• Journal of Korean Tunnelling and Underground Space Association
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• v.12 no.4
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• pp.307-319
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• 2010

As we learned in Daegu subway fire accident, fire in the railway tunnel is prone to develop to large disaster due to the limitation of smoke control and smoke exhaust. In railway tunnel, in order to ensure fire safety, fire prevention and fighting systems are installed by quantitative risk assessment results. Therefore, in this research, developed the program to establish quantitative risk assessment and suggested quantitative safety assessment method including fire scenarios in railway tunnel, fire and evacuation analysis model, fatality estimate model and societal risk criteria. Moreover, this method applys to plan preventing disaster for Honam high speed railway tunnel. As results, we presented the proper distance of escape route and societal risk criteria.

• Journal of Astronomy and Space Sciences
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• v.22 no.4
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• pp.463-472
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• 2005

In this paper, the dynamic model development for interplanetary navigation has been discussed. The Cowell method for special perturbation theories was employed to develop an interplanetary trajectory propagator including the perturbations due to geopotential, the Earth's dynamic polar motion, the gravity of the Sun, the Moon and the other planets in the solar system, the relativistic effect of the Sun, solar radiation pressure, and atmospheric drag. The equations of motion in dynamic model were numerically integrated using Adams-Cowell 11th order predictor-corrector method. To compare the influences of each perturbation, trajectory propagation was performed using initial transfer orbit elements of the Mars Express mission launched in 2003, because it can be the criterion to choose proper perturbation models for navigation upon required accuracy. To investigate the performance of dynamic model developed, it was tested whether the spacecraft can reach the Mars. The interplanetary navigation tool developed in this study demonstrated the spacecraft entering the Mars SOI(Sphere of Influence) and its velocity .elative to the Mars was less than the escape velocity of the Mars, hence, the spacecraft can arrive at the target planet. The obtained results were also verified by using the AGI Satellite Tool Kit. It is concluded that the developed program is suitable for supporting interplanetary spacecraft mission for a future Korean Mars mission.

• Asia pacific journal of information systems
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• v.23 no.2
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• pp.67-86
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• 2013

This study first provides a stylized model that captures the essential features of the SC (Social Commerce) business and the competition process. The model focuses on the relationship between key decision issues such as marketing inputs and market value. As more SCs join the industry, they are inevitably faced with fierce competition, which may lead to sharp increase in the total marketing and advertising expenditure. This type of competition may lead the industry away from its optimal development path, and at worst, toward a disruption of the entire industry ecosystem. Such being the case, another goal of this study is to examine the possibility that the ToC (Tragedy of the Commons) may occur in the SC industry. We build game models, each of which assumes homogeneity and heterogeneity of SC providers, respectively, and derive explicit equilibrium solutions from both models. Our basic analysis presents Nash equilibria in both models and shows that SC providers are inevitably faced with fierce competition, which may lead to sharp increase in the total marketing expenses. We also compare the game outcomes with one with a hypothetical social planner who determines the total marketing level that optimizes the entire market value. Then, ToC can be defined to describe the situation where the total marketing efforts exceed the socially optimal level of marketing efforts. In both models, we examine the possibility of the ecosystem disruption and specify the conditions under which ToC may occur. However, the chance of avoiding ToC is higher with heterogeneous players than with homogeneous players. To supplement our analytical results, we develop a simulation model which incorporates a market dynamics based on the gap between actual marketing efforts and socially optimal marketing level. Simulation experiments present some lessons and insights which also confirm out findings from equilibrium analysis. For example, heterogeneity in SC providers alleviates the severity of ToC and makes it faster for survivors to escape from the ToC trap. As a result, the degree of industrial concentration tends to increase, which also explains the 'rich-get-richer' phenomenon observed in some empirical studies on the SC industry. Lastly, based on our analytical and experimental results, we come up with some measures to avoid ToC and overcome the shortcomings intrinsic to the current business model. And further discussions provide strategic implications and policy directions to overcome the possible trap of ToC in this ecosystem, and eventually help the industry to sustainably develop itself toward the next level. To name a few examples of policy measures, regulations on the marketing activities so that the overall marketing expenses cannot go beyond the socially optimal level; institutional guidelines and rules to straightening up the distortions in the way that SC providers view the marketing costs (the current marketing costs are underestimated, thereby encouraging SC providers to increase marketing expenditure); and so on.

