result : HJT was not observed to be cytotoxic, even at relatively high concentrations, and was effective in protecting the barrier and preventing intestinal inflammation by suppressing the increase in mucus secretion and the expression of inflammatory factors in mucosal cells. HJT treatment affected the increase in the amount and diversity of the gut microbiome in faeces and the increase in metabolites thought to be involved in alleviating inflammation in the gut. Conclusion : This study demonstrates the therapeutic potential of HJT in ulcerative colitis. Further studies should be carried out to confirm our findings.

• 한국음향학회지
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• 제28권3호
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• pp.174-186
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• 2009

경계면이 존재하는 해양에서의 수중 음파 전달 모델링 시 일반적으로 평평한 경계면을 가정하고 Rayleigh가 제안했던 반사계수를 이용해 반사파를 계산할 수 있다. 하지만 해수면이나 해저면과 같은 실제 해양의 경계면은 불규칙적인 거칠기를 가진다. 이러한 경계면에서의 반사 손실은 실험식이나 산란 이론에 기반한 간섭 반사 계수를 계산하여 구할 수 있다. 본 논문에서는 섭동 이론, Kirchhoff 근사법, 작은 가지 근사법과 같은 산란 이론을 이용하여 유체-유체 경계면에 대한 간섭 반사 계수를 각각 유도한다. 이를 이용하여 임의의 거칠기를 가지는 해수면과 해저면에 대한 각 산란 이론의 간섭 반사계수를 계산하며, 이 결과를 Rayleigh 반사 계수와 비교하여 경계면의 거칠기에 따른 반사 손실을 분석한다. 또한, 섭동 이론과 Kirchhoff 근사법의 결과를 일반적으로 적용 범위가 넓은 작은 기울기 근사법의 결과와 비교하여 각 이론의 유효범위에 대해 고찰한다.

• Journal of Mechanical Science and Technology
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• 제20권1호
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• pp.42-50
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• 2006

To evaluate the fatigue lifetime of structures, it is necessary to identify the values of parameters through tests. From the viewpoint of time and cost it is difficult for engineers to get the necessary data through tests. In this study, we surveyed literature and proposed a procedure to identify the fatigue parameters expressed with the Brinell hardness and elastic modulus. After obtaining stress concentration factors by finite element analysis, we calculated fatigue notch factors using Peterson's formula. Taking into account the welding residual stress, which was also obtained by finite element analysis, we evaluated the fatigue lifetime of four kinds of welded joints using the proposed approach. The estimated results are in a good agreement with the experimental results.

• 한국기계연구소 소보
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• 통권9호
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• pp.169-181
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• 1982

This paper presents three methods for ship hull form improvement on the basis of wave pattern analysis. These methods are primarily based on the assumption that a linear relation exists between the small difference of hull sections and the difference of the wave amplitude functions. The improved hull form of ship is made by superposing a thin hull form on that of a parent model. The first method use the simplification of framelines and Michell's Theory to the formula of wave resistance for superposed thin ship. The second method use tent functions and Michell's Theory to that. And the third is experimental method.