• Molecules and Cells
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• v.37 no.12
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• pp.888-898
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• 2014

Pancreatic cancer is one of the most fatal cancers and is associated with limited diagnostic and therapeutic modalities. Currently, gemcitabine is the only effective drug and represents the preferred first-line treatment for chemotherapy. However, a high level of intrinsic or acquired resistance of pancreatic cancer to gemcitabine can contribute to the failure of gemcitabine treatment. To investigate the underlying molecular mechanisms for gemcitabine resistance in pancreatic cancer, we performed label-free quantification of protein expression in intrinsic gemcitabine-resistant and -sensitive human pancreatic adenocarcinoma cell lines using our improved proteomic strategy, combined with filter-aided sample preparation, single-shot liquid chromatography-mass spectrometry, enhanced spectral counting, and a statistical method based on a power law global error model. We identified 1931 proteins and quantified 787 differentially expressed proteins in the BxPC3, PANC-1, and HPDE cell lines. Bioinformatics analysis identified 15 epithelial to mesenchymal transition (EMT) markers and 13 EMT-related proteins that were closely associated with drug resistance were differentially expressed. Interestingly, 8 of these proteins were involved in glutathione and cysteine/methionine metabolism. These results suggest that proteins related to the EMT and glutathione metabolism play important roles in the development of intrinsic gemcitabine resistance by pancreatic cancer cell lines.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.12
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• pp.261-269
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• 2013

In this paper, the evoked potential(EP) was represented by additive delay model to comply with the variational noisy response of stimulus-event synchronization. The hybrid method of delay compensated-Wiener filtered-ensemble averaging(DWEA) was proposed to enhance the EP signal distortion occurred during averaging procedure due to synchronization timing mismatch. The performance of DWEA has been tested by surrogated simulation, which is composed of synthesized arbitrary delay and arbitrary level of added noise. The performance of DWEA is better than those of Wiener filtered-ensemble averaging and of conventional ensemble averaging. DWEA is endurable up to added noise gain of 7 for 10 % mean square error limit. Throughout the experimentation observation, it has been demonstrated that DWEA can be applied to enhance the evoked potential having the synchronization mismatch with added noise.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.3
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• pp.145-152
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• 2017

In this paper, GNSS(global navigation satellite system) to monitoring the fine for the construction of structure displacement based on satellite communications signals of GNSS. At the same time on USN(ubiquitous sensor network) and proposed a new approach to precise positioning by analyzing the results. A major construction structure for the safety diagnosis and prevent disaster from the risk of collapse. Precision measurement methods to mm level GNSS in that case and experiments in the application of new technologies that can most commonly used to replace the current through the permanent. The way a GNSS baseline and tested it on to prove. As a result, at our country at precise positioning and fine displacement monitoring application virtual reference station(VRS) in a GNSS mm of a margin of error of horizontal and vertical directions can be found.

• Spatial Information Research
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• v.5 no.1
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• pp.43-59
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• 1997

There are currently more than tens of thematic maps in Korea. Among them, there are some thematic maps which are used by one organization only by which was made, and there are common thematic maps which are used by several organizations. In this study, among many kinds of common thematic maps which are currently used, the common thematic maps which will be digitized for parts of NGIS project were chosen and the priority of project was established. After selecting five maps from the common thematic maps classified as the first ranking, current land use map, parcel-address map, administrative boundary map, urban planning map and road map, the area of CheJoo Island was digitized as a pilot project. Through the pilot project of CheJoo Island, the level of application was verified, and the method was presented in order to reduce the trial and error in the process of this production after analyzing the matter from the pilot project. The direction for digitizing common thematic maps was presented based on the result of the pilot project, in addition to, the detail plan was established after deciding the number of people needed, the amount of money spent, and the period needed for making digital maps nationwide.

• Journal of Institute of Control, Robotics and Systems
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• v.18 no.12
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• pp.1106-1114
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• 2012

To achieve synchronized motion between a wearable robot and a human user, the redundancy must be resolved in the same manner by both systems. According to the seven DOF (Degrees of Freedom) human arm model composed of the shoulder, elbow, and wrist joints, positioning and orientating the wrist in space is a task requiring only six DOFs. Due to this redundancy, a given task can be completed by multiple arm configurations, and thus there exists no unique mathematical solution to the inverse kinematics. This paper presents analysis on the kinematic and dynamic aspect of the human arm movement and their effect on the redundancy resolution of the human arm based on a seven DOF manipulator model. The redundancy of the arm is expressed mathematically by defining the swivel angle. The final form of swivel angle can be represented as a linear combination of two different swivel angles achieved by optimizing different cost functions based on kinematic and dynamic criteria. The kinematic criterion is to maximize the projection of the longest principal axis of the manipulability ellipsoid for the human arm on the vector connecting the wrist and the virtual target on the head region. The dynamic criterion is to minimize the mechanical work done in the joint space for each two consecutive points along the task space trajectory. As a first step, the redundancy based on the kinematic criterion will be thoroughly studied based on the motion capture data analysis. Experimental results indicate that by using the proposed redundancy resolution criterion in the kinematic level, error between the predicted and the actual swivel angle acquired from the motor control system is less than five degrees.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.10
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• pp.47-54
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• 2007

Since impulse-radio-based ultra wideband (IR-UWB) do not use carrier frequency but use very short pulse to transmit data it sends data not continuously but discretely and this feature gives the potential to reduce collision in multi-user environment. In this paper, we analyse characteristic of IR-UWB and propose a new collision paradigm, Collision Distribution which changes collision level from packet to pulse. In Collision Distribution mechanical each node sends data with its own pulse interval in random time, distributed manner. It prevents packet drop due to packet collision. We show that Collision Distribution can reduce packet error and can provide real time packet transmission with analysis.

