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Risk of Breast Cancer and Total Malignancies in Rheumatoid Arthritis Patients Undergoing TNF-α Antagonist Therapy: a Meta-analysis of Randomized Control Trials

  • Liu, Yang;Fan, Wei;Chen, Hao;Yu, Ming-Xia
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.8
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    • pp.3403-3410
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    • 2014
  • Context: Interest exits in whether TNF-alpha antagonists increase the risk of breast cancer and total malignancies in patients with rheumatoid arthritis (RA). Objectives: To analyze the risk of malignancies, especially breast cancer, in patients with RA enrolled in randomized control trials (RCTs). Methods: A systematic literature search for RCTs from 1 January 1998 to 1 July 2013 from online databases, such as PubMed, WILEY, EMBASE, ISI web of knowledge and Cochrane Library was conducted. Studies included RCTs that compared the safety of at least one dose of the five TNF-${\alpha}$ antagonists with placebo or methotrexate (MTX) (or TNF-${\alpha}$ antagonists plus MTX vs placebo plus MTX) in RA patients for more than 24 weeks and imported all the references into document management software EndNote${\times}6$. Two independent reviewers selected studies and extracted the data about study design, patients' characteristics and the type, number of all malignancies. Results: 28 RCTs from 34 records with 11,741 patients were analyzed. Of the total, 97 developed at least one malignancy during the double-blind trials, and breast cancer was observed in 17 patients (17.5% of total malignancies). However, there was no statistically significant increased risk observed in either the per protocol (PP) model (OR 0.65, 95%CI [0.22, 1.93]) or the modified intention to treat (mITT) model (OR 0.75, 95%CI [0.25, 2.21]). There were also no significant trend for increased risk of total malignancies on anti-TNF-${\alpha}$ therapy administered at approved doses in either model (OR, 1.06, 95%CI [0.64, 1.75], and OR, 1.30, 95%CI [0.80, 2.14], respectively). As to the two models, modified intention to treat model analysis led to higher estimation than per protocol model analysis. Conclusions: This study did not find a significantly increased risk of breast cancer and total malignancies in adults RA patients treated with TNF-${\alpha}$ antagonists at approved doses. However, it cannot be ignored that more patients developed malignancies with TNF-${\alpha}$ antagonists therapy compared with patients with placebo or MTX, in spite of the lack of statistical significance, so that more strict clinical trials and long-term follow-up are needed, and both mITT and PP analyses should be used in such safety analyses.

Information System for Managing Cost Reimbursable Construction Projects (실비정산 비용지불 방식에 적용 가능한 건설 프로젝트 정보관리 시스템)

  • Kang, Namhee;Song, Hojeong;Kim, Hyunjung;Choi, Jaehyun
    • Journal of the Korea Institute of Building Construction
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    • v.15 no.2
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    • pp.237-247
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    • 2015
  • The project management information system (PMIS) has recently been developed by using the information technology(IT) in order to implement advanced information management technology to construction industry in Korea. The PMIS has been applied not only to domestic construction projects, but also to some overseas projects executed by Korean construction companies. This study was performed to develop the PMIS that is tailored to the US construction IT market. It has been monopolized by the US-based IT companies, but other companies are recently emerging with competitive technology and market strategy. As a preceding study, existing commercially available systems were analyzed, and the required features of the PMIS were identified by analyzing the core elements of contract, process and cost management about construction projects in the US. Then, the PMIS was developed based on the aforementioned analysis results. The system includes the document management module with an internal electronic approval system, the cost-plus-based automatic labor cost calculation module, and the progress management module to support the integrated project cost management. In addition, the functionality of the developed system was verified by experts about construction management in the US via questionnaire survey. The developed PMIS, in this study, is expected to be applied not only to the US construction IT market as a system specialized for the US construction industry, but also to other oversea markets in the future.

A Study on Implementation of SVG for ENC Applications (전자해도 활용을 위한 SVG 변환 연구)

  • Oh, Se-Woong;Park, Jong-Min;Suh, Sang-Hyun
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • v.1
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    • pp.133-138
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    • 2006
  • Electronic Navigational Charts(ENCs) are official nautical charts which are equivalent to paper charts with supplementary information. Although their main purpose is to be used for the safe navigation of ships, they also contain much information on coasts and seas which may be interesting to ordinary people. However, there is no easy way to access them because of therir specialized data format, access method and visualization. This paper proposes on implementation of SVG for the access and services of ENCs. SVG(Scalable Vector Graphic) makes it possible to make use of Vector graphics for servicing maps in basic internet browsing environment. Implement of SVG for ENC applications by this research is free of special server side GIS mapping system and client side extra technology. The implementation of SVG for ENC Applications can be summarized as follows: Firstly, SVG provides spatial information to possess searching engine to embody SVG map. Secondly, SVG can provide high-quality vector map graphics and interactive facility without special Internet GIS system. It makes it possible to use services with very low cost. Thirdly, SVG information service targeting on maritime transportation can be used as template, so it can be used dynamically any other purpose such as traffic management and vessel monitoring. Many good characteristics of SVG in mapping at computer screen and reusability of SVG document provide new era of visualization of marine geographic information.

