• 펄프종이기술
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• 제30권4호
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• pp.18-27
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• 1998

Biopulping is defined as the treatment of wood chips with lignin-degrading fungi prior to pulping. Fungal pretreatment prior to mechanical pulping reduces electrical energy requirements during refining or increases mill throughput, improves paper strength, reduces the pitch content, and reduces the environmental impact of pulping. Our recent work involved scaling up the biopulping process towards the industrial level, investigating both the engineering and economic feasibility. We envision the process to be done in either a chip-pile or silo-based system for which several factors need to be considered: the degree of decontamination, a hospitable environment for the fungus, and the overall process economics. Currently, treatment of the chips with low-pressure steam is sufficient for decontamination and a simple, forced ventilation system maintains the proper temperature, humidity, and moisture conditions, thus promoting uniform growth of the fungus. The pilot-scale trial resulted in the successful treatment of 4 tons of wood chips (dry weight basis) with results comparable to those on a laboratory. Larger, 40-ton trials were also successful, with energy savings and paper properties comparable with the laboratory scale. The overall economics of the process also look very favorable and can result in significant annual savings to the mill. Although the current research has focused on biopulping for mechanical pulping, it is also beneficial for sulfite chemical pulping and some applications to recycled fiber have been investigated.

• The Plant Pathology Journal
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• 제21권1호
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• pp.21-26
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• 2005

Homeotic proteins have pivotal roles during the development of both plant and animals. Many homeotic proteins exert control over cell fate in cells where their genes are not expressed, i.e., in a non-cell autonomous manner. Cell-to-cell communication, which delivers critical information for position-dependent specification of cell fate, is an essential biological process in multicellular organisms. In plants, there are two pathways for intercellular communication that have been identified: the ligand/receptor-mediated apoplastic pathway and the plasmodesmata-mediated symplasmic pathway. Regulatory proteins and RNAs traffic symplasmically via plasmodesmata and play a critical role in intercellular communication. Thus, the non-cell autonomous function of homeotic proteins can be explained by the recent discovery of cell-to-cell trafficking of proteins or RNAs. This article specifically focuses on understanding the intercellular movement of homeodomain proteins, a family of homeotic proteins.

• 한국간호교육학회지
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• 제7권2호
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• pp.207-216
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• 2001

To understand the types of interactions between the nurses' college students and patients, this research used Spradley's Cultural Description Method to carry out his eleven- stage research conduct process : participatory observation, cultural description recording, descriptive observation, category analysis, focus observation, classification analysis, selective observation, components analysis, cultural themes, cultural discovery, and cultural description writing. The research participants were 7 nurses' college students practising at the hospital affiliated to E university, and data were collected from May 2000 through primary and secondary in-depth interviews and observations. The cultural characteristics of the subjects extracted from these results were as follows : 1. The students learned through contacts with patients. 2. The students experienced "Sharing" through interactions with patients. 3. The students showed evasive behaviors in difficult situations. 4. The students paltered when faced with difficult situations. 5. The students did not surrender to the refusals of patients. 6. The students identified their studentship. 7. The students regarded human interaction as 'contact'.

• Journal of Magnetics
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• 제2권3호
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• pp.86-92
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• 1997

An artificially modulated magnetic Co/Pd multilayer is one of the promising candidates for high density magneto-optic (MO) recording media in the wavelength of a blue laser beam, due to large Kerr rotation angle. However, since the Co/Pd multilayer is a non-equilibrium state in terms of free energy and MO recording is a kind of thermal recording which is conducted around Curie temperature (Tc) of the recording media, the assessment of the thermal stability in the Co/Pd multilayer is crucially important both for basic research and applications. As the parameter of the thermal stability in this research, effective interdiffusion coefficients (Deff) perpendicular to the interface of the Co/Pd multilayers are measured in terms of Ar sputtering pressure and heat treatment temperature. From the results of the research, we find out that the magnetic exchange energy between Co and Pd sublayers strongly affects Deff of the Co/Pd multilayers. This discovery will provide the understanding of the magnetic exchange energy in the effective interdiffusion process of a magnetic multilayer structure and suggest the operating temperature range for MO recording in the Co/Pd multilayer for the basic research and applications, respectively.

