The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
권호 표지
DOI QR코드

DOI QR Code

Basic Study on Estrogen-like Activity of Herbal Medicine

한약재의 에스트로겐 유사 활성에 대한 기초 연구

  • Son, Bo-Gil (Pusan National University School of Korean Medicine) ;
  • Lee, Hee-Yoon (Pusan National University School of Korean Medicine) ;
  • Bae, Ju-Eun (Pusan National University School of Korean Medicine) ;
  • Yoon, Young-Jin (Pusan National University School of Korean Medicine)
  • 손보길 (부산대학교 한의학전문대학원) ;
  • 이희윤 (부산대학교 한의학전문대학원) ;
  • 배주은 (부산대학교 한의학전문대학원) ;
  • 윤영진 (부산대학교 한의학전문대학원)
  • Received : 2018.09.12
  • Accepted : 2018.11.26
  • Published : 2018.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The aim of this review is to investigate studies on Estrogen-like activity and to contribute to the utilization of herbal medicines including phytoestrogens. Methods: Electric searches were performed with Pubmed from 2013 to June 2018, for the words, 'herb and estrogen', 'traditional Chinese medicine and estrogen', 'Oriental medicine and estrogen', and 'Korean medicine and estrogen'. 49 papers are investigated and classified into 'in vitro', 'in vivo' and 'in vivo and in vitro' experimental studies. Results: 1. In vitro experimental studies have shown that estrogen-like effects of the components extracted from Rhei Radix et Rhizoma, Rubi Fructus, Sparganii Rhizoma, Epimedii Herba, Spatholobi Caulis, Evodiae fructus, Curcumae longae Radix, Ginseng Radix, Bupleuri Radix, Astragali Radix, Salviae Miltiorrhizae Radix, Puerariae Radix, Scutellariae Radix are present. 2. In vivo experimental studies have shown that estrogen-like effects of the components extracted from Phytolaccae Radix, Ligustri Lucidi Fructus, Alismatis Rhizoma, Notoginseng Radix, Puerariae Radix, Ginseng Radix, Cyperi Rhizoma, Cistanchis Herba, Cynomorii Herba, Granati fructus, Astragali Radix, Rehmanniae Radix Crudus, Epimedii Herba, Polygalae Radix, Artemisiae Annuae Herba are present. 3. In vitro and in vivo experimental studies have shown that estrogen-like effects of the components extracted from Cirsii Herba, Dioscoreae Rhizoma, Salviae Miltiorrhizae Radix, Cynomorii Herba, Cinnamomi cortex, Drynariae Rhizoma, Psoraleae Semen, Schisandrae Fructus, Epimedii Herba, Astragali Radix are present. Conclusions: Future studies will require additional research on numerous herbal medicines used in clinical practice.

