• Molecules and Cells
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• v.41 no.9
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• pp.868-880
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• 2018

Pancreatic cancer (PC) is one of the most aggressive cancers presenting with high rates of invasion and metastasis, and unfavorable prognoses. The current study aims to investigate whether EZH2/miR-139-5p axis affects epithelial-mesenchymal transition (EMT) and lymph node metastasis (LNM) in PC, and the mechanism how EZH2 regulates miR-139-5p. Human PC and adjacent normal tissues were collected to determine expression of EZH2 and miR-139-5p, and their relationship with clinicopathological features of PC. Human PC cell line was selected, and treated with miR-139-5p mimics/inhibitors, EZH2 vector or shEZH2 in order to validate the regulation of EZH2-mediated miR-139-5p in PC cells. Dual-luciferase report gene assay and chromatin immunoprecipitation assay were employed to identify the relationship between miR-139-5p and EZH2. RT-qPCR and Western blot analysis were conducted to determine the expression of miR-139-5p, EZH2 and EMT-related markers and ZEB1/2. Tumor formation ability and in vitro cell activity were also analyzed. Highly-expressed EZH2 and poorly-expressed miR-139-5p were detected in PC tissues, and miR-139-5p and EZH2 expressions were associated with patients at Stage III/IV, with LNM and highly-differentiated tumors. EZH2 suppressed the expression of miR-139-5p through up-regulating Histone 3 Lysine 27 Trimethylation (H3K27me3). EMT, cell proliferation, migration and invasion were impeded, and tumor formation and LNM were reduced in PC cells transfected with miR-139-5p mimics and shEZH2. MiR-139-5p transcription is inhibited by EZH2 through up-regulating H3K27me3, thereby down-regulation of EZH2 and up-regulation of miR-139-5p impede EMT and LNM in PC. In addition, the EZH2/miR-139-5p axis presents as a promising therapeutic strategy for the treatment of PC.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.4
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• pp.2320-2323
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• 2014

Piezoelectric inverter for driving CCFL is designed in this study. Of them, CCFL is generally used because it has advantages such as small size, high efficiency and good brightness characteristics. the description of the piezoelectric effect is not present here and can be easily found in numerous publications as well as complex equations and formulae. What is the most important to understand is that "they are different" one cannot just change an electromagnetic transformer(EMT) for a piezoelectric one. The simulation program supports the modeled piezoelectric inverter for this paper and the equivalent circuit. The result of the experiment shows more than 90% improvement in terms of the efficiency.

• BMB Reports
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• v.51 no.9
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• pp.456-461
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• 2018

Chemoresistance is a major barrier to successful cisplatin-based chemotherapy for epithelial ovarian cancer (EOC), and emerging evidences suggest that microRNAs (miRNAs) are involved in the resistance. In this study, it was indicated that miR-363 downregulation was significantly correlated with EOC carcinogenesis and cisplatin resistance. Moreover, miR-363 overexpression could resensitise cisplatin-resistant EOC cells to cisplatin treatment both in vitro and in vivo. In addition, data revealed that EMT inducer Snail was significantly upregulated in cisplatin-resistant EOC cell lines and EOC patients and was a functional target of miR-363 in EOC cells. Furthermore, snail overexpression could significantly attenuate miR-363-suppressed cisplatin resistance of EOC cells, suggesting that miR-363-regulated cisplatin resistance is mediated by snail-induced EMT in EOC cells. Taken together, findings suggest that miR-363 may be a biomarker for predicting responsiveness to cisplatin-based chemotherapy and a potential therapeutic target in EOC.

• The Journal of the Korea Contents Association
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• v.11 no.7
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• pp.210-218
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• 2011

This study was conducted to identify instructor's experience on simulation education. The subjects were nine instructors in simulation education of EMT students. Data were collected through documents and in-depth interview from participants. It was analyzed by phenomenological method, using Colaizzi's method. The results of this study were as a follows. From the protocol, significant statements were organized into formulated meanings. The formulated meanings were identified 28 themes, 9 theme clusters, and 4 categories. The 4 categories were as follows; discomfort of forming the learning environment; burden of instructor's role; difficulty from insufficient education condition; possibility of new education. This study suggested that improvement of simulation education can be accomplished by providing opportunities to learn the simulation technology, using the pre-programmed scenarios, having technical support from specialist or additional operator, and adjusting the current paramedic curriculum.

• The Korean Journal of Emergency Medical Services
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• v.7 no.1
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• pp.135-146
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• 2003

The purpose of this study was to improve EMS-System in Korea through the research in EMS-System of advanced country. The response time is defined as the interval from the time of call receipt to the time of scene arrival. The important factor was to shorten moving distance of ambulance. It should be considered to accomplish this factor that the vehicle must be increased and the convenient location chosen for optimizing of service area. The transport of emergency patients carried out almost by 119 Emergency Medical Service but out of all the employees at 119 EMS only 11.3% have own qualified EMT degree. They should be employed more and more specially at 119 EMS for a superior level of emergency medical care for civilian. In America, EMT can take care of emergency patients following the order from medical Director at the scene of accident. But in Germany, prehospital care was emphasized from the beginning and, in those days, a medical doctor was sent for treatment of emergency patients at the scene, the so-called a Rendezvous system. Hierby this study makes the suggestion to improve the EMS-System, it is effective to use the medical Director system in America and furthermore a Rendezvous system in Germany. The functional integratin and unification of the report system as well as enough personal and equipmental elements saved together invaluable lives.

