• Journal of Genetic Medicine
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• v.10 no.2
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• pp.81-87
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• 2013

Pseudohypoaldosteronism (PHA), a rare syndrome of systemic or renal mineralocorticoid resistance, is clinically characterized by hyperkalemia, metabolic acidosis, and elevated plasma aldosterone levels with either renal salt wasting or hypertension. PHA is a heterogeneous disorder both clinically and genetically and can be divided into three subgroups; PHA type 1 (PHA1), type 2 (PHA2) and type 3 (PHA3). PHA1 and PHA2 are genetic disorders, and PHA3 is a secondary disease of transient mineralocorticoid resistance mostly associated with urinary tract infections and obstructive uropathies. PHA1 includes two different forms with different severity of the disease and phenotype: a systemic type of disease with autosomal recessive inheritance (caused by mutations of the amiloride-sensitive epithelial sodium channel, ENaC) and a renal form with autosomal dominant inheritance (caused by mutations of the mineralocorticoid receptor, MR). In the kidneys, the distal nephron takes charge of the fine regulation of water absorption and ion handling under the control of aldosterone. Two major intracellular actors necessary for the action of aldosterone are the MR and the ENaC. Impairment of the intracellular aldosterone signal transduction pathway results in resistance to the action of mineralocorticoids, which leads to PHA. Herein, ion handling the distal nephron and the clinico-genetic findings of PHA are reviewed with special emphasis on PHA type 1.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.2
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• pp.65-69
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• 2006

The present study was undertaken to explore the role of autonomic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their sympathetic or parasympathetic nerves to the submandibular gland. One week later, the expression of Na,K-ATPase, epithelial sodium channels (ENaC), and aquaporins (AQP) was examined in the denervated and contralateral glands. The sympathetic denervation slightly but significantly decreased the expression of ${\alpha}1$ subunit of Na,K-ATPase, whereas the parasympathetic denervation increased it. The expression of ${\alpha}$-subunit of ENaC was significantly increased in both the denervated and contralateral glands either by the sympathetic or parasympathetic denervation. The sympathetic denervation significantly increased the expression of AQP5 in both the denervated and contralateral glands, whereas the parasympathetic denervation decreased it. It is suggested that the autonomic nerves have a tonic effect on the regulation of sodium transporters and AQP water channels in the salivary gland.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2004.10a
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• pp.10-10
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• 2004

• Proceedings of the Korea Society for Simulation Conference
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• 1999.10a
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• pp.1-6
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• 1999

본 논문에서는 TCP를 사용한 위성망에서의 문제점을 도출하고 그에 대한 성능향상 알고리즘을 제안하였다. 긴 전파 지연과 높은 에러율을 지닌 위성링크는 TCP의 성능을 현저히 떨어뜨린다. 특히 TCP에서는 에러에 의한 세그먼트 손실도 Congestion에 의한 손실로 판단하여 Slow Start나 Congestion Avoidance 알고리즘을 적용시킨다. 따라서 본 논문에서는 에러에 의한 손실과 Congestion의한 손실을 구분해 주는 ENA(Error Notification Ack) 알고리즘을 제안했다. 그리고 위성에서 좋은 성능을 나타내는 SACK TCP에 이 알고리즘을 적용시켜 성능을 평가했다.

• Cross-Cultural Studies
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• v.27
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• pp.81-104
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• 2012

This paper looks into the complexity of the comparative and conflictive elements portrayed on the novel Nada. Through the interpretation of the actions of the female characters, we can classify them into two different categories: pro-Franco and anti-Franco system. Thus, for example, the character Ena is an active, intellectual and liberal woman capable to manipulate and control men who lives at her own free will. This active and liberal personality is clearly not the favored type of woman under Franco, which prefers a society where men are the dominant figures. Another female character, Gloria, places herself far from the Catholicism based morality during the Franco period as she is having an affair with her husband's brother. We also find examples of the opposite, that is, affinity with Franco ideals, such as Angustias' decision to become a member of the convent, in line with the motto "Spain, united and great, through Catholicism"; the example of Ena's mother, nurturing six sons and daughters, also resonates with Franco ideology of a woman's role in the Spanish society, being mostly a reproductive instrument. One of the topics of this novel is the confrontation between the prewar petit bourgeoisie and the new postwar bourgeoisie. We can appreciate a big difference between the lifes of Andrea's family and Pons' family. Andrea has friendly relationships with friends from the new bourgeoisie; however, these interactions are not genuine, but superficial. Because of that, we also conclude that this novel reflects the underlying conflicts between different social strata. We also observe the conflicts and confrontations between republicans and nationalists in this society, through the relationships between two brothers, Juan y $Rom{\acute{a}}n$. During the civil war, Juan collaborates with the national faction, while $Rom{\acute{a}}n$ joins the republican faction. Consequently, they separate from each other due to their different ideologies. We will conclude that this novel also reflects on the idea that the Spanish civil war destroyed fraternity and separated families.