Keywords

References

  1. Yang SH, et al. Sex-hormone replacement effect of silkworm pupa and mixture with herbs. Korean J Food Cookery SCI. 2005;21(6):769-75.
  2. Kang SJ, et al. Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice. Experimental And Therapeutic Medicine. 2017;13(4):1249-66. https://doi.org/10.3892/etm.2017.4109
  3. Park SH, et al. Verification of estrogen like activities of herbal medicines using an in vitro detection system. Korean J Oriental Physiology & Pathology. 2013;27(6):752-8.
  4. Zhao X, et al. Calycosin induces apoptosis in colorectal cancer cells, through modulating the $ER{\beta}$/MiR-95 and IGF-1R, PI3K/Akt signaling pathways. Gene. 2016;591(1):123-8. https://doi.org/10.1016/j.gene.2016.07.012
  5. Park HM. The efficacy of phytoestrogen in postmenopausal women. Korean Journal of Obstetrics and Gynecology. 2007;50(3):389-415.
  6. Sathyapalan T, et al. The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study. Frontiers in Endocrinology. 2018;9:531. https://doi.org/10.3389/fendo.2018.00531
  7. Textbook compliation committee. Herbal medicine. 3rd rev. ed. Seoul:Younglimsa. 2016.
  8. Lee DH, et al. In Vitro Estrogenic and Breast Cancer Inhibitory Activities of Chemical Constituents Isolated from Rheum undulatum L. Molecules. 2018;23(5):1215. https://doi.org/10.3390/molecules23051215
  9. Park EJ, et al. Cytotoxic effect of sanguiin H-6 on MCF-7 and MDAMB-231 human breast carcinoma cells. Bioorganic & Medicinal Chemistry Letters. 2017;27(18):4389-92. https://doi.org/10.1016/j.bmcl.2017.08.019
  10. Wu YZ, Sun J, Wang YB. Selective estrogen receptor modulator: A novel polysaccharide from Sparganii Rhizoma induces apoptosis in breast cancer cells. Carbohydr Polym. 2017;163:199-207. https://doi.org/10.1016/j.carbpol.2017.01.062
  11. Telang NT, et al. The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the luminal a molecular subtype of breast cancer. Oncology Letters. 2017;13(4):2477-82. https://doi.org/10.3892/ol.2017.5720
  12. Sun JQ et al. Spatholobus suberectus Column Extract Inhibits Estrogen Receptor Positive Breast Cancer via Suppressing ER MAPK PI3K/AKT Pathway. Evidence-Based Complementary and Alternative Medicine. 2016;2016:13.
  13. Wang KL, et al. Anti-proliferative effects of evodiamine on human breast cancer cells. Plos One. 2013;8(6):e67297. https://doi.org/10.1371/journal.pone.0067297
  14. Zhang X, Zhang Y, Li Y. $\beta$-elemene decreases cell invasion by upregulating E-cadherin expression in MCF-7 human breast cancer cells. Oncol Rep. 2013;30(2):745-50. https://doi.org/10.3892/or.2013.2519
  15. Zuo YH, et al. Panax ginseng polysaccharide protected H9c2 cardiomyocyte from hypoxia/reoxygenation injury through regulating mitochondrial metabolism and RISK pathway. Front. Physiol. 2018;9:699. https://doi.org/10.3389/fphys.2018.00699
  16. Que R, et al. Estrogen receptor-$\beta$-dependent effects of saikosaponin-d on the suppression of oxidative stressinduced rat hepatic stellate cell activation. International J of Molecular Medicine. 2016;41(3):1357-64.
  17. Liu B, et al. Calycosin inhibits oxidative stress-induced cardiomyocyte apoptosis via activating estrogen receptor-${\alpha}/{\beta}$. Bioorganic & Medicinal Chemistry Letters. 2016;26(1):181-5. https://doi.org/10.1016/j.bmcl.2015.11.005
  18. Zhao P, et al. Anabolic effect of traditional chinese medicine compound tanshinone II A on myotube hypertrophy is mediated by estrogen receptor. Planta Medica. 2015;81(7):578-85. https://doi.org/10.1055/s-0035-1545883
  19. Haihong LV, et al. Puerarin enhances proliferation and osteoblastic differentiation of human bone marrow stromal cells via a nitric oxide/cyclic guanosine monophosphate signaling pathway. Molecular Medicine Reports. 2015;12(2):2283-90. https://doi.org/10.3892/mmr.2015.3647