• Bulletin of the Korean Chemical Society
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• v.32 no.2
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• pp.625-629
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• 2011

A quantitative analysis of the decreasing rate of the monomer and increasing rate of the polymerization was made by monitoring radiation level increments using Raman spectroscopy within the therapeutic radiation range for a normoxic polymethacrylic acid gel dosimeter. The gel dosimeter was synthesized by stirring materials such as gelatin, distilled water, methacrylic acid, hydroquinone and tetrakis phosphonium chloride at $50^{\circ}C$, and the synthesized gel was contained in a 10- mm diameter and 32-mm high vial to conduct measurement. 24 hours after gel synthesis, it was irradiated from 0 Gy to 20 Gy by 2 Gy using a Co-60 radiotherapy unit. With use of the Cryo FE-SEM, structural changes in the 0 Gy and 10 Gy gel dosimeters were investigated. The Raman spectra were acquired using 532-nm laser as the excitation source. In accordance with fitting the changes in C-COOH stretching (801 $cm^{-1}$), C=C stretching (1639 $cm^{-1}$) and vinyl $CH_2$ stretching (3114 $cm^{-1}$) vibrational modes for monomer and $CH_2$ bending vibrational mode (1451 $cm^{-1}$) for polymer, sensitive parameter S for each mode was calculated. The values of S for monomer bands and polymer band were ranged in $6.0{\pm}2.6$ Gy and $7.2{\pm}2.3$ Gy, respectively, which shows a relatively good conformity of the decreasing rate of monomer and the increasing rate of polymerization within the range of error.

• Journal of Digital Contents Society
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• v.7 no.2
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• pp.103-108
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• 2006

Short-range wireless communication and networking technologies are becoming increasingly important in enabling useful mobile applications. for example, ZigBee technology is expected to provide low cost and low power connectivity for equipment that needs battery life as long as several months to several years. In addition, ZigBee can be implemented in mesh networks larger than is possible with Bluetooth. The main features of this ZigBee standard are network flexibility, low cost, very low power consumption, and low data rate in an adhoc self-organizing network among fixed, portable and moving devices. Home network/Home automation is one of the key market areas for Zigbee, with an example of a simple network This paper investigates the effect of short range wireless channel on the performance of Zigbee system and DSSS-BPSK signal transmission in AWGN, interference and Rician fading environments. And we investigate performance degradation due to interference and fading effects in short range wireless channel. In particular, the impacts of the fading and interference level on the bit error probability is shown in BER performance figures.

• Journal of the Society of Naval Architects of Korea
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• v.54 no.5
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• pp.387-392
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• 2017

There is a constant demand for hull variation related to ship design. Various input variables are generally given to achieve the objective functions assigned by each variation process. When dealing with geometric shapes accompanied by nonlinear operations during the variation process, vague relationships or uncertainties among input variables are commonly observed. Therefore, it is strongly recommended to identify those uncertainty factors in advance. A method to modify the shape of a closed hull form with a new area and a centroid had been introduced as a new process of hull variation. Since uncertainty between input variables still existed in the method, however, it was not easy for the user to enter the area and the corresponding centroid. To overcome this problem, a method is presented in this paper to provide the feasible region of centroids for a given area. By utilizing the concept and techniques used in the statistics such as the number of samples, probability, margin error, and level of confidence, this method generates the distribution of possible centroids along the regression curve. The result shows that the method helps the user to choose an appropriate input value following his or her design intention.

• Journal of Korea Spatial Information System Society
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• v.2 no.1 s.3
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• pp.91-107
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• 2000

Geographic Information Systems(GISs) generally use a very large amount of spatial data. and are implemented on various software and hardware system. If it is impossible to exchange the spatial data efficiently among the different hardware, software, and operation systems, data sharing will be very difficult and duplicated storage & management of the spatial data will result in a great economic loss. To solve such problems, a national organization established a national standard for GIS and constructed spatial databases at the national level. In Korea, SDTS(Spatial Data Transfer Standard) is selected as a national standard for the common data transfer format. In this paper, we design and implement a SDTS Data Management System which can support display, insertion, update, deletion of SDTS data, extraction and creation of a specified area, error checking and reporting, setting and verification of a SDTS profile through the GUI (Graphic User Interface) environment. Hereafter, as GIS industry is continually activated and a demand for the SDTS data increases, a requirement for analysis and trust of the SDTS data will grow bigger, so the necessity of the SDTS Data Management System developed in this paper will also grow rapidly.