• KIEAE Journal
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• v.12 no.4
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• pp.13-19
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• 2012

The Earth's surface temperature still continues to rise, and extreme weather phenomena such as heat waves, drought, and precipitation have been repeated every year. It is reported that international communities attribute the main cause of the Earth's surface temperature rise to the excessive use of the fossil energy. Recently, the damage caused by climate change is getting worse, and the place where we live is suffering the most. Cities have been continuously growing not only meeting the basic functions of human habitation, work and leisure but also being places for various economic and social activities. But Cities, the victims of climate change, have grown only considering human needs and convenience rather than predicting their physical and ecological systems(Albedo effects, urban microclimate, resources and energy of the circulatory system, etc). In other words, the cities offer the cause of the problems of climate change, and even worsen the extreme weather phenomena without coping with them. Therefore, it is urgent priorities to protect the climate, to prevent the causes of the extreme weather phenomena and to enhance the adaptive capacity for the worse weather events. This study is to derive the concept for adapting to these climate changes which can make cities escape from exposure to these climate change impacts and make themselves safer places to live. And it analyzes some European cities and present developing models to implement planning methods. In this study, the concept of the climate adaptive cities will be suggested to prepare the adaptation measures for urban planners, and climate change adaptation models will be presented by analyzing some preliminary cases.

• Journal of Microbiology and Biotechnology
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• v.28 no.1
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• pp.122-135
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• 2018

Listeriolysin O (LLO), one of the most immunogenic proteins of Listeria monocytogenes and its main virulence factor, mediates bacterial escape from the phagosome of the infected cell. Thus, its expression in a nonpathogenic bacterial host may enable effective delivery of heterologous antigens to the host cell cytosol and lead to their processing predominantly through the cytosolic MHC class I presentation pathway. The aim of this project was to characterize the delivery of a model antigen, chicken egg ovalbumin (OVA), to the cytosol of dendritic cells by recombinant Bacillus subtilis vegetative cells expressing LLO. Our work indicated that LLO produced by non-sporulating vegetative bacteria was able to support OVA epitope presentation by MHC I molecules on the surface of antigen presenting cells and consequently influence OVA-specific cytotoxic T cell activation. Additionally, it was proven that the genetic context of the epitope sequence is of great importance, as only the native full-sequence OVA fused to the N-terminal fragment of LLO was sufficient for effective epitope delivery and activation of $CD8^+$ lymphocytes. These results demonstrate the necessity for further verification of the fusion antigen potency of enhancing the MHC I presentation, and they prove that LLO-producing B. subtilis may represent a novel and attractive candidate for a vaccine vector.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.77-77
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• 2003

Chimeric animals are referred to as an organism composed of tissues derived from more than one species. In order to examine if a pluripotency of embryonic stem cells can cross the limitation of a species, we tried to establish human-mouse chimeric animals. Human embryonic stem cells were genetically modified to express eGFP using eukaryonic expression vector pcDNA 3.1 (In Vitrogene) for an easy identification. After selection with neomycin, approximately 15 cells were implanted into mouse blastocoele cavity. Ten chimeric blastocysts were transferred to one of the uterine horn of 2.5 days pesudopregnent ICR female. Out of 272 blastocysts transferred to pseudopregnant recipients 20 live newborn were obtained after 20 days. When newborn were obtained, pups were quickly removed immersed into 4% PFA. By histological examination using fluorescent microscope, green fluorescence was observed from the liver, heart, and spleen in newborn mice. Three weeks after born, presence of eGFP sequence within mouse genome (tail and kidney) was reconfirmed by PCR. eGFP sequence was amplified from the progenies of the animal suggesting a genetic transmission of the transgene. These chimeric mice having human cells at the beginning of development, are expected to recognize human cells as “self”, therefore, human cells or tissues will be able to escape the immunological surveillance of the host if grafted into the animal. These animals will serve as a good model system for studying the graft rejection in tissue transplantation and the potential of the cells to work well in many human disease.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.49 no.4
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• pp.368-376
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• 2013

