• Title/Summary/Keyword: Evaluation and Validation Test

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Evaluation of the Kit's Efficiency of Alpha Fetoprotein (AFP) Test (Alpha feto protein(AFP)검사 키트의 유효성 평가실험)

  • Cho, Hyun-su;Noh, Gyeong-woon;You, Tae-min
    • The Korean Journal of Nuclear Medicine Technology
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    • v.22 no.2
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    • pp.101-104
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    • 2018
  • Purpose Alpha fetoprotein(AFP) is a fetal serum protein that increases in germ cell tumors derived from liver cancer or egg yolk. AFP test has been used for screening of liver cancer, determination of tumor stage, determination of therapeutic effect, and fetal congenital malformations. The purpose of this study was to compare the results of the four kits, identify the advantages and disadvantages of each kit, and select the appropriate kits for our laboratory. Materials and Methods Blood samples were obtained from 89 patients attending the Seoul national university hospital. Experiments were carried out in accordance with manufacturer's instructions of four companies(A, B, C, D). The precision, recovery, linearity, and sensitivity test were performed for each kit. Results In case of the precision within the measurement, the CV value of the C kit was less than 5% at the low, middle, and high concentrations. The A, B and D kit's the CV value was less than 5% at the concentrations except the low concentration. The recovery rates of the A, B, C, and D kits were $100{\pm}15%$, $100{\pm}30%$, $100{\pm}16%$ and $100{\pm}14%$, respectively. All kits showed good linearity. Sensitivity was measured as 0.5 IU/mL for A, 0.4 IU/mL for B, 0.98 IU/mL for C, and 0.3 IU/mL for D. Conclusion The CV values of the four kits were within 10%, and the correlation coefficients were close to 1 for $R^2=0.978$, $R^2=0.992$ and $R^2=0.8957$. As a result, they are clinically available. Therefore, each laboratory should select the appropriate kit for their experiment's environment.

Evaluation of the cost-effectiveness of ASF detection with or without the use of on-field tests in different scenarios, in Sardinia

  • Cappai, Stefano;Loi, Federica;Rolesu, Sandro;Coccollone, Annamaria;Laddomada, Alberto;Sgarangella, Francesco;Masala, Sergio;Bitti, Giuseppe;Floris, Vincenzo;Desini, Pietro
    • Journal of Veterinary Science
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    • v.21 no.2
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    • pp.14.1-14.10
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    • 2020
  • African swine fever (ASF) is a highly contagious disease of domestic pigs and wild boars (WBs). Without a vaccine, early antibody and antigen detection and rapid diagnosis are crucial for the effective prevention of the disease and the employment of control measures. In Sardinia, where 3 different suid populations coexisted closely for a long time, the disease persists since 1978. The recent ASF eradication plan involves more stringent measures to combat free-ranging pigs and any kind of illegality in the pig industry. However, critical issues such as the low level of hunter cooperation with veterinary services and the time required for ASF detection in the WBs killed during the hunting season still remain. Considering the need to deliver true ASF negative carcasses as early as possible, this study focuses on the evaluation and validation of a duplex pen-side test that simultaneously detects antibodies and antigens specific to ASF virus, to improve molecular diagnosis under field conditions. The main goal was to establish the specificity of the two pen-side tests performed simultaneously and to determine their ability to detect the true ASF negative carcasses among the hunted WBs. Blood and organ samples of the WBs hunted during the 2018/2019 hunting seasons were obtained. A total of 160 animals were tested using the pen-side kit test; samples were collected for virological and serological analyses. A specificity of 98% was observed considering the official laboratory tests as gold standards. The new diagnostic techniques could facilitate faster and cost-effective control of the disease.

