• Title/Summary/Keyword: Effective size

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The Effect of Dangguijakyak-san on Wound Healing (당귀작약산의 창상 회복에 대한 효과)

  • Yun-Jin Lee;Chang-Hoon Woo;Young-Jun Kim;Hyeon-Ji Kim;Hee-Duk An
    • Journal of Korean Medicine Rehabilitation
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    • v.33 no.3
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    • pp.47-65
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    • 2023
  • Objectives We evaluated the wound healing effects of Dangguijakyak-san (DJ) using C57BL/6 mice that were generated open wound. Methods The study was conducted with seven C57BL/6 mice assigned to each group, divided into the normal group, control group, vitamin E group, DJ low-dose group, DJ high-dose group. We measured total polyphenol, flavonoid contents, the size of the wound, liver function, pro-inflammatory cytokine activity in serum, inflammation-related proteins, adhesion molecules and chemokine proteins, collagen-related proteins in skin tissue and histopathological changes by H&E and Masson's staining. Results DJ treatment significantly reduced the area of the wound compared to the control group. Also, inflammatory cytokines were reduced and the expression of anti-inflammatory-related factors (interleukin-4 [IL-4] and IL-10) was significantly increased in the DJ treatment group. We identified that DJ treatment inhibits both pathways of inflammation, the mitogen-activated protein kinases and nuclear factor-κB pathway. Moreover, the protein expressions of Sirt1 (sirtuin 1), MCP-1 (monocyte chemoattractant protein 1), ICAM-1 (intercellular adhesion molecule 1), and VCAM-1 (vascular cell adhesion molecule 1) were decreased by DJ administration. Also, the expression of α-smooth muscle actin and collagen type I alpha 1, collagen-related proteins, that help skin recovery was significantly increased in the DJ treatment group. Histopathologically, a relatively thin epithelial layer could be observed in the DJ administration group, as well as an increase in fibroblasts and collagen fibers. Conclusions These data suggest that DJ treatment is effective in wound healing, suppressing inflammatory proteins, increasing skin repair factors and improving histopathological changes caused by wounds.

A Method for the Effective Implementation of a Consignment Contract in Road Constructions (도로 수탁공사의 효과적 수행을 위한 방법론)

  • Bak, Gwon-June;Kim, Sung-Keun
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.30 no.2D
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    • pp.153-161
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    • 2010
  • The city planning of a local government is a continuous process that does not end with the creation of a plan but proceeds through decision-making, monitoring and evaluation phases. As a new city planning is changed and confirmed, there is a chance to construct a large scale road that is connected with an under constructed road. In this case, the expansion of the width and length of road, the addition of bridges or tunnels, and the change of the size and location of interchanges lead to many changes on road design and construction. In the past, the consignment contracts for a road construction have been made in limited numbers and for limited civil works. Now, it is growing in numbers and is making for large scale multi-works. However, the standard process and guidelines for the consignment contracts have not been suggested yet, so there is difficulty in performing the consigned road construction effectively. In this paper, the important factors for the consignment contracts are determined by construction document reviews and expert interviews. Based on these results, a standard process for the consigned contracts and a guideline for agreeing on construction cost are suggested. The costs that should be paid by a consignor are also defined.

Sluice Gates Control Monitoring of Oil Pressure-Machine Using FDC Tuning Control Technique (FDC 동조제어기법을 이용한 유압-기계식 수문 제어 모니터링)

  • Heo, Gwanghee;Kim, Chunggil
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.30 no.4A
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    • pp.337-342
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    • 2010
  • Generally most sluice gates are closed and opened by a mechanical winch, a winch using an oil-pressure, or a winch mixing both. Because of their size and structure, they should be safely operated with more than two pulling devices helping each other. At the moment of their opening and closing, there usually occur some additional loads to the structure which cannot be exactly measurable at the stage of designing. Such additional loads can cause the sluice gate to be unbalanced and make it hard to open and close the gate, and by also overloading a winch, they can inflict a significant damage to the safety of the sluice gate. This paper explains a FDC(Force-Displacement Control) system which simultaneously considered the oil-pressure and displacement in order to evenly distribute the force and make a winch balanced at the opening and closing motion. This FDC system was implemented by means of the PID(Proportional Integral Derivative) function of XG 5000 program. It was experimented on a model of the sluice gate winch with the hydraulic oil pressure cylinder. The experiments showed that the developed FDC system made the winch of hydraulic oil pressure cylinder open and close cooperatively in spite of various external loads. Therefore the FDC system is proven effective when it is applied to a winch of sluice gate.

