• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.23 no.2
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• pp.176-184
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• 2013

Quantification of road noise is a challenging issue in the development of tire noise since its transfer paths are complicated. In this paper, a simplified model to estimate the road noise is developed. Transfer path of the model is from wheel to interior. The method uses the wheel excitation force estimated throughout inverse method. In inversion procedure, the Tikhonov regularization method is used to reduce the inversion error. To estimate the wheel excitation force, the vibration of knuckle is measured and transfer function between knuckle and wheel center is also measured. The wheel excitation force is estimated by using the measured knuckle vibration and the inversed transfer function. Finally interior noise due to wheel force is estimated by multiplying wheel excitation force in the vibro-acoustic transfer function. This vibro-acoustic transfer function is obtained throughout measurement. The proposed method is validated by using cleat excitation method. Finally, it is applied to the estimation of interior noise of the vehicle with different types of tires during driving test.

• Journal of the Korea Society of Computer and Information
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• v.18 no.4
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• pp.97-112
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• 2013

The quality of the data is the most basic prerequisite for effective use of data. Problems and the resulting loss due to error data has emerged using case studies and a number of, to a national, quality certification system of the data has been enforced, you must manage to generate data study on the method for selecting the point of view of an organization's data CTQ is a very unsatisfactory state of affairs. Selected CTQ main data is subject to quality control in the organization, to develop criteria for CTQ data side of the business and IT so that it can be managed in a systematic manner, the proposed model, to filter the data accordingly presented in detail how to manage enterprise-wide CTQ data that can be quantified Te. By utilizing SPSS, factor analyzes, for which I used the AHP method for quantification. In particular, we present a framework of management measures along the maturity of the data in the organization due to the enforcement of authentic quality certification system of DB, utilizing the CTQ-DSMM model readily applicable to practice.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.4111-4111
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• 2001

When a drug is prepared in a tablet, the active component represents only a small portion of the dosage form. The other components of the formulation include materials to assist in the dissolution, antioxidants, coloring agents and bulk fillers. The tablets are tested using approved testing methods usually involving separation and subsequent quantification of the active component. Tablets may also be tested by near-Infrared Reflectance spectrometry (NIRS). In the present study, based on NIRS and multivariate calibration methods, a novel and precise method is developed for direct determination of ascorbic acid in vitamin C tablet. Two different tablet formulations were powdered in three different sizes, 63-125 ${\mu}{\textrm}{m}$, and examined. Spectral region of 4750-4950 $cm^{-1}$ / was used and optimized for quantitative operations. Partial least squares (PLS) and multiple linear regression (MLR) methods were performed for this spectral region. The results of optimized PLS and MLR methods showed that reproducibility increase with decreasing grain size and standard error of calibration (SEP) of less than 1% w/w of ascorbic acid and a correlation coefficient of 0.998 can be achieved. The PLS method showed better results than MLR. Seven overdose and underdose samples (prepared in the laboratory to match marketed products) were tested by proposed and iodometric standard methods. A correlation between NIRS predicted ascorbic acid values and iodomet.ic values was calculated ($R^2$=0.9950). Finally, the direct analysis of individual intact tablets in their unit-dose packages (Blistering in aluminum and PVC foils) obtained from market were also carried out and a correlation coefficient of 0.9989 and SEP of 0.931% w/w of ascorbic acid were achieved.

• Journal of Korean Society for Atmospheric Environment
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• v.22 no.1
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• pp.117-126
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• 2006

The purpose of this study is to develop a badge-type passive sampler for the measurement of short-term nitrogen dioxide and to evaluate its performance. The principle of the method is a colorimetric reaction of nitrogen dioxide with sulfanilic acid, N-1-naphthylethylendiamine, and phosphoric acid. First, it has been shown that the filter paper should be rinsed with ultrapure water and ultrasound, and then dried in a vacuumed desiccator. The concentration and volume of absorption reagent (triethanolamine) were $20\%$ and 100 ${\mu}L$, respectively. The extraction time was determined as 60 min. Second, duplicate measurements (n= 116) were carried out for evaluating the precision of the passive sampler. The relative error and the correlation coefficient between duplicates are $3.4\pm 3.0\%$ and 0.994, respectively. In addition, the $95\%$ confidence interval of intraclass correlation coefficient and the estimated value are 0.992$\sim$0.996 and 0.994, respectively. Third, a paired t-test was carried out for evaluating the accuracy of the passive sampler (n=40). In the result of the test, the $95\%$ confidence interval of the difference was -1.710 ppb <$\gamma$< 0.788 ppb. Finally, the average concentration of blanks, measurement detection limit, limit of detection, and limit of quantification are $2.4\pm 0.4$ ppb, 104 ppb, 3.8 ppb, and 7.0 ppb, respectively.

