• 한국시뮬레이션학회논문지
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• 제19권4호
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• pp.209-218
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• 2010

합성 환경/실험 체계 전술객체 표현 기술 연구는 전술객체들의 위치를 실시간으로 탐지·추적하고 이를 가상현실 내에서 모의하기 위한 기반 기술을 확보하는 것을 목적으로 한다. 이를 위한 기술로써 전술객체 위치 추적 및 모의 기술, 모델 간 공유기술에 대한 연구가 필요하다. 본 논문에서는 우선 센서 데이터 융합과 좌표계 통일을 위한 알고리즘을 연구하였고, 추적자의 유도 방식인 PNG(Proportional Navigation Guidance)를 적용한 추적 기술, 공학급 및 상급 모델의 회피 알고리즘을 적용한 회피 기술을 연구하였다. 또한, 잠수함과 어뢰의 추적 회피 시뮬레이션을 통해 전술객체의 위치 모의를 연구하였다.

• Tuberculosis and Respiratory Diseases
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• 제86권4호
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• pp.304-318
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• 2023

Background: Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and significantly contribute to immune evasion. We investigated the effects of CAFs on the immune function of CD4+ and CD8+ T cells in non-small cell lung cancer (NSCLC). Methods: We isolated CAFs and normal fibroblasts (NFs) from tumors and normal lung tissues of NSCLC patients, respectively. CAFs were co-cultured with activated T cells to evaluate their immune regulatory function. We investigated the effect of CAF conditioned medium (CAF-CM) on the cytotoxicity of T cells. CAFs were also co-cultured with activated peripheral blood mononuclear cells and further incubated with cyclooxygenase-2 (COX2) inhibitors to investigate the potential role of COX2 in immune evasion. Results: CAFs and NFs were isolated from the lung tissues (n=8) and lymph nodes (n=3) of NSCLC patients. Immune suppressive markers, such as COX2 and programmed death-ligand 1 (PD-L1), were increased in CAFs after co-culture with activated T cells. Interestingly, CAFs promoted the expression of programmed death-1 in CD4+ and CD8+ T cells, and strongly inhibited T cell proliferation in allogenic and autologous pairs of CAFs and T cells. CAF-CM decreased the cytotoxicity of T cells. COX2 inhibitors partially restored the proliferation of CD4+ and CD8+ T cells, and downregulated the expression of COX2, prostaglandin E synthase, prostaglandin E2, and PD-L1 in CAFs. Conclusion: CAFs promote immune evasion by suppressing the function of CD4+ and CD8+ T cells via their effects on COX2 and PD-L1 in NSCLC. The immunosuppressive function of CAFs could be alleviated by COX2 inhibitors.

• Journal of Photoscience
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• 제9권2호
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• pp.287-289
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• 2002

Planarians show negative phototaxis and have extensive regenerative ability, including the ability to regenerate the brain. Recently the process of regeneration of the planarian brain has been divided into three steps based on the expression of neural markers. In this study, we have analyzed the process of recovery of the light response during head regeneration. Although morphological observations indicated that regeneration of the eyes and optic nerves appeared to be completed by the fourth day, the recovery of the evasion behavior against light was not recovered within 4 days after amputation. Functional recovery of the evasion behavior could be detected starting 5 days after amputation and then gradually recovered. We previously identified genes which are specifically expressed in the brain after the recovery of morphological structures. This characteristic suggested that these genes may be involved in functional recovery of the brain. To investigate the function of these genes, we performed gene knockout analysis using the RNA interference method. The results clearly indicated that these genes are involved in the functional recovery of the visual system.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5353-5361
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• 2012

Interleukin-18 (IL-18) is an immune-stimulatory cytokine with antitumor activity in preclinical models. It plays pivotal roles in linking inflammatory immune responses and tumor progression and is a useful candidate in gene therapy of lymphoma or lymphoid leukemia. A phase I study of recombinant human IL-18 (rhIL-18) in patients with advanced cancer concluded that rhIL-18 can be safely given in biologically active doses to patients with advanced cancer. Some viruses can induce the secretion of IL-18 for immune evasion. The individual cytokine activity might be potentiated or inhibited by combinations of cytokines. Here we focus on combinational effects of cytokines with IL-18 in cancer progression. IL-18 is an important non-invasive marker suspected of contributing to metastasis. Serum IL-18 may a useful biological marker as independent prognostic factor of survival. In this review we cover roles of IL-18 in immune evasion, metastasis and angiogenesis, applications for chemotherapy and prognostic or diagnostic significance.

• 한국생활과학회지
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• 제18권1호
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• pp.29-39
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• 2009

The purpose of this study is to investigate children's emotional regulation and social competence in relation with peer friendliness. Specifically, it examined the hypotheses that children's emotion regulation strategies would be different depending on age, gender, and peer friendliness, and that children's emotion regulation strategies would affect their social competences. The subjects were 197 of the second, fourth, and sixth graders in an elementary school located in Gangdong-gu, Seoul. The findings are as follows: first, children's emotion regulation strategies are different according to gender and age. Girls use more 'external response strategy' than boys do. Elder children use more 'internal response strategy' than younger children, and younger children use more 'problem solving strategy' than elder children. Second, children's emotion regulation strategies are different depending on the degree of peer friendliness. Children employ more 'problem solving' and 'internal response' strategies to close friends rather than to just friends. Children used more the strategies as 'request for social support', 'evasion', and 'external response' to just friends rather than to close friends. Finally, children's social competencies are influenced by the strategies of 'problem solving' and 'evasion'.

