• Fisheries and Aquatic Sciences
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• 제25권2호
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• pp.49-63
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• 2022

Anti-cholinesterase (ChE)s are commonly prescribed as the symptomatic treatment of Alzheimer's disease. They are applied to prevent the breakdown of neurotransmitter acetylcholine (ACh) that bind to muscarinic and nicotinic receptors in the synaptic cleft. Seaweeds are one of the richest sources of bioactive compounds for both nutraceuticals and pharmacognosy applications. This study aimed to determine the anti-ChEs activity of Gracilaria manilaensis, one of the red seaweeds notables for its economic importance as food and raw materials for agar production. Methanol extracts (GMM) of G. manilaensis were prepared through maceration, and further purified with column chromatography into a semi-pure fraction. Ellman assay was carried out to determine the anti-acetylcholinesterase (AChE) and anti-butyrylcholinesterase (BuChE) activities of extracts and fractions. Lineweaver-Burk plot analysis was carried out to determine the inhibition kinetic of potent extract and fraction. Major compound(s) from the most potent fraction was determined by liquid chromatography-mass spectrometry (LCMS). GMM and fraction G (GMMG) showed significant inhibitory activity AChE with EC₅₀ of 2.6 mg/mL and 2.3 mg/mL respectively. GMM and GMMG exhibit mixed-inhibition and uncompetitive inhibition respectively against AChE. GMMG possesses neuroprotective compounds such as cynerine A, graveolinine, militarinone A, eplerenone and curumenol. These findings showed a promising insight of G. manilaensis to be served as a nutraceutical for neuronal health care in the future.

• Computers and Concrete
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• 제20권5호
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• pp.583-593
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• 2017

Applications of fibre-reinforced polymer (FRP) composites for retrofitting, strengthening and repairing concrete structures have been expanded dramatically in the last decade. FRPs have high specific strength and stiffness compared to conventional construction materials, e.g., steel. Ease of preparation and installation, resistance to corrosion, versatile fabrication and adjustable mechanical properties are other advantages of the FRPs. However, there are major concerns about long-term performance, serviceability and durability of FRP applications in concrete structures. Therefore, structural health monitoring (SHM) and damage detection in FRP-retrofitted concrete structures need to be implemented. This paper presents a study on investigating the application of Rayleigh wave for detecting debonding defect in FRP-retrofitted concrete structures. A time-of-flight (ToF) method is proposed to determine the location of a debonding between the FRP and concrete using Rayleigh wave. A series of numerical case studies are carried out to demonstrate the capability of the proposed debonding detection method. In the numerical case studies, a three-dimensional (3D) finite element (FE) model is developed to simulate the Rayleigh wave propagation and scattering at the debonding in the FRP-retrofitted concrete structure. Absorbing layers are employed in the 3D FE model to reduce computational cost in simulating the practical size of the FRP-retrofitted structure. Different debonding sizes and locations are considered in the case studies. The results show that the proposed ToF method is able to accurately determine the location of the debonding in the FRP-retrofitted concrete structure.

• 한국노년학
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• 제39권1호
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• pp.109-125
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• 2019

본 연구는 노인들의 온라인 건강 정보 탐색 및 건강관리를 막는 주요 장애 요인을 살펴보고 증진방안을 검토하였다. 65세 이상의 노인을 대상으로 면대면 설문이 이루어졌고, 총 240명이 참여하였다. 정성적인 자료 검토를 위해 의미 연결망 분석(Semantic Network Analysis)을 실행하였고, 정량적인 자료를 바탕으로 위계적 회귀분석을 하였다. 분석 결과 정보 검색을 막는 주요 장애 요인과 건강관리를 막는 주요 장애 요인으로는 유용성(예, 원하는 정보 없음, 상세정보 부족, 신뢰성)과 이용용이성(예, 검색방법, 앱설치, 잘 안보임)으로 나타났다. 기술수용모델(Technology Acceptance Model)에서 제시하는 인지된 유용성과 인지된 이용용이성이 노인들의 모바일 앱 이용의도와 정적인 관계를 보였다. 즉 유용성과 이용용이성을 높이는 것이 노인들의 모바일 앱의 이용의도를 증진시킬 수 있는 것으로 나타났다.

