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Effects of n-Alcohols on the Amino-Proton Chemical Shift and on the Hindered Rotation About N-C (S) Bond of Thioacetamide (Thioacetamide의 아미노 양성자의 화학적 이동과 N-C (S) 결합 주위의 부자유 회전에 미치는 n-알코올 용매 효과)

  • Jong-Ho Choi;Young-Sang Choi;Chang-Ju Yoon
    • Journal of the Korean Chemical Society
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    • v.33 no.2
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    • pp.149-155
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    • 1989
  • 1H-nmr chemical shifts and lineshapes of amino-protons of thioacetamide in n-alcohols were determined. The chemical shifts are discussed by the Reichardt's solvent polarity parameter, $E_T(30)$. The following relationship between ${delta}_{obs}\;and\;E_T(30)$ was obtained, ${\delta}_{obs}=a{\cdot}E_T(30)+b{\cdot}(E_T(30))_2$ where a is a characteristic constant for the protons of thioacetamide in n-alcohol solutions and b is a constant for the solute(TA)-solvent (n-alcohols) interactions. The barrier of the hindered rotation about the N-C(S) bond in TA was obtained by analysis of the lineshape of the amino-protons in TA. The behavior of the hindered rotation as well as chemical shifts of the amino-protons in TA has been found to be closely related to the $E_T(30)$ of n-alcohols.

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The biblographical study on $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine -(Comparative study between Oriental and Western Medicine)- (두풍(頭風)과 편두통(Migraine)에 대(對)한 동서의학적(東西醫學的) 문헌고찰(文獻考察))

  • Oh, So-Jeo;Jeong, Ji-Cheon;Lee, Won-Chul
    • The Journal of Internal Korean Medicine
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    • v.14 no.1
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    • pp.129-138
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    • 1993
  • This report on the $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine comes to conclude, through the study of the Oriental- Western medical references, as follow; 1. First, $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine had some concurrencies that both the two symptoms have appeared severe and recurrent headache and more often to the female. 2 Many of them e.g. Sensory disturbance, Vertigo, Nausea, Vomiting, Tinnitus etc. in the prodrome and main symptom of $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine were identical, especially the symptom of the $f{\bar{e}}ng\;t{\acute{a}}n\;t{\acute{o}}u\;t{\grave{o}}ng$ was similar to the prodrome of the Migraine. We could find out the semilarity of the symptoms through that Migraine is proximately set in unilateral, and $Pi{\bar{a}}nT{\acute{o}}u\;f{\bar{e}}ng$ is so called alias $B{\grave{a}}n\;bi{\bar{a}}n\;t{\acute{o}}u\;t{\grave{o}}ng$. 3. The pathogeny of $T{\acute{o}}u\;f{\bar{e}}ng$ include the case of ‘$f{\bar{e}}ng\;xi{\acute{e}}\;r{\grave{u}}\;n{\bar{a}}o$’, the patient feeling weak condition, $T{\acute{a}}n,\;T{\acute{a}}nshi,\;T{\acute{a}}nhu{\breve{o}},\;Y{\grave{u}}q{\grave{i}}$, etc. and, ‘$t{\acute{a}}n\;zhu{\grave{o}}\;sh{\grave{a}}ng\;y{\acute{a}}o$’, ‘$G{\bar{a}}n\;y{\acute{a}}ng\;hu{\grave{a}}\;f{\bar{e}}ng$’. There were variable that $F{\bar{e}}ng,\;Xu{\grave{e}},\;F{\bar{e}}ngr{\grave{a}},\;F{\bar{e}}ngx{\bar{u}},\;Xu{\grave{e}}x{\bar{u}},\;Hu{\check{o}}$ in the left, and $t{\acute{a}}n,\;R{\grave{e}},\;t{\acute{a}}nr{\grave{e}},\;Qir{\acute{a}}$ in the right partial pathogeny. It was referred $Sh{\grave{a}}o\;y{\acute{a}}ng\;j{\bar{i}}ng$, $Ju{\acute{e}}\;y{\bar{i}}n\;j{\bar{i}}ng$, $Y{\acute{a}}ng\;m{\acute{i}}ng\;j{\bar{i}}ng$, $T{\grave{a}}i\;y{\acute{a}}ng\;j{\bar{i}}ng$ in connection with the Meridian system. And otherwise the primary cause of Migraine is still unknown to us. Heredity is probably important, but the mode of transmission is uncertain. Recently, the important assumption is the vasomotor change caused by vasoconstrictors like that norepinephrine, epinephrine, and serotonin etc.

