• The KIPS Transactions:PartC
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• v.15C no.4
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• pp.303-310
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• 2008

To increase the lifetime of ad-hoc networks, a ratio of energy consumption for each node should be kept constant by equally distributing network traffic loads into all of the nodes. In this paper, we propose a modified AODV routing protocol to determine a possible route by considering a remaining battery capacity of a node and the degree of its usage. In addition, to reduce the amount of energy consumption during the path rediscovery process due to the huge amount of the AODV control messages the limited number of possible routes are stored into a routing table of a source node. When some links of a route fail, another possible path can be looked up in the table before the route discovery process should be initiated. We have tested our proposed method with a conventional AODV and a MMBCR method which is one of the power-efficient energy routing protocols based on the three performance metrics, i.e., the total remaining battery capacity, network lifetime and the ratio of data packets received by the destination node to compare their performance.

• Communications of Mathematical Education
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• v.24 no.1
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• pp.259-282
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• 2010

In this paper, we introduce a modified Moore Method designed for the multivariable calculus course, and discuss about the effective teaching and learning method by observing the changes in the understanding of students' learning and the effects on students' learning in the class implemented by this modified Moore Method. This teaching experiment research was conducted with the 15 students who took the multivariable calculus course offered as a 3 week summer session in 2008 at H University. To guide the students' active preparation, stepwise course materials structured in the form of questions on the important mathematical notions were provided to the students in advance. We observed the process of the students' small-group collaborative learning activities and their presentations in the class, and analysed the students' class journals collected at the end of every lecture and the survey carried out at the end of the course. The analysis of these results show that the students have come to recognize that a deeper understanding of the subjects are possible through their active process of search and discovery, and the discussion among the peers and teaching each other allowed a variety of learning experiences and reflective thinking.

• Asia Marketing Journal
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• v.15 no.3
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• pp.79-95
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• 2013

New product innovation is a process of embodying new knowledge in a product and technology licensing is getting popular as a means to innovations and introduction of new product to the market in today's competitive global market environment. Incumbents often rely on technology licensing to access new product opportunities created by other firms. Prior research has examined various aspects of technology licensing agreements such as specific contract terms of licensing agreements, e.g., distribution of control rights, exclusivity of licensing agreements, cross-licensing, and the scope of licensing agreements. This study aims to provide answers to an important, but under-researched question: why do some incumbents initiate more licensing agreement for exploratory learning while others do it for exploitative learning along the innovation process? We attempt to extend our knowledge of licensing agreements from an organizational learning perspective. Technology licensing as a specific form of interfirm linkages can be initiated with different learning objectives along the process of new product innovation. The exploratory stages of the innovation process such as discovery or research stages involve extensive searches to create new knowledge or capabilities, whereas the exploitative stages of the innovation process such as application or test stages near the commercialization are more focused on developing specific applications or improving their efficiency or reliability. Thus, different stages of the innovation process generate different types of learning and the resulting technological resources. We examine when incumbents as licensees initiate more licensing agreements for exploratory learning objectives and when more for exploitative learning objectives, focusing on two factors that may influence a firm's formation of exploratory and exploitative licensing agreements: 1) its past radical and incremental innovation experience and 2) its internal investments in R&D and marketing. We develop and test our hypotheses regarding the relationship between a firm's radical and incremental new product experience, R&D investment intensity and marketing investment intensity, and the likelihood of engaging in exploratory and exploitive licensing agreements. Using data collected from various secondary sources (Recap database, Compustat database, and FDA website), we analyzed technology licensing agreements initiated in the biotechnology and pharmaceutical industries from 1988 to 2011. The results of this study show that incumbents initiate exploratory rather than exploitative licensing agreements when they have more radical innovation experience and when they invest in R&D activities more intensively; in contrast, they initiate exploitative rather than exploratory licensing agreements when they have more incremental innovation experience and when they invest in marketing activities more intensively. The findings of this study contribute to the licensing and interfirm cooperation studies. First, this study lays a foundation to understand the organizational learning aspect of technology licensing agreements. Second, this study sheds lights on how a firm's internal investments in R&D and marketing are linked to its tendency to initiate licensing agreements along the innovation process. Finally, the findings of this study provide important insight to managers regarding which technologies to gain via licensing agreements. This study suggests that firms need to consider their internal investments in R&D and marketing as well as their past innovation experiences when they initiate licensing agreements along the process of new product innovation.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2003.10a
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• pp.121-121
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• 2003