• Journal of Information Processing Systems
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• 제12권3호
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• pp.422-435
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• 2016

Despite the convenience brought by the advances in web and Internet technology, users are increasingly being exposed to the danger of various types of cyber attacks. In particular, recent studies have shown that today's cyber attacks usually occur on the web via malware distribution and the stealing of personal information. A drive-by download is a kind of web-based attack for malware distribution. Researchers have proposed various methods for detecting a drive-by download attack effectively. However, existing methods have limitations against recent evasion techniques, including JavaScript obfuscation, hiding, and dynamic code evaluation. In this paper, we propose an emulation-based malicious webpage detection method. Based on our study on the limitations of the existing methods and the state-of-the-art evasion techniques, we will introduce four features that can detect malware distribution networks and we applied them to the proposed method. Our performance evaluation using a URL scan engine provided by VirusTotal shows that the proposed method detects malicious webpages more precisely than existing solutions.

• 한국산학기술학회논문지
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• 제14권11호
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• pp.5442-5447
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• 2013

본 연구는 해상에서 선박간의 충돌상황을 회피하기 위한 선박 충돌 회피 우선순위지정 및 회피모델의 개발에 중점을 두었다. 이 논문에서는 DCPA, TCPA, VCD 등의 개념을 새롭게 접근하였고, 타 함정의 AIS, GPS 등에서 수집 가능한 정보, 즉 침로, 속도, 목적지, 길이 등을 바탕으로 선박의 조함자가 사전에 설정한 DCPA를 적용하는 SCAAM 개념을 제안하였다. 만약 선박이 충돌 위험이 존재한다면 조함자는 SCAAM을 이용하여 회피항해 또는 현재 침로-속도를 유지할 것인지를 결정하게 된다. 그리고 조함자가 회피를 결심하게 되면 선박은 국제해상 충돌예방규칙에 의거 회피를 결정하게 될 것이다. 따라서 이 연구는 사람의 실수로 인한 선박 충돌사고를 감소함으로써 선박의 안전항해에 기여할 수 있다.

• The Journal of Asian Finance, Economics and Business
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• 제7권5호
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• pp.73-80
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• 2020

Tax is the main revenue of Government, so fighting tax evasion and sustainable growth have been the primary macroeconomic goals being pursued by every developing country, Vietnam included. The existence and development of the shadow economic sector are synonymous with the national budget losing out. In Vietnam, foreign direct investment projects do not promote economic growth and is also a sector that gives way to tax evasion.The purpose of this study is to investigate the impact of foreign direct investment, the quality of the informal institution on the size of the shadow economy in Vietnam, during the period 1991-2015. By applying the Autoregressive Distributed Lag approach and Toda and Yamamoto test, we found evidence to conclude that the quality of the informal institution harms the size of the shadow economy. The results of the causality test show that there is a unidirectional causality running from the shadow economy and the quality of the informal institution to foreign direct investment attraction in Vietnam. Political solutions need to be implemented carefully to counter the harmful effects of the shadow economy. Policymakers should adopt several economic policies to improve the 'human capital' and drive the shadow economy into the formal economy.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.305-306
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• 2006

In process for production of Rubber Scheme Product that have the most inferior Working Environment is Medicine mixture and Scheme processing. Applying automation and Environment Treatment technology to the hazardous chemical and mixture processing, Through developed 'Mixture Automatic Machine for hazardous chemical Interruption type that is occurred at mixing rubber medicines', we try to decline worker's intensity of labour, Also overcomes solution of work evasion phenomenon and manpower supply and demand's difficulty by forming agreeable working environment and through the automatic scheme and mixture processing by preventing that hazardous chemical had known as disease causes of various importance disease is exposed to worker during the work. and we plan to do so that production of high added value product may be available.

• Journal of Microbiology and Biotechnology
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• 제20권12호
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• pp.1624-1629
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• 2010

Bacterial cell-to-cell communication, termed quorum sensing (QS), leads to coordinated group behavior in a cell-density-dependent fashion and controls a variety of physiological processes including virulence gene expression. The repressor of the lsr operon, LsrR, is the only known regulator of LuxS/AI-2-mediated QS in Salmonella. Although lack of lsrR did not result in noticeable differences in Salmonella survival, the down-regulation of QS as a result of lsrR overexpression decreased Salmonella survival within macrophages. We found that impaired growth of Salmonella overexpressing lsrR within macrophages was due largely to its hypersensitivity to NADPH-dependent oxidative stress. This, in turn, was a result of decreased expression of genes involved in the oxidative stress response, such as sodA, sodCI, and sodCII, when lsrR was overexpressed. These results suggest that down-regulation of QS by excess LsrR can lower Salmonella virulence by hampering Salmonella evasion from oxidative killing within macrophages.