• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3541-3547
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• 2013

Background: This cross-sectional observational study was undertaken to establish clinico-pathological characteristics of patients with gynecological malignancies, focusing mainly on symptoms, histological type and stage of the disease at presentation, in a tertiary care setting in Eastern India. Materials and Methods: In the gynecology out-patient clinic of a tertiary care hospital in Kolkata, India, the patients with suggestive symptoms of gynecological malignancies were screened. Their diagnoses were confirmed by histopathology. One hundred thirteen patients with histopathologically confirmed gynecological malignancies were interviewed. Results: The most frequently reported symptoms by the patients with histopathologically confirmed gynecological malignancies were excessive, offensive with or without blood stained vaginal discharge (69.0%), irregular, heavy or prolonged vaginal bleeding (36.3%) and postmenopausal bleeding (31.9%). The majority of the patients (61.0%) had squamous cell carcinoma on histopathological examination, followed by adenocarcinoma (30.1%). Nearly half of the patients (48.7%) were suffering from the Federation Internationale des Gynaecologistes et Obstetristes (FIGO) stage III, followed by stage II (40.7%) malignancy. Conclusions: This study highlights that most of the patients with gynecological malignancies present late at an appropriate health care facility. Ovarian cancer may often have non-specific or misleading symptomatic presentation, whereas cervical cancer often presents with some specific symptoms. These observations point to the need for increasing awareness about gynecological malignancies in the community and providing easily accessible adequate facilities for early detection and treatment of the disease by optimal use of available resources, i.e. strengthening the primary health care system.

• The Journal of the Petrological Society of Korea
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• v.18 no.2
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• pp.137-151
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• 2009

Synthetic analyses of field data, including rock facies, contact relationships, petrography, structural elements, and etc., and previous geochemical and absolute age data of the Tertiary Churyeong Breccia and its surrounding volcanics in the Gyeongju city, Korea, have led to the following results. (1) The Tertiary rocks are divided into the dacitic tuffs, Churyeong Breccia, and andesitic rocks in ascending order. The dacitic tuffs are unconformably overlain by the Churyeong Breccia which is intruded by or conformably overlain by the andesitic rocks. (2) The dacitic tuffs are correlated with the Paleocene${\sim}$Eocene Wangsan dacitic volcanics, while the Churyeong Breccia and andesitic rocks are correlated with the early Early Miocene Andongri Formation and Yongdongri Tuffs in the Waeup Basin, respectively. (3) The Churyeong Breccia accumulated rapidly in the NE-trending graben about 1.5 km in width during the crustal extension in the NW-SE direction due to the East Sea opening. (4) Dacitic${\sim}$andesitic volcanism and crustal extension were active during the early Early Miocene times in SE Korean peninsula. During the deposition the Churyeong Breccia, especially, the volcanism ceased for some time, but the active normal faulting led to the formation of grabens in places.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2004.11a
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• pp.250-261
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• 2004

A novel method for ab initio prediction of protein tertiary structures, PROFESY (PROFile Enumerating SYstem), is introduced. This method utilizes secondary structure prediction information and fragment assembly. The secondary structure prediction of proteins is performed with the PREDICT method which uses PSI-BLAST to generate profiles and a distance measure in the pattern space. In order to predict the tertiary structure of a protein sequence, we assemble fragments in the fragment library constructed as a byproduct of PREDICT. The tertiary structure is obtained by minimizing the potential energy using the conformational space annealing method which enables one to sample diverse low lying minima of the energy function. We apply PROFESY for prediction of some proteins with known structures, which shows good performances. We also participated in CASP5 and applied PROFESY to new fold targets for blind predictions. The results were quite promising, despite the fact that PROFESY was in its early stage of development. In particular, the PROFESY result is the best for the hardest target T0161.

