Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Embryotoxic and Teratogenic Effects of Scolopendra Water Extract in Mice

오공(蜈蚣) 추출물의 태아 기형 및 모체 독성 마우스 시험

  • Jeongmin, Lee (College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University) ;
  • Jun-Ho, Song (Department of Biology, Chungbuk National University) ;
  • Soong-In, Lee (College of Oriental Medicine, Dong-Shin University) ;
  • Hyun Jun, Ki (College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University) ;
  • In Sik, Shin (College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University) ;
  • Sung-Ho, Kim (College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University) ;
  • Changjong, Moon (College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University) ;
  • Joong-Sun, Kim (College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University) ;
  • Ji Hye, Lee (College of Oriental Medicine, Semuyng University)
  • 이정민 (전남대학교 수의과대학) ;
  • 송준호 (충북대학교 자연과학대학 생물학과) ;
  • 이숭인 (동신대학교 한의과대학) ;
  • 기현준 (전남대학교 수의과대학) ;
  • 신인식 (전남대학교 수의과대학) ;
  • 김성호 (전남대학교 수의과대학) ;
  • 문창종 (전남대학교 수의과대학) ;
  • 김중선 (전남대학교 수의과대학) ;
  • 이지혜 (세명대학교 한의과대학)
  • Received : 2023.02.02
  • Accepted : 2023.02.14
  • Published : 2023.02.28
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Abstract

Objective : Scolopendra, a dried body of Scolopendra subspinipes mutilans, is one of Korean medicine. Several reports revealed that Scolopendra has therapeutic effects for arthritis, neuroinflammatory diseases and neuropathic pain. However, the fetal adaptive response or teratogenicity associated with administration of Scolopendra is unclear. Therefore, this study aimed to investigate the fetal toxicity effects that were induced following oral administration of Scolopendra water extract (SWE) in pregnant mice. Methods : The pregnant mice were administrated SWE at dosed of 0, 100, 500 and 1000 mg/kg/day during gestation day 0-18. The mortality, body weight and clinical signs of pregnant mice were observed throughout experimental period. Also, the mortality and malformations in foetus were examined. Results : No meaningful changes were observed in the mortality and clinical signs of pregnant mice between the normal control group and SWE administrated groups. Additionally, there are no significant changes in fetal mortalities, and malformations by SWE administration. conclusion : These results suggest that oral exposure to SWE during pregnancy at oral dosages up to 1000 mg/kg/day did not induce teratogenic toxicity in regard to fetal mortality and morphology.

Keywords

Acknowledgement

본 연구는 2022학년도 세명대학교 교내학술연구비 지원에 의해 수행되었으며, 이에 감사드립니다. 또한 본 연구 수행에 필요한 연구시료를 제공해주신 한국한의학연구원 한약자원연구센터 한약표준자원은행 관계자께 감사드립니다.

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