• Journal of Environmental Science International
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• v.32 no.1
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• pp.67-76
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• 2023

Under constant environmental pollution, the incidence of Atopic Dermatitis (AD) caused by air pollutants and allergens has increased. AD is an allergy inflammatory skin disease characterized by pruritus, eczema, and skin dryness. In herbal medicine, Anemarrhena asphodeloides (Anemarrhenae Rhizoma; AR) has been utilized to treat Alzheimer's disease, osteoporosis, hypertension, and inflammation. The purpose of study evaluated the effect of AR in a mouse model of 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions. After acclimatization for 5 days, the mice (6-week-old, male Balb/c) were divided into five groups (n=6/group): NC (normal control), DNCB (control), Dex (5 mg·kg-1, p.o.), AR100 (100 mg·kg-1, p.o.), and AR300 (300 mg·kg-1, p.o.). On days 1 and 3, 1% DNCB was applied to the skin and ears. After 4 days, 0.5% DNCB was applied once every 2 days for 2 weeks. Then, skin and ears eczema area and severity index (EASI); skin nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) levels; and plasma immunoglobulin E (IgE) levels were examined. The AR groups showed lower EASI, skin and ear thickness, mast cell count, and IgE levels than the control groups. Moreover, AR reduced iNOS, COX-2, and PGE2 levels. Therefore, AR possesses anti-inflammatory properties and can improve skin damage, indicating its therapeutic potential against AD.

• 한국디지털정책학회:학술대회논문집
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• 2006.12a
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• pp.355-366
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• 2006

Knowledge sharing is an essential component of effective knowledge management, however, individuals' knowledge does nottransform easiIy into organizational knowledge even with the implementation of knowledge management program, rather , individuals tend to hoard knowledge for various reasons. this article is to explore what factors have influenced the knowledge sharing intent ion and knowledge sharing mechanism. Althoughseveral factors have been identified to help create a high performing knowledge organization, including leadershlp, organizational culture and so on, the major objective of the research. is to explore what kinds of individuals' factors have influence on knowledge sharing intent ion and knowledge sharing mechanism by knowledge types. This paper applied personality trait ability, extrinsic motivation, intrinsic motivation structure to explain knowledge sharing in organization.

• Transactions of the Korean Society of Automotive Engineers
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• v.8 no.6
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• pp.165-175
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• 2000

In order to improve the function of a door seal, its section design technique is discussed in this study, Its roles are prevention of an inflow of dusts, noise interception, insulation, wateproof, and the vibroisolating action which reduces vibration between the body and the door of a car while running, and the buffer action which sustain the proper reacting force as the door is closed. In this study, the optimal cross section of a door seal is designed using nonlinear finite element analysis (commercial finete element analysis program EASi-SEAL) and tables of orthogonal arralys with respect to relations between door and door seal to secure the satisfactory airtight property with the minimum force to shut the door.

• Journal of Microbiology and Biotechnology
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• v.16 no.11
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• pp.1699-1705
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• 2006