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Simplified Clearance Formalities of Northeast Asia port (동북아 항만의 입출항 수속 간소화 방안)

  • Choi Hyung-Rim;Park Nam-Kyu;Park Young-Jae;Cho Jae-Hyung
    • Journal of Navigation and Port Research
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    • v.29 no.5 s.101
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    • pp.439-445
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    • 2005
  • Recently, owing to the increasing demand on the simplification of arrival and departure procedures, IMO's (International Maritime Organization) Facilitation Committee (FAL) is carrying out the standardization project of arrival and departure formalities and clearance form. Also, many port authorities of developed countries are making active researches for the smooth flow and efficiency of the information inbound and outbound ships by way of simplifying their formalities or through electronic means. However, this standardization project cannot be done by one country but by mutual cooperation among related nations. And to carry out this task, the first thing to be done is to standardize the formalities and document form, and to integrate information. To this end, this study has reviewed the model cases of advanced ports of developed countries with regard to their simplification and standardization efforts. And also we have analyzed the formalities and clearance form of the three countries Korea, China, and Japan. And then for the solution of common problems of three countries, this paper has suggested an ebXML-based Global Port B2B framework. Through this framework, we can reuse and automate the necessary information on the arrival and departure of ships, consequently realizing simplification, and laying a foundation for the introduction of e-commerce to the port industry.

A Study on Implementation of SVG for ENC Applications (전자해도 활용을 위한 SVG 변환 연구)

  • Oh, Se-Woong;Park, Jong-Min;Seo, Ki-Yeol;Suh, Sang-Hyun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.11 no.10
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    • pp.1930-1936
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    • 2007
  • Electronic Navigational Charts(ENCs) are official nautical charts which are equivalent to paper charts with supplementary information. Although their main purpose is to be used for the safe navigation of ships, they also contain much information on coasts and seas which may be interesting to ordinary people. However, there is no easy way to access them because of their specialized data format, access method and visualization. This paper proposes m implementation of SVG for the access and services of ENCs. SVG(Scalable Vector Graphic) makes it possible to make use of Vector graphics for map services in basic internet browsing environment. Implementation of SVG for ENC applications by this research is free of special server side GIS mapping system and client side extra technology. The Implementation of SVG for ENC Applications can be summarized as follows: Firstly, SVG provides spatial information to possess searching engine to embody SVG map. Secondly SVG can provide high-quality vector map graphics and interactive facility without special Internet GIS system. It makes it possible to use services with very low cost. Thirdly, SVG information service targeting on maritime transportation can be used as template, so it can be used dynamically any other purpose such as traffic management and vessel monitoring. Many good characteristics of SVG in mapping at computer screen and reusability of SVG document provide new era of visualization of marine geographic information.

A Study on the Records Production Report of Public Institutions (공공기관의 생산현황통보에 관한 연구)

  • Hwang, Jin-hyun
    • The Korean Journal of Archival Studies
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    • no.37
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    • pp.145-188
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    • 2013
  • The purpose of production status report is figuring out the amount of records produced by departments and record centers and establishing plans for transfer and collect of archives. These are the main functions of production status report clarified by Public Records Management Act. Production status report is introduced as the means to control the record management in public institutions which lack the understanding of the record production and management. Up to now, public institutions carry out production status report. However, it only has been done as a formal procedure and records collected unsurely transfer to Archives. The implementation of production status report does not accord with the original purpose. In addition, there are different views about the appropriateness of production status report. Record managers in the field, the researchers who made efforts to state production status report in the law and the archives did not reached the agreement of opinions yet. The objective of this study is not to judge whether production status report is of importance or not. Although its significance is controversial, it's one of the most important record management tasks and it stands the position as the distinct method in Korea. Nonetheless, the issue that production status report lacks efficiency in the field due to the lack of support of forms and systems brings up continuously. Thus, I evaluated current functions of production status report and proposed future improvements so that it accomplishes its original intent and support users in the field.