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Sn2/E2 Branching in Protic Solvents: A Mechanistic Study

  • Oh, Young-Ho;Im, Suk;Park, Sung-Woo;Lee, Sung-Yul;Chi, Dae-Yoon
    • Bulletin of the Korean Chemical Society
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    • v.30 no.7
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    • pp.1535-1538
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    • 2009
  • We present calculations for $S_N$2/E2 reactions in protic solvents (t-butyl alcohol, ethylene glycol). We focus on the role of the hydroxyl (-OH) groups in determining the $S_N$2/E2 rate constants. We predict that the ion pair E2 mechanism is more favorable than the naked ion E2 reaction in ethylene glycol. E2 barriers are calculated to be much larger (~ 9 kcal/mol) than $S_N$2 reaction barriers in protic solvents, in agreement with the experimental observation [Kim, D. W. et al. J. Am. Chem. Soc. 2006, 128, 16394] of no E2 products in the reaction of CsF in t-butyl alcohol.

Solubilization of Mixture of Hydrocarbon Oils by C12E8 Nonionic Surfactant Solution (C12E8 비이온 계면활성제 수용액에 의한 탄화수소 오일 혼합물의 가용화 특성에 관한 연구)

  • Lim, JongChoo
    • Applied Chemistry for Engineering
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    • v.19 no.1
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    • pp.59-65
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    • 2008
  • The equilibrium solubilization capacity of the mixture of hydrocarbon oils by $C_{12}E_8$ nonionic surfactant micellar solution was measured at $23^{\circ}C$ by gas chromatography (GC) analysis. Experimental results indicated that the solubilization capacity for pure alkanes was found to decrease almost linearly with the alkane carbon number (ACN) of the hydrocarbon oil. For the binary mixture systems of the hydrocarbon oils both selective and nonselective solubilization behaviors were observed depending on the difference in ACN of the two hydrocarbon oils. Equilibrium solubilization tests for the hydrocarbon oil mixtures in $C_{12}E_8$ surfactant solutions such as the three n-octane/n-nonane, n-nonane/n-decane and n-decane/n-undecane mixture systems suggest almost non-selective solubilization. On the other hand, the n-octane/n-decane and n-octane/n-undecane systems, where difference in ACN of the two hydrocarbon oils is greater than 1, selective solubilization in favor of n-octane was conclusively demonstrated.

THE NORMING SET OF A SYMMETRIC n-LINEAR FORM ON THE PLANE WITH A ROTATED SUPREMUM NORM FOR n = 3, 4, 5

  • Sung Guen Kim
    • Communications of the Korean Mathematical Society
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    • v.39 no.3
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    • pp.693-715
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    • 2024
  • Let n ∈ ℕ, n ≥ 2. An element (x1, . . . , xn) ∈ En is called a norming point of T ∈ 𝓛(nE) if ||x1|| = ··· = ||xn|| = 1 and |T(x1, . . . , xn)| = ||T||, where 𝓛(nE) denotes the space of all continuous n-linear forms on E. For T ∈ 𝓛(nE), we define Norm(T) = {(x1, . . . , xn) ∈ En : (x1, . . . , xn) is a norming point of T}. Norm(T) is called the norming set of T. Let $0{\leq}{\theta}{\leq}{\frac{{\pi}}{4}}$ and ${\ell}^2_{{\infty},{\theta}}={\mathbb{R}}^2$ with the rotated supremum norm $${\parallel}(x,y){\parallel}_{({\infty},{\theta})}={\max}\{{\mid}x\;cos\;{\theta}+y\;sin\;{\theta}{\mid},\;{\mid}x\;sin\;{\theta}-y\;cos\;{\theta}|\}$$. In this paper, we characterize the norming set of T ∈ 𝓛(n2(∞,θ)). Using this result, we completely describe the norming set of T ∈ 𝓛s(n2(∞,θ)) for n = 3, 4, 5, where 𝓛s(n2(∞,θ)) denotes the space of all continuous symmetric n-linear forms on ℓ2(∞,θ). We generalizes the results from [9] for n = 3 and ${\theta}={\frac{{\pi}}{4}}$.

A Basic Study on the Pattern Distribution of $Wux{\'{\i}}ngr{\'{e}}n$ [五行人] (오행인 유형분류를 위한 기초연구 - <영추(靈樞)${\cdot}$음양이십오인(陰陽二十五人)>을 중심으로)

  • Han, Kyung-Sook;Nam, Tong-Hyun;Kim, Tae-Hee;Park, Young-Bae
    • The Journal of the Society of Korean Medicine Diagnostics
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    • v.10 no.2
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    • pp.31-42
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    • 2006
  • Background and Purpose : The concept of $Wux{\'{\i}}ng$(五行) is central to all elements of the Koran traditional medicine. And $Wux{\'{\i}}ng$ is considered to one of the constitution theories in some of oriental medicine fields in South Korea. The aim of this study is to find necessary and concrete estimation factors for distributing patterns of $Wux{\'{\i}}ngr{\'{e}}n$(五行人) respectively. Methods : We translated and summarized the records about distinguishing characteristics and distributing points of Wu-Xing Ren described in <$L{\'{\i}}ngshu$(靈樞)${\cdot}$Yin-Y${\'{a}}$ng ${\`{e}}rsh{\'{\i}}wur{\'{e}}n$(陰陽二十五人)>. Some review articles were identified through searches of KISS and KERIS databases. Results and Conclusion : Concrete distinguishing characteristics and distributing points of Wu-Xing Ren were described in <$Lingshu{\cdot}Yin-Y{\'{a}}ng\;{\`{e}}rsh{\'{\i}}wur{\'{e}}n$>. According to <$Lingshu{\cdot}Yin-Y{\'{a}}ng\;{\`{e}}rsh{\'{\i}}wur{\'{e}}n$>, the most notable characteristics and distributing points are the skin color and shape of face. but the skin color and shape of face are too ambiguous to be used as distributing criteria in a practical manner. In stead size of head, longitudinal length of back, disposition, and width between both shoulders may be used as distributing criteria in practical clinic fields.

