• Toxicological Research
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• 제17권
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• pp.293-297
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• 2001

The international pharmaceutical and regulatory communities had been recognizing the limited utility of conventional rodent carcinogenicity study particularly on the second species, mouse, after intense investigation of carcinogenicity data base worldwide, and a new scheme for carcinogenicity testing for pharmaceuticals was proposed at the Expert Working Group on Safety in the International Conference on Harmonization (ICH) in 1996. CB6F 1-Tg rasH2 mouse carrying human prototype c-Ha-ras gene with its own promoter/enhancer is one oj the new carcinogenicity assay model for human cancer risk assessment. Studies have been conducted since 1992 to validate the transgenic (Tg) mice for rapid carcinogenicity test-ing, short term (26 weeks) studies with genotoxic (by Salmonella), non-genotoxic carcinogens, genotoxic non-carcinogens, non-genotoxic non-carcinogens revealed relatively high concordance oj the response of the Tg mouse with classical bioassay across classes of carcinogenic agents. Mechanistic basis for carcinogensis in the model are being elucidated in terms of the role of overexpression and/or point mutation of the transgene. This report review the initial studies of validation of the model and preliminary results of on-going ILSI HESI ACT project will be presented.

• Perspectives in Nursing Science
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• 제8권2호
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• pp.148-155
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• 2011

Purpose: The aims of this study were to (1) summarize the HF self-management interventions and (2) identify gaps and priorities for further investigation. Methods: A computer search of the literature over the past decade yielded 9 HF self-management studies. Six studies used non-experimental design; only 3 (33%) studies used quasi-experimental design which were included in this review. Results: The three pivotal HF self-management interventions studies were important because they highlight the positive effects of self-management compliance and other quality of life outcomes as well as discussing various issues. The informational booklet and telephone follow-up were the most common modalities in these interventions. The periodic telephone counseling offered in 2 studies effectively facilitated patient self-management compliance. There were some methodological flaws such as small sample sizes (range 8~21 in each group) and lack of experimental designs, long-term follow-up, and random group assignment. Additionally, the use of valid, reliable outcome measures is necessary to compare the effects of the interventions worldwide. Conclusion: More clinical evidence on HF self-management is needed using a larger sample size and the efficacy needs to be tested for various outcomes, including morbidity, mortality, and health care cost.

• 대한예방한의학회지
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• 제20권3호
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• pp.93-113
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• 2016

Objectives : The focus of the review was laid on differences in research pertaining to thread embedding acupuncture between domestic and foreign journals. Methods : We collected 53 Korean articles on thread embedding acupuncture study from 4 Korean article searching sites, and 80 foreign articles from Pubmed. We analyzed the number of the theses according to the publication year, study method, journal, and subject. Results : A total number of 134 thread embedding acupuncture articles were categorized as 100 clinical trials, 14 experimental papers, and 19 literature reviews. Of the collected clinical trials, 55 were case studies, 6 were CCTs and 39 were RCTs. The domestic clinical trials were comprised of 36 case studies, 1 CCT, and 2 RCTs, and foreign clinical trials were comprised of 19 case studies, 5 CCTs, and 37 RCTs. Although only 12 of the 39 domestic clinical trials exclusively treated thread embedding acupuncture to the experimental group, 38 out of 61 foreign clinical trials undertook thread embedding acupuncture as the sole treatment. While the 2 domestic RCTs research had no significant evidence that the experimental group was different from the control group, the experimental group demonstrated better responses than the control group in 31 of the 37 foreign RCT studies. Conclusions : Studies on thread embedding acupuncture are more intensively studied in the foreign field in comparison to the domestic field. Referring to the results from the foreign thread embedding acupuncture studies, domestic use of thread embedding acupuncture should be expanded. Also, more refined research needs to be conducted in the domestic field in order for the Koran medicine to lead the thread embedding acupuncture. This study is limited in that the literature search in the foreign journals were restricted.

• 대한간호학회지
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• 제28권3호
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• pp.786-800
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• 1998

The purposes of this study were to describe systemically 18 years of oncology nursing research in Korea and suggest it's direction in future. 149 nursing studies published from 1980 to 1998 were selected for the present study. There were examined the source and the design of study, type of subjects, measurement variables, the intervention outcome of experimental research, and theme of qualitative research. The results were as follows : 1. 121 of 149 studies were composed of master thesis and dissertation of graduate school. There were 55 correlations, 30 descriptions, 19 comparisons, 19 qualitative studies and 2 Q-methods as the type of research design. 2. Cancer patients without describing specified diagnosis as subjects' characteristic were 44 of total studies. The others had various diagnoses such as gastric cancer, uterine cancer, breast cancer, leukemia, lymphoma, colorectal cancer, and lung cancer. According to treatment type, patients receiving chemotherapy were the highest number distribution as 53 of all researches. 3. Most measurement instruments used for research were translated it into Korean that developed by foreigners, such as Zung's depression, Spielberg's anxiety, and Wallston's locus of control. 4. Quality of life was shown the most frequently among correlational researches. the next one was depression, the third was hope, and so on. 5. There was the most frequent comparison between cancer and non-cancer patients in comparative researches. It was surveyed those variables as diet habits, risk factors, stressful life events, anxiety and depression, and self-care capacity between two groups. 6. The subjects were mostly chemotherapy patients as 15 of 24 experimental studies. Oral care and education were respectively the highest experimental interventions. 7. Qualitative researches about cancer were reported since 1991. Their themes were illness experience, adaptation process, dying experience, family experience, hope, caring, experience of health behavior, meaning of chemotherapy and experience of cancer survivor. Phenomenologic methodology was designed above 50% of qualitative researches. According to the above findings, cancer research had increased since 1990 and done mostly by descriptive design but a few experimental studies. As recommendations for the future, It is necessary to study the comparison of oncology nursing research internationally, the replication to establish the effect of nursing intervention, and the family care of cancer patient.