Fishing experiments were carried out in the adjacent sea of Yeongil Bay, the eastern cost of Korea from 2003 to 2004 using the dome-shaped pots with different five mesh sizes (17.1, 24.8, 35.3, 39.8, and 48.3mm) in order to determine the size selectivity of pots for the whelk, Buccinum opisthoplectum. The catch species were composed of Buccinum opisthoplectum (45.4%), Buccinum striatissimum (30.1%), Pandalopsis japonica (9.3%), Chionoecetes opilio (8.9%), and so on. The shell height (l) of Buccinum opisthoplectum caught in the experimental fishing pots was measured. The SELECT (Share Each Length's Catch Total) analysis method was applied with fishing data to obtain master selection curve. The model with the estimated split parameter was found to fit the catch data best. The master selection curve was estimated to be s (R)〓exp (7.833R-10.871)/[1 + exp (7.833R-10.871], where R is the ratio of shell height to mesh size. The relative shell length for 50% retention was 1.388, and the selection range was 0.281. It means that the pots of larger mesh size allow more whelks of small size to escape.

• The Journal of the Korea Contents Association
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• v.18 no.10
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• pp.644-656
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• 2018

This study focused on relationships among leisure involvement, experience quality and behavioral intention in the urban parks. A total of 335 were collected, and during the data refinement process, 39 questionnaires were eliminated from the study due to partial and inconsistent responses. thus leading to 296 usable questionnaires out of 335. In the final result, 296 questionnaires were coded for the analysis purpose. The hypothesized conceptual model was used to analyze the Descriptive Analysis and Frequency Analysis, Exploratory Factor Analysis, and Multiple Regression Analysis using SPSS 24.0. The result indicated this: residents' experience quality in urban parks depends on more attraction and centrality of leisure involvement than on the self-experience quality of leisure involvement. The results of this study also indicate that not all experience dimensions are important for resulting in positive behavioral intentions to urban parks. The quality of education, esthetic, and escape experience showed a significant predictor of behavioral intentions, while the quality of entertainment experience did not show a significant positive relationship with behavioral intentions.

• The Journal of Korean Association of Computer Education
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• v.18 no.1
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• pp.13-20
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• 2015

The new plan for the current computer engineering involved in education and research in the values of the major and one of the female students, and you can improve your major satisfaction and retention training and development assessment process is the point of need. in computer engineering majors can be linked to the process of targeted quantitative and qualitative research conducted by the results of major and career choices of students turned out to be a mismatch could result in the phenomenon of female engineering escape. How to study ICT in education for female students to computer engineering major regional, historical and social context should be re-designed to suit the characteristics and analysis of exposed female students majoring computer engineering from anxiety and weak organization that has a sense of belonging, and to offer the first and is the appropriate teaching methods seems to be.

• The Journal of Internal Korean Medicine
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• v.19 no.2
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• pp.88-106
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• 1998

This study was designed to elucidate the antiinflammatory, cardiovascular, antithrombotic, and analgesic effect of Sambitang. The antiinflammatory effects was measured by the method of carrageenin induced edema, protein leakage test using CMC-pouch, and the effect of Sambitang on the cardiovascular system was observed by the change of flow rate of Ringer solution in the vascular system in the ear of rabbit, and the contraction and dilatation of rat tail artery. Death rate, platelet aggregation, plasma coagulation activity was observed for the measurement of the anticoagurative effect of Sambitang, and the analgesic effect was measured by the acetic acid method and hot plate method. The result was as follows: 1. Sambitang administration, edema and protein leakage was significantly decreased. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 4. The drug inhibited the death rate of mouse which was led to thromboembo- lism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The slight anagesic effect of Sambitang extract was confirmed by the observation of writhing syndrome, paw licking time, and escape time.