• Title/Summary/Keyword: EAST 모델

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Cognitive Improvement Effects of Krill Oil in a Scopolamine-induced Mice Model (Scopolamine 유도 인지 저하 마우스 모델에서 크릴 오일의 인지 개선 효과)

  • Hye-Min Seol;Jeong-Ah Lee;Mi-Sun Hwang;Sang-Hoon Park;Hyeong-Soo Kim
    • Journal of Life Science
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    • v.34 no.7
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    • pp.509-519
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    • 2024
  • A previous study showed that krill oil improved recognition and memory through anti-oxidative effects in an amyloid β model, but the authors noted that further investigations are necessary of alterations to neurotransmitters' states and of serum lipid profile improvements related to serum lipid peroxidation. Accordingly, in this study, ICR mice were pre-treated intraperitoneally with scopolamine prior to induced neurotransmission impairment, and the effects of krill oil provision on their capabilities of cognition were tested by performing a passive avoidance test (PAT), water maze test (WMT), and novel object recognition test. Then, parameters including the acetylcholine (ACh) concentration, acetylcholinesterase activity (AChE), lipid peroxidation, serum lipid levels, and nerve cell proliferation were investigated. The results showed that krill oil improved the mice's abilities in recognition and memory as the times taken to complete the PAT and WMT were reduced compared to the mice in a comparison scopolamine-treated group. Krill oil produced an increased concentration of Ach, and this was accompanied by a decrease in AChE. As shown in a scopolamine-treated SH-SY5Y cell line, krill oil reduced the activity of AChE. Moreover, the suppression of lipid peroxidation-reflected in the finding that malondialdehyde was decreased with krill oil provision-is speculated to affect the recorded serum triglyceride and cholesterol decreases and LDL cholesterol increase. The intake of krill oil was also found to produce an improvement in brain-derived neurotrophic factor expression by stimulating the activation of cyclic AMP response element binding protein in the brain tissue. Overall, the current results imply that the provision of krill oil raises the cognition and memory by elevating neurotransmitters and by improving the serum lipid profile and nerve cell proliferation, which occur as lipid peroxidation is suppressed in the brain tissue.

Setting Development Priorities of Undeveloped Neighborhood Parks in the Downtown of Cheongju City using a Park Development Pressure Index (공원조성 압력지수를 이용한 공원개발 우선순위 선정 - 청주시 도심 미개발근린공원을 대상으로 -)

  • Ban, Yong-Un;Lee, Tae-Ho
    • Journal of the Korean Institute of Landscape Architecture
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    • v.37 no.4
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    • pp.1-11
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    • 2009
  • This study was intended to set development priorities for five undeveloped neighborhood parks scattered throughout the downtown area of Cheongju City using a PDPI(Park Development Pressure Index). In order to calculate the PDPI, this study employed an additive integration method. The PDPI was graded from 1 to 5, based on the evaluation scores in accordance with nine indicators selected through literature reviews and interviews with public officials. The indicators have been classified into three categories: physical environment, utilization possibility, and facility distribution. The indicators are as follows: 1) 'altitude and inclination' and 'NDVI' as physical environment indicators; 2) 'ratio of residential area', 'forecasted utility population', 'undeveloped period', 'redevelopment near parks', 'ratio of area divided by main streets', reflecting utilization possibility; and 3) 'Distance between Neighborhood Parks' and 'Distribution of alternative facilities' as facility distribution. The following results were found: 1) three neighborhood parks including 'Sagic 2', 'Sachen', and 'Dangsan' were ranked in the first grade of PDPI; and, 2) one neighborhood park 'Samsungdang' was ranked in the fifth grade of PDPI. The above results mean that among undeveloped neighborhood parks, three have been exposed to extremely strong park development pressure, and that while two neighborhood parks have had strong exposure to park development pressure due to potential users according to their close location to Sagic Ro, an east-west main axis of Cheongju City, one neighborhood park has had weak exposure to development pressure because of the close location to 'Chuungbuk National University' and a lack of residential areas, showing a low possibility for development.

