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http://dx.doi.org/10.5483/BMBRep.2018.51.9.104

MiR-363 inhibits cisplatin chemoresistance of epithelial ovarian cancer by regulating snail-induced epithelial-mesenchymal transition  

Cao, Lanqin (Department of Obstetrics, Xiangya Hospital, Central South University)
Wan, Qian (Department of Obstetrics, Xiangya Hospital, Central South University)
Li, Fengjie (Department of Obstetrics, Xiangya Hospital, Central South University)
Tang, Can-e (The Institute of Medical Science Research, Xiangya Hospital, Central South University)
Publication Information
BMB Reports / v.51, no.9, 2018 , pp. 456-461 More about this Journal
Abstract
Chemoresistance is a major barrier to successful cisplatin-based chemotherapy for epithelial ovarian cancer (EOC), and emerging evidences suggest that microRNAs (miRNAs) are involved in the resistance. In this study, it was indicated that miR-363 downregulation was significantly correlated with EOC carcinogenesis and cisplatin resistance. Moreover, miR-363 overexpression could resensitise cisplatin-resistant EOC cells to cisplatin treatment both in vitro and in vivo. In addition, data revealed that EMT inducer Snail was significantly upregulated in cisplatin-resistant EOC cell lines and EOC patients and was a functional target of miR-363 in EOC cells. Furthermore, snail overexpression could significantly attenuate miR-363-suppressed cisplatin resistance of EOC cells, suggesting that miR-363-regulated cisplatin resistance is mediated by snail-induced EMT in EOC cells. Taken together, findings suggest that miR-363 may be a biomarker for predicting responsiveness to cisplatin-based chemotherapy and a potential therapeutic target in EOC.
Keywords
Chemoresistance; Cisplatin; Epithelial-mesenchymal transition; Epithelial ovarian cancer; MiR-363; Snail;
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