• Economic and Environmental Geology
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• v.27 no.1
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• pp.65-80
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• 1994

The Tertiary $Ch{\check{o}}ngja$ basin is located in the southeastern coastal area of the Korean Peninsula. It is a lozenge shaped fault-bounded basin with circa $5{\times}5km$ areal extent, isolated from other Tertiary basins by the Cretaceous Ulsan Formation in-between. The northwestern boundary of the basin is a domino/listric type normal fault trending $N30^{\circ}E$, whereas its southwestern boundary is a dextral strike-slip fault (trending $N20^{\circ}W$) with a lateral offset of more than 1 km. The basin is bounded by the East Sea on the eastern margin. Basin-fills consist of extrusive volcanic rock (Tangsa Andesites) of Early Miocene (16~22 Ma in radiometric age), unconsolidated fluviatile conglomerate (Kangdong Formation) and shallow brackish-water sandstone ($Sinhy{\check{o}}n$ Formation). The latter yields abundant Vicarya-Anadara molluscan fossils of early Middle Miocene age. The Tertiary strata become younger toward the northwestern boundary-fault of the basin, showing a zonal distribution pattern parallel to the fault: the younger sedimentary formations occupy a narrow zone of 2 km width along the northwestern boundary-fault, whereas the older Tangsa Andesites underlie them unconformably in the eastern and southeastern portions of the basin. The strata in the basin, including the Tangsa Andesites, are tilted (about $20^{\circ}$) toward the northwestern boundary-fault Sedimentary strata thicken toward the boundary-fault, forming a wedge shaped half-graben structure. A number of small-scale syndepositional normal growth faults and graben structures are observed in the sedimentary strata. These extensional structures have the same trend as the normal northwestern boundary-fault which we interpret as a pull-apart detachment fault. These characteristics imply persistent extension during the basin evolution, caused by a NW-SE directed tensional force. The $Ch{\check{o}}ngja$ basin is, thus, a kind of syndepositional tectonic basin evolved in a strike-slip (pull-apart) regime. The latter was caused by a dextral simple shear associated with the NNW-SSE opening of the East Sea. In view of the fact that the normal growth faults do not cut through the uppermost portion of the youngest $Sinhy{\check{o}}n$ Formation, it is inferred that the tensional force came to be inactive in the early Middle Miocene. This is coincident in timing with the termination of the East Sea opening (15 Ma).

• Applied Chemistry for Engineering
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• v.1 no.2
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• pp.147-153
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• 1990

Poly(hydroxypropyl methacrylate) membranes and matrix devices having tertiary amine moiety were prepared by sintering method, and their permeation characteristics were investigated. The water content of this membrane was increased with decreasing the pH of the medium. The permeability of this membrane was increased with decreasing the sintering pressure. Using sintered matrix device 'burst effect' was found at the early stage, and initial insulin release of glucose oxidase immobilized matrix device could be controlled by glucose concentration of the solution.

• Bulletin of the Korean Chemical Society
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• v.13 no.5
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• pp.517-520
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• 1992

Solvent exchange rates of selected protons were measured by NMR saturation recovery method for yeast $tRNA^{Phe}$, at temperature from 25 to $40^{\circ}C$, in the presence of 0.1 M NaCl and various low levels of added magnesium ion. The exchange rates in zero $Mg^{2+}$ concentration indicate early melting of acceptor stem, D stem, and tertiary structure. Addition of magnesium ion stabilizes the entire D stem more effectively than any other secondary or tertiary interactions.

• Economic and Environmental Geology
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• v.18 no.1
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• pp.23-39
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• 1985

The northeastern part of Ogcheon zone which consisted mainly of Cambro-Ordovician arenaceous, argillaceous and calcareous formations and Carboni-Triassic arenaceous and argillaceous formations is delineated as the eastern mass of a thrust fault along Choongju-Moongyong-Cheongsan in the middle of the zone. The present study proposes a geotectonic line, Imgye-Samchog fault(see, figure 1) which divides the northeastern part into two blocks, Hambacksan block in the west and East coast block in the east. The igneous rocks in the Hambacksan block ranging from granite to gabbro are distributed in a symmetrical zones parallel to general direction of Ogcheon zone as follows (Fig. 2 and Table 2). Southeast igneous rock zone: it aligns Jurassic granites in its south and Precambrian leucocratic granites in its north. Central igneous rock zone: it aligns Cretaceous granites in its south and Jurassic granites, and some of diorite and gabbro in its north. Northwest igneous rock zone: aligns Jurassic granites in its south and huge batholithic granodiorite in its north. The distribution of the igneous rocks in the East coast block shows an entirely different features from those of Hanbacksan block. In the southern part of the block they assemble in a narrow area ranging in age from Early Proterozoic, through Middle to Late Proterozoic, Devonian, Jurassic, Cretaceous to Tertiary, whereas, the igneous rocks in the northern part of the block gathered to a restricted area, in ages of Middle Proterozoic and Cretaceous. The assemblage of the igneous rocks in the studied area shows a compositionally restricted, mixed S-type and I-type granites, $^{87}Sr/^{86}Sr$ > 0.706, rare volcanics and shortening with upright folding. These lithologic and structural features suggest that the igneous activity in this part related intimately to Hercynotype Orogeny of Pitcher(1979). Chronological episodes of igneous activity from Early Proterozoic to Early Tertiary in the northeastern part are figured.