Estimation of Global Horizontal Insolation over the Korean Peninsula Based on COMS MI Satellite Images (천리안 기상영상기 영상을 이용한 한반도 지역의 수평면 전일사량 추정)

  • Lee, Jeongho;Choi, Wonseok;Kim, Yongil;Yun, Changyeol;Jo, Dokki;Kang, Yongheack
    • Korean Journal of Remote Sensing
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    • v.29 no.1
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    • pp.151-160
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    • 2013
  • Recently, although many efforts have been made to estimate insolation over Korean Peninsula based on satellite imagery, most of them have utilized overseas satellite imagery. This paper aims to estimate insolation over the Korean Peninsula based on the Korean stationary orbit satellite imagery. It utilizes level 1 data and level 2 cloud image of COMS MI, the first meteorological satellite of Korea, and OMI image of NASA as input data. And Kawamura physical model which has been known to be suitable for East Asian area is applied. Daily global horizontal insolation was estimated by using satellite images of every fifteen minutes for the period from May 2011 to April 2012, and the estimates were compared to the ground based measurements. The estimated and observed daily insolations are highly correlated as the $R^2$ value is 0.86. The error rates of monthly average insolation was under ${\pm}15%$ in most stations, and the annual average error rate of horizontal global insolation ranged from -5% to 5% except for Seoul. The experimental results show that the COMS MI based approach has good potential for estimating insolation over the Korean Peninsula.

Grounding Line of Campbell Glacier in Ross Sea Derived from High-Resolution Digital Elevation Model (고해상도 DEM을 활용한 로스해 Campbell 빙하의 지반접지선 추정)

  • Kim, Seung Hee;Kim, Duk-jin;Kim, Hyun-Cheol
    • Korean Journal of Remote Sensing
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    • v.34 no.3
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    • pp.545-552
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    • 2018
  • Grounding line is used as evidence of the mass balance showing the vulnerability of Antarctic glaciers and ice shelves. In this research, we utilized a high resolution digital elevation model of glacier surface derived by recently launched satellites to estimate the position of grounding line of Campbell Glacier in East Antarctica. TanDEM-X and TerraSAR-X data in single-pass interferometry mode were acquired on June 21, 2013 and September 10, 2016 and CryoSat-2 radar altimeter data were acquired within 15 days from the acquisition date of TanDEM-X. The datasets were combined to generate a high resolution digital elevation model which was used to estimate the grounding line position. During the 3 years of observation, there weren't any significant changes in grounding line position. Since the average density of ice used in estimating grounding line is not accurately known, the variations of the grounding line was analyzed with respect to the density of ice. There was a spatial difference from the grounding line estimated by DDInSAR whereas the estimated grounding line using the characteristics of the surface of the optical satellite images agreed well when the ice column density was about $880kg/m^3$. Although the reliability of the results depends on the vertical accuracy of the bathymetry in this study, the hydrostatic ice thickness has greater influence on the grounding line estimation.

Multi-perspective process modeling (프로세스 모델링을 위한 개념적 틀)

  • 권태형;연광호;최은희
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 1995.09a
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    • pp.233-248
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    • 1995
  • 조직변혁(OT:Organizational Tranformation)은 Macro(거시적), Micro(미시 적), Meso(중간적) 관점과 사회적, 기술적 관점을 혼합하여 전체적으로 6가 지의 가능성을 갖는 영역을 생성할 수 있다. 최근 조직 설계와 관련된 많은 연구들은 급변하는 환경에 대한 조직의 반응으로써 기능 중심의 조직설계 대신 Meso관점의 프로세스 중심의 조직 설계를 통한 조직 변혁을 제안해 왔다. 프로세스 재설계 혹은 리엔지니어링과 같은 용어로 등장하는 이 관점 은 서로 다른 연구분야 사이의 상호 연계적 적용을 증가시키고 적절한 자원 할당 및 혼합을 가능하게 함으로써 고객요구와 경쟁력 같은 외부요구사항과 내부적 생산성등을 연계시키고자 한다. 프로세스 모델링은 프로세스 중심의 조직 설계를 통한 조직 변혁의 중요한 도구로 사용될 수 있다. 조직 변혁의 6개 영역과 프로세스의 구성요소 중 일부에만 관심을 갖는 기존의 프로세스 모델링 관점들-기능적 업무(task) 중심의 '기능 관점', 행위적 논리(logic) 중 심의 '행위 관점', 조직적 역할 (roles) 중심의 '조직 관점'-을 반영한 프로세 스 모델은 프로세스 수행목적의 표현과 프로세스 재설계의 기회 발견에 한 계가 있다. 본 연구에서는 프로세스 모델링 기법에 의해 표현되어야 하는 프 로세스 구성요소들을 5W1H를 기준으로 분류하고, 기존 모델링 관점들이 가 지는 한계점의 해결을 위해 두 가지의 새로운 프로세스 모델링 관점-프로세 스 목적과 가치를 표현하는 '정보 관점', 프로세스의 측정에 대한 계량적 정 보를 표현하는 '측정 관점'-을 제시하고, 조직 변혁이 여러 관점들의 통합을 지원하는 프로세스 모델링을 위한 개념적 틀(MPPM)과 프로세스 모델에서 표현되어야 하는 프로세스 구성요소들을 제시하였다.용자 만족도가 보다 높은 것으 로 나타났다. 할 수 있는 효율적인 distributed system를 개발하는 것을 제시하였다. 본 논문은 데이타베이스론의 입장에서 아직 정립되어 있지 않은 분산 환경하에서의 관계형 데이타베이스의 데이타관리의 분류체계를 나름대로 정립하였다는데 그 의의가 있다. 또한 이것의 응용은 현재 분산데이타베이스 구축에 있어 나타나는 기술적인 문제점들을 어느정도 보완할 수 있다는 점에서 그 중요성이 있다.ence of a small(IxEpc),hot(Tex> SOK) core which contains two tempegatlue peaks at -15" east and north of MDS. The column density of HCaN is (1-3):n1014cm-2. Column density at distant position from MD5 is larger than that in the (:entral region. We have deduced that this hot-core has a mass of 10sR1 which i:s about an order of magnitude larger those obtained by previous studies.previous studies.업순서들의 상관관계를 고려하여 보다 개선된 해를 구하기 위한 연구가 요구된다. 또한, 준비작업비용을 발생시키는 작업장의 작업순서결정에 대해서도 연구를 행하여, 보완작업비용과 준비비용을 고려한 GMMAL 작업순서문제를 해결하기 위한 연구가 수행되어야 할 것이다.로 이루어 져야 할 것이다.태를 보다 효율적으로 증진시킬 수 있는 대안이 마련되어져야 한다고 사료된다.$\ulcorner$순응$\lrcorner$의 범위를 벗어나지 않는다. 그렇기

