• Toxicological Research
• /
• v.23 no.3
• /
• pp.197-205
• /
• 2007

Cancer metastasis is a major determinant of cancer patient mortality. Mounting evidence favors a strong positive role for $TGF-{\beta}$ in human cancer progression. The complex pattern on cross-talk of $TGF-{\beta}$ and the related other signaling pathways is an important area of investigation that will ultimately contribute to understanding of the bifunctional role of $TGF-{\beta}$ in cancer progression. This review summarizes some of the current understanding of $TGF-{\beta}$ signaling with a major focus in its contribution to the tumor cell invasion and metastasis. Five issues are addressed in this review: (1) $TGF-{\beta}$ signaling, (2) $TGF-{\beta}$ and EMT, (3) $TGF-{\beta}$ and MMP, (4) $TGF-{\beta}$ and Ras, and (5) Role of $TGF-{\beta}$ in invasion and metastasis. Due to the bifunctional cellular effects of $TGF-{\beta}$, as a tumor promoter and a tumor suppressor, more precisely defined $TGF-{\beta}$ signaling pathways need to be elucidated. According to the current literature, $TGF-{\beta}$ is clearly a major factor stimulating tumor progression through a complex spectrum of the interplay and cross-talk between various signaling molecules. Understanding the role of $TGF-{\beta}$ in invasion and metastasis will provide valuable information on establishing strategies to manipulate $TGF-{\beta}$ signaling which should be a high priority for the development of anti-metastatic therapeutics.

• Journal of Environmental Science International
• /
• v.27 no.12
• /
• pp.1195-1203
• /
• 2018

Many consumers intend to make environmentally purchase. However, this is not always what occurs. A gap exists between consumer intentions to purchase environmentally friendly products and their actual purchase behavior. In this study, we examined the effect of situational factors such as price sensitivity, product quality perception, and label trust on the relationship between purchase intention and purchase behavior for environmentally friendly products. First, we conducted a theoretical consideration through a review of literature on price sensitivity, product quality perception, label trust, purchase intention and purchase behavior. Based on the literature review, we designed a structural model and developed the hypotheses. Next, we collected data using a survey and processed them statistically in order to verify the hypotheses. A total of 213 samples were collected and the data were analyzed using a structural equation model (LISREL 8.70). The results suggest that the situational factor of label trust has a moderating effect on the relationship between purchase intention and purchase behavior for environmentally friendly products. However, price sensitivity and product quality perception have no moderating effect. This means that trust in labels is important when consumers want to buy environmentally friendly products. Although this study has some limitations, it is expected that it will positively trigger follow-up research.

• KIEAE Journal
• /
• v.9 no.4
• /
• pp.3-10
• /
• 2009

It is not an overstatement to say the factory are the number one cause in creating environmental load. However, only a few studies have been done upto this date on environmentally friendly factory. Thus, This study is to present the characteristics of environmentally friendly factory. A survey of current literatures and cases show the characteristics of environmentally friendly factories and buildings and environment assessment method and plan. To better measure the environmentally friendly qualities as written in literature across the globe, classification system was constructed. The classification system was made and important factors were found based on the precedent paper on environmentally friendly building plan and environment assessment method at building and cases and abroad in the literature review. The classification used 4 different sectors : Land & Transportation, Architectural Planning Technique, Environment & Equipment, Energy & Material. Within these 4 sectors 33 discrete factors are applied to the factory according to literature and case review and specialist advice.

• Journal of the Architectural Institute of Korea Planning & Design
• /
• v.34 no.1
• /
• pp.71-81
• /
• 2018

The purpose of this study is to develop neighborhood assessment tools from the perspective of women in order to evaluate neighborhood environments and suggest better policies and planning practices for women-friendly neighborhood environments. To do so, we analyze correlations between women's quality of life and the neighborhood environment. Specifically, we gave female participants a mapping survey, interview, and questionnaire to collect data targeting women living in Onyang 2-dong and 5-dong in Asan city. First, we developed a neighborhood assessment tool derived from an extensive literature review and particular case studies. The mapping and interview surveys indicated that specific aspects neighborhood life needed to be improved in a similar area. In particular, women complained about Onyangoncheon station, a commercial area, and detached house area. Second, analysis of the neighborhood environmental factors affecting women's neighborhood satisfaction, crime safety, traffic and walking environment, accessibility of living facilities, green and public spaces and childcare environment were statistically significant. Of these, the inclusion of green and public spaces was the most influential factor. Third, the neighborhood environmental factors affecting women's neighborhood attachment, crime safety, traffic and walking environment, accessibility of living facilities, green and public spaces and childcare environment were statistically significant. Of these, accessibility of living facilities appeared to be the most influential factor. Fourth, the neighborhood environmental factors affecting women's housing mobility decisions, crime safety, traffic and walking environment, accessibility of living facilities, green and public spaces and childcare environment were statistically significant. Of these, childcare environment was the most influential factor.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.13 no.4
• /
• pp.1-9
• /
• 2010

In response to climate change under a university level, this study has intended to find carbon-neutral campus development measures for Chungbuk National University (CBNU), which is composed of such facilities as education, research, and residential buildings. To reach this goal, we reviewed related literatures to find development measures for carbon neutral campus, employed a survey method asking students to show their preference and suitability toward provided measures, and statistical analyses to find appropriate measures using factor analysis. We have found the following results. First, based on literature review, we have identified several concepts regarding carbon-neutral city and has found the elements of carbon-neutral campus development. Second, we have drawn carbon-neutral campus development measures of CBNU through factor analysis. Finally, based on the characteristics and the present carbon-neutral campus conditions of the CBNU, we presented development measures.