Real-Time Terrain Visualization with Hierarchical Structure (실시간 시각화를 위한 계층 구조 구축 기법 개발)

  • Park, Chan Su;Suh, Yong Cheol
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.29 no.2D
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    • pp.311-318
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    • 2009
  • Interactive terrain visualization is an important research area with applications in GIS, games, virtual reality, scientific visualization and flight simulators, besides having military use. This is a complex and challenging problem considering that some applications require precise visualizations of huge data sets at real-time rates. In general, the size of data sets makes rendering at real-time difficult since the terrain data cannot fit entirely in memory. In this paper, we suggest the effective Real-time LOD(level-of-detail) algorithm for displaying the huge terrain data and processing mass geometry. We used a hierarchy structure with $4{\times}4$ and $2{\times}2$ tiles for real-time rendering of mass volume DEM which acquired from Digital map, LiDAR, DTM and DSM. Moreover, texture mapping is performed to visualize realistically while displaying height data of normalized Giga Byte level with user oriented terrain information and creating hill shade map using height data to hierarchy tile structure of file type. Large volume of terrain data was transformed to LOD data for real time visualization. This paper show the new LOD algorithm for seamless visualization, high quality, minimize the data loss and maximize the frame speed.

A Survey Study of IT Vocational Education Contents Development in Ubiquitous Learing for Persons with Hearing Impairments (u-Learning 기반 IT 직업교육과정 개발을 위한 청각장애인의 욕구조사)

  • Rhee, Kun Min;Kim, Dong Ok;Lee, Shin Young
    • 재활복지
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    • v.15 no.4
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    • pp.351-375
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    • 2011
  • The purpose of this study is to research the actual condition of on-line and off-line computer education in order to create more opportunities for the possibility of effective learning and u-Learning - based IT vocational education development of persons with hearing impairments. To carry out this study, we had a preliminary education of this study for a sign language interpreters who had working in a association of the deaf in Daegu, and had conducted a survey study participating for 100 persons with hearing impairments living in Daegu-Kyungbook Region. The results of this study were as follows: First, during on-line and offline education environment for persons with hearing impairments, factors such as teaching methods and contents, screen organization, learning effects, offering lecture material and subtitle, subtitle and sign language video of position and size, offering computer instructor who have a sign language interpreter with IT mentoring, on-line educational user environment setting must be considered factors for u-Learning - based IT vocational education development. Second, 74% of the subjects showed their interest in taking a course, after u-Learning contents are developed for persons with hearing impairments. Third, the subjects preferred IT device was a tablet PCs and IT certification related courses as their IT vocational education curriculum. Also, to link between professional training and job opportunity, subjects will need a IT vocational education courses such as computer intermediate and advanced levels.

A Study on Antecedents of Suicidal Ideation among Korean Older Adults: A test of the Stress-diathesis Model (노인의 자살 생각에 영향을 미치는 선행요인에 관한 연구: 스트레스 소질 모델(Stress-diathesis Model)을 중심으로)

  • Ahn, Joonhee;Chun, Miae
    • 한국노년학
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    • v.29 no.2
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    • pp.489-511
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    • 2009
  • While late-life suicide has been increasing and become an important issue for public health in Korea, little is known about the phenomenon and its contributing risk factors based on which effective preventive measures can be made. Since suicidal ideation is a major precursor to attempted and completed suicide, the objective of the present study was to reveal primary contributors to suicidal ideation. Data were collected from a cross-sectional survey of 247 community-dwelling Korean older adults (age≥60) in the mid-size city in Korea. The statistical methodology employed a robust hierarchical regression procedure that iteratively downweights outliers. Based on the stress-diathesis model, the study examined major diathesis and stressors directly explaining suicidal ideation. The study also explored the significant interaction among these factors. The findings revealed that living alone and depression were significant main antecedents of suicidal ideation. In addition, neuroticism X life events and neuroticism X depression were significant interaction terms with the strongest explanatory power, which provides an empirical evidence to support the stress-diathesis model in explaining suicidal phenomenon of the Korean elderly. The result demonstrates the theoretical implication as well as the practical implication for developing and implementing late-life suicide prevention strategies. Limitations and directions for future research are discussed.

Building robust Korean speech recognition model by fine-tuning large pretrained model (대형 사전훈련 모델의 파인튜닝을 통한 강건한 한국어 음성인식 모델 구축)

  • Changhan Oh;Cheongbin Kim;Kiyoung Park
    • Phonetics and Speech Sciences
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    • v.15 no.3
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    • pp.75-82
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    • 2023
  • Automatic speech recognition (ASR) has been revolutionized with deep learning-based approaches, among which self-supervised learning methods have proven to be particularly effective. In this study, we aim to enhance the performance of OpenAI's Whisper model, a multilingual ASR system on the Korean language. Whisper was pretrained on a large corpus (around 680,000 hours) of web speech data and has demonstrated strong recognition performance for major languages. However, it faces challenges in recognizing languages such as Korean, which is not major language while training. We address this issue by fine-tuning the Whisper model with an additional dataset comprising about 1,000 hours of Korean speech. We also compare its performance against a Transformer model that was trained from scratch using the same dataset. Our results indicate that fine-tuning the Whisper model significantly improved its Korean speech recognition capabilities in terms of character error rate (CER). Specifically, the performance improved with increasing model size. However, the Whisper model's performance on English deteriorated post fine-tuning, emphasizing the need for further research to develop robust multilingual models. Our study demonstrates the potential of utilizing a fine-tuned Whisper model for Korean ASR applications. Future work will focus on multilingual recognition and optimization for real-time inference.