• 전기의세계
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• 제16권2호
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• pp.1-8
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• 1967

From the discovery of Alago's disk, a number of trials and efforts have been concentrated on a small-sized and light-weighted induction motor. They have devoted themseleves, however, mainly to a improvement of cooling effect, a proper weight-distribution of copper and iron and desirable number of slots. In consequence, such an effort restricted only to the field of design, has resulted in unsatisfactory developments in the insulating materials consisting of the main parts of an induction motor. The quality of fibre and paper which are used as class-A insulation materials with their "compound" and "varnish" has been increased to some extent. Similarly Class-B insulation materials like asbest mica has been almost a combination of inorganic and binding materials. But nowadays synthesic chemistry is making a remarkable progress. So it comes possible for us to have silicon resin and other good ones of similar charateristics. And even a thin silicon resin insures us to get excellent heat-pro f and insulation, so a better space factor and cost-down in motor design have come possible in most advanced nations of the world, but not in our country. Furthermore, a consideration of productivity and economy in manufacturing process has been neglected by a majority of engineers. This is more unpleasant und more undesirable. I think this rational method of induction motor design using new synthesic resin will devote in making your productivity and economy better. And the nation-wide standard value of electric motor size is sited here. size is sited here.

• IMMUNE NETWORK
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• 제22권1호
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• pp.2.1-2.22
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• 2022

Targeting immune evasion via immune checkpoint pathways has changed the treatment paradigm in cancer. Since CTLA-4 antibody was first approved in 2011 for treatment of metastatic melanoma, eight immune checkpoint inhibitors (ICIs) centered on PD-1 pathway blockade are approved and currently administered to treat 18 different types of cancers. The first part of the review focuses on the history of CTLA-4 and PD-1 discovery and the preclinical experiments that demonstrated the possibility of anti-CTLA-4 and anti-PD-1 as anti-cancer therapeutics. The approval process of clinical trials and clinical utility of ICIs are described, specifically focusing on non-small cell lung cancer (NSCLC), in which immunotherapies are most actively applied. Additionally, this review covers the combination therapy and novel ICIs currently under investigation in NSCLC. Although ICIs are now key pivotal cancer therapy option in clinical settings, they show inconsistent therapeutic efficacy and limited responsiveness. Thus, newly proposed action mechanism to overcome the limitations of ICIs in a near future are also discussed.

• 한국정보전자통신기술학회논문지
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• 제12권6호
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• pp.681-689
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• 2019

웹 사용 패턴 발견은 웹 로그 데이터를 사용하는 고급 수단이며 웹 로그 데이터 마이닝에 데이터 마이닝 기술을 적용한 특정 응용이다. 교육 분야에서 데이터 마이닝 (DM)은 데이터 마이닝 기술을 교육 데이터 (대학의 웹 로그, e-러닝, 적응형 하이퍼미디어 및 지능형 튜터링시스템 등)에 적용한다. 따라서 교육 연구 문제를 해결하기 위해 이러한 유형의 데이터를 분석하는 것이 목표이다. 본 논문에서는 대학의 웹 로그 데이터가 데이터 마이닝의 연구 대상으로 사용되어 진다. 데이터베이스 OLAP 기술을 사용하여 웹 로그 데이터가 데이터 마이닝에 사용될 수 있는 데이터 형식으로 사전 처리되고 그 처리 결과가 MSSQL에 저장된다. 동시에 처리 된 웹 로그 레코드를 기반으로 기본 데이터 통계 및 분석이 완료된다. 또한 웹 사용 패턴 마이닝의 Apriori Algorithm 및 구현 프로세스를 소개하고 Python 개발 환경에서 Apriori Algorithm 프로그램을 개발했다. 그런 다음 Apriori Algorithm의 성능을 보이고 웹 사용자 액세스 패턴의 마이닝을 실현했다. 이 연구 결과는 교육 시스템 개발에 패턴을 적용하는데 중요한 이론적 의미를 갖는다. 다음 연구로는 분산 컴퓨팅 환경에서 Apriori Algorithm의 성능 향상을 연구하는 것이다.