• Journal of the Korean earth science society
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• v.29 no.3
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• pp.255-262
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• 2008

Late Cretaceous to early Tertiary paleostress was evaluated by analyzing the healed microcracks in the Cretaceous granite of the Goheung area, south Korea. Healed microcracks in five granite samples (GH-1, GH-3, GH-4, GH-5, GH-8) were investigated and measured according to direction. The directions of maximum horizontal principal stress in GH-1, GH-3, and GH-4 are dominantly $N60^{\circ}W\;and\;N70^{\circ}E,\;N20^{\circ}W\;and\;N50^{\circ}W$, while minor directions are N-S and $N30^{\circ}E$. In GH-5 and GH-8, $N40^{\circ}E\;and\;N10^{\circ}E$ are the most dominant directions, while $N40^{\circ}W$ is the minor direction. Thus overall, the most dominant directions of healed microcracks in the study area are oriented $N60^{\circ}W$, while minor directions are oriented $N20^{\circ}W,\;N20^{\circ}E\;and\;N70^{\circ}E$, essentially NE. Combining the paleostress results of this study with other studies, the direction of the maximum horizontal principal stress in the study area during the late Cretaceous to the early Tertiary should perhaps be changed WNW to NE. The reason for this is thought to be the complex tectonic movements which occurred in northeast Asia at that time.

• Journal of Korean Critical Care Nursing
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• v.4 no.1
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• pp.65-73
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• 2011

Purpose: This study was to develop and evaluate stability and effects of an early exercise program for patients with open heart surgery. Methods: The subjects of this study were 30 patients who had either a coronary bypass surgery or a valvular heart surgery at a tertiary hospital in Seoul. The data was collected by observation and measurement from October 1, 2004 to November 15, 2004. Results: The early exercise program developed for this study consisted of range of motion exercise and walking. Intensity of walking was 1~3 METs and increased progressively to daily target distance. During exercise, the subjects were monitored heart rate, blood pressure and RPE (Rating of Perceived Exertion). The mean FIM (Functional Independent Measurements) score of subjects was significantly improved after the early exercise program. However, several complaints such as dizziness or pain were also reported. Most complaints were associated with chest tube and RPE. Conclusion: The early exercise program can help to recover patients' physical activities after surgery, and can be applied to most patients. Patients' RPE, dizziness and pain was possible limitations, therefore, active pain control and prevention of accidents for patients would be needed.

• Communications of Mathematical Education
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• v.23 no.4
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• pp.977-998
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• 2009

In this article, we give a comparative study on the last 300 years of USA and Korean tertiary mathematics. The first mathematics classes in United States were offered before July, 1638, but the real founding of tertiary mathematics courses was in 1640 when Henry Dunster assumed the duties of the presidency at Harvard. President Dunster read arithmetics and geometry on Mondays and Tuesdays to the third year students during the first three quarters, and astronomy in the last quarter. So tertiary mathematics education in United States began at Harvard which is the oldest college in USA. After 230 years since then, Benjamin Peirce in 1870 made a major and first American contribution to mathematics and got an attention from European mathematicians. Major change on the role of Harvard mathematics from teaching to research made by G.D. Birkhoff when he joined as an assistant professor in 1912. Tertiary mathematics education in Korea started long before Chosun Dynasty. But it was given to only small number of government actuarial officers. Modern mathematics education of tertiary level in Korea was given at Sungkyunkwan, Ewha, Paichai, and Soongsil. But all college level education opportunity, particularly in mathematics, was taken over by colonial government after 1920. And some technical and normal schools offered some tertiary mathematics courses. There was no college mathematics department in Korea until 1945. After the World War II, the first college mathematics department was established, and Rimhak Ree in 1949 made a major and first Korean contribution to modern mathematics, and later found Ree group. He got an attention from western mathematicians for the first time as a Korean. It can be compared with Benjamin Peirce's contribution for USA.