A Study on the Appropriate School Placement in Urban Development Area - Centerde on Sejong Special Self-Governing City - (도시개발지역 학교 적정배치 방안 연구 - 세종특별자치시를 중심으로 -)

  • Son, Byung-Gil;Lee, Yong-Hwan
    • The Journal of Sustainable Design and Educational Environment Research
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    • v.22 no.4
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    • pp.9-17
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    • 2023
  • This study explores school location, school environment, educational conditions, and appropriate scale of schools in the context of Sejong City's development area and identifies effective school establishment plans based on the analysis of the needs of the educational community. The research questions for this study include, first, what is the change trend in the number of students as a result of the opening of schools in the development area of Sejong City to the present, and what differences are there between Sejong and other new cities? Second, what challenges arise in school location due to the occurrence of oversized schools and undergraduate institutions? Third, what challenges arise in school location that would limit the ability to create a safe school environment? Fourth, what aspects need to be improved in school location decisions to promote proper placement? A survey was conducted among parents and faculty members to collect data. The findings revealed that first, when establishing a school, identifying an appropriate location for the school was the top priority of the respondents. The second was the proximity of the school to dense housing, with a parent drop zone next to the school site. Third, to address the issue of lack of playgrounds and special class and care classes, respondents called for various measures such as securing school sites within a certain area. Finally, integrated operation schools and school facilities are required in preparation for decreasing school-age populations due to low birth rates.

A Study on Anti-Inflammatory, Antioxidant Activity and Skin Barrier Improvement of Lactobacillus rhamnosus-derived Exosomes (락토바실러스 람노서스 유래 엑소좀의 항염증, 항산화 효능 및 피부 장벽 개선에 관한 연구)

  • Hee-Sik Kim;Jong Woo Hyeon;Min Woo Kim;Ji Yeon Lee;Jun-Hwan Jang;Jun-Tae Bae
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.49 no.4
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    • pp.299-306
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    • 2023
  • In this study, exosomes were isolated by ultrafiltration from Lactobacillus rhamnosus J2K-821 and their various effects for skin were evaluated. Their size and concentration were identified 50 ~ 200 nm and 3.22 × 108 particles/mL, respectively through nanoparticle tracking analysis. In order to verify the inflammatory relief effect of Lactobacillus rhamnosus-derived exosomes (LRDEs), their nitric oxide (NO) production inhibitory ability in RAW 264.7 macrophages induced an inflammatory reaction with lipopolysaccharide (LPS) was confirmed. It was revealed that they inhibited NO production in a concentration-dependent manner. To evaluate the antioxidant activity and skin barrier improvement effect of LRDEs, their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and hyaluronidase inhibitory activity were confirmed. It was also revealed that their activities were increased by concentration-dependent manner. Through these results, It is believed that LRDEs can be used as a effective natural cosmetic ingredient for anti-inflammation, antioxidation and skin barrier improvement.

Warpage and Solder Joint Strength of Stacked PCB using an Interposer (인터포저를 이용한 Stacked PCB의 휨 및 솔더 조인트 강도 연구)

  • Kipoong Kim;Yuhwan Hwangbo;Sung-Hoon Choa
    • Journal of the Microelectronics and Packaging Society
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    • v.30 no.3
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    • pp.40-50
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    • 2023
  • Recently, the number of components of smartphones increases rapidly, while the PCB size continuously decreases. Therefore, 3D technology with a stacked PCB has been developed to improve component density in smartphone. For the s tacked PCB, it i s very important to obtain solder bonding quality between PCBs. We investigated the effects of the properties, thickness, and number of layers of interposer PCB and sub PCB on warpage of PCB through experimental and numerical analysis to improve the reliability of the stacked PCB. The warpage of the interposer PCB decreased as the thermal expansion coefficient (CTE) of the prepreg decreased, and decreased as the glass transition temperature (Tg) increased. However, if temperature is 240℃ or higher, the reduction of warpage is not large. As FR-5 was applied, the warpage decreased more compared to FR-4, and the higher the number and thickness of the prepreg, the lower the warpage. For sub PCB, the CTE was more important for warpage than Tg of the prepreg, and increase in prepreg thickness was more effective in reducing the warpage. The shear tests indicated that the dummy pad design increased bonding strength. The tumble tests indicated that crack occurrence rate was greatly reduced with the dummy pad.