• The Korean Journal of Emergency Medical Services
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• v.21 no.3
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• pp.59-71
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• 2017

Purpose: The purpose of the study was to evaluate the ergonomic risk factors of 119 emergency medical technicians (EMT) with musculoskeletal disorders, performing emergency medical services (EMS) procedures in a firefighter combat challenge. Methods: The evaluated EMT procedures were cardiopulmonary resuscitation (CPR) & intubation, trauma patient assessment, and intravenous (IV) injection. Measurement of working posture was done during training. Results: In CPR & intubation, OWAS-score was 2 (mean 1.9, maximum 4), requiring correction action, while REBA-score was 11 (mean 7.28, maximum 11), requiring immediate improvement. In trauma patient assessment & IV injection, OWAS-score was 4 (mean 2.9, maximum 4), requiring immediate correction action, while the REBA score was 7 (mean 7.5, maximum 11), requiring improvement. Conclusion: Both OWAS score and REBA-score showed improvement of posture and high-risk of musculoskeletal disorders. Occupational health management in EMS procedures during combat challenge and effective injury prevention program in fire stations are warranted.

• KEPCO Journal on Electric Power and Energy
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• v.3 no.1
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• pp.17-21
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• 2017

Recently, the Korea Enhanced Power system Simulator (KEPS) was upgraded with new processor cards and various peripheral devices. The purpose of the upgrade is for the large-scale AC/DC simulation studies for different purposes such as FACTS, PMU applications, and SPS. The need for such study is now growing in KEPCO network. Frequently, traditional ways of performing the necessary study had been found to be less adequate for guiding the key decisions in the company. Therefore, the growing needs, as well as the revealed inadequacy of the traditional system studies, had been attributing to the momentum for the upgrade project. This paper explains the details of the upgrade project. As an example of presenting the effectiveness of the upgraded RTDS system in KEPRI-KEPCO, a large-scale AC/DC real time simulation case which includes the entire Korean network and a planned MMC-HVDC system is introduced.

• Journal of the Korean Society of Clothing and Textiles
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• v.41 no.1
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• pp.60-70
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• 2017

This study selects representative materials and sewing methods used to: produce medical compression clothing in domestic garment, understand physical properties according to sewing conditions before and after knitting, and propose a sewing method that can improve the functional properties of the medical pressure clothing for burn patients. This experiment used samples from two knitted fabrics of high-frequency, produced and sold among fabrics used to produce medical compression clothing in Korea. Sewing methods were N321, N502 and N601, most commonly used in the press clothing industry. Fabric A is most often reduced in EMT values when sewing N502. However, N321 and N502 are suitable sewing methods for the reliable to twist at the larger torsional shear and the larger 2HG, 2HG5 value. Fabric B is sewn with N601, the EMT value is the most elevated, LT value is also low and extensibility improves after sewing. N601 is shown as an appropriate sewing method for warp knitting. When sewing with N321, the torsional is stable but elongation is lacking. N502 is not good for torsional stability.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.4
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• pp.1229-1232
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• 2010

In this study, in order to develop multilayer piezoelectric transformer for high electromechanical coupling factor and mechanical quality factor. and to show the general approach to the design of inverters utilizing PT as a circuit element. The description of the piezoelectric effect is not present here and can be easily found in numerous publications as well as complex equations and formulae. What is the most important to understand is that "they are different" -one cannot just change an electromagnetic transformer (EMT) for a piezoelectric one. Several examples of PT-based circuitry will help to start and use multilayer piezoelectric transformer advantages most effectively.

• The Korean Journal of Emergency Medical Services
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• v.15 no.1
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• pp.25-35
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• 2011

Purpose & Method : This purpose of this paper was to show the importance of paramedics. The trauma patients receiving a temporary treatment from emergency medical technician filled out a self-administered questionnaire. The questionnaire consisted of the satisfaction for EMS. The data collection was from October 23 to November 12, 2006. The patients were in the Kyeonggi province hospital having more than 500 beds. At the time of discharge, the questionnaire forms were distributed. Results : Males showed higher satisfaction than females when they had a paramedics, and this indicated statistically significant difference(p<.05). The groups showing higher satisfaction for EMT 1 practice included patients over 40 years old, educated under high school, and income over 2 million won. Before the trauma patients were treated, they were satisfied with short waiting time less than 10 minutes. They showed higher satisfaction within 2 hours duration. Conclusion : Summing up the above result, it was found that the group treated by an emergency medical technician showed higher satisfaction than the group not treated by an emergency medical technician. Therefore, it is necessary to arrange paramedics in emergency medical centers to improve satisfaction with emergency medical services. And since it is a crucial factor that affects patient's satisfaction significantly, it is urgent to increase the roles of emergency medical technicians and lay the foundation for legal institutions.