The standard protocol for the production of transgenic mouse from ES-injected embryo has to process via chimera producing and several times breeding steps, In contrast, tetraploid-ES cell complementation method allows the immediate generation of targeted murine mutants from genetically modified ES cell clones. The advantage of this advanced technique is a simple and efficient without chimeric intermediates. Recently, this method has been significantly improved through the discovery that ES cells derived from hybrid strains support the development of viable ES mice more efficiently than inbred ES cells do. Therefore, the objective of this study was to generate transgenic mice overexpressing human resistin gene by using tetrapioid-ES cell complementation method. Human resistin gene was amplified from human fetal liver cDNA library by PCR and cloned into pCR 2.1 TOPO T-vector and constructed in pCMV-Tag4C vector. Human resistin mammalian expression plasmid was transfected into D3-GL ES cells by lipofectamine 2000, and then after 8~10 days of transfection, the human resistin-expressing cells were selected with G418. In order to produce tetraploid embryos, blastomeres of diploid embryos at the two-cell stage were fused with two times of electric pulse using 60 V 30 $\mu$sec. (fusion rate : 93.5%) and cultured upto the blastocyst stage (development rate : 94.6%). The 15~20 previously G418-selected ES cells were injected into tetraploid blastocysts, and then transferred into the uterus of E2.5d pseudopregnant recipient mice. To investigate the gestation progress, two El9.5d fetus were recovered by Casarean section and one fetus was confirmed to contain human resistin gene by genomic DNA-PCR. Therefore, this finding demonstrates that tetraploid-ES mouse technology can be considered as a useful tool to produce transgenic mouse for the rapid analysis of gene function in vivo.

• The KIPS Transactions:PartD
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• v.10D no.4
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• pp.567-576
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• 2003

Spatial data mining, i.e., discovery of interesting characteristics and patterns that may implicitly exists in spatial databases, is a challenging task due to the huge amounts of spatial data. Clustering algorithms are attractive for the task of class identification in spatial databases. Several methods for spatial clustering have been presented in recent years, but have the following several drawbacks increase costs due to computing distance among objects and process only memory-resident data. In this paper, we propose an efficient grid cell based spatial clustering method for spatial data mining. It focuses on resolving disadvantages of existing clustering algorithms. In details, it aims to reduce cost further for good efficiency on large databases. To do this, we devise a spatial clustering algorithm based on grid ceil structures including cell relationships.

• The KIPS Transactions:PartC
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• v.14C no.2
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• pp.191-198
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• 2007

A mobile ad-hoc network (MANET) is an autonomous, infrastructure-less system that consists of mobile nodes. In MANET, on demand routing protocols are usually used because network topology changes frequently. AODV, which is a representative on demand routing protocol, operates using the routing table of each node that includes next hop of a route for forwarding packets. It maintains the established route if there is not an expiration of route or any link break. In the paper, we propose a partially adaptive route maintenance scheme (AODV-PA) based on AODV, which provides dynamic route modification of initial route for selecting the effective route using not only next hop but also next-hop of next-hop (i.e. 2-hop next node) acquired through route discovery process. In addition, the proposed scheme additionally manages the routing table for preventing exceptional link breaks by route modification using HELLO messages. We use NS 2 for the computer simulation and validate that the proposed scheme is better than general AODV in terms of packet delivery ratio, latency, routing overhead.

• Toxicological Research
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• v.26 no.1
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• pp.21-28
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• 2010

As the frequency and the intensity of so called Asian dust (AD) events have increased, public concerns about the adverse health effects has spiked sharply over the last two decades. Despite the recent reports on the correlation between AD events and the risk for cardiovascular and respiratory disease, the nature of the toxicity and the degree of the risk are yet largely unknown. In the present study, we investigated the effects of the dichloromethane extract of AD (AD-X) and that of urban dust (NAD-X) collected during a non-AD period on gene expression in HL-60 cells using Illumina Sentrix HumanRef-8 Expression BeadChips. Global changes in gene expression were analyzed after 24 h of incubation with 50 or 100 ${\mu}g$/ml AD-X and NAD-X. By one-way analysis of variance (p < 0.05) and Benjamini-Hochberg multiple testing correction for false discovery rate of the results, 573 and 297 genes were identified as AD-X- and NAD-X-responsive, respectively. The genes were classified into three groups by Venn diagram analysis of their expression profile, i.e., 290 AD-X-specific, 14 NAD-X-specific, and 283 overlapping genes. Quantitative realtime PCR confirmed the changes in the expression levels of the selected genes. The expression patterns of five genes, namely SORL1, RABEPK, DDIT4, AZU1, and NUDT1 differed significantly between the two groups. Following rigorous validation process, these genes may provide information in developing biomarker for AD exposure.