• Archives of Pharmacal Research
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• v.27 no.9
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• pp.901-905
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• 2004

A rapid, sensitive and selective hydrophilic interaction liquid chromatography-tandem mass spectrometric(HILIC-MS/MS) method for the determination of tiapride in human plasma was developed. Tiapride and internal standard, metoclopramide were extracted from human plasma with dichloromethane at basic pH and analyzed on an Atlantis HILIC silica column with the mobile phase of acetonitrile-ammonium formate (190 mM, pH 3.0) (94：6, v/v). The ana-Iytes were detected using an electrospray ionization tandem mass spectrometry in the multi-ple-reaction-monitoring mode. The standard curve was linear (r＝0.999) over the concentration range of 1.00-200 ng/mL. The coefficient of variation and relative error for intra- and inter-assay at three QC levels were 6.4∼8.8％ and -2.0∼3.6％, respectively. The recoveries of tiapride ranged from 96.3 to 97.4％, with that of metoclopramide (internal standard) being 94.2％. The lower limit of quantification for tiapride was 1.00 ng/mL using 1 00 $\mu$L of plasma sample.

• Molecules and Cells
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• v.37 no.12
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• pp.888-898
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• 2014

Pancreatic cancer is one of the most fatal cancers and is associated with limited diagnostic and therapeutic modalities. Currently, gemcitabine is the only effective drug and represents the preferred first-line treatment for chemotherapy. However, a high level of intrinsic or acquired resistance of pancreatic cancer to gemcitabine can contribute to the failure of gemcitabine treatment. To investigate the underlying molecular mechanisms for gemcitabine resistance in pancreatic cancer, we performed label-free quantification of protein expression in intrinsic gemcitabine-resistant and -sensitive human pancreatic adenocarcinoma cell lines using our improved proteomic strategy, combined with filter-aided sample preparation, single-shot liquid chromatography-mass spectrometry, enhanced spectral counting, and a statistical method based on a power law global error model. We identified 1931 proteins and quantified 787 differentially expressed proteins in the BxPC3, PANC-1, and HPDE cell lines. Bioinformatics analysis identified 15 epithelial to mesenchymal transition (EMT) markers and 13 EMT-related proteins that were closely associated with drug resistance were differentially expressed. Interestingly, 8 of these proteins were involved in glutathione and cysteine/methionine metabolism. These results suggest that proteins related to the EMT and glutathione metabolism play important roles in the development of intrinsic gemcitabine resistance by pancreatic cancer cell lines.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.15 no.3 s.96
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• pp.320-328
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• 2005

Last target of architectural acoustics is that people wish to convey voice effectively from the space adaptively in use purpose in building. But, how exactly through space sound (sound source) that wish to deliver from indoor can be passed method to do quantification and evaluate quantity of sound by method to serve indoor architectural acoustics estimation summer period and methods to estimate definition propose. This Study searches special quality of sound source about MLS signal that is occurred short-answer sound source (pistol sound source) and nondirectional speaker among indoor sound estimation method, and measure and analyzed reverberation time (RT60), definition (C80, D50) by regulation of each ISO 3382 in age place (classroom, hall, gymnasium). Analysis result and sound factor among could know that d of two sound sources converges in measurement error extent about reverberation time (RT60) of analysis incidental and sound factors and value shows change irregularly about sound factor of D50, C80, pistol sound source judged there is problem. Also, could know that problem is happened in deflection except reverberation time is in deflection analysis with wave that measure each in fixed distance in branch. Finally, when differ size of sound source and measure about change of sound pressure level in case measure sound pressure level giving difference about 10 dB, sound factor could know that there is no different effect.