Recent studies have suggested that oral bacteriotherapy with probiotics might be useful for preventing and managing childhood atopic dermatitis (AD). The purpose of this investigation was to evaluate the efficacy and safety of oral treatment with probiotics for adolescent and adult AD patients as well as for childhood AD patients. Sixty-four patients with mild to moderate AD were recruited for treatment with a mixture of four probiotic strains (Lactobacillus rhamnosus, Lactobacillus plantarum, Lactobacillus casei, and Biftdobacterium lactis) twice daily for 8 weeks. The degree of pruritus was determined by a 10-point visual analog scale every other week, and the patients' global assessments of their clinical responses (i.e., better, unchanged, or worse) was done at the end of intervention. The clinical severity of the eczema was evaluated by eczema area and severity index (EASI) score every other week. As laboratory markers, total immunoglobulin E (IgE), eosinophil cationic protein (ECP) in the serum, and cytokine production [interleukin-4 (IL-4), interleukin-10 (IL-10), and $interferon-{\gamma}\;(IFN-{\gamma})$ by the peripheral blood mononuclear cells (PBMCs) were measured at the beginning and at the end of intervention. Of the 64 enrolled AD patients, only 50 patients finally completed the 8-week study. After 8-week treatment with probiotics, the EASI score was significantly improved (p<0.0001), 50% of the patients experienced improvement of their eczema, and significant improvement of the pruritus was also observed (p=0.0002). The effect was more pronounced for the patients with very high IgE levels (>1,000 ku/l) or for the patients with moderate disease severity. There was no significant difference in the therapeutic effects between the childhood AD and adolescent and adult AD patients. There were no significant changes of cytokines, as well as the total IgE and ECP levels, in the patients' serum. Treatment with the mixture of four probiotic strains was generally well tolerated. Our results suggest that the treatment with the mixture of four probiotic strains is beneficial for the management of the adolescent and adult AD patients, as well as for the childhood AD patients.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.2
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• pp.68-93
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• 2019

Objective : This study summarized the characteristics of clinical trials for atopic dermatitis medicines approved by the Ministry of Food and Drug Safety(MFDS). This study may be a reference for the design of clinical trials of atopic dermatitis herbal medicine treatment which may be carried out later. Method : The characteristics of the clinical trial were analyzed for clinical trials registered with ClinicalTrials.gov, CRIS, and the Korea Health Industry Development Institute among the clinical trial approval statuses posted on the website of the MFDS. Result : 1. Clinical trial drugs were developed in various formulations such as oral medicines, injections, dermatologic agents, and similar proportions. Relatively little clinical trials were found for herbal medicine. 2. In the control evaluation test, most of the treatments for the control group were performed with placebo using Vehicle. 3. In most clinical trials, one intervention group was in the form of a parallel assignment with only one treatment. 4. The age of the subjects was 11 out of 28 studies including minors, and clinical trials targeting minors were also found to be significant. 5. In the case of atopic dermatitis, the cases of subacute chronic or atopic dermatitis more than 6 months or more than 1 year were often used. 6. Most clinical trials were divided into mild to moderate atopic dermatitis or moderate to severe atopic dermatitis. The SCORAD index, EASI, IGA, BSA, and NRS were used as the evaluation criteria. 7. Regulations for the drugs used prior to the trial period for the treatment of atopic dermatitis vary somewhat from one clinical trial to another. 8. IGA was used most often as a primary efficacy tool, and SCORAD index, EASI, and NRS were also used.

• Nuclear Engineering and Technology
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• v.52 no.8
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• pp.1661-1668
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• 2020

A physical protection system (PPS) is used for the protection of critical facilities. This paper proposes a structure analytic hierarchy approach (SAHA) for the hierarchical evaluation of the PPS effectiveness in critical infrastructure. SAHA is based on the traditional analysis methods "estimate of adversary sequence interruption, EASI". A community algorithm is used in the building of the SAHA model. SAHA is applied to cluster the associated protection elements for the topological design of complicated PPS with graphical vertexes equivalent to protection elements.

• Korean Journal of Child Studies
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• v.12 no.2
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• pp.173-191
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• 1991

The purpose of the present study was to examine the relationship between infants' crying associated with their temperament and mothers' subjective responses to their crying. The subjects were 212 mothers and their 4- to 8-month-old infants living in Seoul, Korea. RITQ and EASI were administered to mothers. Mothers' perceptions of tape recordings of infants' crying were recorded. The data were analyzed by t-test and ${\chi}^2$ test. The main results were that (1) infant's temperament could be divided into five groups: the easy, the intermediate-low, the intermediate-high, the difficult, and the slow-to-warm up infant groups. The more negatively emotional and impulsive the mother's temperament, the more difficult was the infant's temperament. (2)The crying of the difficult infants was perceived more as an indication of major physical discomfort than that of the easy infants. (3)Both mothers of difficult and mothers of easy infants displayed differences in maternal interventions by type of infant cries: cries of difficult infants elicited more maternal intervention of "soothing" or "picking up" than those of easy infants. On the other hand, cries of easy infants elicited more maternal intervention of "playing with toy" and "leaving him alone, if possible" than those of difficult infants.

