• 산경연구논집
• /
• 제15권8호
• /
• pp.21-27
• /
• 2024

Purpose: There is a significant opportunity for ESG management to act as a useful guideline for social welfare organizational structures when dealing with sustainability and ethical leadership. The ESG guidelines should allow these companies to improve their business efficacy. This paper aims to explore the specific impacts of ESG management on social welfare. Research design, data and methodology: The systematic review approach ensures that quality work is undertaken in tackling the existing gaps in the literature on ESG management in social welfare organizations. The outcomes of this review will give a useful 'real-life' picture of the consequences of ESG practices and suggestions that can increase the efficiency and sustainability of social welfare organizations. Results: The principal favorable consequences are discussed in this chapter regarding the social welfare organization due to the implementation of ESG management. Subsequently, each effect is posted under different sub-titles and evidence from previously conducted research studies. Conclusions: ESG management is vital for social welfare organizations since it increases their efficiency in operations, public image, and opportunities to receive funds, and it helps improve relations with stakeholders. More so, these organizations can embrace the ESG practices and as a result bring more efficiency to the general welfare of the society.

• 근관절건강학회지
• /
• 제17권1호
• /
• pp.79-88
• /
• 2010

Purpose: The purpose of this study was to analyze the published research in the Journal of Muscle and Joint Health and to suggest the future perspectives. Methods: In this study, we reviewed the contents of 195 articles published in this journal from the first issue of the year 1994 to 2007. Results: The majority of subjects were adult, mostly with arthritis. The position of the authors was mostly professor (73.3%). Most of studies did not clearly describe about ethical consideration. The data collection was mostly conducted in the hospital (53.8%) or community (36.9%), with the questionnaire (62.6%). The types of research design were correlational study (36.4%), experimental study (31.8%), survey (18.5%), and qualitative research (4.6%). Physical variables included pain, fatigue, activities of daily living, joint flexibility, muscle strength, etc., psychosocial variables were measured by self-efficacy, depression, quality of life, etc., and cognitive variables by knowledge, education, etc. The most utilized nursing intervention for experimental study were exercise, self-help, and education. Conclusion: Further research is needed to extend the target population research design from multidisciplinary perspectives.

• 한국융합학회논문지
• /
• 제12권9호
• /
• pp.295-305
• /
• 2021

본 연구의 목적은 국내에서 발표된 간호전문직관 연구 주제 동향을 양적 내용분석을 통해 탐색하는 것이다. 연구방법은 학술논문수집, 단어 정제 및 추출, 자료 분석의 절차를 수행하였다. 351편의 논문을 수집하여 영문초록에서 단어를 추출하여 텍스트네트워크를 개발하였고, 네트워크분석과 토픽모델링을 융합하여 자료를 분석하였다. 연구결과 핵심 주제는 간호사, 간호전문직관, 간호학생, 간호, 전문직자아개념, 보건의료인, 만족, 임상역량, 자기효능감 등이었다. 토픽모델링을 통해 간호사 전문직관, 간호학생 전문직관, 간호전문직 정체성, 간호역량의 토픽그룹을 파악하였다. 시간이 흘러도 핵심 주제는 변화가 없었지만, 1990년대 역할갈등, 윤리적 가치, 2000년대 셀프리더십, 사회화, 2010년대 임상실습스트레스, 지지체계와 같은 주제들이 부상하였다. 결론적으로 본 연구를 통해 국내에서 임상간호사와 간호학생의 간호전문직관과 이에 영향을 미치는 요소들에 대한 연구가 활발하게 발표되고 있었으나, 간호전문직관 형성 및 향상에 효과적인 다차원적인 중재 전략을 모색한 연구는 부족하였음을 알 수 있었다.