• International Journal of Highway Engineering
• /
• v.17 no.2
• /
• pp.135-141
• /
• 2015

PURPOSES : While driving, drivers are usually limited in communicating with others except for using the horn. Excessive use of the horn may cause noise pollution, quarrels between drivers and pedestrians, damage, etc. This study developed a methodology for environmental adaptation and improvements of vehicle horns. METHODS: In this study, we performed a literature review of previous studies and related technologies regarding the overuse and damage of the horn. The proposed methodology employed the paired comparison method, as well as the semantic differential method. These methods can consider various vehicle horns, such as the Sport Utility Vehicle(SUV) Horn, Van Horn, and Buzzer. In addition, we conducted a factor analysis in order to provide a direction for improvement of future horns. This research provides a means of complimenting existing intellectual property related to vehicle horns. RESULTS: As a result, the most preferred of the selected horns were the Buzzer at 86.7%. In addition, based on the factor analysis, the horns could be classified into pleasantness and comfort factors. The results indicate a positive reaction for various vehicle horns. The horn type and size of the process control have been properly developed considering the position of the vehicle and the surrounding noise measurements. CONCLUSIONS : Based on the proposed methodology, public and private sectors can use fundamental data for reasonable traffic-noise control policies.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2014.05a
• /
• pp.26-27
• /
• 2014

Sustainable development has become a growing concern throughout the world. Construction industry also has participated in the efforts to minimize the environmental impacts. In Korea, the government has already established the green construction certification(G-seed) and guidelines for sustainable construction. However, domestic guidelines are focused on the design and construction phase, not on the construction project. In addition, it is difficult to find instructions due to the complex structure based on the work unit. Therefore this study aims to deduct the component structure for sustainable construction guidelines in the planning, design and construction phases by utilizing the Factor Analysis. Following the literature review, a total of 26 criteria were identified. Further, a survey was conducted to capture the perceptions on the importance of the criteria. According to the factor analysis, the criteria can be grouped into 8 factors : Environmental factors management, Management planning, Cost and Design management, Energy management, Material management, Certification and regulation management, General Management and Others.

• Journal of Environmental Health Sciences
• /
• v.27 no.2
• /
• pp.30-36
• /
• 2001

This review begins with a brief expression of aerosol capture mechanism of fibrous filter(s) and performance of particulate removing respirators. The more complicated and detailed discussion is not included in this articles. Filtration efficiency and pressure drop are introduced as quality factor ( $q_{F}$) and the way in which filtration efficiency varies with particle size is discussed. Quality factors fro filters recently certified in USA were found to be very higher than those of filters made in Korea, China and USA filters certified with old certified standards. Electrically charged filters are widely used because they have high filtration efficiency and low pressure drop, but their efficiency decreases sharply at the condition occurring wet and oil mist. A discussion is given of respirator leakage through face seal and filter media with fit testing and total inward leakage testing. Since fit factor (FF) refers to the reciprocal of the fraction of the total air entering a respirator through face seal leakage , the degree of fitting performance for respirators is expected with FF. Because respirators made in Korea had generally lower FFs than respirators made in USA, it is necessary to develope respirators that fit properly for Koreans or establish regulations for fit testing.g.

• Environmental and Resource Economics Review
• /
• v.24 no.2
• /
• pp.251-281
• /
• 2015

This paper examines the perceptions of sustainability, which is conceptualised as cross-generational social preferences, on the formation of international environmental agreements (IEAs) in a two-stage game in two periods. There are two scenarios are considered: myopic and sustainable development scenarios. The myopic scenario assumes the decision makers only concern the present welfare. Whilst the scenario of sustainable development has two characters: cross-generational fairness and altruism. When both are taken into account, a coalition will be expanded. The numerical example indicates that the marginal cost of the total emissions is the crucial factor for the formation of IEAs. Only when the marginal cost is low, a sustainable system can be succeeded. While, the technological advancement may lead to a more efficient production per unit of emissions, it also encourages countries to emit more in total and have a lower level of welfare. The results confirm the importance of sustainability to IEAs. The lesson learnt from this study is: when decision makers are myopic, the system is unsustainable even if an IEA is formed. Only when the perception of sustainability is considered, the system could be sustainable. Regardless of the existence of IEAs, international environmental conventions shall not neglect the fundamental goal to pursue sustainable development.

• Journal of Korea Technical Association of The Pulp and Paper Industry
• /
• v.46 no.1
• /
• pp.11-17
• /
• 2014

This study analyzed the effects of specific factors on the fluorescence index of the fluorescent whitening agent (FWA) that is used for internal addition. The specific factors were identified by the literature review, and a statistical survey was carried out to analyze the effects of those factors on the fluorescence index. Bulk, grammage, fillers and internal sizing agents were selected as the specific factors. The paper samples were prepared with internal FWA in a laboratory. The fluorescence indices of the model papers were measured, and p-values of the specific factors on the fluorescence index were calculated by the SPSS program. Most of p-values were greater than 0.05, so the specific factors do not have a significant impact on the internal FWA fluorescence index.