• Communications of Mathematical Education
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• v.24 no.3
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• pp.731-744
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• 2010

Nowadays in school mathematics, the skill and method for solving problems are often emphasized in preference to the theoretical principles of mathematics. Students pay attention to how to make an equation mechanically before even understanding the meaning of the given problem. Furthermore they do not get to really know about the principle or theorem that were used to solve the problem, or the meaning of the answer that they have obtained. In contemporary textbooks the conic section such as circle, ellipse, parabola and hyperbola are introduced as the cross section of a cone. But they do not mention how conic section are connected with the quadratic equation or how these curves are related mutually. Students learn the quadratic equations of the conic sections introduced geometrically and are used to manipulating it algebraically through finding a focal point, vertex, and directrix of the cross section of a cone. But they are not familiar with relating these equations with the cross section of a cone. In this paper, we try to understand the quadratic curves better through the analysis of the discussion made in the process of the discovery and eventual development of the conic section and then seek for way to improve the teaching and learning methods of quadratic curves.

• Korean Journal of Pharmacognosy
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• v.49 no.4
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• pp.328-335
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• 2018

'EGCG(epigallocatechin gallate) rich Green Tea extract(EGTE)' was prepared by a convenient chromatographical manner using water and alcohol which was regarded as the most suitable and appropriate process for food manufacturing. The EGCG content in EGTE was estimated above 97%. Analysis of polyphenol components in green tea, i.e., catechin(C), epigallocatechin(EGC), epicatechin(EC), epigallocatechin gallate(EGCG), epicatechin gallate(ECG) and caffeine was performed by HPLC. The optimized HPLC method exhibited a good linearity of calibration curve, accuracy and precision. The long-term stability evaluation of EGTE was carried out with a powdered formulation and solution formulation by estimating the color change and measuring the EGCG content by HPLC analysis for one year. The EGCG content of the powdered EGTE stored in a transparent bottle at room temperature was retained over 97% at the end of the experimental period. The EGCG content of 0.1% water solution of EGTE stored in a transparent bottle at RT were observed to decrease below 30%, whereas that stored at $2^{\circ}C$ retained over 70%, respectively. These results suggested that a powdered formulation could be recommended for the commercialized nutraceutical product of EGTE rather than a solution formulation.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.70.4-70.4
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• 2019

Complex organic molecules (COMs) are increasingly observed in the environs of young stellar objects (YSOs), including hot cores/corinos around high-mass/low-mass protostars and protoplanetary disks. It is widely believed that COMs are first formed in the ice mantle of dust grains and subsequently released to the gas by thermal sublimation at high temperatures (T>100 K) in strong stellar radiation fields. In this paper, we report a new mechanism that can desorb COMs from icy grain mantles at low temperatures (T<100K), which is termed rotational desorption. The rotational desorption process of COMs comprises two stages: (1) ice mantles on suprathermally rotating grains spun-up by radiative torques (RATs) are first disrupted into small fragments by centrifugal stress, and (2) COMs and water ice then evaporate rapidly from the tiny fragments (i.e., radius a <1nm) due to thermal spikes or enhanced thermal sublimation due to increased grain temperature for larger fragments (a>1 nm). We discuss the implications of rotational desorption for releasing COMs and water ice in the inner region of protostellar envelopes (hot cores and corinos), photodissociation regions, and protoplanetary disks (PPDs). In shocked regions of stellar outflows, we find that nanoparticles can be spun-up to suprathermal rotation due to supersonic drift of neutral gas, such that centrifugal force can be sufficient to directly eject some molecules from the grain surface, provided that nanoparticles are made of strong material. Finally, we find that large aggregates (a~ 1-100 micron) exposed to strong stellar radiations can be disrupted into individual icy grains via RAdiative Torque Disruption (RATD) mechanism, which is followed by rotational desorption of ice mantles and evaporation of COMs. In the RATD picture, we expect some correlation between the enhancement of COMs and the depletion of large dust grains in not very dense regions of YSOs.