• Asian Spine Journal
• /
• 제12권6호
• /
• pp.998-1009
• /
• 2018

Study Design: Olfactory ensheathing cells (OECs) from rat olfactory mucosa were cultured, characterized, and transplanted into a rat model of spinal cord injury (SCI). Purpose: To evaluate different doses of OECs in a rat model of SCI. Overview of Literature: SCI causes permanent functional deficit because the central nervous system lacks the ability to perform spontaneous repair. Cell therapy strategies are being explored globally. The clinical use of human embryonic stem cell is hampered by ethical controversies. Alternatively, OECs are a promising cell source for neurotransplantation. This study aimed to evaluate the efficacy of different doses of allogenic OEC transplantation in a rat model of SCI. Methods: OECs were cultured from the olfactory mucosa of Albino Wistar rats; these cells were characterized using immunohistochemistry and flow cytometry. Rats were divided into five groups (n=6 rats each). In each group, different dosage ($2{\times}10^5$, $5{\times}10^5$, $10{\times}10^5$, and >$10{\times}10^5$) of cultured cells were transplanted into experimentally injured spinal cords of rat models. However, in the SCI group, only DMEM (Dulbecco's modified Eagle's medium) was injected. Rats were followed up upto 8 weeks post-transplantation. The outcome of transplantation was assessed using the Basso, Beattie, Bresnahan (BBB) scale; motor-evoked potential studies; and histological examination. Results: Cultured cells expressed 41% of p75NTR, a marker for OEC, and 35% of anti-fibronectin, a marker for olfactory nerve fibroblast. These cells also expressed $S100{\beta}$ and glial fibrillary acid protein of approximately 75% and 83%, respectively. All the transplanted groups showed promising BBB scores for hind-limb motor recovery compared with the SCI group (p<0.05). A motor-evoked potential study showed increased amplitude in all the treated groups compared with the SCI. Green fluorescent protein-labeled cells survived in the injured cord, suggesting their role in the transplantation-mediated repair. Transplantation of $5{\times}10^5$ cells showed the best motor outcomes among all the doses. Conclusions: OECs demonstrated a therapeutic effect in rat models with the potential for future clinical applications.

• Laboraroty Animal Research
• /
• 제34권4호
• /
• pp.232-238
• /
• 2018

Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been proposed to help overcome potential drawbacks related to animal experiments and avoid ethical issues, their use remains vital for the testing of new drug candidates and to identify the most effective strategies for therapeutic intervention. Particularly, the study of metabolic diseases requires the use of animal models to monitor whole-body physiology. In line with this, the National Institute of Food and Drug Safety Evaluation (NIFDS) in Korea has established their own animal strains to help evaluate both efficacy and safety during new drug development. The objective of this study was to characterize the response of C57BL/6NKorl mice from the NIFDS compared with that of other mice originating from the USA and Japan in a chemical-induced diabetic condition. Multiple low-dose treatments with streptozotocin were used to generate a type-1 diabetic animal model which is closely linked to the known clinical pathology of this disease. There were no significantly different responses observed between the varying streptozotocin-induced type-1 diabetic models tested in this study. When comparing control and diabetic mice, increases in liver weight and disturbances in serum amino acids levels of diabetic mice were most remarkable. Although the relationship between type-1 diabetes and BCAA has not been elucidated in this study, the results, which reveal a characteristic increase in diabetic mice of all origins are considered worthy of further study.

• 한방재활의학과학회지
• /
• 제27권4호
• /
• pp.33-53
• /
• 2017

Objectives This study was designed to review animal studies about the efficacy of herbal medicine for Rheumatoid arthritis animal model which was published in Korea after 2008. We also systematically investigated the reporting quality of the animal studies. Methods We systematically searched original articles in 8 databases since 2008. And manual searching was conducted through 10 Korean medicine journals from 2008. Studies were included if they used animal experimental model(s) with orally administered herbal medicine. Data were extracted regarding animal model, rheumatoid arthritis indicator and detail of intervention. Reporting quality of each study was also assessed by the STARA and ARRIVE guidelines. Results Nine hundred two articles were screened. Finally, 35 articles were included. 35 studies all showed that the herbal medicine used in the studies has significant effect on alleviating the macroscopic indicators, hematological indicators, histological indicators, genetic indicators, osteological indicator of Rheumatoid Arthritis and others. Species of animals was reported in 100% while ventilation and noise were reported in 0% in STRASA guidelines. Ethical statement was reported in 42.9%, experimental animals and sample size were reported in 24%, 29% and there was no study reporting funding. Conclusions These results suggest that herbal medicine might be effective treatment for Rheumatoid Arthritis. It should be improved by clinical studies. And there is a need for studying about efficacy and safety of each specific herbal medicine. And we should improve the Reporting quality of the animal studies published in Korea.