Development of a Simulation Model for Supply Chain Management of Modular Construction based Steel Bridge (모듈러 공법 기반 강교 공급사슬 관리를 위한 시뮬레이션 모형 개발)

  • Lee, Jaeil;Jeong, Eunji;Kim, Sinam;Jeong, Keunchae
    • Korean Journal of Construction Engineering and Management
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    • v.23 no.2
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    • pp.3-15
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    • 2022
  • In this study, we develop a simulation model for Supply Chain Management (SCM) of modular construction based steel bridge. To this end, first, Factory Production/Site Construction system data for the steel bridge construction were collected, and supply chain, entities, resources, processes were defined based on the collected data. After that, a steel bridge supply chain simulation model was developed by creating data, flowchart, and animation modules using Arena software. Finally, verification and validation of the model were performed by using animation check, extreme condition check, average value test, Little' s law test, and actual case value test. As a result, the developed simulation model appropriately expressed the processes and characteristics of the steel bridge supply chain without any logical errors, and provided accurate performance evaluation values for the target system. In the future, we expect that the model will faithfully play a role as a performance evaluation platform in developing management techniques for optimally operating the steel bridge supply chain.

Comparison of the Standard Floor Impact Sound with Living Impact Source by Subjective Evaluation

  • Park, Hyeon Ku;Kim, Kyeong Mo;Kim, Sun-Woo
    • KIEAE Journal
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    • v.14 no.1
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    • pp.39-48
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    • 2014
  • In the previous test, the verification of the standard floor impact source was carried out comparing the physical characteristics with living impact sources. The result was appeared the validation of the standard impact source was very low because of differences of physical characteristics. This study aims to evaluate annoyance and loudness of standard impact source which is used for the measurement of floor impact sound, and to compare the annoyance and loudness of living impact sources which are produced in real life. The impact sources considered are tapping machine, tire and impact ball as standard sources, and nine real sources which were chosen from the existing researches. The result showed differences of annoyance and loudness between standard impact sources and living impact sources, which means the standard impact sources may rate the performance of floor system inappropriately. In the future, the rating method should be examined how the standard impact sources are similar with real sources in the point of rating the performance of floor system.

Development and its Validation of Sky Simulator Facilities for Daylighting Evaluation (자연채광 성능평가용 인공천공돔(Sky Simulator)의 개발 및 신뢰성 검증)

  • Kim, Jeong-Tai;Kim, Gon;Yu, In-Hye
    • KIEAE Journal
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    • v.5 no.4
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    • pp.51-57
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    • 2005
  • For the evaluating daylighting performance, field measurement, scale model test and a set of computer tools can be applied. For the scale model measurements, the sky simulator is a vital facility to represent the desired sky conditions consistently. Recently K university has developed a large size sky simulator, 6m-diameter and 3.7m-height, that is suitable for the international standard. To verify the reliability of the sky simulator, the luminance distribution on the inner sky surface was measured and compared with the CIE standard overcast sky model. It is found that the sky simulator can be reproduced the CIE standard overcast sky condition with 4.3% as mean difference. K university sky simulator is fully validated for usability and accuracy for daylighting researches.

Heat and Flow Analysis on Cabin Room of Battle Tank (전차 포탑 승무원실의 내부 열/유동장에 관한 수치적 연구)

  • NamKoung, H.J.;Lee, K.H.;Park, B.H.;Roh, K.L.
    • Journal of the Korea Institute of Military Science and Technology
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    • v.9 no.2 s.25
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    • pp.5-10
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    • 2006
  • The heavy thermal load to battle tanks can cause electronic components' malfunction and crew to be put out of action. The thermal load is generated from Internal heat sources such as electronic devices installed in the room as well as extremely hot weather. In this study, heat and flow analysis for the cabin room of a battle tank was performed to deal with this thermal problem. This study presented the validation of simulation results in comparison with those of test, the investigation of optimal flow design for effective cooling in cabin room and finally the evaluation of thermal comforts to crew.