• 대한지리학회지
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• 제46권6호
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• pp.767-780
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• 2011

이 논문은 '인정(recognition)'을 통해 인간과 공간의 관계에 대해 살펴보았다. 인정은 인간의 근원적 욕구이다. 인간은 누구든지 어디서나 인정받으려 한다. 자신의 정체성을 강화하고, 자신의 존재이유를 확인받기 위해 인정투쟁을 벌인다. 헤겔이 제시한 '인정'은 주체-객체의 인간관에 근거한 상호인정 과정에 근거한다. 반면에, 서로 주체성을 토대로 하는'인정'은 나와 너의 관계를 토대로'우리'를 강조하는 인간관에 근거한다. '인정'은 인간과 공간의 관계에 대한 새로운 인식을 가능하게 한다. 지금까지 지리학에서 다루었던 보이는 공간에 대한 지리적 인식을 넘어, 보이지 않는 공간에 대한 지리학의 역할을 채근한다. 보이지 않는 공간을 보이게 하는 과정을 통해 지리학의 본질을 회복하는데 기여한다. 목소리가 들리지 않는 공간과 이야기가 쓰여지지 않는 공간에 담겨있는 지리적 의미를 발견하도록 돕는다. 이를 통해 우리 사회의 모순과 부조리한 모습을 고발하고, 본질적으로 문제를 해결할 수 있는 방법을 제시한다. 이같은 논의의 궁극적 목적은 지리학이 당면한 위기를 극복하고, 인문학으로서 세상과 소통하기 위한 것이다.

• 동의생리병리학회지
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• 제31권4호
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• pp.213-219
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• 2017

Atopic dermatitis (AD) is a common skin disease characterized by chronic and relapsing inflammatory dermatitis with immunological disturbances. Spleen deficiency (脾虛) is one of the major causes of AD, so development of animal model is required for AD research that reflects the pattern identification. The groups that we have used in this study included Senna folium extracts (SFE), 2,4-dinitrochlorobenzene (DNCB), and normal mice. Therefore, the present study was developed to atopic dermatitis mouse model with spleen deficiency in 2,4-dinitrochlorobenzene (DNCB) and senna leaves extracts induced AD in NC/Nga mice. The results demonstrated that senna leaves extract treatment significantly increased the dermatitis clinical score and epidermal thickness in AD-like skin lesions. We also proved beyond doubt that there was occurrence of erythema and skin moisture indices in the senna leaves extract groups. Further, we also found that the level of serum immunoglobulin E (IgE) in the senna leaves extract-treated group was increased. The amount of IL-4, IL-13, $TNF-{\alpha}$ and $TGF-{\beta}$ mRNA determined by real-time PCR was increased remarkably when senna leaves extract groups were treated on dorsal skin. Senna leaves extract groups significantly promoted the number of CD11B+/Gr-1 cell in skin, as well as the number of CD4+/CD8+ cell in dorsal skin compared with control. The review summarizes recent process in our understanding of the immunopathophysiology of spleen deficiency AD and the implications for spleen deficiency mouse models of AD on drug discovery from medical plants.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제28권1호
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• pp.97-130
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• 2014

본 연구의 목적은 조립제법 소재의 탐구활동에서 나타난 고등학생들의 사고 과정을 분석하여 유추의 양상을 조사하는 것이다. 인문계 고등학교 1학년 학생 2명을 대상으로 질적 사례연구로 수행되었다. 자료의 분석을 위하여 연구자가 제안한 유사성 분류 틀과 Gentner의 Structure-mapping Model(구조사상 모형, 줄여서 SMM)을 이용하였다. 두 학생 모두 유추를 도구로 사용하여 2차 이상의 조립제법을 발견하였으나, 유추적 사고의 능력에 따라 수학적 발견에 차이를 보였다. 탐구활동 과정에서 표면 유사성은 유추에서 중요한 역할을 수행하였다. 구조 유사성에 근거한 유추는 학생들도 수학자처럼 탐구하고 발견할 수 있도록 하였으며, 체계성의 원리에 의한 유추는 다른 영역에 대한 예측과 설명을 가능하게 하였고, 절차 유사성에 의한 유추는 내면화를 이끌어 냈다. 또한 유추의 성격이 도구적, 발견적이고 또한 반성적이라는 결론을 얻었다.