• Title/Summary/Keyword: ESD

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Predictive Significance of Promoter DNA Methylation of Cysteine Dioxygenase Type 1 (CDO1) in Metachronous Gastric Cancer

  • Kubota, Yo;Tanabe, Satoshi;Azuma, Mizutomo;Horio, Kazue;Fujiyama, Yoshiki;Soeno, Takafumi;Furue, Yasuaki;Wada, Takuya;Watanabe, Akinori;Ishido, Kenji;Katada, Chikatoshi;Yamashita, Keishi;Koizumi, Wasaburo;Kusano, Chika
    • Journal of Gastric Cancer
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    • v.21 no.4
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    • pp.379-391
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    • 2021
  • Purpose: Promoter DNA methylation of various genes has been associated with metachronous gastric cancer (MGC). The cancer-specific methylation gene, cysteine dioxygenase type 1 (CDO1), has been implicated in the occurrence of residual gastric cancer. We evaluated whether DNA methylation of CDO1 could be a predictive biomarker of MGC using specimens of MGC developing on scars after endoscopic submucosal dissection (ESD). Materials and Methods: CDO1 methylation values (TaqMeth values) were compared between 33 patients with early gastric cancer (EGC) with no confirmed metachronous lesions at >3 years after ESD (non-MGC: nMGC group) and 11 patients with MGC developing on scars after ESD (MGCSE groups: EGC at the first ESD [MGCSE-1 group], EGC at the second ESD for treating MGC developing on scars after ESD [MGCSE-2 group]). Each EGC specimen was measured at five locations (at tumor [T] and the 4-point tumor-adjacent noncancerous mucosa [TAM]). Results: In the nMGC group, the TaqMeth values for T were significantly higher than that for TAM (P=0.0006). In the MGCSE groups, TAM (MGCSE-1) exhibited significantly higher TaqMeth values than TAM (nMGC) (P<0.0001) and TAM (MGCSE-2) (P=0.0041), suggesting that TAM (MGCSE-1) exhibited CDO1 hypermethylation similar to T (P=0.3638). The area under the curve for discriminating the highest TaqMeth value of TAM (MGCSE-1) from that of TAM (nMGC) was 0.81, and using the cut-off value of 43.4, CDO1 hypermethylation effectively enriched the MGCSE groups (P<0.0001). Conclusions: CDO1 hypermethylation has been implicated in the occurrence of MGC, suggesting its potential as a promising MGC predictor.

Development of Impression Management Education Program for Career Women (직장 여성을 위한 인상관리 교육프로그램 설계)

  • Hwang, Jung-Sun;Lee, Yoon-Jung
    • Journal of Korean Home Economics Education Association
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    • v.34 no.1
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    • pp.97-111
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    • 2022
  • The purpose of this study is to systematically develop an impression management education program for career women by applying the Educational System Development Model [ESD] (Kwon, 1997) based on the research results of Hwang and Lee(2019) on social attractiveness. Since the previous impression management education programs were generally developed by content experts, few of them were developed systematically by considering the learner characteristics, clearly setting the educational goals, and structuring the contents accordingly. In this study, 'social attractiveness' defined by Hwang and Lee (2019) was considered as the educational goal of the impression management education program. In particular, this study focused on the design stage of the ESD model, set teaching goals based on the components of social attractiveness derived from previous studies, and conducted an analysis of teaching activities, the establishment of the educational goals at the specific function level, allocation of time, and establishment of an evaluation plan. The research process was intended to improve the learners' social image directly related to success through a systematic educational program designed to enhance the social attractiveness of working women with various hands-on activities and information. The impression management education program designed in this study has the educational advantage of a learner-centered education program configured to meet the needs and goals of career women. In addition, based on the ESD model, the sub-factors necessary for impression management were identified, and the curriculum was configured to reflect them through mutual communication between the instructor and learners. Therefore, this education program meets the basic requirements of impression management education necessary for career women and is expected to contribute to enhancing the social attractiveness of working women.

Dynamic License Control in Online Electronic Software Distribution (소프트웨어 온라인 전자 유통에서의 동적 사용권 관리 기술)

  • Ha, Young-Guk;Lim, Shin-Young;Ham, Ho-Sang;Park, Hyo-Joon;Kim, Tai-Yun
    • IE interfaces
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    • v.13 no.1
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    • pp.133-140
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    • 2000
  • As the internet dramatically grows, internet electronic commerce is being increased. But, as products distributed with ESD(Electronic Software Distribution) are in the form of electronic file, it is difficult to prohibit illegal copy of products. Therefore, new technology is needed to distinguish legal products from illegal ones. In this paper, we present the ESD's requirements, characteristics and a new dynamic license management technology to prevent illegal copy.

