• KIEE International Transactions on Power Engineering
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• 제11A권4호
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• pp.45-50
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• 2001

The impact evaluation of a DSM program is a very important issue since the results are used to determine the sustainability of a program. In general. to estimate the impacts of a DSM program it is required to measure the electricity usage changes before and after a program. Since the measurement-based approaches cost highly, most of the conventional evaluations are based on the average figures. However estimation of the average-based impacts can lead to both distorted results of over/under estimation of kW and kWh savings and non-optimal DSM planning. In this paper, we have developed a new multi-point measurement approach which can evaluate kW and kWh savings of a DSM program more exactly. To do this, the saving rate and operating rate are defined and set as the function of load factor of a customer, and these rates are incorporated with the conventional diffusion function of Bass to project the future impacts of a DSM program. The case study is performed on the inverter program of Korea by using the suggested approach.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 추계 학술발표회
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• pp.1282-1288
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• 2010

In this study, Site Investigation Program of cut slope is developed using related techniques and experience got from practical application of Inventory Survey Program of cut slope in work for last 4 years. The Site Investigation Program is designed to can be loaded to the Mobile PC for convenience of carrying in filed, convenience of data input and revision, application of diverse programs, convenience of confirming data and facility of establishment of real-time database system using wireless communication like Inventory Survey Program. Also, for connection with Inventory Survey Program, it has a same work process and can establish real-time database system of almost data obtained in filed using stability analysis tool loaded in this program. Application of this developed program is expected to be an opportunity that can contribute to development of slope investigation and database system area using IT techniques.

• 시스템엔지니어링학술지
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• 제4권2호
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• pp.35-43
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• 2008

Application of system engineering should be realized on necessary condition being to propel National Defense R&D Program. But, these necessity is yet not realized easily to many project managers of Defense Acquisition Program Administration(DAPA). As one person of DAPA project manager, system engineering hard to approaches easily by the word itself. There are a lot of difficult sections where should apply how. This paper established DAPA Project Manager and Acquisition Point of Contact of demand Military by main customer (reader), and wished to make understood more easily and approach system engineering application to these. Also, this paper studied project management example that scientific project management techniques of Earned Value Management(EVM) and Cost As an Independent Variable(CAIV) etc. is taken abuzz in DAPA inside by Project management technique that become reform, arc Integrated in system engineering.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.243-244
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• 1998

The second telemetry is designed for supplying additional function which the first telemetry system doesn't have and as a part system of the External Management System (EMS). It makes a patient and an animal move more freely with wireless communication at a distance of free activity from the PC and can get most data from the first telemetry to send to the PC. Recently, our laboratory is developing a RF system for the second telemetry.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.241-242
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• 1998

For the aritificial heart valve, two types of valves-polymer and mechanical valve- are generally used. The polymer valve is used as a new low-cost artificial valve. Among the several properties of the artificial valve, the low-regurgitation property is important because it can provide better cardiac output characteristic. So in this study we analyzed and compared the regurgitation property of the mechanical valve which is generally used nowdays and the polymer valve which was made in our group. As results, the polymer valve showed the better regurgitation property compared to the mechanical valve approximately by 3 times, and increased the cardiac output by 10%.

• 공학교육연구
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• 제14권6호
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• pp.41-47
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• 2011

Professional communication skills in writing and speaking with multiple and complex audiences are required to engineers in society of modern technology. In this paper, we proposed the effective assessment system for the Program Outcomes on the communication skill competence(PO7), which is one of the 12 program outcomes stipulated by ABEEK (Accreditation Board for Engineering Education of Korea). To ensure logical connectivity of the assessment system, we carefully selected the performance criteria by defining the core concept of "written communication" and "verbal communication". Based on the selected performance criteria, the whole process of creating assessment tools and rubrics was explained in detail. It can be expected that the assessment for the Program Outcomes on the communication skill competence would be more systematic by using the proposed assessment system.