• The Journal of Advanced Prosthodontics
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• v.13 no.5
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• pp.281-291
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• 2021

PURPOSE. To evaluate the wear of computer-aided design/computer-aided manufacturing (CAD-CAM) dental ceramic materials opposed by enamel as a function of increased chewing forces. MATERIALS AND METHODS. The enamel cusps of healthy human third molar teeth (n = 40) opposed by materials from CAD-CAM dental ceramic groups (n = 10), including Vita Enamic^® (ENA), a polymer-infiltrated ceramic network (PICN); GC Cerasmart^® (CERA), a resin nanoceramic; Celtra^® Duo (DUO), a zirconia-reinforced lithium silicate (ZLS) ceramic; and IPS e.max ZirCAD (ZIR), a polycrystalline zirconia, were exposed to chewing simulation (1,200,000 cycles; 120 N load; 1 Hz frequency; 0.7 mm lateral and 2 mm vertical motion). The wear of both enamel cusps and materials was quantified using a 3D laser scanner, and the wear mechanisms were evaluated by scanning electron microscopy (SEM). The results were analysed using Welch ANOVA and Kruskal Wallis test (α = .05). RESULTS. ZIR showed lower volume loss (0.02 ± 0.01 mm³) than ENA, CERA and DUO (P = .001, P = .018 and P = .005, respectively). The wear of cusp/DUO [0.59 mm³ (0.50-1.63 mm³)] was higher than cusp/CERA [0.17 mm³ (0.04-0.41 mm³)] (P = .007). ZIR showed completely different wear mechanism in SEM. CONCLUSION. Composite structured materials such as PICN and ZLS ceramic exhibit more abrasive effect on opposing enamel due to their loss against wear, compared to uniform structured zirconia. The resin nano-ceramic causes the lowest enamel wear thanks to its flexible nano-ceramic microstructure. While zirconia appears to be an enamel-friendly material in wear volume loss, it can cause microstructural defects of enamel.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2005.04a
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• pp.371-374
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• 2005

We accomplished optimization for pump and treat (P&T) designs in consideration of degradation processes such as retardation and biodegradation, which are significant for contaminant fate in hydrogeology. For more desirable remediation, optimal pumping duration and minimum pumping rate constraint problems are studied. After a specific P&T duration, it replaces the P&T with the enhanced natural attenuation (ENA), which induces aerobic biodegradation by maintaining oxygen concentration. The design in this strategy carries out the optimization for the number and locations of oxygen injection wells.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2005.11a
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• pp.99-100
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• 2005

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1998.06a
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• pp.219-222
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• 1998

In this study, The water tree characteristics were investigated when crosslinking coagent was added in XLPE/EnBA blends. When XLPE was blended with EnBA, there was a decrease of water tree length as an increase of nBA contents in XLPE/EnBA20 blends. The effect of crosslinking coagent. A was better than those of other crosslinking coagents B, C and D in water tree retardation. In case of XLPE/EnBA/Crosslinking coagent blends, water tree length was increased as the crosslinking coagents were increased from 0.2 to 2 phr in 2.0 phr DCP content. To clarify the effects of crosslinking coagent, the DCP contents were changed from 1.5 to 2.0 par in the same crosslinking coagent contents. Then, there was a decrease of water tree length as an increase of crosslinking coagent contents in 1.5 and 1.8 phr DCP contents.

• YAKHAK HOEJI
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• v.43 no.5
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• pp.665-673
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• 1999

This study was performed in order to investigate the effect of ketanserin, a specific antagonist of 5-HT2 receptor, on renal function in dogs. Ketanserin (50.0 and $150.0{\;}\mu\textrm{g}/kg$), when given intravenously, produced antidiuretic action accompanied with the decreased amounts of sodium and potassium excreted in urine (ENa, EK) and the increased reabsorption rates of sodium and potassium in renal tubules (RNa, RK). Ketanserin (50.0 and $50.0{\;}\mu\textrm{g}/kg$), when administered into a renal artery, elicited antidiuretic action in both experimental and control kidney, this time changes of renal function showed the same aspect as when given intravenously. Ketanserin (15.0 and $50.0{\;}\mu\textrm{g}/kg$) injected into the carotid artery exhibited also antidiuretic action and this antidiuretic action was not affected by renal denervation. Above results suggest that ketanserin elicits antidiuretic through central function, this central antidiuretic action is not mediated by renal nerves.