• 동의신경정신과학회지
• /
• 제29권1호
• /
• pp.35-46
• /
• 2018

Objectives: The aim of this trial is to evaluate the efficacy and safety of Yukwool-tang (Liuyu-tang) for the treatment of major depression in women by comparing the Yukwool-tang (Liuyu-tang)-treated group with the placebo-treated group and assessing the association of various biological factors related to depression through various outcome measures. Methods: This study is a single-center, randomized, double-blind, placebo-controlled, parallel-design clinical trial. The subjects to be selected are women between the ages of 19 and 65, and the registered subjects are to be randomly assigned to treatment with Yukwool-tang or the placebo control. The Yukwool-tang group will take 1 bottle of Yukwool-tang (30 mg) for 8 weeks, 3 times a day, before meals. The control group will take the placebo in the same way. The primary outcome to be examined will be the change between the total score after 8 weeks and the total score before the start of the study of the K-HDRS score. Secondary outcomes are assessed by the change in total score after 12 weeks of K-HDRS, K-HDRS remission rate, K-HDRS improvement rate, BDI-K, PITD, KSCL-95, ISI, STAI-K, EQ-5D, VAS, Emotional Stimulation Test, BDNF test, inflammatory cytokine and tumor necrosis factor test, intestinal microbiome test, dietary report and Beck's hopelessness scale. Results: This protocol has been approved by the IRB of Dunsan Korean Medicine Hospital of Daejeon University and is registered in the CRIS, and it is made public in advance to ensure transparency of the research process and conduct ethical clinical trials. Conclusions: Based on this protocol, when the trial is completed, its data can be used to access the validity and safety of Yukwool-tang for major depression in women, and it is also expected to be helpful in the study of the correlation between future treatment of Korean medicine for depression and related biological factors, and quality of life.

• Journal of Genetic Medicine
• /
• 제8권1호
• /
• pp.28-34
• /
• 2011

대부분의 의사들은 임상시험을 치료약제개발 후 의료현장에서 사용하기 위해 진행되는 과정으로 생각할 것이다. 실험실에서 개발된 기술이 진단검사로써 도입되기 위해서는 치료약제의 경우와 유사한 임상시험 과정을 거쳐 그 안정성과 유효성에 대한 검증을 필요로 한다. 치료약제의 효과검증에서 가장 우수한 근거를 얻을 수 있는 연구방법은 무작위대조연구 방법이지만, 이를 검체진단검사에 그대로 적용하기는 어렵다. 검체진단검사의 경우 비교연구가 진단정확도의 검증을 위해 현실적으로 사용할 수 있는 연구방법이지만 대상군의 모집 방법과 구분 방법, 질환대상자의 질환 심각도, 참고표준의 선택과 적용, 눈가림 여부 등 여러 요인들이 진단정확도 지표에 직접적인 영향을 주기 때문에, 좋은 근거수준의 연구결과를 얻기 위해서는 이러한 요소들을 고려한 잘 고안된 연구디자인이 중요하다. 또한 검체진단검사는 치료약제의 경우와 달리 결과를 얻기 위한 검사과정이 사용자인 일선 검사실에 의해 계속 생산되어야 하고, 검사의 개발과 발전의 속도가 빠르며, 일선검사실이 최종사용자이자 개발자인 경우가 흔하다는 특성이 있다. 저자들은 이러한 검사의 특성을 고려하여 검사법 자체의 수행능력에 대한 검증으로부터 검사법 성능평가를 위한 질환확진군과 정상군에 대한 비교연구, 일련의 질환의심자 대상의 진단정확도 평가와 임상 효과성 평가, 도입 후 일상감시로 이어지는 임상시험의 진행단계를 제안하고자 한다.