• 대한한방부인과학회지
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• 제31권4호
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• pp.54-72
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• 2018

Objectives: The aim of this review is to investigate studies on Estrogen-like activity and to contribute to the utilization of herbal medicines including phytoestrogens. Methods: Electric searches were performed with Pubmed from 2013 to June 2018, for the words, 'herb and estrogen', 'traditional Chinese medicine and estrogen', 'Oriental medicine and estrogen', and 'Korean medicine and estrogen'. 49 papers are investigated and classified into 'in vitro', 'in vivo' and 'in vivo and in vitro' experimental studies. Results: 1. In vitro experimental studies have shown that estrogen-like effects of the components extracted from Rhei Radix et Rhizoma, Rubi Fructus, Sparganii Rhizoma, Epimedii Herba, Spatholobi Caulis, Evodiae fructus, Curcumae longae Radix, Ginseng Radix, Bupleuri Radix, Astragali Radix, Salviae Miltiorrhizae Radix, Puerariae Radix, Scutellariae Radix are present. 2. In vivo experimental studies have shown that estrogen-like effects of the components extracted from Phytolaccae Radix, Ligustri Lucidi Fructus, Alismatis Rhizoma, Notoginseng Radix, Puerariae Radix, Ginseng Radix, Cyperi Rhizoma, Cistanchis Herba, Cynomorii Herba, Granati fructus, Astragali Radix, Rehmanniae Radix Crudus, Epimedii Herba, Polygalae Radix, Artemisiae Annuae Herba are present. 3. In vitro and in vivo experimental studies have shown that estrogen-like effects of the components extracted from Cirsii Herba, Dioscoreae Rhizoma, Salviae Miltiorrhizae Radix, Cynomorii Herba, Cinnamomi cortex, Drynariae Rhizoma, Psoraleae Semen, Schisandrae Fructus, Epimedii Herba, Astragali Radix are present. Conclusions: Future studies will require additional research on numerous herbal medicines used in clinical practice.

• 한방비만학회지
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• 제10권2호
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• pp.1-16
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• 2010

Objectives Obesity is one of the most important health problem in modern society and constant studies are still in progress domestically without the effective treatment so far. The objective of this study is to analyze the recent trend of the studies about obesity in oriental medicine and to provide background for further studies. Methods All of the articles in the journal of 'Korean oriental association for study of obesity' were collected published after 2006. Search were conducted through 'http://oasis.kiom.re.kr' and the journal of 'the Korean academy of oriental rehabilitation medicine'(January 2006~October 2010) with the search word "obesity". Collected articles were classified into clinical study, experimental study, literary study, case report. Results Total 177 articles were analysed. The number of studies were increasing until 2008 and went down afterwards. According to the classification by the type of study, percentage of clinical study took 45.2%, experimental study took 31.6%, literary study took 14.7%, case report took 8.5%. Conclusion Domestic clinical studies and experimental studies are conducted more focused on the treatment and diagnosis of obesity. Future study on the obesity should be focused on the prevention in the aspect of public health and social cost.

• 대한한방내과학회지
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• 제41권6호
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• pp.1089-1099
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• 2020

Objective: The purpose of this study was to investigate the effect of cinnamon on the treatment of Parkinson's disease (PD) and to introduce its use in Korea. Method: We searched the experimental studies in electronic databases (PubMed, CNKI, Wanfang, CiNii, J-STAGE, Science ON, and OASIS) using the key search terms "cinnamic acid", "cinnamon", "cinnamomum", "Parkinson's disease", "Parkinson disease", "Parkinsonism", and "dopamine". This study only involved experimental studies (in vivo and in vitro) that adopted cinnamon as a single administration and measured indicators relating to Parkinson's disease, including parkin, tyrosine hydroxylase (TH), and dopamine. Results: A Total of 11 literature studies were selected, and they all showed that treatment with cinnamon has a neuroprotective effect. Cinnamon activated neuroprotective factors and restored neurotransmitters and it reduced the rate of oxidative stress and inflammation in neurons. As a result, cell viability was upregulated, while cell apoptosis and neurodegeneration were downregulated. Five in vivo studies, through behavioral tests, also confirmed that cinnamon recovers locomotor function in PD models. Conclusion: We identified that cinnamon is an effective neural protector and improves motor performance in behavioral testing in the experimental PD studies.