• Korean Journal of Remote Sensing
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• v.27 no.3
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• pp.303-314
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• 2011

Surface albedo is an important parameter of the surface energy budget, and its accurate quantification is of major interest to the global climate modeling community. Therefore, in this paper, we consider the direct solution of kernel based bidirectional reflectance distribution function (BRDF) models for retrieval of normalized reflectance of high resolution satellite. The BRD effects can be seen in satellite data having a wide swath such as SPOT/VGT (VEGETATION) have sufficient angular sampling, but high resolution satellites are impossible to obtain sufficient angular sampling over a pixel during short period because of their narrow swath scanning when applying semi-empirical model. This gives a difficulty to run BRDF model inferring the reflectance normalization of high resolution satellites. The principal purpose of the study is to estimate normalized reflectance of high resolution satellite (RapidEye) through BRDF components from SPOT/VGT. We use semi-empirical BRDF model to estimated BRDF components from SPOT/VGT and reflectance normalization of RapidEye. This study used SPOT/VGT satellite data acquired in the S1 (daily) data, and within this study is the multispectral sensor RapidEye. Isotropic value such as the normalized reflectance was closely related to the BRDF parameters and the kernels. Also, we show scatter plot of the SPOT/VGT and RapidEye isotropic value relationship. The linear relationship between the two linear regression analysis is performed by using the parameters of SPOTNGT like as isotropic value, geometric value and volumetric scattering value, and the kernel values of RapidEye like as geometric and volumetric scattering kernel Because BRDF parameters are difficult to directly calculate from high resolution satellites, we use to BRDF parameter of SPOT/VGT. Also, we make a decision of weighting for geometric value, volumetric scattering value and error through regression models. As a result, the weighting through linear regression analysis produced good agreement. For all sites, the SPOT/VGT isotropic and RapidEye isotropic values had the high correlation (RMSE, bias), and generally are very consistent.

• Current Optics and Photonics
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• v.1 no.4
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• pp.263-270
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• 2017

Solar radiation data measured by pyranometers is of fundamental use in various fields. In the field of atmospheric optics, the measurement of solar energy must be precise, and the equipment needs to be maintained frequently. However, there seem to be many errors with the existing type of pyranometer, which is an element of the solar-energy observation apparatus. In particular, the error caused by the thermal dome effect occurs because of the thermal offset generated from a temperature difference between outer dome and inner casing. To resolve the thermal dome effect, intensive observation was conducted using the method and instrument designed by Ji and Tsay. The characteristics of the observed global solar radiation were analyzed by classifying the observation period into clear, cloudy, and rainy cases. For the clear-weather case, the temperature difference between the pyranometer's case and dome was highest, and the thermal dome effect was $0.88MJ\;m^{-2}\;day^{-1}$. Meanwhile, the thermal dome effect in the cloudy case was $0.69MJ\;m^{-2}\;day^{-1}$, because the reduced global solar radiation thus reduced the temperature difference between case and dome. In addition, the rainy case had the smallest temperature difference of $0.21MJ\;m^{-2}\;day^{-1}$. The quantification of this thermal dome effect with respect to the daily accumulated global solar radiation gives calculated errors in the cloudy, rainy, and clear cases of 6.53%, 6.38%, and 5.41% respectively.

• YAKHAK HOEJI
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• v.42 no.5
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• pp.473-479
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• 1998

Lovastatin (LOVA), a fungal metabolite isolated from cultures of Aspergillus terreus, is a competitive HMG-CoA reductase inhibitor used for the treatment of primary hyper cholesterolemia, and has also been shown to suppress growth in a variety of non-glioma tumor cell lines. A sensitive reversed-phase high-perfonnance liquid chromatographic method with ultraviolet (UV) absorbance detection has been developed to quantitate LOVA in human plasma and urine samples using liquid-liquid extraction procedure. Baseline separation of LOVA and internal standard, simvastatin was achieved on a Novapak $C_{18}$ analytical column with a mobile phase containing 0.025M $NaH_2PO_4$: CAN (35:65, v/v%), adjusted pH to 4.5. The flow rate was set at 1.5ml/min, and the column effluent was monitored by a UV detection at 238nm. The limit of quantification was determined to be 0.5${\mu}$g/ml while extraction efficiency of LOVA ranged from 73.4-82.9% at LOVA concentrations of 0.5 to 10${\mu}$g/ml. Good linearity with correlation coefficients greater than 0.999 was obtained in the range of LOVA concentrations from 0.5 to 10${\mu}$g/ml. The accuracy and the precision were proven excellent with relative standard deviation (RSD, %) and relative error (RE, %) of less than 4.2 and 4.0, respectively. Intraday precision, evaluated at five LOVA concentrations (0.5, 1, 2, 5, 10${\mu}$g/ml) and expressed as RSD ranged from 0-1.82% while the interday precision at the same concentrations ranged from 0.7-10.5%. The analytical method described was then successfully employed for the determination of LOVA concentrations in plasma samples obtained during a phase II clinical trial using high doses of LOVA (30-40mg/kg/day). This method could be further utilized for the ongoing pharmacolkinetic studies and therapeutic drug monitoring of the high-dose LOVA therapy in adenocarcinoma patients.