  20. Wang Y, et al. Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-${\kappa}B$ ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells. Phytomedicine. 2014;21(8-9):1032-6. https://doi.org/10.1016/j.phymed.2014.04.012
  21. Wang Y, et al. Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ERdependent MEK/ERK and PI3K/Akt activation. Phytomedicine. 2013;20(10):787-96. https://doi.org/10.1016/j.phymed.2013.03.005
  22. Liu LJ, et al. Puerarin suppress apoptosis of human osteoblasts via ERK signaling pathway. International J of Endocrinology. 2013;2013:6.
  23. Shi C, et al. Tanshinone II A promotes non-amyloidogenic processing of amyloid precursor protein in platelets via estrogen receptor signaling to phosphaticylinositol 3-kinase/Akt. Biomedical Reports. 2014;2(4):500-4. https://doi.org/10.3892/br.2014.263
  24. Wang H, et al. An estrogen receptor dependent mechanism of Oroxylin A in the repression of inflammatory response. Plos One. 2013;8(7):e69555. https://doi.org/10.1371/journal.pone.0069555
  25. Fan GW, et al. Anti-inflammatory Activity of Baicalein in LPS-Stimulated RAW264.7 Macrophages via Estrogen Receptor and NF-${\kappa}B$-Dependent Pathways. Inflammation. 2013;36(6):1584-91. https://doi.org/10.1007/s10753-013-9703-2
  26. Ji M, et al. Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-$\alpha$. Journal of Steroid Biochemistry & Molecular Biology. 2013;138:421-6. https://doi.org/10.1016/j.jsbmb.2013.07.006
  27. Li X, et al. Anti-hyperplasia effects of total saponins from phytolaccae radix in rats with mammary gland hyperplasia via inhibition of proliferation via inhibition of proliferation and induction of apoptosis. Front. Pharmacol. 2018;9:467. https://doi.org/10.3389/fphar.2018.00467
  28. Tang YQ, et al. Fructus ligustri lucidi modulates estrogen receptor expression with no uterotrophic effect in ovariectomized rats. BMC Complementary And Alternative Medicine. 2018;18(1):118. https://doi.org/10.1186/s12906-018-2171-3
  29. Hwang YH, et al. The protective effects of alisol A 24-acetate from Alisma canaliculatum on ovariectomy induced bone loss in vivo. Molecules. 2016;21(1):74. https://doi.org/10.3390/molecules21010074
  30. Fan JZ, et al. Panax notoginseng saponins mitigate ovariectomy-induced bone loss and inhibit marrow adiposity in rats. The J of The North American Menopause Society. 2016;22(12):1343-50.
  31. Lim DK, Kim JG, Kim YT. Effects of Dietary Isoflavones from Puerariae Radix on Lipid and Bone Metabolism in Ovariectomized Rats. Nutrients. 2013;5(7):2734-46. https://doi.org/10.3390/nu5072734
  32. Cao Y, et al. Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway. Plos One. 2017;12(11):e0186520. https://doi.org/10.1371/journal.pone.0186520
  33. Ju Y, Xiao B. Chemical constituents of Cyperus rotundus L. and their inhibitory effects on uterine fibroids. African Health Sciences. 2016;16(4):16.
  34. Jiang Z, et al. Echinacoside and Cistanche tubulosa(Schenk) R, wight ameliorate bisphenol A-induced testicular and sperm damage in rats through gonad axis regulated steroidogenic enzymes. J of Ethnopharmacology. 2016;193:321-8. https://doi.org/10.1016/j.jep.2016.07.033
  35. Miao M, et al. Effect of Cynomorium total flavone on depression model of perimenopausal rat. Saudi J of Biological Sciences. 2017;24(1):139-48. https://doi.org/10.1016/j.sjbs.2016.09.009
  36. Wang Y, et al. Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats. J of The Neurological Sciences. 2014;339(1-2):144-8. https://doi.org/10.1016/j.jns.2014.02.002
  37. Xu Y, et al. Treatment with Panax ginseng antagonizes the extrogen decline in ovariectomized mice. Int J Mol Sci. 2015;15(5):7827-40. https://doi.org/10.3390/ijms15057827
  38. Wei M, et al. Ovarian Failure-Resistant Effects of Catalpol in Aged Female Rats. Biol. Pharm. Bull. 2014;37(9):1444-9. https://doi.org/10.1248/bpb.b14-00064