A Study on the Dynamic Characteristic Analysis of the Horizontal Axis Wind Turbine System Blade (수평축 풍력발전기의 Blade 동특성분석에 관한 연구)

  • 손충렬;변효인;박명우;류지윤
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2001.11b
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    • pp.1394-1399
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    • 2001
  • The purpose of this paper is that investigates the dynamic behavior characteristic of W.T.S(Wind Turbine System) and carries out the evaluation analysis during operating W.T.S. To investigate the dynamic behavior characteristic of W.T.S. the experiments to measure vibration of the blade from the attached accelerometer on the flap and edge section of the blade that is one of the most important elements of dynamic characteristic of W.T.S are performed. Natural frequency and mode shape are calculated with commercial program (STAR MODAL) using the measured vibration acceleration that receives the signal with F.F.T Analyzer from the accelerometer. For validation of these experiments. the finite element analysis is performed with commercial F.E.M Program (ANSYS) on the basis of the natural frequency and mode shape. The results indicate that experimental values have good agreements with the finite element analysis.

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A Study on the Design and Validation of Switching Control Law (전환제어법칙 설계 및 검증에 관한 연구)

  • Kim, Chong-Sup
    • Journal of Institute of Control, Robotics and Systems
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    • v.17 no.1
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    • pp.54-60
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    • 2011
  • The flight control law designed for prototype aircraft often leads to degraded stability and performance, although developed control law verify by non-real time simulation and pilot based evaluations. Therefore, the proper evaluation methods should be applied such that flight control law designed can be verified in real flight environment. The one proposed in this paper is IFS (In-Flight Simulator). Currently, this system has been implemented into the F-18 HARV (High Angle of Attack Research Vehicle), SU-27 and F-16 VISTA (Variable stability In flight Simulation Test Aircraft) programs. The IFS necessary switching control law such as fader logic and integrator stand-by mode to reduce abrupt transient and minimize the integrator effect for each flight control laws switching. This paper addresses the concept of switching mechanism with fader logic of "TFS (Transient Free Switch)" and stand-by mode of "feedback type" based on SSWM (Software Switching Mechanism). And the result of real-time pilot evaluation reveals that the aircraft is stable for inter-conversion of flight control laws and transient response is minimized.

Research and practice of health monitoring for long-span bridges in the mainland of China

  • Li, Hui;Ou, Jinping;Zhang, Xigang;Pei, Minshan;Li, Na
    • Smart Structures and Systems
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    • v.15 no.3
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    • pp.555-576
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    • 2015
  • The large number of long-span bridges constructed in China motivates the applications of structural health monitoring (SHM) technology. Many bridges have been equipped with sophisticated SHM systems in the mainland of China and in Hong Kong of China. Recently, SHM technology has been extended to field test systems. In this view, SHM can serve as a tool to develop the methods of life-cycle performance design, evaluation, maintenance and management of bridges; to develop new structural analysis methods through validation and feedback from SHM results; and to understand the behavior of bridges under natural and man-made disasters, rapidly assess the damage and loss of structures over large regions after disasters, e.g., earthquake, typhoon, flood, etc. It is hoped that combining analytical methods, numerical simulation, small-scale tests and accelerated durability tests with SHM could become the main engine driving the development of bridge engineering. This paper demonstrates the above viewpoint.

Development and Validation of the Strengths Assessment Indicators for Daycare Centers (어린이집 강점평가지표 개발 및 타당화)

  • Hong, Sung hee;Hwang, Hae-Ik
    • Korean Journal of Childcare and Education
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    • v.14 no.6
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    • pp.143-170
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    • 2018
  • Objective: The purpose of this study was to develop assessment indicators and to verify the validity and reliability of the developed assessment indicators. Methods: A Delphi survey, focus group interviews, and content verification were conducted in order for experts to develop an evaluation index of the strengths of the day care center. A main survey was conducted on 438 daycare center principals and teachers to test their item quality, validity and reliability. Results: The final assessment indicators consisted of three areas, seven assessment criteria, 19 evaluation factors, 41 assessment items and a five-point rubric rating scale. As for the common strengths indicators, there were three assessment areas, five assessment criteria, 12 assessment elements and 22 assessment items. In regard to the selective strengths indicators, there were 3 assessment areas, 5 assessment criteria, 12 assessment elements and 16 assessment items. Conclusion/Implications: The efforts to confirm the strengths of daycare centers are expected to facilitate the identity building of the daycare center itself and for its organizational members to make a contribution to the qualitative improvement of childcare.