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Dynamic analysis of charged human body electrostatic discharge - comparison with quasi-static discharge (대전인체의 정전기 방전에 대한 동적해석 - 준정적해석과의 비교)

  • 이종호;김두현;김상철;김상렬
    • Proceedings of the Korean Institute of Industrial Safety Conference
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    • 1998.05a
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    • pp.257-262
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    • 1998
  • In order to understand the characteristics of electrostatic discharge (ESD) by a charged human body, a dynamic analysis method based on RCL circuit and a quasi-static analysis method based on two-body model are introduced. In this paper, these methods calculate waveforms, discharge energy and potential difference to analyze the ESD phenomena from given initial conditions and geometry. Results are compared and discussed.

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An Analytical Approach to the Spark Resistance Formula Caused by Electrostatic Discharge

  • Kang, In-Ho;Kim, Dong-Il
    • Journal of the Korean Institute of Navigation
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    • v.21 no.2
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    • pp.69-75
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    • 1997
  • A modern electric system located at a certain distance from the discharge may respond with unexpected sensitivity, when an electrostatic discharge (ESD) phenomenon occurs heteronomously between metallic objects. For analyzing the transient electromagnetic fields caused by ESD, two resistance formulas - Toepler and Rompe-Weizel -are introduced. The experimental result given by Wilson-Ma are used to compare which of these resistance formulas is proper.

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Latchup Characteristics of N-Type SCR Device for ESD Protection (정전기 보호를 위한 n형 SCR 소자의 래치업 특성)

  • Seo, Y.J.;Kim, K.H.;Lee, W.S.
    • Proceedings of the KIEE Conference
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    • 2006.07c
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    • pp.1372-1373
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    • 2006
  • An electrostatic discharge (ESD) protection device, so called, N-type SCR with P-type MOSFET pass structure (NSCR_PPS), was analyzed for high voltage I/O applications. A conventional NSCR_PPS device shows typical SCR-like characteristics with extremely low snapback holding voltage, which may cause latchup problem during normal operation. However, a modified NSCR_PPS device with proper junction/channel engineering demonstrates highly latchup immune current- voltage characteristics.

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Reduction of Entrance Surface Dose Depending on Shielding Methods for Panoramagraphy (파노라마 X선 검사시 차폐방법에 따른 Entrance Surface Dose 저감)

  • Choi, Jung-Hyun;Kim, Sung-Chul;Han, Dong-Kyoon
    • Journal of radiological science and technology
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    • v.38 no.3
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    • pp.199-203
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    • 2015
  • Panoramagraphy was the second most used intraoral radiography utilized in Korea, resulting in 17.8% in university dental hospitals, 24.8% in dental hospitals, and 31.4% in dental clinics. Depending on increased demand like orthodontics and implant, panoromagraphy tends to consistently increase. This study were used lead glasses and lead shielding to reduce unnecessary radiation to the eyeballs and thyroid. ESD was 41.4% when radiation was shielded with the lead glasses while reducing 47.3% of ESD by shielding the X-ray tube area with shielding lead. There was no statistically significant difference. The lead glasses is appropriated to reduce unnecessary radiation exposure to the eyeballs.

Comparisons and Measurements the Dose Value Using the Semiconductor Dosimeter and Dose Area Product Dosimeter in Skull, Chest and Abdomen (두개부, 흉부, 복부검사 시 반도체 선량계와 면적 선량계를 이용한 선량 값의 측정 및 비교)

  • Kim, Ki-Won;Son, Jin-Hyun
    • Journal of radiological science and technology
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    • v.38 no.2
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    • pp.101-106
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    • 2015
  • Recently, There has been a growing interests in exposure dose to the patient who take a examination using radiation. The radiological technologists should be concerned about the exposure dose to patients and make an efforts to reduce the patient dose without decreasing the image quality. In the case of foreign, the exposure dose of general X-ray examination have been managed by standard value of exposure dose using dose area product (DAP) and entrance surface dose (ESD) dosimeter. This study is to compare DAP and ESD in skull anterior posterior (AP), chest posterior anterior (PA), and abdomen AP projections of phantom by using DAP and ESD dosimeter. In the results, there were no differences between DAP and ESD dosimeter.