• Child Health Nursing Research
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• 제23권4호
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• pp.416-428
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• 2017

Purpose: Tonsillectomy is a very common surgical procedure, particularly in children. The purpose of this study was to identify current evidence in nursing research on pediatric tonsillectomy by analyzing and evaluating Korean nursing studies related to pediatric tonsillectomy. Methods: An integrative literature review of Korean pediatric tonsillectomy research was conducted. Databases were searched to identify research that related to nursing care for pediatric tonsillectomy children. Results: Of the 115 studies identified, 13 studies met the inclusion criteria for this review. All studies were experimental studies and most of those studies had a quasi experimental design. No correlational studies or qualitative studies were found. Providing nursing information and education for children and their mothers at pre, during, and post tonsillectomy by pediatric nurses were found to be effective in reducing children's pain and anxiety and their mother's anxiety and uncertainty, and increasing children's appropriate sick role behaviors and their mother's satisfaction with nursing services provided and knowledge related to tonsillectomy. Conclusion: Although most studies reported positive effects in terms of post tonsillectomy outcomes, lack of methodological rigor limits the current evidences for pediatric tonsillectomy nursing interventions. Greater attention to improve methodological rigor for Korean research on pediatric tonsillectomy is needed.

• 척추신경추나의학회지
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• 제8권2호
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• pp.47-56
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• 2013

Objectives : Many studies are being done in the method of experimental chuna science in China. The aim of this review is to understand and study the methods of experimental chuna science, focusing on the effects of chuna on nervous system. Methods : We reviewed "實驗推拿學"(experimental tuina science) and Chinese journals were searched using China National Knowledge Infrastructure(CNKI). Korean journals were searched using 3 Korean web databases(OASIS, NDSL, RISS). Results : By experimental chuna science, analgesic effect of chuna, therapeutic action of chuna on stroke, therapeutic action on polio, effect of modulating autonomic nerves of chuna and effect of modulating thermoregulatory centers of chuna were proved. Conclusions : Experimental chuna science is necessary for development of chuna to a higher level. In Korea, not a lot experimental studies are being done, especially in chuna. For this reason we need to learn and adapt the methods of experimental chuna science of China.

• Child Health Nursing Research
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• 제9권2호
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• pp.149-161
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• 2003

Purpose: The purpose of this study is to identified patterns and trend of studies and to analyzed the nursing research related to the mother-child interaction in Korea and to improve direction of nursing research in mother-child interaction in Korea. Method: The research studies related to the mother-child interaction were selected from the Korean Nurses Academic Society Journal, and from dissertation, which were conducted between 1961 and 2002 with the consideration of the condition and the cultural specialty of Korea. The total numbers of the studies were 34. These studies were classified according to 1)time of publication or presentation, 2)research design, 3)type of interaction objects, 4)measurement tool, and 5)chief content of studies. Ressult: 1) Until 1984, there was no research studies related to mother-child interaction. The number of studies on the mother-child interaction on the mother-child interaction has been increased rapidly after 1985. The mother-child interaction studies were 13(38.2％) from the doctoral dissertation, 4(11.8％) from the Master's theses and 17(50％) other papers were published in academic journals. 2) Experimental studies of research design was used in these research studies was 13(38.2％). Descriptive studies was 8(23.6％), correlational studies was 4(11.8％) and comparative studies was 4(11.8％). Qualitative study was just one(2.9％) and literature review was 4(11.8％). Especially experimental studies has been increased. 3) Participants of these studies were mother and infant 29(85.5％), father and infant 2(5.9％), mother and fetus 2(5.9％) and nurse and infant 1(2.9％) 4) Utilization of instruments as follows: 13 studies used Walker et al(1986)'s MIPIS (Mother-Infant Play Interaction Scale), 6 studies used Barnard(1978)'s NCAFS (Nursing Child Assessment Feeding Scale), 4 studies used NCATS(Nursing child Assessment Teaching Scale) for assessing mother-infant interaction. 3 studies used Stainton(1981)'s Parent-Infant Interaction Scale. Choi(1987), Kim(1999) and Kim and Son(1997) used measurement tool researcher made which was modified from NCATS (Nursing child Assessment Teaching Scale) and AMIS(Assessment of Mother-Infant Sensitivity Scale). Other tools used to survey influencing factors of interaction. 5) Content of the research studies were classified 3 different types, such as ① studies about the mother-child interactions' pattern, ② studies about influencing factors of the mother-child interaction, ③ studies about effect of nursing intervention program to improve the mother-child interaction. Conclusion: Therefore we make following suggestions which are made based on the above research analysis : 1) In the future research studies need to compare with other area of discipline in mother-child interaction. 2) More attention and in depth research is needed to validate in terms of research design and statistical data analysis. 3) It is important to develop the instruments which is culturally acceptable in Korea society. 4) The results of correlational studies and experimental studies needs to the integrated by meta analysis.