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Internal and External Assessment of Contract Management Competences in the Overseas Construction Projects (해외 건설프로젝트 계약관리 역량의 대내적·대외적 평가)

  • Park, Seunghoon;Kim, Yea Sang
    • Korean Journal of Construction Engineering and Management
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    • v.18 no.6
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    • pp.109-120
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    • 2017
  • Even though domestic construction companies are expanding into overseas construction markets, the profitability of overseas project are decreasing and finally some biggest domestic construction companies recorded heavy deficit one after another in 2013. Contract management, which is very deeply related to profitability, is the most difficult area to domestic construction companies, especially in Middle East and Asia where they have the highest market share and a high level of contract management is required. The purpose of this study is to assess their contract management competences to help them improve contract management skills and strategies. First, we defined the overseas project contract management process and selected competences from the each process stage. Then, we conducted a survey with overseas project experts. For considering their competences from various angles, we divided survey groups into domestic construction groups and other groups (Contract consultancy agencies and Construction research institutes) to understand the internal and external perspective of the domestic construction companies' contract management competences. The results of survey was analyzed by using paired samples t-test, Borich Needs Assessment Model and Independent t-test. We expected that the results of this study could contributes to establish strategies for enhancing the domestic construction companies' contract management competencies.

Discussions on the September 2016 Gyeongju Earthquakes (2016년 9월 경주지진 소고(小考))

  • Lee, Kiehwa
    • Geophysics and Geophysical Exploration
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    • v.20 no.3
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    • pp.185-192
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    • 2017
  • A sequence of earthquakes with the main shock $M_L$ 5.8 occurred on September 12 2016 in the Gyeongju area. The main shock was the largest earthquakes in the southern part of the Korean peninsula since the instrumental seismic observation began in the peninsula in 1905 and clearly demonstrated that the Yangsan fault is seismically active. The mean focal depth of the foreshock, main shock, and aftershock of the Gyeongju earthquakes estimated by the crustal model of single layer of the Korean peninsula without the Conrad discontinuity turns out to be 12.9 km, which is 2.8 km lower than that estimated based on the IASP91 reference model with the Conrad discontinuity. The distribution of the historical and instrumental earthquakes in the Gyeongju area indicates that the Yangsan fault system comprising the main Yangsan fault and its subsidiary faults is a large fracture zone. The epicenters of the Gyeongju earthquakes show that a few faults of the Yangsan fault system are involved in the release of the strain energy accumulated in the area. That the major earthquakes of Gyeongju earthquakes occurred not on the surface but below 10 km depth suggests the necessity of the study of the distribution of deep active faults of the Yangsan fault system. The magnitude of maximum earthquake of the Gyeongju area estimated based on the earthquake data of the area turns out to be 7.3. The recurrence intervals of the earthquakes over magnitudes 5.0, 6.0 and 7.0 based on the earthquake data since 1978, which is the most complete data in the peninsula, are estimated as 80, 670, and 5,900 years, respectively. The September 2016 Gyeongju earthquakes are basically intraplate earthquakes not related to the Great East Japan earthquake of March 11 2011 which is interplate earthquake.