• 대한치과기공학회지
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• 제23권1호
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• pp.85-93
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• 2001

The purpose of this study was to evaluate the effects of commercial home-tooth bleaching agents on the color of tooth. Twenty five sound extracted teeth were randomly divided into five groups. The color differences between before and after treatment with five types of tooth bleaching agents (7.5% hydrogen peroxide Nite White $Excel^{(R)}$, 10% carbamide peroxide Nite White $Excel^{(R)}$, 16% carbamide peroxide Nite White $Excel^{(R)}$, 10% carbamide peroxide Insta-BriteTM, 20% carbamide peroxide Insta-$Brite^{TM}$) were evaluated. The results were as follows: 1. By 2 week home tooth bleaching agent applications, the values ($L^*$) of bovine teeth increased as high as 4.38 $\sim$ 8.80 when comparing to those of the samples before treatment, and the color difference (${\Delta}E^*$) showed as high as 10.16 $\sim$ 15.04. 2. 16% carbamide peroxide Nite White Excel induced significantly greater ${\Delta}L^*$ than other test edgroups except for 7.5% hydrogen peroxide Day White Excel, and significantly greater ${\Delta}E^*$ than other tested groups by 2 week bleaching agent treatments (p<0.01). 3. 16% carbamide peroxide Nite White Excel(${\Delta}L^*$=8.80, ${\Delta}E^*$=15.04) induced significantly greater ${\Delta}L^*$ and ${\Delta}E^*$ than 10% carbamide peroxide Nite White Excel(${\Delta}L^*$=5.01, ${\Delta}E^*$=10.16)(p<0.01), but significant difference between 10% carbamide peroxide Insta-Brite(${\Delta}L^*$=4.38, ${\Delta}E^*$=10.51) and 20% carbamide peroxide Insta-Brite(${\Delta}L^*$=5.63, ${\Delta}E^*$=11.23) was not shown in ${\Delta}L^*$ and ${\Delta}E^*$(p>0.01). 4. 16% carbamide peroxide Nite White Excel(${\Delta}L^*$=8.80, ${\Delta}E^*$=15.04) which were applied in night time induced significantly greater ${\Delta}L^*$ and ${\Delta}E^*$ than 7.5% hydrogen peroxide Day White Excel(${\Delta}L^*$=8.47, ${\Delta}E^*$=12.75) which were applied in day time. Conclusions: These results demonstrate that all the commercial home-tooth bleaching agents have appreciable bleaching effect on teeth, and the effects of home-tooth bleaching agents which are used during night time are affected by content of carbamide peroxide. Especially the whitening effect of home tooth bleaching agents that are used through night time is greater than that of short time-applying tooth bleaching agent.

• Fisheries and Aquatic Sciences
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• 제24권12호
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• pp.394-399
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• 2021

Song-Gang^® bio-stone (SGS) is a microporous crystalline hydrated aluminosilicate which has found various applications because of their very unique physiochemical characteristics such as ion exchange and absorptive-desorptive properties. Significant progress has been made in recent years on applications of these inorganic adsorbents in different industries including agriculture, aquaculture, water and wastewater treatment. This review article intends to summarize the published reports on the applications of SGS in aquaculture industry. SGS application as a feed additive to enhance fish growth and promote their health and nutritional parameters is the most important discussed areas. According to the technical data that are discussed in this review, SGS should be considered as a material with tremendous potential for application in the aquaculture industry. Considerable amounts of research works are under way to explore other opportunities for application of SGS to benefit aquaculture industry.

• Nonlinear Functional Analysis and Applications
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• 제28권2호
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• pp.497-520
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• 2023

Numerous problems in science and engineering defined by nonlinear functional equations can be solved by reducing them to an equivalent fixed point problem. Fixed point theory provides essential tools for solving problems arising in various branches of mathematical analysis, such as split feasibility problems, variational inequality problems, nonlinear optimization problems, equilibrium problems, complementarity problems, selection and matching problems, and problems of proving the existence of solution of integral and differential equations.The theory of fixed is known to find its applications in many fields of science and technology. For instance, the whole world has been profoundly impacted by the novel Coronavirus since 2019 and it is imperative to depict the spread of the coronavirus. Panda et al. [24] applied fractional derivatives to improve the 2019-nCoV/SARS-CoV-2 models, and by means of fixed point theory, existence and uniqueness of solutions of the models were proved. For more information on applications of fixed point theory to real life problems, authors should (see [6, 13, 24] and the references contained in).