• 치위생과학회지
• /
• 제15권2호
• /
• pp.129-137
• /
• 2015

본 연구는 개인의 행동 변화를 설명하는 이론적 모형인 건강신념모형(health belief model)을 적용해 임신부의 구강건강관련행위에 영향을 미치는 요인을 분석하여 임신부의 구강건강증진과 구강보건교육프로그램 개발의 기초자료를 제공할 목적으로 시행하였다. 2014년 8월 1일부터 8월 31일까지 서울특별시, 경기도, 인천광역시에 소재한 8개의 산부인과의원과 1개의 산모교실을 방문한 임신부 총 217명을 대상으로 자기기입식 설문지를 배부하였다. 수집된 자료는 PASW Statistics ver. 18.0 프로그램을 이용하여 다음과 같은 결론을 얻었다. 임신부의 건강신념 수준은 총 3.61점이었으며 인지된 유익성이 4.37점으로 가장 높았고 자기 효능감 4.04점, 인지된 민감성 3.98점, 인지된 장애성 3.15점 순이었으며 인지된 심각성이 2.91점으로 가장 낮았다. 건강신념요인과 구강건강관련행위의 상관관계로 인지된 심각성은 치아에 좋은 식품섭취 노력, 임신 중 구강검진과 양의 상관관계를 보였으며 인지된 유익성은 임신 중 구강검진과 양의 상관관계를 보였다. 인지된 장애성은 매 간식 후 칫솔질, 회전법 칫솔질, 임신 중 구강검진, 임신 전 구강검진과 음의 상관관계를 보였으며 자기 효능감은 매 칫솔질 후 구강위생용품 사용, 임신 중 구강검진과 양의 상관관계를 보였다. 구강건강관련행위에 영향을 미치는 건강신념요인으로 인지된 심각성은 임신 중 구강검진, 임신 중 치과치료에, 인지된 유익성은 임신 중 구강검진에, 인지된 장애성은 매 간 식 후 칫솔질, 회전법 칫솔질, 임신 중 구강검진에, 자기 효능감은 매 칫솔질 후 구강위생용품 사용, 임신 중 구강검진에 영향을 미치는 요인으로 나타났다. 이상의 연구결과로 건강신념요인의 인지된 심각성, 인지된 유익성, 인지된 장애성, 자기 효능감이 임신부의 구강건강관련행위에 영향을 미치는 요인임을 제시하며, 임신부의 인지된 심각성, 인지된 유익성, 자기 효능감을 높이고 인지된 장애성을 낮출 수 있는 임신부를 위한 구체적인 구강보건교육프로그램 개발이 필요하다.

• 의료법학
• /
• 제11권2호
• /
• pp.113-145
• /
• 2010

Nowadays, it is surely the quack which stands as one of the most controversial, problematic. the quack has been a consistent target of contested public protection strategies in the past few centuries in many countries. Recently, complementary and alternative medicine (CAM) is increasingly utilized and accepted by patients and providers throughout the health care system in the world, most accounts attribute this growing acceptability to the shortcomings of conventional medicine, the appeal of CAM's core beliefs, and the growing body of research indicating that CAM actually works. However, the governments of western countries have called for measures to ensure that the public are protected from incompetent and dangerous practitioners. Common to these controversies has been a suggestion to ban, exclude or limit the medical practice of those deemed to be damaging rather than improving the health of individuals as a measure of public protection. This article describes the experiences of western counties' health care system which is moving in a more pluralistic direction. By examining the ways in which regulatory efforts in the countries have come to address what is invariably described as a growing interest in CAM, this study show how the problem of CAM/quackery today is increasingly located in an ethical field of practitioner competency, qualifications, conduct, responsibility and personal professional development, regardless of the form of therapy in question. Many countries developed a series of measures and strategies to contain the acceptance of CAM groups, such as insisting on scientific evidence of safety and efficacy, resisting integration of CAM with conventional medicine and opposing government support for research and education. In a sense, those countries' movements serve to protect not only patients, but the dominant position of medicine and its allied professions, and to maintain existing jurisdictional boundaries within the healthcare system. The popular support for CAM will require that health professional stakeholders continue to address the challenges this poses, and at the same time protect their position at healthcare system. To cope with the quack, professional body, public sector and health authorities should consider the safety of consumers of healthcare and responding to the demands of the community for CAM therapies as well as the claims of the established healthcare professions. Finally, some implications for future health care were suggested.