  39. Kim HG, et al. Cyperi Rhizoma inhibits the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced reduction in nigrostriatal dopaminergenic neurons in estrogendeprived mice. Journal of Ethnopharmacology. 2013;148(1):322-8. https://doi.org/10.1016/j.jep.2013.04.038
  40. Indran IR, et al. Selective Estrogen Receptor Modulator Effects of Epimedium Extracts on Breast Cancer and Uterine Growth in Nude Mice. Planta Med. 2014;80(1):22-8. https://doi.org/10.1055/s-0033-1360112
  41. Cai ZL, et al. Tenuigenin ameliorates learning and memory impairments induced by ovariectomy. Physiology & Behavior. 2013;118:112-7. https://doi.org/10.1016/j.physbeh.2013.05.025
  42. Abolaji AO, et al. A safety assessment of the antimalarial herb Artemisia annua during pregnancy in wistar rats. Phytother Res. 2013;27(5):647-54. https://doi.org/10.1002/ptr.4760
  43. Park JY, et al. Beneficial effects of Cirsium japonicum var. maackii on menopausal symptoms in ovariectomized rats. Food Funct. 2018;9(4):2480-9. https://doi.org/10.1039/C7FO01258F
  44. Wong KL, et al. A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome. Scientific Reports. 2015;5:10179. https://doi.org/10.1038/srep10179
  45. Xu Y, et al. Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice. AGING. 2017;9(1):156-72. https://doi.org/10.18632/aging.101145
  46. Wang X, et al. Compounds from cynomorium songaricum with estrogenic and androgenic activities suppress the oestrogen/androgen-induced BPH process. Evidence-Based Complementary and Alternative Medicine. 2017:6438013.
  47. Choi HM, et al. Cinnamomi cortex (Cinnamomum verum) suppresses testosterone-induced benign prostatic hyperplasia by regulating $5{\alpha}$-reductase. Scientific Reports. 2016;6:31906. https://doi.org/10.1038/srep31906
  48. Wang C, et al. The prevention and treatment effects of tanshinone II A on oestrogen/androgen-induced benign prostatic hyperplasia in rats. Journal of Steroid Biochemistry & Molecular Biology. 2015;145:28-37. https://doi.org/10.1016/j.jsbmb.2014.09.026
  49. Song SH, et al. Effects of total flavonoids from Drynariae rhizoma prevent bone loss in vivo and in vitro. Bone Reports. 2016;5:262-73. https://doi.org/10.1016/j.bonr.2016.09.001
  50. Weng ZB, et al. Positive skeletal effect of two ingredients of Psoralea corylifolia L. on estrogen deficiencyinduced osteoporosis and the possible mechanisms of action. Molecular And Cellular Endocrinology. 2015;417:103-13. https://doi.org/10.1016/j.mce.2015.09.025
  51. Kim MH, et al. Ameliorative effects of Schiandra chinensis on osteoporosis via activation of estrogen recoptor (ER)-$\alpha$/-$\beta$. Food Funct. 2015;5(7):1594-601. https://doi.org/10.1039/c4fo00133h
  52. Xiao HH, et al. Flavonoids from Herba epimedii selectively activate estrogen receptor alpha ($ER{\alpha}$) and stimulate ER-dependent osteoblastic functions in UMR-106 cells. Journal of Steroid Biochemistry & Molecular Biology. 2014;143:141-51. https://doi.org/10.1016/j.jsbmb.2014.02.019
  53. Wong KC, et al. Drynaria fortuneiderived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone. British J of Nutrition. 2014;110(3):475-85. https://doi.org/10.1017/S0007114512005405
  54. Li L, et al. Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Antibreast Cancer Effects by Inducing S Phase Arrest and Apoptosis. Frontiers in Pharmacology. 2016;7:128.
  55. Brooks SC, Elizabeth RL, Herbert DS. Estrogen receptor in a human cell line(MCF-7) from breast carcinoma. J Biol Chem. 1973;248(17):6251-3.
  56. Jerng UM, et al. Recent Studies of Breast Cancer in Traditional Chinese Medicine Journals. The J of Oriental Obstetrics & Gynecology. 2009;22(1):263-78.
  57. Ranki HJ, et al. $17{\beta}$-Estradiol regulates expression of KATP channels in heartderived H9c2 cells. JACC. 2002;40(2):367-74. https://doi.org/10.1016/S0735-1097(02)01947-2