• 공학교육연구
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• 제11권2호
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• pp.90-101
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• 2008

이 연구는 STEM 통합 접근의 사전 공학 교육 프로그램 모형을 개발하기 위해 수행되었다. 연구의 목적을 달성하기 위해서 관련 문헌 고찰과 전문가를 대상으로 한 타당도 조사를 실시하였다. 이 연구에서는 STEM 통합 접근의 교육 프로그램 모형 개발과 관련하여 다음과 같은 세 가지 결과를 산출하였다. 첫째, 과학, 기술학, 공학, 수학 각각에 대한 개념, 고유의 탐구 방법과 지식 구조 및 영역을 확인하고, 이에 대한 타당도 조사를 통해 STEM 통합 접근의 개념 모형을 구성하였다. 둘째, STEM 통합 접근의 통합 핵심 요소, 활동유형, 교육 프로그램 수행 학습 인원, 교육 프로그램 수준을 탐색하고 이를 바탕으로 하여 STEM 통합 접근의 교육 프로그램 개념 모형을 구안하였다. 셋째, 주제 중심 통합 접근에 따른 탐구 프로젝트 활동, 문제 중심 통합 접근에 따른 문제 해결 활동, 설계 중심 통합 접근에 따른 창의 공학 설계 활동 각각의 교육 프로그램 구성 단계를 제시하여 STEM 통합 접근의 교육 프로그램 구조화를 꾀하였다.

• Biomolecules & Therapeutics
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• 제30권3호
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• pp.274-283
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• 2022

KRAS activating mutations, which are present in more than 90% of pancreatic cancers, drive tumor dependency on the RAS/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Therefore, combined targeting of RAS/MAPK and PI3K/AKT signaling pathways may be required for optimal therapeutic effect in pancreatic cancer. However, the therapeutic efficacy of combined MAPK and PI3K/AKT signaling target inhibitors is unsatisfactory in pancreatic cancer treatment, because it is often accompanied by MAPK pathway reactivation by PI3K/AKT inhibitor. Therefore, we developed an inRas37 antibody, which directly targets the intra-cellularly activated GTP-bound form of oncogenic RAS mutation and investigated its synergistic effect in the presence of the PI3K inhibitor BEZ-235 in pancreatic cancer. In this study, inRas37 remarkably increased the drug response of BEZ-235 to pancreatic cancer cells by inhibiting MAPK reactivation. Moreover, the co-treatment synergistically inhibited cell proliferation, migration, and invasion and exhibited synergistic anticancer activity by inhibiting the MAPK and PI3K pathways. The combined administration of inRas37and BEZ-235 significantly inhibited tumor growth in mouse models. Our results demonstrated that inRas37 synergistically increased the antitumor activity of BEZ-235 by inhibiting MAPK reactivation, suggesting that inRas37 and BEZ-235 co-treatment could be a potential treatment approach for pancreatic cancer patients with KRAS mutations.

• 공학교육연구
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• 제18권6호
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• pp.18-23
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• 2015

Nowadays, IT that leads information era is closely connected to our lives. The importance of training human resources for global empowerment on IT is being emphasized all over the world. With the growth of international society, the cultivation of global human resources now includes the cultivation of future human resources and the educations related with the career development program. However, the programs that colleges are operating for the cultivation of global human resources have been limited only to supporting the participation in international training program, operating camp and conferences, etc. On the contrary, to give many learners chances of experiencing courses for global empowerment and employment capability, We are operating the Internet of Everything online education program with Cisco Networking Academy Korea. Based on the management cases of Internet of Everything online education program, this thesis is suggesting a career program on global empowerment that many learners can experience, different from the limitation of the existing program.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 춘계학술발표회논문집(1)
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• pp.404-410
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• 1998

In Yonggwang nuclear units 3 and 4 currently under commercial operation, the cold leg temperature was very close to the technical specification limit of 298$^{\circ}C$ during initial startup testing, which was caused by the higher-than-expected reactor coolant system flow. Accordingly, the reference temperature (Tref) program needed to be revised to allow more flexibility for plant operations. In this study, the method of a specific test performed at Yonggwang nuclear unit 4 to revise the Tref program was described and the test results were discussed. In addition, the modified Tref program was evaluated on its potential impacts on system performance and safety. The methods of changing the Tref program and the associated pressurizer level setpoint program were also explained. Finally, for Ulchin nuclear unit 3 and 4 currently under initial startup testing, the effects of reactor coolant system flow rate on the coolant temperature were evaluated from the thermal hydraulic standpoint and an optimum Tref program was recommended.