A Case Study on the Application of AI-OCR for Data Transformation of Paper Records (종이기록 데이터화를 위한 AI-OCR 적용 사례연구)

  • Ahn, Sejin;Hwang, Hyunho;Yim, Jin Hee
    • Journal of the Korean Society for information Management
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    • v.39 no.3
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    • pp.165-193
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    • 2022
  • It can be said that digital technology is at the center of the change in the modern work environment. In particular, in general public institutions that prove their work with records produced by business management systems and document production systems, the record management system is also the work environment itself. Gimpo City applied for the 2021 public cloud leading project of the National Information Society Agency (NIA) to proactively respond to the 4th industrial revolution technology era and implemented a public cloud-based AI-OCR technology enhancement project with 330 million won in support of 330 million won. Through this, it was converted into data beyond the limitations of non-electronic records limited to search and image viewing that depend on standardized index values. In addition, a 98% recognition rate was realized by applying a new technology called AI-OCR. Since digital technology has been used to improve work efficiency, productivity, development cost, and record management service levels of internal and external users, we would like to share the direction of enhancing expertise in the record management and implementation of work environment innovation.

A neck healthy warning algorithm for identifying text neck posture prevention (거북목 자세를 예방하기 위한 목 건강 경고 알고리즘)

  • Jae-Eun Lee;Jong-Nam Kim;Hong-Seok Choi;Young-Bong Kim
    • Journal of the Institute of Convergence Signal Processing
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    • v.23 no.3
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    • pp.115-122
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    • 2022
  • With the outbreak of COVID-19 a few years ago, video conferencing and electronic document work have increased, and for this reason, the proportion of computer work among modern people's daily routines is increasing. However, as more and more people work on computers in the wrong posture for a long time, the number of patients with poor eyesight and text neck is increasing. Until recently, many studies have been published to correct posture, but most of them have limitations that users may experience discomfort because they have to correct posture by wearing equipment. A posture correction sensor algorithm is proposed to prevent access to the minimum distance between a computer monitor and a person using an ultrasonic sensor device. At this time, an algorithm for minimizing false alarms among warning alarms that sound at the minimum distance is also proposed. Because the ultrasonic sensor device is used, posture correction can be performed without attaching a device to the body, and the user can relieve discomfort. In addition, experimental results showed that accuracy can be improved by reducing false alarms by removing more than half of the noise generated during distance measurement.

An Empirical Study on the Driving Force for Diffusion of Surrender B/L as an International Trade Payment Document (무역결제서류로서 Surrender B/L의 확산 동인에 관한 실증연구)

  • Hye-Young Joo;Byoung-Boo You
    • Korea Trade Review
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    • v.48 no.2
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    • pp.153-174
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    • 2023
  • Electronic bill of lading, Letter of Guarantee, Surrender B/L, Seaway Bill, etc. have been proposed as alternative tools to overcome the crisis of bill of lading, but the most useful of these is by far the Surrender B/L. However, since the Surrender B/L has various problems due to the absence of a legal basis, studies so far have been conducted focusing on these legal limitations or problems in use of the Surrender B/L. This study tried to empirically identify the factors that affect the spread of Surrender B/L by expanding this point of research view. A hierarchical regression analysis was conducted by acquiring 190 valid samples centered on member companies of the Korea International Freight Forwarders Association. In addition, the R program was used to diagnose the research data and analyze the degree of spread by region. As a result of the empirical analysis, it was found that the utilization of Surrender B/L increased due to the convenience and cost reduction effect of Surrender B/L and the apprenticeship training of forwarding companies. In addition, as a result of regional analysis, the spread of Surrender B/L was notable not only in neighboring regions but also even in areas far from Korea.

Analysis of Generative AI Technology Trends Based on Patent Data (특허 데이터 기반 생성형 AI 기술 동향 분석)

  • Seongmu Ryu;Taewon Song;Minjeong Lee;Yoonju Choi;Soonuk Seol
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.17 no.1
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    • pp.1-9
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    • 2024
  • This paper analyzes the trends in generative AI technology based on patent application documents. To achieve this, we selected 5,433 generative AI-related patents filed in South Korea, the United States, and Europe from 2003 to 2023, and analyzed the data by country, technology category, year, and applicant, presenting it visually to find insights and understand the flow of technology. The analysis shows that patents in the image category account for 36.9%, the largest share, with a continuous increase in filings, while filings in the text/document and music/speech categories have either decreased or remained stable since 2019. Although the company with the highest number of filings is a South Korean company, four out of the top five filers are U.S. companies, and all companies have filed the majority of their patents in the U.S., indicating that generative AI is growing and competing centered around the U.S. market. The findings of this paper are expected to be useful for future research and development in generative AI, as well as for formulating strategies for acquiring intellectual property.