• Journal of Communications and Networks
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• v.13 no.2
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• pp.113-124
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• 2011

Electrocardiography (ECG) is a widely accepted approach for monitoring of cardiac activity and clinical diagnosis of heart diseases. Since cardiologists have been well-trained to accept 12-lead ECG information, a huge number of ECG systems are using such number of electrodes and placement configuration to facilitate fast interpretation. Our goal is to design a wireless ECG system which renders conventional 12-lead ECG information.We propose the three-pad ECG system (W3ECG). W3ECG furthers the pad design idea of the single-pad approach. Signals obtained from these three pads, plus their placement information, make it possible to synthesize conventional 12-lead ECG signals.We provide one example of pad placement and evaluate its performance by examining ECG data of four patients available from online database. Feasibility test of our selected pad placement positions show comparable results with respect to the EASI lead system. Experimental results also exhibit high correlations between synthesized and directly observed 12-lead signals (9 out of 12 cross-correlation coefficients higher than 0.75).

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.31 no.2
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• pp.104-112
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• 2018

Objectives : The purpose of this study is to examine whether the topical preparations containing 12 herbal extracts is effective for patients with atopic dermatitis. Methods : We retrospectively reviewed the medical records of 11 patients who were prescribed topical preparations containing 12 herbal extracts on the outpatient clinic of 4 hospitals; Noble Korean Medicine Clinic, Amar Korean Medicine Clinic, Chung-Yeon Korean Medical Hospital, Donggwangju Chung-Yeon Korean Medical Hospital. Results and Conclusions : A total of 11 patients were included in the selection and exclusion criteria. The OSI mean value before treatment and at the last treatment day decreased significantly from $37.03{\pm}16.75$ to $13.32{\pm}9.83$, and the mean value of EASI decreased from $13.33{\pm}12.85$ to $2.78{\pm}5.00$, which was statistically significant. No safety concerns were reported. The results of this study confirmed the possibility that the topical preparations can be effective in moderate to severe infants, adolescents, and adult atopic dermatitis patients.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.17 no.1
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• pp.271-278
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• 1987

The purpose of the present study was to investigate associations between periapical and bitewing techniques by assessing the crestal alveolar bone. This article also reports the ability of these two techniques to correctly detect evidence of interproximal dental caries, and comparison between the interproximal overlapping of teeth. Bitewing and periapical radiographs were used from posterior quardants of 243 dental students in Seoul National University. The distance from cemento-enamel junction to the alveolar crest (CEJ-AC) was measured for each proximal surface from the distal of cuspid to the distal of second molar. Data were arranged according to the proximal surface examined, and bitewing and periapical measurements were compared using paired tests. The obtained results were as follows: 1. In maxilla, a significant t ratio with a P value of 0.05 or less reached for 100% and in mandible, reached for 94%. 2. The anatomic limitations imposed on periapical radiographic technique, most often result in somewhat foreshortened radiographic images. This situation would tend to be accentuated by the anatomical restrictions of the hard palate. 3. Consequently, since the significant differences frequently exist between measurements obtained from bitewing and periapical techniques, it is important to define which technique is used. 4. The number of the interproximal overlapping was the largest medial side of the maxillary second molar, while the smallest at the distal side of the mandibular second premolar. And the overall number of the interproximal overlapping was more (538) in the periapical technique than in the bitewing technique (372). 5. The interproximal dental carious lesions were detected more (74) on the bitewing films than on the periapical ones (23). The fact was resulted from the small number of interproximal overlapping and relative easi- ness of obtaining horizontal angulation in taking the bitewing radiographs.