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A useful material isolation from the Bombycis corpus (Beauveria bassiana) growing of the silkworm, Bombyx mori L. (백강잠(Bombysis corpus)으로부터 유용물질 분리)

  • 정이연;남성희;홍인표;유승헌;권학철;이강노
    • Journal of Sericultural and Entomological Science
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    • v.45 no.1
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    • pp.25-30
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    • 2003
  • This study was carried out to investigate active constituents of Bombysis corpus on the neurite outgrowth from PC 12 cells led to isolate three new and a known sphingolipids from the n-hexane soluble portion and five amines from the butanol soluble portion of its methanol extract. On the basis of spectroscopic data, their structures have been elucidated as (4E,6E,2S,3R)-2-N-eicosanoyl-4,6-tetradecasphingadienine, (4E,2S,3R)-2-N-eicosanoyl-4-tetradecasphingenine,(4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine,(4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine,(4E,2S,3R)-2-N-octadecanoyl-4-tetradecasphingenine, 1,7-dimethyl-xanthine, uracil, urea, betaine and tyrosine, respectively. The neurite outgrowth activities of these compounds were examined in PC12 cells by measuring the length of neurites. These compounds promoted neurite outgrowth in PC12 cells significantly.

Existence and Uniqueness of Fuzzy Solutions for the nonlinear Fuzzy Integro-Differential Equation on EnN

  • Kwun, Young-Chel;Han, Chang-Woo;Kim, Seon-Yu;Park, Jong-Seo
    • International Journal of Fuzzy Logic and Intelligent Systems
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    • v.4 no.1
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    • pp.40-44
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    • 2004
  • In this paper we study the existence and uniqueness of fuzzy solutions for the nonlinear fuzzy integro-differential equations on $E^{n}_{N}$ by using the concept of fuzzy number of dimension n whose values are normal, convex, upper semicontinuous and compactly supported surface in $E^{n}_{N}$. $E^{n}_{N}$ be the set of all fuzzy numbers in $R^{n}$ with edges having bases parallel to axis $x_1$, $x_2$, …, $x_n$.

A NEW LOWER BOUND FOR THE VOLUME PRODUCT OF A CONVEX BODY WITH CONSTANT WIDTH AND POLAR DUAL OF ITS p-CENTROID BODY

  • Chai, Y.D.;Lee, Young-Soo
    • Honam Mathematical Journal
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    • v.34 no.3
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    • pp.403-408
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    • 2012
  • In this paper, we prove that if K is a convex body in $E^n$ and $E_i$ and $E_o$ are inscribed ellipsoid and circumscribed ellipsoid of K respectively with ${\alpha}E_i=E_o$, then $\[({\alpha})^{\frac{n}{p}+1}\]^n{\omega}^2_n{\geq}V(K)V({\Gamma}^{\ast}_pK){\geq}\[(\frac{1}{\alpha})^{\frac{n}{p}+1}\]^n{\omega}^2_n$. Lutwak and Zhang[6] proved that if K is a convex body, ${\omega}^2_n=V(K)V({\Gamma}_pK)$ if and only if K is an ellipsoid. Our inequality provides very elementary proof for their result and this in turn gives a lower bound of the volume product for the sets of constant width.

Design, Synthesis and Biological Activity of Certain 3,4-Disubstituted-5-mercapto-1,2,4-triazoles and Their Hydrazino Derivatives

  • Udupi, R.H.;Sudheendra, Sudheendra;Bheemachari, Bheemachari;Srinivasulu, N.;Varnekar, Rajesh;Purushottamachar, Puranik
    • Bulletin of the Korean Chemical Society
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    • v.28 no.12
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    • pp.2235-2240
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    • 2007
  • 3-Aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-mercapto-1,2,4-triazoles (3a1-a14) were prepared starting from potassium dithio carbazinates (2a1-a14). These triazoles were then employed in the synthesis of 3-aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-hydrazino-1,2,4-triazoles (4a1-a14). All the newly synthesized compounds were characterized by analytical, IR, NMR spectral studies. The compounds were screened for their antibacterial, antifungal, anti-inflammatory and analgesic properties. Most of the compounds have shown significant antifungal activity while few have shown excellent anti-inflammatory and analgesic activity. An attempt is made to study the structure activity relationship (SAR).