• Communications for Statistical Applications and Methods
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• 제23권6호
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• pp.517-529
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• 2016

This study compares the inverse transform and the composition methods for generating data from the Lindley distribution. The expression for the inverse of the distribution function for the Lindley distribution does not exist in closed form. Hence, authors of many empirical studies on the Lindley distribution used methods for generating Lindley variates other than the inverse transform. We generated data from the Lindley distribution using the inverse transform approach by obtaining the Lindley variates numerically; we also generated data from this distribution using the composition approach. Following the generation of the Lindley variates using these two methods, we compare some statistical properties of the estimates of the Lindley model parameters based on the generated data. We conclude that the two methods produce similar results.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2015년도 추계학술발표대회
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• pp.763-766
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• 2015

Smart Healthcare System as an Open Platform (Shesop) is an integrated healthcare system and have several features, one of them is Steppy Application. Steppy does count your step and display on Shesop website. In this system security issues are not properly addressed, while Personal Health Record (PHR) patient stored in the cloud platform could be at risk. In fact, the huge electronic information available online, people needs reliable and effective technique for privacy preserving. In order to improve the security of data which are displayed on the Shesop website, so that anyone who access could not tamper without permission. Recently Xu et al. showed a pseudonym scheme using smart card as a solution in e-health systems which uses discrete logarithm problem with cyclic group. In this paper, we adopt their scheme and use it application into smartphone using Near Field Communication (NFC) to construct security in Steppy apps.

• 대한의생명과학회지
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• 제8권1호
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• pp.29-37
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• 2002

Listeria monocytogenes poses an increasing health risk, which in part is due to increasing health risk, consumption of ready-to-eat food products and the introduction of increasing numbers of food products from regions with different dietary habits. L. monocytogenes can be present in meat, shellfish, vegetables, unpasteurised milk and soft cheese and poses a risk if food containing these products is stored at refrigeration temperature and is not properly heated before consumption, as L. monocytogenes is psychrophilic. Amplified-fragment length polymorphism (AFLP) analysis is the method of genotypic techinique in which adaptor oligonucleotides are ligated to restriction enzyme fragments and then used as target sites for primers in a PCR amplification. The amplified fragments are electrophoretically separated to give strain-specific band profiles. Single-enzyme approach that did not require costly equipment or reagents for the fingerprinting of strains of Listeria monocytogenes was developed. Single-enzyme amplified fragment length polymorphism (SE-AFLP) analysis was used to perform species and strain identification of Salmonella, Shigella, Yersinia and E. coli. By careful selection of AFLP primers, it was possible to obtain reproducible and sensitive identification to strain level. The AFLP patterns of L. monocytogenes are divided by the kinds of specimens in which were isolated. SE-AFLP fragments can be analyzed using standard gel electrophoresis, and can be easily scored by visual inspection, due to the low complexity of the fingerprint obtained by this method. These features make SE-AFLP suitable for use in either field or laboratory applications.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 추계학술대회
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• pp.699-700
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• 2014

The use of Radio Frequency Identification technology (RFID) in medical context enables not only drug identification, but also a rapid and precise identification of patients, physicians, nurses or any other healthcare giver. The combination of RFID tag identification with structured and secured Internet of Things (IoT) solutions enables ubiquitous and easy access to medical related records, while providing control and security to all interactions. This paper defines a basic security architecture, easily deployable on mobile platforms, which would allow to establish and manage a medication prescription service in mobility context making use of electronic Personal Health Records. This security architecture is aimed to be used with a mobile e-health application (m-health) through a simple and intuitive interface, supported by RFID technology. This architecture, able to support secured and authenticated interactions, will enable an easy deployment of m-health applications. The special case of drug administration and ubiquitous medication control system, along with the corresponding Internet of Things context, is presented.