Effects of Herbal Mixture Extracts Containing Angelica gigas Nakai and Cuscuta chinensis Lam. on Menopausal Symptoms in Ovariectomized Rats (당귀(Angelica gigas N.)와 토사자(Cuscuta chinensis Lam.)를 포함하는 생약 복합 추출물의 폐경 동물모델에서의 갱년기 증상 완화 효과)

  • Kim, Suji;Jang, Byung-Hyun;Chang, Seo-Hyuk;Kang, Hee;Park, Ki-Moon;Ahn, Duk Kyun;Kim, Soohyun;Kim, Sunmi;Seo, Daebang;Shin, Song Seok;Park, Kye Won
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.45 no.8
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    • pp.1083-1089
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    • 2016
  • During menopause, elderly woman experience physical and emotional symptoms, including hot flashes, night sweats, weight gain, vaginal dryness, and mood swings. In this study, we investigated the effects of mixed herbal extracts containing Angelica gigas Nakai and Cuscuta chinensis Lam. on menopause symptoms in ovariectomized (OVX) rats. Daily oral treatments of 500 mg/kg and 1,000 mg/kg in OVX rats for 8 weeks significantly reduced weight gain, inhibited hepatic lipid accumulation, and lowered serum lipid levels comparable to the effects induced by estradiol treatments. Mixed herbal extracts (named Jaeummidan) also prevented vaginal dryness as measured by increased vaginal weight. Increased vaginal weight was associated with enlarged epithelium thickness. These data show the preventive actions of Jaeummidan against menopause symptoms and further suggest the possibility of developing functional ingredients in elderly human populations experiencing menopause symptoms.

Feasibility Study for Tidal Power Plant Site in Garolim Bay Using EFDC Model (EFDC모형을 이용한 가로림만의 조력발전 위치 타당성 검토)

  • Shin, Bum-Shick;Kim, Kyu-Han;Kim, Jong-Hyun;Baek, Seung-Hwa
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.23 no.6
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    • pp.489-495
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    • 2011
  • Fossil fuel energy has become a worldwide environmental issue due to its effect on global warming and depletion in its supply. Therefore, the interest in developing alternative energy source has been rising. Ocean energy, especially, has gained strength as an alternative energy source for its unlimited supply with low secondary risks. Among all the ocean energy, the west coast of Korea holds the field of large-scale energy development because of its distinctive tidal range. Tidal power plant construction at the sea may expedite multi development effects such as bridge roles, tourism resource effects and adjustability of flood inundation at the inner bay. This study introduces the validity of tidal power plant construction at Garilim Bay in west coast of Korea by examining anticipated hydraulic characteristics using EFDC model. Through EFDC numerical simulations, the feasibility of Garolim Bay as a tidal power plant field has been proved. And the most effective tidal power plant construction would be to install hydraulic turbine in the west side of bay entrance where ebb current is stronger, and install water gate in the east side of bay entrance where the flood current is superior.

Spherical Slepian Harmonic Expression of the Crustal Magnetic Vector and Its Gradient Components (구면 스레피안 함수로 표현된 지각 자기이상값과 구배 성분)

  • Kim, Hyung Rae
    • Economic and Environmental Geology
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    • v.49 no.4
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    • pp.269-280
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    • 2016
  • I presented three vector crustal magnetic anomaly components and six gradients by using spherical Slepian functions over the cap area of $20^{\circ}$ of radius centered on the South Pole. The Swarm mission, launched by European Space Agency(ESA) in November of 2013, was planned to put three satellites into the low-Earth orbits, two in parallel in East-West direction and one in cross-over of the higher altitude. This orbit configuration will make the gradient measurements possible in North-South direction, vertical direction, as well as E-W direction. The gravity satellites, such as GRACE and GOCE, have already implemented their gradient measurements for recovering the accurate gravity of the Earth and its temporal variation due to mass changes on the subsurface. However, the magnetic gradients have little been applied since Swarm launched. A localized magnetic modeling method is useful in taking an account for a region where data availability was limited or of interest was special. In particular, computation to get the localized solutions is much more efficient and it has an advantage of presenting high frequency anomaly features with numbers of solutions fewer than the global ones. Besides, these localized basis functions that were done by a linear transformation of the spherical harmonic functions, are orthogonal so that they can be used for power spectrum analysis by transforming the global spherical harmonic coefficients. I anticipate in scientific and technical progress in the localized modeling with the gradient measurements from Swarm and here will do discussion on the results of the localized solution to represent the three vector and six gradient anomalies over the Antarctic area from the synthetic data derived from a global solution of the spherical harmonics for the crustal magnetic anomalies of Swarm measurements.